Destructive

Distribution by Scientific Domains

Terms modified by Destructive

  • destructive arthritis
  • destructive behavior
  • destructive behaviour
  • destructive cholangitis
  • destructive disease
  • destructive earthquake
  • destructive effects
  • destructive harvest
  • destructive interference
  • destructive lesion
  • destructive periodontal disease
  • destructive process
  • destructive therapy

  • Selected Abstracts


    The Role of Government Policy on Entrepreneurial Activity: Productive, Unproductive, or Destructive?

    ENTREPRENEURSHIP THEORY AND PRACTICE, Issue 5 2008
    Maria Minniti
    This paper serves as an introduction to the special issue of Entrepreneurship Theory and Practice on government policy and entrepreneurial activity. Entrepreneurship is an important engine of growth. Government policy, in turn, shapes the institutional environment in which entrepreneurial decisions are made. Thus, government policy is important for entrepreneurship. But what policies are more conducive to productive entrepreneurship? In spite of a significant amount of work on this and related topics, there is still much we do not know about this important relationship. After reviewing recent literature on entrepreneurship policy, this paper summarizes the contributions included in this volume and puts them in the context of the ongoing research debate. The goal of the special issue is to address important unanswered questions and trigger a constructive debate among diverging views. [source]


    The Relation Between Popularity and Aggressive, Destructive, and Norm-Breaking Behaviors: Moderating Effects of Athletic Abilities, Physical Attractiveness, and Prosociality

    JOURNAL OF RESEARCH ON ADOLESCENCE, Issue 3 2009
    Jan Kornelis Dijkstra
    The aim of this study was to examine the relations between popularity and different types of aggressive, destructive, and norm-breaking behaviors in a large cross-sectional sample of adolescents (N=3,312, M age=13.60). We were interested in the extent to which the relations of these behaviors with popularity were moderated by positive features (i.e., athletic abilities, physical attractiveness, and prosociality). From a goal-framing perspective, it was argued that positive features evoke positive affect, which in turn enhances the positive impact of aggressive, destructive, and norm-breaking behaviors on popularity. The results supported our notion that these latter behaviors are especially related to popularity in adolescents who also exhibit positive features. [source]


    Pre- and postnatal influences on preschool mental health: a large-scale cohort study

    THE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 10 2008
    Monique Robinson
    Background:, Methodological challenges such as confounding have made the study of the early determinants of mental health morbidity problematic. This study aims to address these challenges in investigating antenatal, perinatal and postnatal risk factors for the development of mental health problems in pre-school children in a cohort of Western Australian children. Methods:, The Raine Study is a prospective cohort study of 2,868 live born children involving 2,979 pregnant women recruited at 18 weeks gestation. Children were followed up at age two and five years. The Child Behaviour Checklist (CBCL) was used to measure child mental health with clinical cut-points, including internalising (withdrawn/depressed) and externalising (aggressive/destructive) behaviours (n = 1707). Results:, Multinomial logistic regression analysis showed that the significant risk factors for behaviour problems at age two were the maternal experience of multiple stress events in pregnancy (OR = 1.20, 95% CI = 1.06, 1.37), smoking during pregnancy (OR = 1.30, 95% CI = 1.06, 1.59) and maternal ethnicity (OR = 3.34, 95% CI = 1.61, 6.96). At age five the experience of multiple stress events (OR = 1.17, 95% CI = 1.08, 1.27), cigarette smoking (OR = 1.19, 95% CI = 1.03, 1.37), male gender (OR = 1.43, 95% CI = 1.02, 2.00), breastfeeding for a shorter time (OR = .97, 95% CI = .94, .99) and multiple baby blues symptoms (OR = 1.08, 95% CI = 1.02, 1.14) were significant predictors of mental health problems. Conclusions:, Early childhood mental health is significantly affected by prenatal events in addition to the child's later environment. Interventions targeting adverse prenatal, perinatal and postnatal influences can be expected to improve mental health outcomes for children in the early years. [source]


    Reconstructing ripeness I: A study of constructive engagement in protracted social conflicts

    CONFLICT RESOLUTION QUARTERLY, Issue 1 2008
    Peter T. Coleman
    What moves people to work with each other rather than against each other when locked into destructive, long-term conflicts? Ripeness theory has been a useful starting point for understanding such motives, but has limited explanatory power under conditions of intractable conflict. This article is the first of a two-part series presenting the findings from a study that explored various methods of eliciting constructive engagement from stakeholders through interviews with expert scholarpractitioners working with protracted conflicts. A grounded theory analysis was applied to the interviews to allow new insights into constructive conflict engagement to emerge from the data. Our objective was to develop more robust theories and practices. A dynamical systems synthesis of the findings is presented, and its implications for reconceptualizing ripeness are discussed. [source]


