Home About us Contact
|
Home About us Contact | ||
|
|
||
Delamination
Selected AbstractsEarly lens development in the zebrafish: A three-dimensional time-lapse analysisDEVELOPMENTAL DYNAMICS, Issue 9 2009Teri M.S. Greiling Abstract In vivo, high-resolution, time-lapse imaging characterized lens development in the zebrafish from 16 to 96 hr postfertilization (hpf). In zebrafish, the lens placode appeared in the head ectoderm, similar to mammals. Delamination of the surface ectoderm resulted in the formation of the lens mass, which progressed to a solid sphere of cells separating from the developing cornea at approximately 24 hpf. A lens vesicle was not observed and apoptosis was not a major factor in separation of the lens from the future cornea. Differentiation of primary fibers began in the lens mass followed by formation of the anterior epithelium after delamination was complete. Secondary fibers differentiated from elongating epithelial cells near the posterior pole. Quantification characterized three stages of lens growth. The study confirmed the advantages of live-cell imaging for three-dimensional quantitative structural characterization of the mechanism(s) responsible for cell differentiation in formation of a transparent, symmetric, and refractile lens. Developmental Dynamics 238:2254,2265, 2009. © 2009 Wiley-Liss, Inc. [source] Fracture analysis of composite co-cured structural joints using decohesion elementsFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 9 2004P. P. CAMANHO ABSTRACT Delamination is one of the predominant forms of failure in laminated composite structures, especially when there is no reinforcement in the thickness direction. To develop composite structures that are more damage tolerant, it is necessary to understand how delamination develops, and how it can affect the residual performance. A number of factors such as residual thermal stresses, matrix-curing shrinkage and manufacturing defects affect how damage will grow in a composite structure. It is important to develop computationally efficient analysis methods that can account for all such factors. The objective of the current work is to apply a newly developed decohesion element to investigate the debond strength of skin-stiffener composite specimens. The process of initiation of delaminations and the propagation of delamination fronts is investigated. The numerical predictions are compared with published experimental results. [source] An enriched element-failure method (REFM) for delamination analysis of composite structuresINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 6 2009X. S. Sun Abstract This paper develops an enriched element-failure method for delamination analysis of composite structures. This method combines discontinuous enrichments in the extended finite element method and element-failure concepts in the element-failure method within the finite element framework. An improved discontinuous enrichment function is presented to effectively model the kinked discontinuities; and, based on fracture mechanics, a general near-tip enrichment function is also derived from the asymptotic displacement fields to represent the discontinuity and local stress intensification around the crack-tip. The delamination is treated as a crack problem that is represented by the discontinuous enrichment functions and then the enrichments are transformed to external nodal forces applied to nodes around the crack. The crack and its propagation are modeled by the ,failed elements' that are applied to the external nodal forces. Delamination and crack kinking problems can be solved simultaneously without remeshing the model or re-assembling the stiffness matrix with this method. Examples are used to demonstrate the application of the proposed method to delamination analysis. The validity of the proposed method is verified and the simulation results show that both interlaminar delamination and crack kinking (intralaminar crack) occur in the cross-ply laminated plate, which is observed in the experiment. Copyright © 2009 John Wiley & Sons, Ltd. [source] Delamination of multilayer packaging caused by exfoliating cream ingredientsPACKAGING TECHNOLOGY AND SCIENCE, Issue 3 2007Gustavo Ortiz Abstract Exfoliating creams were packed in sachets of composite packaging consisting of polyethylene, aluminium and polyester layers stuck together by polyurethane adhesive, and they were kept in an oven at 40°C in order to accelerate the delamination process. The sachets were then delaminated and the resulting layers were analysed. A headspace solid-phase microextraction mass spectrometry method (HS,SPME,GC,MS) using a 75µm carboxen polydimethylsiloxane fibre was used to identify the compounds migrating from the exfoliating creams