Home About us Contact
|
Home About us Contact | ||
|
|
||
Detailed Information (detailed + information)
Selected AbstractsThe Network Perspective: An Integration of Attachment and Family Systems Theories,FAMILY PROCESS, Issue 3 2002FRANZCP, Kasia Kozlowska MBBS In this article we discuss the network paradigm as a useful base from which to integrate attachment and family systems theories. The network perspective refers to the application of general systems theory to living systems, and provides a framework that conceptualizes the dyadic and family systems as simultaneously distinct and interconnected. Network thinking requires that the clinician holds multiple perspectives in mind, considers each system level as both a part and a whole, and shifts the focus of attention between levels as required. Key epistemological issues that have hindered the integration of the theories are discussed. These include inconsistencies within attachment theory itself and confusion surrounding the theoretical conceptualizations of the relationship between attachment and family systems theories. Detailed information about attachment categories is provided using the Dynamic Maturational model. Case vignettes illustrating work with young children and their families explore the clinical implications of integrating attachment data into family therapy practice. [source] The upper continental crust, an aquifer and its fluid: hydaulic and chemical data from 4 km depth in fractured crystalline basement rocks at the KTB test siteGEOFLUIDS (ELECTRONIC), Issue 1 2005I. STOBER Abstract Detailed information on the hydrogeologic and hydraulic properties of the deeper parts of the upper continental crust is scarce. The pilot hole of the deep research drillhole (KTB) in crystalline basement of central Germany provided access to the crust for an exceptional pumping experiment of 1-year duration. The hydraulic properties of fractured crystalline rocks at 4 km depth were derived from the well test and a total of 23100 m3 of saline fluid was pumped from the crustal reservoir. The experiment shows that the water-saturated fracture pore space of the brittle upper crust is highly connected, hence, the continental upper crust is an aquifer. The pressure,time data from the well tests showed three distinct flow periods: the first period relates to wellbore storage and skin effects, the second flow period shows the typical characteristics of the homogeneous isotropic basement rock aquifer and the third flow period relates to the influence of a distant hydraulic border, probably an effect of the Franconian lineament, a steep dipping major thrust fault known from surface geology. The data analysis provided a transmissivity of the pumped aquifer T = 6.1 × 10,6 m2 sec,1, the corresponding hydraulic conductivity (permeability) is K = 4.07 × 10,8 m sec,1 and the computed storage coefficient (storativity) of the aquifer of about S = 5 × 10,6. This unexpected high permeability of the continental upper crust is well within the conditions of possible advective flow. The average flow porosity of the fractured basement aquifer is 0.6,0.7% and this range can be taken as a representative and characteristic values for the continental upper crust in general. The chemical composition of the pumped fluid was nearly constant during the 1-year test. The total of dissolved solids amounts to 62 g l,1 and comprise mainly a mixture of CaCl2 and NaCl; all other dissolved components amount to about 2 g l,1. The cation proportions of the fluid (XCa approximately 0.6) reflects the mineralogical composition of the reservoir rock and the high salinity results from desiccation (H2O-loss) due to the formation of abundant hydrate minerals during water,rock interaction. The constant fluid composition suggests that the fluid has been pumped from a rather homogeneous reservoir lithology dominated by metagabbros and amphibolites containing abundant Ca-rich plagioclase. [source] Assessing functional health status in adults with haemophilia: towards a preliminary core set of clinimetric instruments based on a literature search in Rheumatoid Arthritis and OsteoarthritisHAEMOPHILIA, Issue 4 2005P. De Kleijn Summary., People with haemophilia experience a progressive deterioration of their functional health status. Regular clinical assessment of functional health status provides insight into their process of disablement. As such, the development of a core-set of measurement tools is warranted. The aim of this study was to gather data to prepare a (preliminary) core set of clinically relevant and feasible instruments to assess the functional health status of adults with haemophilia, and to indicate their psychometric qualities. Therefore, clinimetric instruments frequently used in two haemophilia-resembling diseases (Rheumatoid Arthritis and Osteoarthritis) were reviewed from the literature. An extensive search in Medline yielded 13 relevant review articles, incorporating a total of 182 instruments, of which 40 were appropriate for haemophilia. Of these 40 instruments 3 measure body structures, 13 body functions, 19 activities (of which 5 are performance based and 14 self-report based), and 3 measure participation. This classification is based on the International Classification of Functioning, Disability and Health. Detailed information regarding the psychometrics (reliability, validity and responsiveness) of four instruments is described fully in the literature, whereas the psychometrics of the majority of the other instruments are only partly described. The results of this literature study may contribute to the formation of a (preliminary) core set of clinimetric instruments to assess the functional health status of adults with haemophilia. Decisions on the final core set should be held within the Musculoskeletal Committee of the World Federation of Haemophilia. [source] Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition CohortINTERNATIONAL JOURNAL OF CANCER, Issue 10 2006Karen Steindorf Abstract Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50,0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54,0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20,2.05) and men with standing occupations (RR = 1.35; 1.02,1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. © 2006 Wiley-Liss, Inc. [source] Data transmission over analog TV broadcastingINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 4 2008Christos S. Koukourlis Abstract The implementation of a contemporary method that enables the transmission of digital information at a rate of 2,Mbps over TV signal using the existing broadcasting infrastructure is described. Detailed information on the prototype hardware is given along with experimental results that prove the validity of the proposed method. Finally, a concept for including the method to the existing TV broadcasting network is proposed. Copyright © 2007 John Wiley & Sons, Ltd. [source] Husbandry and breeding of the Striped possum Dactylopsila trivirgata at London ZSLINTERNATIONAL ZOO YEARBOOK, Issue 1 2005A. McKENNA Detailed information on either