    Mediation, power, and cultural difference

    CONFLICT RESOLUTION QUARTERLY, Issue 3 2003
    Morgan Brigg
    In Western mediation practice, conflict and violence are typically seen as destructive and unhelpful ways of being, and this does not allow for the constitutive and productive role of conflict in many non-Western traditions. The playing out of these assumptions in mediation practice effects an operation of power that is particularly significant in intercultural mediations. Explicit and implicit mediator techniques lead disputants in intercultural mediations to behave in ways consistent with the goals of mediation and Western norms around conflict and selfhood. The specificity of this analysis means that the findings are indicative and explorative rather than comprehensive. Nevertheless, the results highlight the need to consider ways in which researchers and mediators can begin to mitigate this operation of power and respond to cultural difference in ethical ways. [source]


    ,Resisting Creativity, Creating the New'.

    CREATIVITY AND INNOVATION MANAGEMENT, Issue 2 2006
    A Deleuzian Perspective on Creativity
    Create/Innovate or die. This is the taken-for-granted ,truth' in the social, political and economic context in which we currently live. In fact, so accepted is this mantra that criticism seems foolish; mere evidence of the entrenched conservatism that needs to be challenged. This article posits an alternative view of creativity, drawing in particular on the thinking of the philosopher Gilles Deleuze. The writing of Deleuze is used to explore our understanding of creativity, in terms of what ,creativity' is (and what it is not), and the destructive (and sometimes pointless) nature of creativity. In doing so it is hoped that this article challenges clichéd representations of ,creativity', the typical ,creativity is wonderful and we need a lot more of it . . .' type arguments and assist scholars to become more creative (or at least more reflective) in their own practice. [source]


    Silicone Gel Sheeting for the Management and Prevention of Onychocryptosis

    DERMATOLOGIC SURGERY, Issue 3 2003
    A. Burhan Aksakal MD
    BACKGROUND Onychocryptosis, commonly referred to as ingrown nails, has many therapeutic alternatives for its management. Although mild cases can be treated conservatively, in severe cases, surgical treatment is preferred. Silicone gel sheeting is found to be effective in the treatment of hypertrophic scars and keloids. OBJECTIVE To document the effectiveness of silicone gel sheeting in the management of patients with onychocryptosis and in the prevention of the recurrences by breaking the devil's circle, which usually took place after the surgical procedures used in the treatment of the onychocryptosis. METHODS Fourteen patients were enrolled in the study. Entry criteria required the presence of slight (2 patients), moderate (2 patients), or severe (10 patients) onychocryptosis. The simple technique used in the study was the excision of the one-quarter part of the lesional side of the nail plate without excising the granulation tissue. After 24 hours, the silicone was placed on the granulation tissue and the exposed nail bed. Silicone gel sheet was bandaged loosely without applying any pressure. Patients entering the study were given detailed instructions in applying and using the gel for 12 hours during the daytime. The study lasted for 14 months and was composed of a treatment period of 4 months and a follow-up period of 10 months. The patients were evaluated every 2 weeks in the first month and then monthly. The change in thickness of granulation tissue was evaluated by comparing them with the baseline photographs and those taken at each visit. RESULTS The management and prevention of onychocryptosis were achieved in 12 of 14 patients (85.71%). The silicone gel sheeting treatment was well tolerated except for an occasional transient exudation, which was resolved when the treatment was withdrawn. CONCLUSION The results show that the new method that we used for the treatment of onychocryptosis is successful in reducing the thickness of the hypertrophic nail fold and prevents the recurrence of the condition during the regrowth of the nail plate by breaking the devil's circle. The advantage of this method is that it is not destructive to the nail matrix and the adjacent tissue. [source]


    Satellite Remote Sensing as a Tool in Lahar Disaster Management

    DISASTERS, Issue 2 2002
    Norman Kerle
    At least 40,000 deaths have been attributed to historic lahars (volcanic mudflows). The most recent lahar disaster occurred in 1998 at Casita volcano, Nicaragua, claiming over 2,500 lives. Lahars can cover large areas and be highly destructive, and constitute a challenge for disaster management. With infrastructure affected and access frequently impeded, disaster management can benefit from the synoptic coverage provided by satellite imagery. This potential has been recognised for other types of natural disasters, but limitations are also known. Dedicated satellite constellations for disaster response and management have been proposed as one solution. Here we investigate the utility of currently available and forthcoming optical and radar sensors as tools in lahar disaster management. Applied to the Casita case, we find that imagery available at the time could not have significantly improved disaster response. However, forthcoming satellites, especially radar, will improve the situation, reducing the benefit of dedicated constellations. [source]