through the polyethylene layer to the aluminium interface and suspected to be responsible for packaging delamination. Several volatile compounds used in the cosmetic industry as perfumes, fixing agents and preservatives, such as menthol, dihydromyrcenol and 2-phenoxyethanol, were detected in the aluminium/polyester delaminated layer. The exfoliating creams were also analysed by HS,SPME,GC,MS. The study of loss of adhesion of the laminated material exposed to the exfoliating products revealed that the product with a higher concentration of 2-phenoxyethanol caused a faster decrease in adhesion strength, but the lower adhesion values were found in products with higher concentrations of menthol and dihydromyrcenol. The results obtained showed that the analytical method used was suitable for identifying volatile compounds that migrate through polyethylene to the inner layers of the packaging of exfoliating products, as well as for providing prior information on which products may be difficult to package in sachets. Copyright © 2006 John Wiley & Sons, Ltd. [source] Sandwich structures with composite inserts: Experimental studiesPOLYMER COMPOSITES, Issue 5 2009N.K. Naik Experimental studies are presented on the performance of insert assemblies of the sandwich structures under localized through-the-thickness compressive loading. Through-the-thickness and partially inserted fully potted inserts are studied. Insert materials considered are: aluminum and 3D woven composite. Experimental results are compared with the analytical predictions. It is observed that the specific strength of 3D woven composite inserts is more than that of aluminum inserts. Further, it is observed that the specific strength of through-the-thickness inserts is more than that of partially inserted fully potted inserts. Delamination between upper face plate and core material and sliding of attachment/insert within the core are the main modes of failure initiation. Quantitative results are presented for typical cases. POLYM. COMPOS., 2009. © 2008 Society of Plastics Engineers [source] A Risk-Cost Optimized Maintenance Strategy for Corrosion-Affected Concrete StructuresCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 5 2007Chun-Qing Li It is also observed that some severely deteriorated concrete structures survive for many years without maintenance. This raises the question of why and how to maintain corrosion-affected concrete structures, in particular in the climate of an increasing scarcity of resources. The present article attempts to formulate a maintenance strategy based on risk-cost optimization of a structure during its whole service life. A time-dependent reliability method is employed to determine the probability of exceeding a limit state at each phase of the service life. To facilitate practical application of the formulated maintenance strategy, an algorithm is developed and programmed in a user-friendly manner with a worked example. A merit of the proposed maintenance strategy is that models used in risk assessment for corrosion-affected concrete structures are related to some of the design criteria used by practitioners. It is found in the article that there exists an optimal number of maintenances for cracking and delamination that returns the minimum total cost for the structure in its whole life. The maintenance strategy presented in the article can help structural engineers, operators, and asset managers develop a cost-effective management scheme for corrosion-affected concrete structures. [source] Early lens development in the zebrafish: A three-dimensional time-lapse analysisDEVELOPMENTAL DYNAMICS, Issue 9 2009Teri M.S. Greiling Abstract In vivo, high-resolution, time-lapse imaging characterized lens development in the zebrafish from 16 to 96 hr postfertilization (hpf). In zebrafish, the lens placode appeared in the head ectoderm, similar to mammals. Delamination of the surface ectoderm resulted in the formation of the lens mass, which progressed to a solid sphere of cells separating from the developing cornea at approximately 24 hpf. A lens vesicle was not observed and apoptosis was not a major factor in separation of the lens from the future cornea. Differentiation of primary fibers began in the lens mass followed by formation of the anterior epithelium after delamination was complete. Secondary fibers differentiated from elongating epithelial cells near the posterior pole. Quantification characterized three stages of lens growth. The study confirmed the advantages of live-cell imaging for three-dimensional quantitative structural characterization of the mechanism(s) responsible for cell differentiation in formation of a transparent, symmetric, and refractile lens. Developmental Dynamics 238:2254,2265, 2009. © 