wild or captive Striped possums Dactylopsila trivirgata (Gray, 1858) is sparse. In 1996 a number of specimens became available to the European Monotreme and Marsupial Taxon Advisory Group (TAG), which recommended that the animals should be distributed to three zoos (London ZSL, Poznan Zoo and Berlin Zoologischer Garten) so that a management and breeding protocol could be developed in case this fairly common species becomes threatened in the future. London ZSL acquired 3.3 Striped possums to establish a founder captive population and two joeys were born, one in April 1999 and the other in March 2000. This article charts the husbandry protocols, breeding behaviour and infant development for Striped possums in captivity. [source] Feeding Practices of Dog and Cat Owners Reflect Attitudes Toward Pet FoodsJOURNAL OF ANIMAL PHYSIOLOGY AND NUTRITION, Issue 11-12 2005K. N. Willoughby The PET DINER study was a telephone survey conducted to better understand why pet owners make certain nutritional decisions for their pets. Both dog and cat owners were included, which allowed us to differentiate the way people feed pet cats vs. pet dogs and how that might reflect owners' attitudes about pet foods. Prospective survey respondents were selected from local telephone books using a randomized process. A total of 18,194 calls were made from the five study sites between May and August, 2004. 1074 people (6%) representing 619 dogs and 455 cats completed the survey. Detailed information about feeding practices was collected. Pet owners' perceptions were assessed based on agreement/disagreement with statements regarding pet foods and the pet food industry. The Mann,Whitney Rank Sum test was used to detect differences between dog and cat owners and the Kruskal,Wallis one-way analysis of variance on ranks was used to evaluate differences among pet owners based on both type of pet and feeding practices (,75% commercial vs. ,50% home-prepared diets). More cats than dogs ate commercial pet food as ,75% of their main diet (96% vs. 87%, respectively; p < 0.001), and more dogs than cats ate a home-prepared food as ,50% of their main diet (6% vs. 3%, respectively; p < 0.009). For five of the statements, a difference in the attitudes of cat vs. dog owners was detected (p < 0.05). In general, this reflected more positive attitudes regarding commercial foods and less positive attitudes regarding home-prepared foods on the part of cat vs. dog owners. Analysis based on both type of pet and feeding practices identified significant differences among groups for 18/26 statements. However, when the Dunn's Method for pairwise multiple comparisons was applied, significant differences were due to feeding practices rather than type of pet for 17/18 statements. Only differences in attitudes about the statement ,raw bones can be safely fed to pets' remained significant for cat vs. dog owners feeding commercial foods. In conclusion, more cat owners than dog owners feed ,75% commercial foods to their pets and this is reflected in different attitudes about the nutritional soundness of commercial pet foods. [source] Cloning and comparison of phylogenetically related chitinases from Listeria monocytogenes EGD and Enterococcus faecalis V583JOURNAL OF APPLIED MICROBIOLOGY, Issue 6 2009J.J. Leisner Abstract Aims:, To compare enzymatic activities of two related chitinases, ChiA and EF0361, encoded by Listeria monocytogenes and Enterococcus faecalis, respectively. Methods and Results:, The chiA and EF0361 genes were amplified by PCR, cloned and expressed with histidine tags, allowing easy purification of the gene products. ChiA had a molecular weight as predicted from the amino acid sequence, whereas EF0361 was 1840 Da lower than expected because of C-terminal truncation. The ChiA and EF0361 enzymes showed activity towards 4-nitrophenyl N,N,-diacetyl-,- d -chitobioside with Km values of 1·6 and 2·1 mmol l,1, respectively, and kcat values of 21·6 and 6·5 s,1. The enzymes also showed activity towards 4-nitrophenyl ,- d - N, N,, N,-triacetylchitotriose and carboxy-methyl-chitin-Remazol Brilliant Violet but not towards 4-nitrophenyl N- acetyl-,- d -glucosaminide. Chitinolytic specificities of the enzymes were supported by their inactivity towards the substrates 4-nitrophenyl ,- d -cellobioside and peptidoglycan. The pH and temperature profiles for catalytic activities were relatively similar for both the enzymes. Conclusion:, The ChiA and EF0361 enzymes show a high degree of similarity in their catalytic activities although their hosts share environmental preferences only to some extent. Significance and Impact of the Study:, This study contributes to an understanding of the chitinolytic activities by L. monocytogenes and Ent. faecalis. Detailed information on their chitinolytic systems will help define potential reservoirs in the natural environment and possible transmission routes into food-manufacturing plants. [source] Effect of selective logging on forest structure and nutrient cycling in a seasonally dry Brazilian Atlantic forestJOURNAL OF BIOGEOGRAPHY, Issue 3 2006Dora Maria Villela Abstract Aim, The Brazilian Atlantic forest covers c. 10% of its original extent, and some areas are still being logged. Although several ecological studies in Atlantic forest have been published over the past two to three decades, there has been little research on forest dynamics and there is a particular lack of information on the effects of disturbance. The aim of the present study was to assess the impact of selective logging on forest structure, floristic composition soil nutrients, litterfall and litter layer in a seasonally dry Atlantic forest. Location, The Mata do Carvão is located in the Guaxindiba Ecological Reserve in São Francisco do ltabapoana district (21°24, S, 41°04, W), Rio de Janeiro, Brazil. Methods, Four plots (50 × 50 m) were set up in 1995 in each of two stands: unlogged and logged. In each plot, all trees , 10 cm d.b.h. were enumerated, identified and measured. Vouchers were lodged at UENF Herbarium. Five surface soil samples were collected in each plot in the dry season (in October 1995). Litterfall was collected in eight traps (0.50 m2) in each plot over a year from 14 November 1995 to 11 November 1996. The litter layer was sampled in eight quadrats (0.25 m2) in each plot in the dry and wet seasons. Soils were air-dried, sieved, and chemically analysed. The litter was dried (80 °C), sorted into six fractions, weighed and bulked samples analysed for nutrients. Results, Forest stands did not differ in stem density and total basal area, with a total of 1137 individuals sampled in 1996 (564 unlogged and 573 logged), and a total basal area of 15 m2 (unlogged) and 13.0 m2 (logged). However, unlogged stands had more large trees (, 30 cm in d.b.h.) and greater mean canopy height. Among the families, Rutaceae and Leguminosae were the most abundant families in both sites, although the Rutaceae had a higher density in unlogged and Leguminosae in the logged stand. The species diversity index was similar between stands. Late-successional species, such as