    An attenuation model for distant earthquakes

    EARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 2 2004
    Adrian Chandler
    Abstract Large magnitude earthquakes generated at source,site distances exceeding 100km are typified by low-frequency (long-period) seismic waves. Such induced ground shaking can be disproportionately destructive due to its high displacement, and possibly high velocity, shaking characteristics. Distant earthquakes represent a potentially significant safety hazard in certain low and moderate seismic regions where seismic activity is governed by major distant sources as opposed to nearby (regional) background sources. Examples are parts of the Indian sub-continent, Eastern China and Indo-China. The majority of ground motion attenuation relationships currently available for applications in active seismic regions may not be suitable for handling long-distance attenuation, since the significance of distant earthquakes is mainly confined to certain low to moderate seismicity regions. Thus, the effects of distant earthquakes are often not accurately represented by conventional empirical models which were typically developed from curve-fitting earthquake strong-motion data from active seismic regions. Numerous well-known existing attenuation relationships are evaluated in this paper, to highlight their limitations in long-distance applications. In contrast, basic seismological parameters such as the Quality factor (Q -factor) could provide a far more accurate representation for the distant attenuation behaviour of a region, but such information is seldom used by engineers in any direct manner. The aim of this paper is to develop a set of relationships that provide a convenient link between the seismological Q -factor (amongst other factors) and response spectrum attenuation. The use of Q as an input parameter to the proposed model enables valuable local seismological information to be incorporated directly into response spectrum predictions. The application of this new modelling approach is demonstrated by examples based on the Chi-Chi earthquake (Taiwan and South China), Gujarat earthquake (Northwest India), Nisqually earthquake (region surrounding Seattle) and Sumatran-fault earthquake (recorded in Singapore). Field recordings have been obtained from these events for comparison with the proposed model. The accuracy of the stochastic simulations and the regression analysis have been confirmed by comparisons between the model calculations and the actual field observations. It is emphasized that obtaining representative estimates for Q for input into the model is equally important.Thus, this paper forms part of the long-term objective of the authors to develop more effective communications across the engineering and seismological disciplines. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    The Internet, Economic Growth and Governance

    ECONOMIC AFFAIRS, Issue 1 2000
    Gordon L. Brady
    The Internet developed largely as a ,spontaneous order' without central co-ordination. Further development will increase the mobility of capital and labour and make tax collection more difficult. Attempts at self-regulation and government regulation are now under way but meddling is likely to be ,wealth destructive and counter productive.' [source]


    Graphium agamemnon Linnaeus (Lepidoptera: Papilionidae), a pest of soursop (Annona muricata Linnaeus), in Vietnam: Biology and a novel method of control

    ENTOMOLOGICAL RESEARCH, Issue 2 2008
    Nga Thi VU
    Abstract Few butterflies are pests of economic significance, but some may be locally destructive, such as the papilionid Graphium agamemnon Linnaeus, which is known to feed on the commercially important soursop (Annona muricata Linnaeus) in Vietnam. This paper documents the life history and ecology of G. agamemnon and investigates commonly used control measures in south-east Vietnam. A novel method of controlling G. agamemnon infestation is described. If soursop basal rootstock (Annona glabra Linnaeus) is encouraged to shoot during times of peak butterfly activity, ovipositing G. agamemnon females are preferentially attracted to the new growth where the resulting early stages may be easily detected and removed by hand. [source]


    Host immune responses in ex vivo approaches to cutaneous gene therapy targeted to keratinocytes

    EXPERIMENTAL DERMATOLOGY, Issue 10 2005
    Z. Lu
    Abstract:, Epidermal gene therapy may benefit a variety of inherited skin disorders and certain systemic diseases. Both in vivo and ex vivo approaches of gene transfer have been used to target human epidermal stem cells and achieve long-term transgene expression in immunodeficient mouse/human chimera models. Immunological responses however, especially in situations where a neoantigen is expressed, are likely to curtail expression and thereby limit the therapy. In vivo gene transfer to skin has been shown to induce transgene-specific immune responses. Ex vivo gene transfer approaches, where keratinocytes are transduced in culture and transplanted back to patient, however, may avoid signals provided to the immune system by in vivo administration of vectors. In the current study, we have developed a stable epidermal graft platform in immunocompetent mice to analyze host responses in ex vivo epidermal gene therapy. Using green fluorescent protein (GFP) as a neoantigen and an ex vivo retrovirus-mediated gene transfer to mouse primary epidermal cultures depleted of antigen-presenting cells (APCs), we show induction of GFP-specific immune responses leading to the clearance of transduced cells. Similar approach in immunocompetent mice tolerant to GFP resulted in permanent engraftment of transduced cells and continued GFP expression. Activation of transgene-specific immune responses in ex vivo gene transfer targeted to keratinocytes require cross-presentation of transgene product to APCs, a process that is most amenable to immune modulation. This model may be used to explore strategies to divert transgene-specific immune responses to less destructive or tolerogenic ones. [source]