2009 Wiley-Liss, Inc. [source] An amphioxus winged helix/forkhead gene, AmphiFoxD: Insights into vertebrate neural crest evolutionDEVELOPMENTAL DYNAMICS, Issue 3 2002Jr-Kai Yu Abstract During amphioxus development, the neural plate is bordered by cells expressing many genes with homologs involved in vertebrate neural crest induction. However, these amphioxus cells evidently lack additional genetic programs for the cell delaminations, migrations, and differentiations characterizing definitive vertebrate neural crest. We characterize an amphioxus winged helix/forkhead gene (AmphiFoxD) closely related to vertebrate FoxD genes. Phylogenetic analysis indicates that the AmphiFoxD is basal to vertebrate FoxD1, FoxD2, FoxD3, FoxD4, and FoxD5. One of these vertebrate genes (FoxD3) consistently marks neural crest during development. Early in amphioxus development, AmphiFoxD is expressed medially in the anterior neural plate as well as in axial (notochordal) and paraxial mesoderm; later, the gene is expressed in the somites, notochord, cerebral vesicle (diencephalon), and hindgut endoderm. However, there is never any expression in cells bordering the neural plate. We speculate that an AmphiFoxD homolog in the common ancestor of amphioxus and vertebrates was involved in histogenic processes in the mesoderm (evagination and delamination of the somites and notochord); then, in the early vertebrates, descendant paralogs of this gene began functioning in the presumptive neural crest bordering the neural plate to help make possible the delaminations and cell migrations that characterize definitive vertebrate neural crest. © 2002 Wiley-Liss, Inc. [source] The dorsal neural tube: A dynamic setting for cell fate decisionsDEVELOPMENTAL NEUROBIOLOGY, Issue 12 2010Shlomo Krispin Abstract The dorsal neural tube first generates neural crest cells that exit the neural primordium following an epithelial-to-mesenchymal conversion to become sympathetic ganglia, Schwann cells, dorsal root sensory ganglia, and melanocytes of the skin. Following the end of crest emigration, the dorsal midline of the neural tube becomes the roof plate, a signaling center for the organization of dorsal neuronal cell types. Recent lineage analysis performed before the onset of crest delamination revealed that the dorsal tube is a highly dynamic region sequentially traversed by fate-restricted crest progenitors. Furthermore, prospective roof plate cells were shown to originate ventral to presumptive crest and to progressively relocate dorsalward to occupy their definitive midline position following crest delamination. These data raise important questions regarding the mechanisms of cell emigration in relation to fate acquisition, and suggest the possibility that spatial and/or temporal information in the dorsal neural tube determines initial segregation of neural crest cells into their derivatives. In addition, they emphasize the need to address what controls the end of neural crest production and consequent roof plate formation, a fundamental issue for understanding the separation between central and peripheral lineages during development of the nervous system. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 796,812, 2010. [source] Modeling of Coating Process, Phase Changes, and Damage of Plasma Sprayed Thermal Barrier Coatings on Ni-Base Superalloys,ADVANCED ENGINEERING MATERIALS, Issue 3 2010Tilmann Beck The paper gives an overview on the modeling activities on plasma sprayed thermal barrier coating in the frame of TFB 63. In the first part, through-process modeling of the APS deposition of a ZrO2 based TBC is described. Starting from simulation of the plasma jet, heat transfer into the powder particles, particle melting, particle impact on the substrate surface, and solidification is simulated. A homogenization method is introduced to describe the mechanical properties of the resulting TBC. The second part shows simulation of interdiffusion and phase transformations of MCrAlY and intermetallic oxidation protection coatings on several cast Ni-base alloy substrates. Finally, FEM-based damage simulation of oxidation protection coatings by transversal fatigue cracks during thermomechanical fatigue loading as well as by delamination of the TBC during thermocyclic loading is discussed. [source] A simple model for the prediction of the fatigue delamination growth of impacted composite panelsFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 10 2004D. G. KATERELOS ABSTRACT The fatigue behaviour of composite panels that have been subjected to low-velocity impact was studied. Impacted specimens were tested under compression,compression fatigue. A delamination propagation model based on the derivation of the strain energy release rate was used. The