Metrodorea nigra var. brevifolia and Paratecoma peroba, were less abundant in the logged stand. Selective logging did not affect nutrient concentrations in the soil or in the litter. However, quantities of the nutrients in the total litterfall and in the leaf litterfall and litter layer were higher in unlogged than in logged stands, mainly as a result of fallen M. nigra leaves. Metrodorea nigra was considered a key species in the nutrients dynamics in Carvão forest. Main conclusions, Despite the fact that effects on tree diversity and soil nutrients were not clear, selective logging in this Atlantic forest altered canopy structure, increased the relative abundance of some early-secondary species and decreased the litter input and stock of nutrients. Detailed information on the influence of logging on the distribution and structure of plant populations and in nutrient processes is fundamental for a sustainable logging system to be developed. [source] Contrasting effects of grazing and hay cutting on the spatial and genetic population structure of Veratrum album, an unpalatable, long-lived, clonal plant speciesJOURNAL OF ECOLOGY, Issue 2 2002David Kleijn Summary 1 ,Vegetation change induced by large herbivores is driven by the effects of grazers on populations of individual plant species. Short-term experimental or demographic studies may be insufficient when investigating the population responses of long-lived clonal plant species. 2 ,We therefore examined the effects of grazing on such a plant (Veratrum album) by comparing the spatial and genetic structure of populations in grasslands subject to long-term grazing or mowing for hay. 3 , V. album is a locally dominant species that is avoided by large herbivores due to its toxicity. RAPD-phenotypes of a subsample of c. 50 shoots, and co-ordinates and dry weight of all shoots, were determined in a 5 × 10 m plot in each of four meadow and four pasture populations. 4 ,The breeding system of the genus Veratrum was previously unknown but our experimental finding that cross-pollinated but not self-pollinated or unpollinated flowers produced as many seeds as freely pollinated flowers suggested that V. album is a predominantly cross-pollinating species. 5 ,Both the spatial and genetic population structure differed markedly between the two grassland types. Clonal expansion of established plants in pastures led to populations consisting of larger shoots that were significantly more aggregated at a small spatial scale. Populations also had a higher proportion of flowering shoots, less seedling recruitment and a lower genotypic diversity in pastures than hay meadows. 6 ,The differences in population structure appear to be due to hay meadow populations reproducing primarily by seeds, whereas clonal reproduction accounts for half of the population growth in pastures. We suggest that, as livestock selectively avoids V. album shoots, grazing indirectly promotes plant growth, which results in an enhanced vegetative reproduction as well as a higher seed production. Experimental studies are, however, needed to determine why and how grazing adversely affects seedling recruitment. 7 ,Detailed information on population level responses of unpalatable dominant plant species, such as provided by the present study, may help us understand and predict vegetation change in response to changing levels of herbivory. [source] Dietary habits and health status of African-Caribbean adultsJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 3 2010J. Earland Abstract Background:, Although African-Caribbeans in the UK are more likely to suffer from a number of diet-related health conditions, including obesity, hypertension and type II diabetes, there have been few dietary studies on this group. The present study is based on a small survey of food and nutrient intakes and traditional dietary habits of African-Caribbean adults living in Staffordshire. Methods:, A questionnaire, designed to collect demographic data and information on medical status, physical activities, dietary, cooking and food shopping habits was administered to a convenience sample of 39 adults. Detailed information on food intakes was gathered using a modified existing Food Frequency Questionnaire with 169 items. Height and weight were measured for the calculation of body mass index. Results:, The average age of the subjects was 47 years (range 19,65 years). The prevalence of obesity was 39% and one-third of subjects reported having at least one health condition. Physical activities, outside of work, were undertaken by 95% of the sample. Traditional foods were used by 92% of respondents, including fruit and vegetables purchased at markets outside of their local area. A wide variety of foods were consumed and the percentages of energy provided by fats and carbohydrates (30% and 53%, respectively) appeared to be meeting government recommendations. However, absolute energy intakes were high and salt consumption, often in the form of commercial seasonings, exceeded government recommendations. Conclusions:, The positive aspects of the diets of this population need to be encouraged. Interventions need to focus on ways of reducing total energy intakes, as well as levels of salt consumption. [source] Sorption of HOC in soils with carbonaceous contamination: Influence of organic-matter compositionJOURNAL OF PLANT NUTRITION AND SOIL SCIENCE, Issue 3 2005Kerstin Abelmann Abstract Detailed information about structure and composition of organic sorbents is required to understand their impact on sorption capacity and sorption kinetic of organic pollutants. Therefore, the chemical composition of organic material from 18 geosorbents was investigated by solid-state 13C nuclear-magnetic-resonance (NMR) spectroscopy. Structural parameters such as aromaticity, polarity, and alkyl-C content were related to the Freundlich sorption exponent (1/n) and the sorption coefficient . The geosorbents included three natural and four combusted coals (carbonaceous material), three Histosols, five mineral soils from Germany containing inputs of technogenic carbonaceous material, derived from industrial activities, and four non-contaminated mineral soils from Germany. Equilibrium sorption was measured for five hydrophobic organic compounds and analyzed with the solubility-normalized Freundlich sorption isotherm. With increasing maturation degree, the proportion of polar constituents decreases from the natural soils to the coals. In contrast to the non-polluted mineral soils, the soils with technogenic input are characterized by high aromaticity and low polarity. A positive correlation between sorption coefficient and aromaticity was found. The Freundlich exponent (1/n) is negatively correlated with the aromaticity, denoting an increase of adsorption processes with increasing aromaticity. Likewise, the contribution of partitioning decreases. This sorption mechanism predominates only if the organic matter in the samples contains a high proportion of polar compounds. Sorption von HOC in Böden mit kohleartiger Kontamination: Einfluss der Zusammensetzung