    The effects of burrowing activity on archaeological sites: Ndondondwane, South Africa

    GEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 5 2004
    Kent D. Fowler
    Burrowing activity is a widely recognized source of site modification. Most taphonomic studies of burrowers emphasize their destructive aspects on the archaeological record. Excavations at Ndondondwane, South Africa, suggest burrowing activity is destructive in some ways, but may also preserve cultural behavior. Drawing on both direct and indirect sources of evidence, we discuss how burrowing activity by rodents, earthworms, and termites can inform about pedogenic and depositional processes at archaeological sites and both preserve and destroy evidence of intra-settlement patterns and early African cultigens. Specifically, we demonstrate the limited effect of earthworms on site stratigraphy, how the localized activity of termites have preserved casts of early African cultigens, and how the ability of archaeologists to distinguish the devastating effects of rodent burrowing from remains of architectural features have permitted important inferences about social and ritual life in early African farming communities. © 2004 Wiley Periodicals, Inc. [source]


    Pyoderma gangrenosum: a report of 21 cases

    INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 2 2002
    Rym Benmously Mlika MD
    Background Pyoderma gangrenosum (PG) is an uncommon, destructive, cutaneous ulceration, belonging to the neutrophilic disease spectrum. It is associated with systemic disease in 50% of cases. Methods We report a retrospective study of 21 cases of PG. All cases studied fulfilled the following criteria: (i) clinical features of PG; (ii) histopathology consistent with a diagnosis of PG, and excluding other specific dermatoses. Results The average age of our patients was 41.8 years. The male to female ratio was 1.1. The typical ulcerative variant was found in 17 patients, bullous PG in two patients, and the granulomatous variant in two patients. Sixty-two per cent of our patients had lesions on their lower legs. Two patients had neutrophilic pulmonary involvement concurrent with the ulcers. An association with other internal diseases was noted in 12 patients. Histopathologic study showed vasculitis in 13 patients. Of these, 11 were leukocytoclastic and the others predominantly lymphocytic. Conclusions PG is a rare disease, with the ulcerative variant being most frequent. The lower legs are the most commonly affected sites. The recurrence rate in our study was about 46% regardless of the treatment prescribed. Pulmonary involvement was fatal in two patients. [source]


    Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses

    INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 11 2001
    John E. Wolf Jr MD
    Background Actinic keratoses (AKs) are epidermal skin lesions with the potential to develop into invasive squamous cell carcinoma (SCC). Treatment at an early stage may prevent development of SCC. Current treatment options are highly destructive and associated with significant side-effects. Early studies with topical diclofenac were encouraging and led to its evaluation for the treatment of actininic keratosis. Previous studies have demonstrated that 3% diclofenac in 2.5% hyaluronan gel is effective and well tolerated in the treatment of AK. The present study was designed to further explore the therapeutic potential of this gel. Methods This randomized, double-blind, placebo-controlled trial involved outpatients with a diagnosis of five or more AK lesions contained in one to three 5 cm2 blocks. Patients received either active treatment (3% diclofenac gel in 2.5% hyaluronan gel) or inactive gel vehicle (hyaluronan) as placebo (0.5 g b.i.d. in each 5 cm2 treatment area for 90 days). Assessments included the Target Lesion Number Score (TLNS), Cumulative Lesion Number Score (CLNS), and Global Improvement Indices rated separately by both the investigator (IGII) and patient (PGII). Results Results obtained from 96 patients at follow up (30 days after end of treatment) indicated that a significantly higher proportion of patients who received active treatment had a TLNS = 0 compared to the placebo group (50% vs. 20%; P < 0.001). There was also a significant difference between the two groups in CLNS, with 47% of patients in the active treatment group having a CLNS = 0 compared with only 19% in the placebo group (P < 0.001). The proportion of patients with an IGII score of 4 (completely improved) at follow-up was 47% in the active treatment group compared with only 19% in the placebo group (P < 0.001); for PGII these values were 41% vs. 17%, P < 0.001. Both treatments were well tolerated, with most adverse events related to the skin. Conclusions Topical 3% diclofenac in 2.5% hyaluronan gel was effective and well tolerated for the treatment of AK. [source]