stress distribution around the initially induced delamination was derived analytically. The shape of the delamination was experimentally monitored by c-scan imaging and is assumed to be an ellipse. The orientation and aspect ratio of the ellipse were used to calculate the corresponding strain energy-release rates, which were subsequently used to predict the direction of delamination propagation. [source] Fracture analysis of composite co-cured structural joints using decohesion elementsFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 9 2004P. P. CAMANHO ABSTRACT Delamination is one of the predominant forms of failure in laminated composite structures, especially when there is no reinforcement in the thickness direction. To develop composite structures that are more damage tolerant, it is necessary to understand how delamination develops, and how it can affect the residual performance. A number of factors such as residual thermal stresses, matrix-curing shrinkage and manufacturing defects affect how damage will grow in a composite structure. It is important to develop computationally efficient analysis methods that can account for all such factors. The objective of the current work is to apply a newly developed decohesion element to investigate the debond strength of skin-stiffener composite specimens. The process of initiation of delaminations and the propagation of delamination fronts is investigated. The numerical predictions are compared with published experimental results. [source] Inherent flammability parameters,Room corner test applicationFIRE AND MATERIALS, Issue 8 2009J. G. Quintiere Abstract It has been hypothesized that four parameters are solely responsible for a material's performance in a flammability scenario. This excludes effects of material physical integrity, i.e. melting, delamination, etc. They are (1) the critical heat flux below which piloted ignition cannot occur (CHF), (2) the ratio of heat of combustion to heat of gasification (HRP), (3) the thermal response parameter related to the thermal inertia and the ignition temperature (TRP), and (4) the available energy per unit area (AEP). The fire scenario controls the process by its initial heat flux and region of ignition. The hypothesis is applied to 54 tests of the ISO Room Corner Test to assess its validity. It is shown that these four parameters give good correlations in predicting the time to flashover and whether it occurs. In principle, different correlations could be developed for other scenarios of tests and fire configurations. Copyright © 2009 John Wiley & Sons, Ltd. [source] Siloxane Copolymers for Nanoimprint Lithography,ADVANCED FUNCTIONAL MATERIALS, Issue 1 2007P. Choi Abstract Presented here is the novel use of thermoplastic siloxane copolymers as nanoimprint lithography (NIL) resists for 60,nm features. Two of the most critical steps of NIL are mold release and pattern transfer through dry etching. These require that the NIL resist have low surface energy and excellent dry-etching resistance. Homopolymers traditionally used in NIL, such as polystyrene (PS) or poly(methyl methacrylate) (PMMA), generally cannot satisfy all these requirements as they exhibit polymer fracture and delamination during mold release and have poor etch resistance. A number of siloxane copolymers have been investigated for use as NIL resists, including poly(dimethylsiloxane)- block -polystyrene (PDMS- b -PS), poly(dimethylsiloxane)- graft -poly(methyl acrylate)- co -poly(isobornyl acrylate) (PDMS- g -PMA- co -PIA), and PDMS- g -PMMA. The presence of PDMS imparts the materials with many properties that are favorable for NIL, including low surface energy for easy mold release and high silicon content for chemical-etch resistance,in particular, extremely low etch rates (comparable to PDMS) in oxygen plasma, to which organic polymers are quite susceptible. These properties give improved NIL results. [source] A simplified analysis of interface failure under compressive normal stress and monotonic or cyclic shear loadingINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 4 2005Zenon Mróz Abstract Interface damage and delamination is usually accompanied by frictional slip at contacting interfaces under compressive normal stress. The present work is concerned with an analysis of progressive interface failure using the cohesive crack model with the critical stress softening and frictional traction present at the contact. Both monotonic and cyclic loadings are considered for anti-plane shear of an elastic plate bonded to a rigid substrate by means of cohesive interface. An analytical solution can be obtained by neglecting the effect of minor shear stress component. The analysis of progressive delamination process revealed three