des organischen Materials Um den Einfluss von organischen Sorbenten auf die Sorptionskapazität und die Kinetik organischer Schadstoffe zu verstehen, müssen detaillierte Informationen über deren Struktur und Zusammensetzung vorliegen. Aus diesem Grund wurde das organische Material von 18 Geosorbenten mittels der Festkörper- 13C-NMR-Spektroskopie untersucht. Strukturelle Parameter wie zum Beispiel die Aromatizität, die Polarität und der Alkyl-C-Gehalt wurden mit dem Freundlich-Exponenten 1/n und dem Sorptionskoeffizienten korreliert. Die Geosorbenten bestehen aus drei natürlichen und vier thermisch behandelten Kohlen, drei Histosolen und fünf deutschen Mineralböden, die technogenes kohlehaltiges Material aus industriellen Aktivitäten enthalten, sowie vier nicht kontaminierten deutschen Böden. Die Gleichgewichtssorption wurde für fünf hydrophobe, organische Verbindungen gemessen und mit Hilfe der löslichkeitsnormalisierten Freundlich-Isotherme analysiert. Der Anteil der polaren Komponenten nimmt von den natürlichen Böden zu den Kohlen mit zunehmendem Inkohlungsstadium ab. Im Gegensatz zu den nicht kontaminierten Mineralböden weisen die Böden mit technogenen Bestandteilen eine hohe Aromatizität und eine geringe Polarität auf. Zwischen dem und der Aromatizität ergab sich ein positiver Zusammenhang. Der Freundlich Exponent (1/n) korreliert negativ mit der Aromatizität. Dies weist auf eine Zunahme der Adsorptionsprozesse mit Erhöhung der Aromatizität hin. Der Beitrag der Partitionierung sinkt ebenfalls. Dieser Sorptionsmechanismus dominiert nur in den Proben, in denen das organische Material einen hohen Anteil polarer Bestandteile besitzt. [source] Acrylonitrile-Butadiene Rubber (NBR) Prepared via Living/Controlled Radical Polymerization (RAFT)MACROMOLECULAR RAPID COMMUNICATIONS, Issue 18 2010Andreas Kaiser Abstract In the current work we present results on the controlled/living radical copolymerization of acrylonitrile (AN) and 1,3-butadiene (BD) via reversible addition fragmentation chain transfer (RAFT) polymerization techniques. For the first time, a solution polymerization process for the synthesis of nitrile butadiene rubber (NBR) via the use of dithioacetate and trithiocarbonate RAFT agents is described. It is demonstrated that the number average molar mass, , of the NBR can be varied between a few thousand and 60,000,g,·,mol,1 with polydispersities between 1.2 and 2.0 (depending on the monomer to polymer conversion). Excellent agreement between the experimentally observed and the theoretically expected molar masses is found. Detailed information on the structure of the synthesized polymers is obtained by variable analytical techniques such as infrared spectroscopy (IR), nuclear magnetic resonance (NMR) spectroscopy, differential scanning calorimetry, and electrospray ionization-mass spectrometry (ESI-MS). [source] Risk factors for asthma among children in Maputo (Mozambique)ALLERGY, Issue 4 2004S. Mavale-Manuel Background:, Few studies have looked at risk factors for asthma in African children. We aimed to identify the risk factors associated with childhood asthma in Maputo (Mozambique). Methods:, This case,control study included 199 age-matched children (100 asthmatic and 99 nonasthmatic) who attended Maputo Central Hospital between January 1999 and July 2000. We collected information concerning their familial history of atopy, birth weight, environment and breast-feeding. Detailed information about morbidity and treatment was obtained for each asthmatic child. Results:, The children were aged between 18 months and 8 years; 60% were male. The asthmatic children were hospitalized more frequently than the nonasthmatic children (P < 0.0001). Most of the asthmatic children lived in the urban area of Maputo [odd ratio (OR) = 6.73, CI = 3.1,14.0, P < 0.0001], had a parental history of asthma (OR = 26.8, CI = 10.8,68.2, P < 0.0001) or rhinitis (OR = 4, CI = 1.2,13.3, P = 0.005), had at least parent who smoked and were weaned earlier than the nonasthmatic children (OR = 2.4, CI = 1.3,4.4, P < 0.001). Conclusion:, Childhood asthma was strongly associated with a family history of asthma and rhinitis, the place of residence, having smokers as parents and early weaning from maternal breast milk. These results highlight the need to reassess the management of asthmatic children in Maputo. [source] Complaints related to respiratory events in anaesthesia and intensive care medicine from 1994 to 1998 in DenmarkACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 1 2001C. Rosenstock Background: In Denmark, a National Board of Patients' Complaints (NBPC) was founded in 1988. This study analyses anaesthetic complaints related to adverse respiratory events filed at the NBPC from 1994 to 1998 to point out directions for possible preventive measures. Methods: All decisions made by the NBPC from 1994 to 1998 concerning personnel employed in the Danish health care system were scrutinized. Cases related to anaesthesia and intensive care medicine were reviewed. Adverse respiratory events were identified and classified by mechanism of the incident that had caused the complaint. Detailed information on anaesthetic technique, personnel involved, sequence of events, clinical manifestation of injury, and outcome was recorded. Results: A total of 284 cases was identified. One-fifth (n=60) of the complaints were related to an adverse respiratory event. The overall mortality in these cases was 50% (n=30). In 19 complaints (32%), the treatment was considered substandard. Conclusion: Complaints related to respiratory events reveal that inadequate anaesthetic and intensive care medicine treatment leads to patient damage and death. Preventive strategies should be directed at the development of guidelines for handling the difficult airway, education in the management of the difficult airway, instruction in the correct use of anaesthetic equipment, improvement of interpersonnel communication routines, as well as implementation of simulator training. [source] Critical management in patients with severe enterovirus 71 infectionPEDIATRICS INTERNATIONAL, Issue 3 2006JIEH-NENG WANG Abstract Objective: The aim of this study was to analyze clinical details occurring in children with severe enterovirus 71 (EV71) infection and synthesize the critical care experience for patients with severe EV71 infection. Methods: A retrospective clinical, laboratory, and hemodynamic study was performed in a pediatric intensive care unit in a university hospital. From March 1998 to April 2000, seven consecutive pediatric patients with severe EV71 infection were retrospectively analyzed as the comparison group. From May 2000 to March 2003, eight consecutive patients with severe EV71 infection who had received the protocol therapy were enrolled as the study group. Detailed information about clinical treatment and pharmacological therapy was collected for comparison. Results: The clinical presentations and laboratory findings between the comparison and the study groups were not significantly different. The amount of intravenous fluid in the first 24 h was significantly higher in the comparison group (9.2 ± 5.0 vs 4.9 ± 1.3 mL/kg per h). More patients in the study group received low doses of dopamine infusion, patients in the comparison group received more epinephrine, and none of them received milrinone. The acute-stage and long-term survival rates were higher in the study group (100% vs 43%, 87% vs 29%). Conclusion: Early cardiopulmonary support may prevent the vicious cycle of cardiopulmonary failure and improve the clinical outcome of severe EV71 infection. Milrinone may be the ideal inotropic agent for these patients. Echocardiography, a central line, and an arterial line could be an alternate method to replace direct intracardiac hemodynamic monitoring for guiding critical management. [source] REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra- and Extracellular RegulationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 6 2010Justine S. Fitzgerald Citation Fitzgerald JS, Germeyer A, Huppertz B, Jeschke U, Knöfler M, Moser G, Scholz C, Sonderegger S, Toth B, Markert UR. Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. Am J Reprod Immunol 2010 This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a possible mechanism for opening and connecting uterine glands into the intervillous space. Amongst others, two intracellular signalling pathways are crucial for regulation of trophoblast functions and development: Wnt- and signal transducer and activator of transcription (STAT)3 signalling. Wnt signalling promotes implantation, placentation and trophoblast differentiation. Several Wnt-dependent cascades and regulatory mechanisms display different functions in trophoblast cells. The STAT3 signalling system is fundamental for induction and regulation of invasiveness in physiological trophoblastic cells, but also in tumours. The role of galectins (Gal) in trophoblast regulation and placenta development comes increasingly into focus. The Gal- 1,4, 7,10 and 12,14 have been detected in humans. Detailed information is only available for Gal-1, -2, -3, -4, -9 and -12 in endometrium and decidua. Gal-1, -3 and -13 (-14) have been detected and studied in trophoblast cells. [source] The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperatureTHE JOURNAL OF PHYSIOLOGY, Issue 4 2008Deeptankar Demazumder Detailed information about the ligand-binding site of nicotinic acetylcholine receptors has emerged from structural and mutagenesis experiments. However, these approaches provide only static images of ligand,receptor interactions. Kinetic measurements of changes in protein function are needed to develop a more dynamic picture. Previously, we measured association and dissociation rate constants for competitive inhibition of current through embryonic muscle acetylcholine receptor channels at 25°C. Little is known about competitive antagonism at physiological temperatures. Here, we performed measurements at 37°C and used thermodynamics to estimate the energetics of antagonism. We used rapid solution exchange protocols to determine equilibrium and kinetics of inhibition of acetylcholine-activated currents in outside-out patches by (+)-tubocurarine, pancuronium and cisatracurium. Kinetic rates as high as 600 s,1 were resolved by this technique. Binding was primarily enthalpy driven. The 12°C increase in temperature decreased equilibrium antagonist binding by 1.7- to 1.9-fold. In contrast, association and dissociation rate constants increased 1.9- to 6.0-fold. Activation energies for dissociation were 90 ± 6, 106 ± 8 and 116 ± 10 kJ mol,1 for cisatracurium, (+)-tubocurarine and pancuronium, respectively. The corresponding apparent activation energies for association were 38 ± 6, 85 ± 6 and 107 ± 13 kJ mol,1. The higher activation energy for association of (+)-tubocurarine and pancuronium compared with cisatracurium is notable. This may arise from either a more superficial binding site for the large antagonist cisatracurium compared to the other ligands, or from a change in receptor conformation upon binding of (+)-tubocurarine and pancuronium but not cisatracurium. Differences in ligand desolvation and ligand conformation are not likely to be important. [source] Use of Illicit Drugs and Erectile Dysfunction Medications and Subsequent HIV Infection among Gay Men in Sydney, AustraliaTHE JOURNAL OF SEXUAL MEDICINE, Issue 8 2009Garrett Prestage PhD ABSTRACT Introduction., Use of illicit drugs and oral erectile dysfunction medications (OEM) have been associated with risk behavior among gay men. Aim., To determine the effects of illicit drugs and OEM as risk factors for HIV seroconversion in a community-based cohort of HIV-negative homosexually active men in Sydney, Australia. Main Outcome Measures., Drug use in the previous 6 months and at the most recent sexual encounter; Most recent occasions of unprotected and protected anal intercourse; HIV-positive diagnosis. Methods., From June 2001 to June 2007, participants were followed up with 6-monthly detailed behavioral interviews and annual testing for HIV. Detailed information about sexual, drug-using and other behavior was collected. Results., Among 1,427 participants enrolled, 53 HIV seroconverters were identified by June 2007. At baseline, 62.7% reported using illicit drugs in the previous 6 months, including 10.7% who reported at least weekly use. Illicit drug use was associated with unprotected anal intercourse with casual partners (P < 0.001). Use of illicit drugs was associated with increased risk of HIV infection at a univariate level, and this risk increased with greater frequency of use. This was also true of the use of OEM. Use of each type of illicit drug was included in multivariate analysis, and after controlling for sexual risk behaviors, only use of OEM remained significantly predictive of HIV infection (Hazard ratios [HR] = 1.75, CI = 1.31,2.33, P < 0.001), although amyl nitrite was of borderline significance (HR = 1.26, CI = 0.98,1.62, P = 0.074). Conclusion., The association between drug use and increased risk of HIV infection was strongest for drugs used specifically to enhance sexual pleasure, particularly OEM. The risk of infection was substantially increased when both OEM and methamphetamine were used. Within more "adventurous" gay community subcultures, the interconnectedness of sexual behavior and drug use may be key to understanding HIV risk and is an appropriate priority in HIV-prevention efforts in this population. Prestage G, Jin F, Kippax S, Zablotska I, Imrie J, and Grulich A. Use of illicit drugs and erectile dysfunction medications and subsequent HIV infection among gay men in Sydney, Australia. J Sex Med 2009;6:2311,2320. [source] Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis,,ARTHRITIS & RHEUMATISM, Issue 1 2006Paulo J. Nicola Objective Although mortality among patients with rheumatoid arthritis (RA) is higher than in the general population, the relative contribution of comorbid diseases to this mortality difference is not known. This study was undertaken to evaluate the contribution of congestive heart failure (CHF) and ischemic heart disease (IHD), including