    A procedural guide to metacarpal radiogrammetry in archaeology

    INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 1 2004
    R. Ives
    Abstract The technique of metacarpal radiogrammetry was devised in 1960 as a clinical method to aid in the identification of thinned cortical bone, which may help in diagnosis of osteoporosis. Through taking measurements from radiographs, calculations of the amount of cortical bone can be made. The technique is relatively simple and is not destructive. This paper examines the value of the application of this technique to archaeological remains. A standardized methodology of bone assessment is incorporated to enhance the comparability of future research. Statistical tests demonstrate that the technique is robust, as the position of the bone on the film, radiographic enlargement and use of either the left or right metacarpal will not affect the results obtained. However, differences in film type and measurement position can introduce unacceptable variance into the results. Therefore, guidance is given on future applications of the technique. The technique does have value as a widely available, non-destructive technique for assessing cortical bone loss and the probable prevalence of osteoporosis in archaeological collections. Copyright © 2004 John Wiley & Sons, Ltd. [source]


    Global Religious Transformations, Political Vision and Christian Witness,

    INTERNATIONAL REVIEW OF MISSION, Issue 375 2005
    Vinoth Ramachandra
    From the nineteenth-century onwards religion has been, and continues to be, an important resource for nationalist, modernizing movements. What was true of Protestant Christianity in the world of Victorian Britain also holds for the nationalist transformations of Hindu Neo-Vedanta, Theravada Buddhism, Shintoism and Shi'ite Islam in the non-Western world. Globalizing practises both corrode inherited cultural and personal identities and, at the same time, stimulate the revitalisation of particular identities as a way of gaining more influence in the new global order. However, it would be a gross distortion to identify the global transformations of Islam, and indeed of other world religions, with their more violent and fanatical forms. The globalization of local conflicts serves powerful propaganda purposes on all sides. If global Christian witness in the political arena is to carry integrity, this essay argues for the following responses, wherever we may happen to live: (a) Learning the history behind the stories of ,religious violence' reported in the secular media; (b) Identifying and building relationships with the more self-critical voices within the other religious traditions and communities, so avoiding simplistic generalizations and stereotyping of others; (c) Actively engaging in the political quest for truly participatory democracies that honour cultural and religious differences. In a hegemonic secular culture, as in the liberal democracies of the West, authentic cross-cultural engagement is circumvented. There is a militant secularist ,orthodoxy' that is as destructive of authentic pluralism as its fundamentalist religious counterpart. The credibility of the global Church will depend on whether Christians can resist the totalising identities imposed on them by their nation-states and/or their ethnic communities, and grasp that their primary allegiance is to Jesus Christ and his universal reign. [source]


    Putting a Human Face on Development

    INTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 166 2000
    Rubens Ricupero
    The century is ending with failure to solve two major threats to the future: mass unemployment and growing inequality. Furthermore, in the poor parts of the world, the very possibility of sustainable development has been questioned by the economic crisis that started in Asia two years ago. This monetary and financial crisis truly deserved to be called a "crisis of development", for three main reasons. First, it hit almost exclusively most of the developing countries, at the same time sparing and even benefitingthe industrial economies. Second, paradoxically, it was much more destructive in the most advanced of the developing nations. Third, it has created uncertainties and questions regarding the possibility of regaining the previous levels of economic performance that characterised "the Asian tigers". Competition is very analogous to games. Both need fair rules and impartial arbiters. Governments and trade negotiators think that these are sufficient, forgetting a third and fundamental element. To play a game, you have to learn how to play it; through education and time to train. A key to success will be access to information. [source]


    Rethinking Crowd Violence: Self-Categorization Theory and the Woodstock 1999 Riot

    JOURNAL FOR THE THEORY OF SOCIAL BEHAVIOUR, Issue 2 2004
    STEPHEN VIDER
    According to self-categorization theory (SCT), incidents of crowd violence can be understood as discrete forms of social action, limited by the crowd's social identity. Through an analysis of the riot at Woodstock 1999, this paper explores the uses and limitations of SCT in order to reach a more complex psychology of crowd behavior, particularly those instances that appear unmotivated, irrational, and destructive. Psychological and sociological literature are synthesized to explore the role of communication in establishing social norms within the crowd. Several modifications to current crowd psychology are proposed, including a false consensus effect of motivation and the mediation of personal and social identities. [source]