solution types, namely: short, medium and long plate solutions. The long plate solution was obtained under an assumption of quasistatic progressive growth of the delamination zone. In view of snap back response, the quasistatic deformation process cannot be executed by either traction or displacement control. The states of frictional slip accompanied by shake down or incremental failure are distinguished in the case of cyclic loading, related to load amplitude and structural dimensions. The analysis provides a reference solution for numerical treatment of more complex cases. Copyright © 2005 John Wiley & Sons, Ltd. [source] An enriched element-failure method (REFM) for delamination analysis of composite structuresINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 6 2009X. S. Sun Abstract This paper develops an enriched element-failure method for delamination analysis of composite structures. This method combines discontinuous enrichments in the extended finite element method and element-failure concepts in the element-failure method within the finite element framework. An improved discontinuous enrichment function is presented to effectively model the kinked discontinuities; and, based on fracture mechanics, a general near-tip enrichment function is also derived from the asymptotic displacement fields to represent the discontinuity and local stress intensification around the crack-tip. The delamination is treated as a crack problem that is represented by the discontinuous enrichment functions and then the enrichments are transformed to external nodal forces applied to nodes around the crack. The crack and its propagation are modeled by the ,failed elements' that are applied to the external nodal forces. Delamination and crack kinking problems can be solved simultaneously without remeshing the model or re-assembling the stiffness matrix with this method. Examples are used to demonstrate the application of the proposed method to delamination analysis. The validity of the proposed method is verified and the simulation results show that both interlaminar delamination and crack kinking (intralaminar crack) occur in the cross-ply laminated plate, which is observed in the experiment. Copyright © 2009 John Wiley & Sons, Ltd. [source] Strain Rate Effects in the Mechanical Response of Polymer-Anchored Carbon Nanotube Foams,ADVANCED MATERIALS, Issue 3 2009Abha Misra Strain rate effects on the mechanical properties of carbon nanotube forests are studied, and several related interesting new phenomena are reported. Dense vertically aligned foam-like forests of carbon nanotubes are anchored on a thin, flexible polymer layer to provide structural stability, particularly at the higher strain rates. Permanent deformation and for the first time the delamination and crumbling of carbon nanotube walls is observed. [source] Numerical simulation of fatigue-driven delamination using interface elementsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 13 2005Paul Robinson Abstract This paper presents a computational technique for the prediction of fatigue-driven delamination growth in composite materials. The interface element, which has been extensively applied to predict delamination growth due to static loading, has been modified to incorporate the effects of cyclic loading. Using a damage mechanics formulation, the constitutive law for the interface element has been extended by incorporating a modified version of a continuum fatigue damage model. The paper presents details of the fatigue degradation strategy and examples of the predicted fatigue delamination growth in mode I, mode II and mixed mode I/II are presented to demonstrate that the numerical model mimics the Paris law behaviour usually observed in experimental testing. Copyright © 2005 John Wiley & Sons, Ltd. [source] On the peel behavior of polymer coating,steel system: Effect of hygrothermal agingADVANCES IN POLYMER TECHNOLOGY, Issue 3 2010N. Guermazi Abstract This paper describes the development and application of a new peel protocols for the evaluation of adhesion of a flexible-to-rigid assembly. The developed apparatus allows simulating and predicting the delamination of the polymer coating from the steel substrate. The effect of certain test parameters such as a peel angle and peel speed was discussed. The durability of the retained assembly was equally investigated by considering an accelerated hygrothermal aging. The interfacial damages after conditioning and peel tests were characterized. Using two peeling angles of 90° and 180°, no significant difference was observed in terms of peel responses. The interface behavior seems to be not sensitive to the peel angle. However, an increase in the peel rate induces an increase in the peel strength. The