myocardial infarction, to the excess mortality in patients with RA, compared with that in individuals without RA. Methods We assembled a population-based inception cohort of individuals living in Rochester, Minnesota, in whom RA (defined according to the criteria of the American College of Rheumatology [formerly, the American Rheumatism Association]) first developed between 1955 and 1995, and an age- and sex-matched non-RA cohort. All subjects were followed up until either death, migration from the county, or until 2001. Detailed information from the complete medical records was collected. Statistical analyses included the person-years method, cumulative incidence, and Cox regression modeling. Attributable risk analysis techniques were used to estimate the number of RA deaths that would be prevented if the incidence of CHF was the same in patients with RA and non-RA subjects. Results The study population included 603 patients with RA and 603 subjects without RA. During followup, there was an excess of 123 deaths among patients with RA (345 RA deaths occurred, although only 222 such deaths were expected). The mortality rates among patients with RA and non-RA subjects were 39.0 and 29.2 per 1,000 person-years, respectively. There was a significantly higher cumulative incidence of CHF (but not IHD) in patients with RA compared with non-RA subjects (37.1% versus 27.7% at 30 years of followup, respectively; P < 0.001). The risk of death associated with either CHF or IHD was not significantly different between patients with RA and non-RA subjects. If the risk of developing CHF was the same in patients with RA and individuals without RA, the overall mortality rate difference between RA and non-RA hypothetically would be reduced from 9.8 to 8.0 excess deaths per 1,000 person-years; that is, 16 (13%) of the 123 excess deaths could be prevented. Conclusion CHF, rather than IHD, appears to be an important contributor to the excess overall mortality among patients with RA. CHF contributes to this excess mortality primarily through the increased incidence of CHF in RA, rather than increased mortality associated with CHF in patients with RA compared with non-RA subjects. Eliminating the excess risk of CHF in patients with RA could significantly improve their survival. [source] Alterations of intraretinal layers in acute central serous chorioretinopathyACTA OPHTHALMOLOGICA, Issue 5 2009Christian Ahlers Abstract. Purpose:, Optical coherence tomography (OCT) is restricted by its low scanning speed and limited resolution. High-definition raster-scanning OCT (HD-OCT) was used to evaluate changes in retinal microstructure in patients with acute central serous chorioretinopathy (CSCR) and to find new morphological features. Methods:, Eighteen patients with subretinal fluid accumulation caused by acute CSCR were imaged in a cross-sectional study design. High-speed frequency-domain HD-OCT was used to image an area of 6 × 6 mm in the macular retina. Three-dimensional analyses were performed using en-face imaging and section analysis of single HD-OCT scans. Results:, Detailed information about fluid accumulation can be obtained in all compartments. Discrete changes in reflectivity are visualized within the outer nuclear or plexiform layers in > 90% of patients. Subretinal fluid appears as a dome-shaped pool of fluid and is not associated with a loss of photoreceptor layer integrity. Deposits are demarcated beneath the outer cone segments. Multiple small pigment epithelial detachments are present in > 60% of patients. Conclusions:, High-definition OCT provides extensive information regarding precise topographic and layer-specific localization of discrete morphological changes. Along with well-known changes in the retinal microstructure, hyper-reflectivity can be imaged in the outer nuclear or plexiform layers and may represent intraretinal changes indicating the presence of subretinal pathologies or retinal maladjustment caused by the underlying pathology. [source] Microscopic imaging of extended tissue volumesCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 12 2004Ian LeGrice Summary 1.,Detailed information about three-dimensional structure is key to understanding biological function. 2.,Confocal laser microscopy has made it possible to reconstruct three-dimensional organization with exquisite resolution at cellular and subcellular levels. 3.,There have been few attempts to acquire large image volumes using the confocal laser scanning microscope. 4.,Previously, we have used manual techniques to construct extended volumes (several mm in extent, at 1.5 µm voxel size) of myocardial tissue. 5.,We are now developing equipment and efficient automated methods for acquiring extended morphometric databases using confocal laser scanning microscopy. [source] Clinical predictors of self-limited urinalysis abnormality in childhood Henoch-Schönlein purpura nephritisACTA PAEDIATRICA, Issue 3 2006Shuo-Hsun Hung Abstract Background and aim: The majority of patients (85,95%) with Henoch-Schönlein purpura nephritis (HSPN) suffer from a prolonged course of urinalysis abnormality. We sought to identify favourable prognostic factors predicting a self-limited urinalysis abnormality within 1 y. Methods: Fifty-eight HSPN patients admitted to the University Hospital between 1990 and 2003 were retrospectively analysed. Detailed information on clinical and laboratory manifestations on admission and sequential follow-up clinics were recorded. The ,2 or Fisher's exact test were used for univariate analysis, and multiple logistic regression was used for multivariate analysis. Results: The study cohort included 31 boys and 27 girls, with a mean age of onset of 8.0±4.3 y and a median follow-up duration of 5.9 y (range 1 to 25). Of 58 patients, 39 (67.3%) had a self-limited urinalysis abnormality within 1 y. On multivariate analysis, onset age less than 9 (p=0.038), low-grade proteinuria (p=0.044) and interval between purpura onset and renal manifestations less than 2 wk (p=0.005) predicted self-resolved urinalysis abnormality within 1 y. With two or more predictive factors, the sensitivity for short-term course was 84.6%, the specificity was 73.7%, and the positive predictive value was 84.8%. Conclusion: A small number of variables were important for detecting a favourable short-term course of urinalysis abnormality. [source] Isolated levocardia: Prenatal diagnosis and managementCONGENITAL ANOMALIES, Issue 2 2009Satoko Katsuya ABSTRACT Isolated levocardia (IL) is a rare condition of situs anomaly in which there is a normal left-sided heart (levocardia) with dextro position of the abdominal viscera. IL has been reported in children and adults with complex cardiac defects, whereas there are only few published reports regarding the prenatal diagnosis of IL. We report two prenatal cases of IL diagnosed by ultrasonography and magnetic resonance imaging (MRI). In both cases, fetal cardiac function remained within the normal range throughout pregnancy, and no treatment for the heart was required after birth. For the dextro position of abdominal