    Online collection and analysis of X-ray fluorescence spectra on the macromolecular crystallography beamlines of the ESRF

    JOURNAL OF APPLIED CRYSTALLOGRAPHY, Issue 2 2009
    Gordon A. Leonard
    X-ray fluorescence (XRF) measurements on solutions or crystals of biological macromolecules provide additional information that can be used in structure determination and/or refinement protocols. Here details are presented of an experimental setup, employed on all the ESRF Macromolecular Crystallography Group beamlines, that allows the online collection and qualitative analysis of XRF spectra. This experimental setup uses a highly attenuated beam and short exposures, meaning it is minimally destructive but retains high sensitivity. [source]


    Relating Instrumental Texture, Determined by Variable-Blade and Allo-Kramer Shear Attachments, to Sensory Analysis of Rainbow Trout, Oncorhynchus mykiss, Fillets

    JOURNAL OF FOOD SCIENCE, Issue 7 2010
    Aunchalee Aussanasuwannakul
    Abstract:, Texture is one of the most important quality attributes of fish fillets, and accurate assessment of variation in this attribute, as affected by storage and handling, is critical in providing consistent quality product. Trout fillets received 4 treatments: 3-d refrigeration (R3), 7-d refrigeration (R7), 3-d refrigeration followed by 30-d frozen storage (R3F30), and 7-d refrigeration followed by 30-d frozen storage (R7F30). Instrumental texture of raw and cooked fillets was determined by 3 approaches: 5-blade Allo-Kramer (AK) and variable-blade (VB) attachment with 12 blades arranged in perpendicular (PER) and parallel (PAR) orientations to muscle fibers. Correlation between instrumental texture and sensory hardness, juiciness, elasticity, fatness, and coarseness was determined. Muscle pH remained constant at 6.54 to 6.64. Raw fillets lost 3.66% of their original weight after 30-d frozen storage. After cooking, weight loss further increased to 15.97%. Moisture content decreased from 69.11 to 65.02%, while fat content remained constant at 10.41%. VBPER detected differences in muscle sample strength (P= 0.0019) and demonstrated effect of shear direction reported as maximum force (g force/g sample). AKPER detected differences in energy of shear (g × mm; P= 0.0001). Fillets that received F30 treatments were less extensible. Cooking increased muscle strength and toughness. Force determined by VBPER was correlated with sensory hardness (r= 0.423, P= 0.0394) and cook loss (r= 0.412, P= 0.0450). VB attachment is accurate, valid, and less destructive in fillet texture analysis. Practical Application:, A new shearing device was validated with sensory analysis. Settings and parameters obtained could be used to define fillet texture quality associated with muscle fiber orientation. [source]


    Adults with intellectual disabilities: prevalence, incidence and remission of aggressive behaviour and related factors

    JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 3 2009
    S.-A. Cooper
    Abstract Introduction Aggressive behaviours can be disabling for adults with intellectual disabilities (ID), with negative consequences for the adult, their family and paid carers. It is surprising how little research has been conducted into the epidemiology of these needs, given the impact they can have. This study investigates point prevalence, 2-year incidence and 2-year remission rates for aggressive behaviour (physically aggressive, destructive and verbally aggressive), and it investigates which factors are independently associated with aggressive behaviour. Methods All adults with ID , within a geographically defined area of Scotland, UK , were recruited to a longitudinal cohort. At baseline, assessments were undertaken of demography, lifestyle, supports, development, problem behaviours, disabilities and physical and mental health. These were repeated for a 2-year period. Results At baseline, the participation rate was 1023 (65.5%). After 2 years, the cohort retention was 651 adults. The point prevalence of Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation (DC-LD) aggressive behaviour was 9.8% (95% confidence interval = 8.0,11.8%), 2-year incidence was 1.8%, and 2-year remission rate from all types of aggressive behaviour meeting DC-LD criteria was 27.7%. The factors independently associated with aggressive behaviours were lower ability, female gender, not living with a family carer, not having Down syndrome, having attention-deficit hyperactivity disorder and having urinary incontinence. Incidence of aggressive behaviour meeting DC-LD criteria in adult life is similar to that for each of psychotic, anxiety and organic disorders. Conclusions Aggressive behaviour is common among adults with ID, but contrary to previous suggestions, more than a quarter remit within the short to medium term. This is important knowledge for professionals as well as the person and her/his family and paid carers. There is much yet to learn about the mechanisms underpinning aetiology and maintenance of aggressive behaviour in this population, and exploratory epidemiological investigations such as this have a role to play in progressing research towards further hypothesis testing and trials to influence clinical practice, service development and policy. [source]