characterization of the interface exhibits two mechanisms: The delamination process of the polymer coating is characterized by cohesive and mixed rupture, respectively, at low and high peel rates. Studying the effects of aging and coating defects on the interface behavior displays a continuous loss of adhesion of the polymer coating especially when it presents physical defects. © 2010 Wiley Periodicals, Inc. Adv Polym Techn 29:185,196, 2010; View this article online at wileyonlinelibrary. DOI 10.1002/adv.20188 [source] Polyamide 66 binary and ternary nanocomposites: Mechanical and morphological propertiesJOURNAL OF APPLIED POLYMER SCIENCE, Issue 1 2010Miray Mert Abstract Polyamide 66 (PA 66)/impact modifier blends and polyamide/organoclay binary and PA 66/organoclay/impact modifier ternary nanocomposites were prepared by the melt-compounding method, and the effects of the mixing sequences on the morphology and mechanical and flow properties were investigated. Lotader AX8840 and Lotader AX8900 were used as impact modifiers. The concentrations of the impact modifiers and the organoclay (Cloisite 25A) were maintained at 2 and 5 wt %, respectively. Both the binary and ternary nanocomposites displayed high tensile strength and Young's modulus values compared to the PA 66/impact modifier blends. Decreases occurred in the strength and stiffness of the binary nanocomposites upon incorporation of the elastomeric materials into the polymeric matrix. In general, the mixing sequence in which all three ingredients were added simultaneously and extruded twice (the All-S mixing sequence) exhibited the most enhanced mechanical properties in comparison with the mixing sequences in which two of the components were extruded in the first extrusion step and the third ingredient was added in the second extrusion step. The mechanical test results were in accordance with the organoclay dispersion. The impact strength was highly affected by the elastomeric domain sizes, interdomain distances, interfacial interactions, and organoclay delamination. The smallest elastomeric domain size was obtained for the All-S mixing sequence, whereas the elastomeric domain sizes of the other mixing sequences were quite close to each other. Drastic variations were not observed between the melt viscosities of the ternary nanocomposites prepared with different mixing sequences. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 [source] Stability of poly(3,4-ethylene dioxythiophene) materials intended for implants,JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 2 2010Elin M. Thaning Abstract This study presents experiments designed to study the stability of the conducting polymer poly(3,4-ethylene dioxythiophene) (PEDOT), under simulated physiological conditions using phosphate-buffered saline (PBS) and hydrogen peroxide (H2O2) (0.01M) at 37°C over a 5- to 6-week period. Voltage pulsing in PBS was used as an additional test environment. The influence of switching the counter ion used in electropolymerization from polystyrene sulphonate (PSS) to heparin was investigated. Absorbance spectroscopy and cyclic voltammetry were used to evaluate the material properties. Most of the samples in H2O2 lost both electroactivity and optical absorbance within the study period, but PEDOT:PSS was found slightly more stable than PEDOT:heparin. Polymers were relatively stable in PBS throughout the study period, with around 80% of electroactivity remaining after 5 weeks, disregarding delamination, which was a significant problem especially for polymer on indium tin oxide substrates. Voltage pulsing in PBS did not increase degradation. The counter ion influenced the time course of degradation in oxidizing agents. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010 [source] Surface damage analysis of retrieved highly crosslinked polyethylene tibial components after short-term implantation,JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 1 2008B. M. Willie Abstract The use of highly crosslinked polyethylene (PE) in the knee remains controversial, because of reduced fatigue fracture properties of the material. The current study investigated postmelt surface damage as well as potential contributors to this damage in retrieved highly crosslinked PE tibial components, after short-term in vivo durations. Retrieved conventional PE tibial components were examined for comparison, as well as unused time zero highly crosslinked and conventional PE tibial components for inherent manufacturing surface characterization. Predominant surface damage modes on highly crosslinked PE components were machine mark loss and abrasion, while conventional PE components primarily had machine mark loss, abrasion, and delamination. In vivo duration, PE thickness, and