viscera, one case was followed without any surgical procedure, but the other case required prophylactic operation due to malrotation of the small intestine. Although the prognosis of IL largely depends on the severity of associated cardiac anomaly, future bowel obstruction caused by intestinal malrotation may also be life-threatening. In this respect, prenatal diagnosis of IL is important, even when there is no associated cardiac structural anomaly. If IL is suspected in routine fetal ultrasonography, MRI may be recommended to obtain more detailed information on the anatomy of abdominal viscerae, and careful observation for bowel problems is required, especially after oral nutrition is started. [source] Sesquiterpene lactone dermatitis in the young: is atopy a risk factor?CONTACT DERMATITIS, Issue 1 2008Evy Paulsen Screening for Compositae contact allergy has documented fairly high prevalence in adults, and recent studies indicate that the allergy may be more common in children than previously believed. However, detailed information on sensitization in this age group is sparse. The objective of this study was to present another 2 cases in children and review the literature. Screening with sesquiterpene lactone (SL) mix has shown prevalence of 0.5% and 1.8% in 2 studies, while screening with 2 different Compositae mixes detected 4.2% and 2.6% positives among children and adolescents. All individual case reports describe sensitization in atopic children, and the largest screening study showed a prevalence of Compositae mix sensitization that was significantly higher in children with atopic dermatitis compared with non-atopics. Compositae sensitization should be considered in children with a family or personal history of atopy, summer-related, or -exacerbated dermatitis of any kind, and a history of plant exposure. Screening with SL mix is recommended but should be supplemented with plant extracts based on exposure history. Compositae weeds, especially dandelions, seem to be important sensitizers in children. [source] Effects of annealing on structural, electrical and optical properties of AgGa(Se0.5S0.5)2 thin films deposited by using sintered stoichometric powderCRYSTAL RESEARCH AND TECHNOLOGY, Issue 4 2009H. Karaagac Abstract The structural, electrical and optical properties of AgGa(Se0.5S0.5 )2 thin films deposited by using the thermal evaporation method have been investigated as a function of annealing in the temperature range of 450,600 °C. X-ray diffraction (XRD) analysis showed that the structural transformation from amorphous to polycrystalline structure started at 450 oC with mixed binary phases of Ga2Se3, Ga2S3, ternary phase of AgGaS2 and single phase of S. The compositional analysis with the energy dispersive X-ray analysis (EDXA) revealed that the as-grown film has different elemental composition with the percentage values of Ag, Ga, Se and S being 5.58, 27.76, 13.84 and 52.82 % than the evaporation source powder, and the detailed information about the stoichometry and the segregation mechanisms of the constituent elements in the structure have been obtained. The optical band gap values as a function of annealing temperature were calculated as 2.68, 2.85, 2.82, 2.83, and 2.81 eV for as-grown, annealed at 450, 500, 550, and 600 °C samples, respectively. It was determined that these changes in the band gap are related with the structural changes with annealing. The temperature dependent conductivity measurements were carried out in the temperature range of 250-430 K for all samples. The room temperature resistivity value of as-grown film was found to be 0.7x108 (,-cm) and reduced to 0.9x107 (,-cm) following to the annealing. From the variation of electrical conductivity as a function of the ambient temperature, the activation energies at specific temperature intervals for each sample were evaluated. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The clinical presentation of mitochondrial diseases in children with progressive intellectual and neurological deterioration: a national, prospective, population-based studyDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 5 2010CHRISTOPHER M VERITY Aim, Our aim was to study the clinical presentation, mode of diagnosis, and epidemiology of mitochondrial disorders in children from the UK who have progressive intellectual and neurological deterioration (PIND). Method, Since April 1997, we have identified patients aged 16 years or younger with suspected PIND through the monthly notification card sent to all UK consultant paediatricians by the British Paediatric Surveillance Unit. Clinical details obtained from reporting paediatricians are classified by an Expert Group. Results, By July 2008, 2493 cases of PIND had been reported, among which there were 112 children (69 males, 43 females) with mitochondrial diseases presenting between birth and 14 years 7 months (median 12mo), divided into 13 subgroups. In some instances, clinical features were characteristic of mitochondrial disease, but many children presented non-specifically with combinations of developmental delay, hypotonia, failure to thrive, and seizures; 16 children had multisystem disease at presentation. Mortality was high: 40 children had died. Blood and/or cerebrospinal fluid lactate measurements were abnormal in 87 children, and 47 of 78 brain magnetic resonance images showed increased basal ganglia signal. Definite diagnoses were usually made by muscle enzyme or genetic studies. Interpretation, This is a unique population-based study of the mitochondrial disorders that cause childhood neurodegenerative disease. It provides detailed information about the clinical presentation and investigation of these complex cases. [source] "Demographic Futures for Christianity and the World Religions"DIALOG, Issue 1 2004By Todd M. Johnson Abstract:, Since before 1970 Christian researchers have been tracking the massive demographic shift of Christianity to the Southern Hemisphere and noting the increasingly religious nature of populations around the world. At the same time, writers on the future of religion have been drawn to extreme portrayals of decline or revival of religion. However, the world's religious situation is replete with detailed information, drawn from enormous data collections on religious affiliation and questions about religion in government censuses. Quantitative tools, utilizing this information in the context of demography provide a more nuanced view of humankind's religious future. Demographic trends coupled with conservative estimates of conversions and defections envision over 80% of the world's population will continue to be affiliated with religions 200 years into the future. This religious future will have a profound influence on Christian theology, relations between religions, and the interaction between religion and politics. [source] Long-term landscape evolution: linking tectonics and surface processesEARTH SURFACE PROCESSES AND LANDFORMS, Issue 3 2007Paul Bishop Abstract Research in landscape evolution over millions to tens of millions of years slowed