    Families and family study in international perspective

    JOURNAL OF MARRIAGE AND FAMILY, Issue 5 2004
    Bert N. Adams
    Many changes are occurring in the world's families. Some observers feel that the changes are destructive, whereas others see them as leading to new opportunities and understanding. Issues in international family studies include regional limitations and the various aspects of doing research cross-culturally. Knowledge regarding certain categories of families, inheritance, and the social psychology of families is incomplete. There are, however, some universals and universal or worldwide changes, including movement toward individual partner choice, more divorces, lower fertility, and greater opportunities for women. [source]


    Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes

    JOURNAL OF MEDICAL VIROLOGY, Issue 7 2007
    A. Paananen
    Abstract Several enterovirus serotypes should be considered as potentially diabetogenic. The capacity of an enterovirus to kill or impair the functions of human ,-cells can vary among the strains within a given serotype as shown previously for echovirus 9 and 30 (E-30). The evolution of E-30 has also shown patterns correlating with the global increase of type 1 diabetes incidence. In the present study, antigenic properties of a set of E-30 isolates were investigated and the results correlated with the previously documented ,-cell destructive phenotype of the strains, or to genetic clustering of the strains. No simple correlation between the three properties was observed. A full-length infectious clone was constructed and sequenced from one of the isolates found to be most destructive to ,-cells (E-30/14916net87). Phylogenetic analyses demonstrated that this strain was closely related to the E-30 prototype strain at the capsid coding region while outside the capsid region prototype strains of several other human enterovirus B serotypes clustered more closely. This suggests that the relatively greater pathogenicity of the strain might be based on properties of the genome outside of the structural protein coding region. Neutralizing antibody assays on sera from 100 type 1 diabetic patients and 100 controls using three different E-30 strains did not reveal differences between the groups. This finding does not support a previous proposition of aberrant antibody responses to E-30 in diabetic patients. It is concluded that identification of the genetic counterparts of pathogenicity of E-30 strains requires further studies. J. Med. Virol. 79:945-955, 2007. © 2007 Wiley-Liss, Inc. [source]


    Activation of epidermal growth factor receptors in astrocytes: From development to neural injury

    JOURNAL OF NEUROSCIENCE RESEARCH, Issue 16 2007
    Bin Liu
    Abstract The epidermal growth factor receptor (EGFR) pathway controls the phenotypic characteristics of astrocytes. In the developing central nervous system (CNS), activation of the EGFR pathway induces astrocyte differentiation, forming the cribriform structure that surrounds axons and providing a supportive environment for neurons. In the adult CNS, the EGFR pathway is absent from astrocytes but is highly up-regulated and activated following neuronal injury. Activation of the EGFR pathway triggers quiescent astrocytes to become reactive astrocytes. Although astrocytes regulated by the EGFR pathway play constructive roles in the developing CNS, astrocytes that become reactive in response to activation of the EGFR pathway appear to be destructive to neurons in the adult CNS. The reappearance and activation of EGFRs in astrocytes under pathological conditions may activate a developmental process in an adult tissue. Regulation of EGFR function in astrocytes may be a new therapeutic strategy for the treatment of neural disorders. © 2007 Wiley-Liss, Inc. [source]


    Conflict values and team relationships: conflict's contribution to team effectiveness and citizenship in China

    JOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 1 2003
    Dean Tjosvold
    Although conflict has traditionally been considered destructive, especially in collectivist societies like China, recent studies indicate that valuing and approaching conflict can contribute to effective teamwork. A hundred and six pairs of employees and their leaders were recruited from State Owned Enterprises in Shanghai and Nanjing. Employees described their conflict values and relationships. Their immediate supervisors rated the effectiveness of their teams and the extent of their citizenship behavior. Results indicate that positive conflict attitudes and approaching conflict can contribute to strong relationships, which in turn strengthen team effectiveness and employee citizenship. Findings suggest that how conflict values affect relationships and outcomes are more differentiated than originally expected. Results were interpreted as supporting the traditional idea that relationships are critical for effective organization work in China but also challenging future research to understand the processes by which conflict has a positive contribution to work relationships. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    IDENTIFICATION OF BACTERIA ASSOCIATED WITH DINOFLAGELLATES (DINOPHYCEAE) ALEXANDRIUM SPP.