conformity of the design were significant predictors of surface damage on retrieved conventional PE components. Donor weight and the conformity of the design were significant predictors of surface damage on retrieved highly crosslinked PE components. This retrieval data on highly crosslinked PE tibial components suggest that in vivo wear occurred, observed as postmelt surface damage. The highly crosslinked Durasul material examined in this retrieval study appeared to outperform the conventional PE components made from 4150 resin, ram-extruded and ,-sterilized in air, but not the conventional components made from 1020 resin, compression molding and , sterilization in nitrogen. Early retrieval data of highly crosslinked PE tibial components are important to serve as a benchmark to be compared with future longer-term retrieval studies investigating whether surface damage translates to clinically relevant particulate wear debris generation and PE clinical performance. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008 [source] Gamma irradiation alters fatigue-crack behavior and fracture toughness in 1900H and GUR 1050 UHMWPEJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 5 2002Jantzen C. Cole Abstract Pitting and delamination remain causative factors of polyethylene failure in total knee replacement. Gamma irradiation induces cross linking in ultra-high-molecular-weight polyethylene, which has been shown to improve wear resistance. Irradiation may reduce fracture toughness and fatigue strength, however, and the effects of irradiation are dependent upon the resin, processing technique, and radiation dose. The effects of varying levels of gamma irradiation (0, 33, 66, and 100 kGy) on the fracture toughness and fatigue-crack resistance of UHMWPE, isostatically molded from 1900H and GUR 1050 resins, were examined. Paris law regressions were performed to quantify fatigue-crack propagation rates as functions of change in stress intensity, and J -integral methods were used to quantify the elastic,plastic fracture toughness. The results indicated that gamma irradiation reduced the resistance of both materials to fatigue-crack growth, and that the reductions were radiation dosage and resin dependent. Irradiation at any level was detrimental to the fracture toughness of the 1900H specimens. Irradiation at 33 kGy increased fracture toughness for the GUR 1050 specimens, and substantial reductions were observed only at the highest irradiation level. Scanning electron microscopy of the fracture surface revealed diamond-like fracture patterns of the nonirradiated specimens indicative of ductile, multilevel fracture. Pronounced striations were apparent on these fracture surfaces, oriented perpendicular to the direction of crack growth. The striations appeared as folds in surface layers of the GUR 1050 specimens. At the highest irradiation levels, the striations were nearly eliminated on the fracture surfaces of the 1900H specimens, and were markedly less severe for the GUR 1050. These results demonstrated that at higher irradiation levels the materials became more brittle in fatigue, with less ductile folding and tearing of the fracture surfaces. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 559,566, 2002 [source] The Short-Term Effect on Restenosis and Thrombosis of a Cobalt-Chromium Stent Eluting Two Drugs in a Porcine Coronary Artery ModelJOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 5 2009YINGYING HUANG Ph.D. The aim of this article was to study the effect of dual drug-eluting stent (DES) on both restenosis and thrombosis in a porcine coronary artery model. This study reports on the use of two drugs coated on the stent to simultaneously minimize both restenosis and thrombosis. The DES was prepared by spray coating a bare metal stent with a biodegradable polymer loaded with sirolimus and triflusal, to treat against restenosis and thrombosis, respectively. The two-layered dual drug-coated stent was characterized in vitro for surface properties before and after expansion, as well as for possible delamination by cross-sectioning the stent in vitro. In vivo animal studies (in a pig model) were then performed for acute thrombosis, inflammation, and restenosis. The results show a significant reduction in restenosis with a stent coated with both drugs compared with the controls (a bare metal stent, a sirolimus-coated, and a pure polymer-coated stent). The reduction in restenosis with a sirolimus/triflusal-eluting stent is associated with an inhibition of inflammation and thrombus formation, suggesting that such dual DES have a role to play for the treatment of coronary artery diseases. [source] Ultrahigh-pressure eclogite transformed from mafic granulite in the Dabie orogen, east-central ChinaJOURNAL OF METAMORPHIC GEOLOGY, Issue 9 2007Y.