considerably in the mid-20th century, when Davisian and other approaches to geomorphology were replaced by functional, morphometric and ultimately process-based approaches. Hack's scheme of dynamic equilibrium in landscape evolution was perhaps the major theoretical contribution to long-term landscape evolution between the 1950s and about 1990, but it essentially ,looked back' to Davis for its springboard to a viewpoint contrary to that of Davis, as did less widely known schemes, such as Crickmay's hypothesis of unequal activity. Since about 1990, the field of long-term landscape evolution has blossomed again, stimulated by the plate tectonics revolution and its re-forging of the link between tectonics and topography, and by the development of numerical models that explore the links between tectonic processes and surface processes. This numerical modelling of landscape evolution has been built around formulation of bedrock river processes and slope processes, and has mostly focused on high-elevation passive continental margins and convergent zones; these models now routinely include flexural and denudational isostasy. Major breakthroughs in analytical and geochronological techniques have been of profound relevance to all of the above. Low-temperature thermochronology, and in particular apatite fission track analysis and (U,Th)/He analysis in apatite, have enabled rates of rock uplift and denudational exhumation from relatively shallow crustal depths (up to about 4 km) to be determined directly from, in effect, rock hand specimens. In a few situations, (U,Th)/He analysis has been used to determine the antiquity of major, long-wavelength topography. Cosmogenic isotope analysis has enabled the determination of the ,ages' of bedrock and sedimentary surfaces, and/or the rates of denudation of these surfaces. These latter advances represent in some ways a ,holy grail' in geomorphology in that they enable determination of ,dates and rates' of geomorphological processes directly from rock surfaces. The increasing availability of analytical techniques such as cosmogenic isotope analysis should mean that much larger data sets become possible and lead to more sophisticated analyses, such as probability density functions (PDFs) of cosmogenic ages and even of cosmogenic isotope concentrations (CICs). PDFs of isotope concentrations must be a function of catchment area geomorphology (including tectonics) and it is at least theoretically possible to infer aspects of source area geomorphology and geomorphological processes from PDFs of CICs in sediments (,detrital CICs'). Thus it may be possible to use PDFs of detrital CICs in basin sediments as a tool to infer aspects of the sediments' source area geomorphology and tectonics, complementing the standard sedimentological textural and compositional approaches to such issues. One of the most stimulating of recent conceptual advances has followed the considerations of the relationships between tectonics, climate and surface processes and especially the recognition of the importance of denudational isostasy in driving rock uplift (i.e. in driving tectonics and crustal processes). Attention has been focused very directly on surface processes and on the ways in which they may ,drive' rock uplift and thus even influence sub-surface crustal conditions, such as pressure and temperature. Consequently, the broader geoscience communities are looking to geomorphologists to provide more detailed information on rates and processes of bedrock channel incision, as well as on catchment responses to such bedrock channel processes. More sophisticated numerical models of processes in bedrock channels and on their flanking hillslopes are required. In current numerical models of long-term evolution of hillslopes and interfluves, for example, the simple dependency on slope of both the fluvial and hillslope components of these models means that a Davisian-type of landscape evolution characterized by slope lowering is inevitably ,confirmed' by the models. In numerical modelling, the next advances will require better parameterized algorithms for hillslope processes, and more sophisticated formulations of bedrock channel incision processes, incorporating, for example, the effects of sediment shielding of the bed. Such increasing sophistication must be matched by careful assessment and testing of model outputs using pre-established criteria and tests. Confirmation by these more sophisticated Davisian-type numerical models of slope lowering under conditions of tectonic stability (no active rock uplift), and of constant slope angle and steady-state landscape under conditions of ongoing rock uplift, will indicate that the Davis and Hack models are not mutually exclusive. A Hack-type model (or a variant of it, incorporating slope adjustment to rock strength rather than to regolith strength) will apply to active settings where there is sufficient stream power and/or sediment flux for channels to incise at the rate of rock uplift. Post-orogenic settings of decreased (or zero) active rock uplift would be characterized by a Davisian scheme of declining slope angles and non-steady-state (or transient) landscapes. Such post-orogenic landscapes deserve much more attention than they have received of late, not least because the intriguing questions they pose about the preservation of ancient landscapes were hinted at in passing in the 1960s and have recently re-surfaced. As we begin to ask again some of the grand questions that lay at the heart of geomorphology in its earliest days, large-scale geomorphology is on the threshold of another ,golden' era to match that of the first half of the 20th century, when cyclical approaches underpinned virtually all geomorphological work. Copyright © 2007 John Wiley & Sons, Ltd. [source] RATIONAL PARTISAN THEORY, UNCERTAINTY, AND SPATIAL VOTING: EVIDENCE FOR THE BANK OF ENGLAND'S MPCECONOMICS & POLITICS, Issue 2 2010ARNAB BHATTACHARJEE The transparency and openness of the monetary policy-making process at the Bank of England has provided very detailed information on both the decisions of individual members of the Monetary Policy Committee (MPC) and the information on which they are based. In this paper, we consider this decision-making process in the context of a model in which inflation forecast targeting is used, but there is heterogeneity among the members of the committee. We find that rational partisan theory can explain spatial voting behavior under forecast uncertainty about the output gap. Internally generated forecasts of output and market-generated expectations of medium-term inflation provide the best description of discrete changes in interest rates, in combination with uncertainty in the macroeconomic environment. There is also a role for developments in asset, housing and labor markets. Further, spatial voting patterns clearly differentiate between internally and externally apzpointed members of the MPC. The results have important implications for committee design and the conduct of monetary policy. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||