    JOURNAL OF PHYCOLOGY, Issue 2 2002
    FLUORESCENT IN SITU HYBRIDIZATION AND CONFOCAL MICROSCOPY, USING TYRAMIDE SIGNAL AMPLIFICATION
    In the marine environment, phytoplankton and bacterioplankton can be physically associated. Such association has recently been hypothesized to be involved in the toxicity of the dinoflagellate genus Alexandrium. However, the methods, which have been used so far to identify, localize, and quantify bacteria associated with phytoplankton, are either destructive, time consuming, or lack precision. In the present study we combined tyramide signal amplification,fluorescent in situ hybridization (TSA-FISH) with confocal microscopy to determine the physical association of dinoflagellate cells with bacteria. Dinoflagellate attached microflora was successfully identified with TSA-FISH, whereas FISH using monolabeled probes failed to detect bacteria, because of the dinoflagellate autofluorescence. Bacteria attached to entire dinoflagellates were further localized and distinguished from those attached to empty theca, by using calcofluor and DAPI, two fluorochromes that stain dinoflagellate theca and DNA, respectively. The contribution of specific bacterial taxa of attached microflora was assessed by double hybridization. Endocytoplasmic and endonuclear bacteria were successfully identified in the nonthecate dinoflagellate Gyrodinium instriatum. In contrast, intracellular bacteria were not observed in either toxic or nontoxic strains of Alexandrium spp. Finally, the method was successfully tested on natural phytoplankton assemblages, suggesting that this combination of techniques could prove a useful tool for the simultaneous identification, localization, and quantification of bacteria physically associated with dinoflagellates and more generally with phytoplankton. [source]


    Experiencing psychiatric diagnosis: client perspectives on being named mentally ill,

    JOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 6 2003
    Y. M. HAYNE rn phd
    In this article is reported result of a phenomenological study whereby privileged view was gained into the lives of persons who had experienced receiving a diagnosis which named ,severe and enduring mental illness'. Thematic analysis yielded the four essential themes of diagnosis as the experience of ,a knowledge that knows', ,destructive (gift) of difference', ,making visible the invisible' and ,making knowledge knowledgeable'. Each of the themes is discussed under its own heading in this paper as a means for describing the nature of ,experiencing psychiatric diagnosis'. Effort is made to provide glimpse into the ,lifeworld' of being diagnosed mentally ill, and the reader's attention is directed to a particular kind of power that exists in the medical language of diagnoses. Discernment is highlighted as most consequential to an ,action sensitive practice' and a case is made for care-providers in psychiatric-mental health care to be sensitized to how medical terminology is experienced and the need to strive for balance within the ,economy of power' contained in these specialized words. [source]


    Kierkegaard on the Problems of Pure Irony

    JOURNAL OF RELIGIOUS ETHICS, Issue 3 2004
    Brad Frazier
    ABSTRACT Søren Kierkegaard's thesis, The Concept of Irony, contains an interesting critique of pure irony. Kierkegaard's critique turns on two main claims: (a) pure irony is an incoherent and thus, unrealizable stance; (b) the pursuit of pure irony is morally enervating, psychologically destructive, and culminates in bondage to moods. In this essay, first I attempt to clarify Kierkegaard's understanding of pure irony as "infinite absolute negativity." Then I set forth his multilayered critique of pure irony. Finally, I consider briefly a distinctly theological component in Kierkegaard's critique. I argue that this feature of Kierkegaard's account can and should be distinguished from the broadly ethical critique of pure irony that I sketch in the second section, even if these components of Kierkegaard's position are found together as a unified whole in The Concept of Irony. My overall goal in this essay is to reveal the subtlety and plausibility of Kierkegaard's critique of pure irony. I also attempt to disclose the richness of the Hegelian account of ethical life to which Kierkegaard recurs in his thesis. [source]


    The Relation Between Popularity and Aggressive, Destructive, and Norm-Breaking Behaviors: Moderating Effects of Athletic Abilities, Physical Attractiveness, and Prosociality

    JOURNAL OF RESEARCH ON ADOLESCENCE, Issue 3 2009
    Jan Kornelis Dijkstra
    The aim of this study was to examine the relations between popularity and different types of aggressive, destructive, and norm-breaking behaviors in a large cross-sectional sample of adolescents (N=3,312, M age=13.60). We were interested in the extent to which the relations of these behaviors with popularity were moderated by positive features (i.e., athletic abilities, physical attractiveness, and prosociality). From a goal-framing perspective, it was argued that positive features evoke positive affect, which in turn enhances the positive impact of aggressive, destructive, and norm-breaking behaviors on popularity. The results supported our notion that these latter behaviors are especially related to popularity in adolescents who also exhibit positive features. [source]