-C. LIU Abstract Although ultrahigh-pressure (UHP) metamorphic rocks are present in many collisional orogenic belts, almost all exposed UHP metamorphic rocks are subducted upper or felsic lower continental crust with minor mafic boudins. Eclogites formed by subduction of mafic lower continental crust have not been identified yet. Here an eclogite occurrence that formed during subduction of the mafic lower continental crust in the Dabie orogen, east-central China is reported. At least four generations of metamorphic mineral assemblages can be discerned: (i) hypersthene + plagioclase ± garnet; (ii) omphacite + garnet + rutile + quartz; (iii) symplectite stage of garnet + diopside + hypersthene + ilmenite + plagioclase; (iv) amphibole + plagioclase + magnetite, which correspond to four metamorphic stages: (a) an early granulite facies, (b) eclogite facies, (c) retrograde metamorphism of high-pressure granulite facies and (d) retrograde metamorphism of amphibolite facies. Mineral inclusion assemblages and cathodoluminescence images show that zircon is characterized by distinctive domains of core and a thin overgrowth rim. The zircon core domains are classified into two types: the first is igneous with clear oscillatory zonation ± apatite and quartz inclusions; and the second is metamorphic containing a granulite facies mineral assemblage of garnet, hypersthene and plagioclase (andesine). The zircon rims contain garnet, omphacite and rutile inclusions, indicating a metamorphic overgrowth at eclogite facies. The almost identical ages of the two types of core domains (magmatic = 791 ± 9 Ma and granulite facies metamorphic zircon = 794 ± 10 Ma), and the Triassic age (212 ± 10 Ma) of eclogitic facies metamorphic overgrowth zircon rim are interpreted as indicating that the protolith of the eclogite is mafic granulite that originated from underplating of mantle-derived magma onto the base of continental crust during the Neoproterozoic (c. 800 Ma) and then subducted during the Triassic, experiencing UHP eclogite facies metamorphism at mantle depths. The new finding has two-fold significance: (i) voluminous mafic lower continental crust can increase the average density of subducted continental lithosphere, thus promoting its deep subduction; (ii) because of the current absence of mafic lower continental crust in the Dabie orogen, delamination or recycling of subducted mafic lower continental crust can be inferred as the geochemical cause for the mantle heterogeneity and the unusually evolved crustal composition. [source] Reconstructing P,T paths during continental collision using multi-stage garnet (Gran Paradiso nappe, Western Alps)JOURNAL OF METAMORPHIC GEOLOGY, Issue 6 2006B. LE BAYON Abstract Garnet,chloritoid-bearing micaschists from the Gran Paradiso massif (Western Alps) contain evidence of a polymetamorphic evolution. Detailed textural observations reveal that two stages of garnet growth are present in the micaschists, interpreted as: (i) relics of an early metamorphism of pre-Alpine age and (ii) newly grown Alpine garnet, respectively. Both generations of garnet preserve growth zoning. From thermocalc -based numerical modelling of mineral assemblages in pressure,temperature (P,T) pseudosections, we infer that garnet 1 grew at increasing temperature and slightly increasing pressure, whereas garnet 2 grew at decreasing pressure and slightly increasing temperature. Estimated P,T conditions are ,620 °C, 6 kbar for the peak of the pre-Alpine event, and of 490 °C, 18,20 kbar for the pressure peak of the Alpine event. Modelling of the modal proportion and chemical composition of garnet (i) shows that the subsequent decompression (to 14,15 kbar at 550 °C) must have been accompanied by moderate heating and (ii) does not support a stage of final temperature increase following decompressional cooling. This argues against a late thermal pulse associated with mantle delamination. Preservation of growth zoning in both generations of garnet and the limited amount of diffusive re-equilibration at the boundary between the two garnets suggests that the rocks were subjected to fast burial and exhumation rates, consistent with data obtained from other internal Alpine units. [source] Wear, delamination, and fatigue resistance of melt-annealed highly crosslinked UHMWPE cruciate-retaining knee inserts under activities of daily livingJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 9 2010Oludele O. Popoola Abstract The wear, delamination, and fatigue resistance of artificially aged gamma irradiation-sterilized conventional polyethylene (CPE) and gas-plasma-sterilized melt-annealed highly crosslinked polyethylene tibial inserts (HXPE) were compared. Six CPE and 12 HXPE (six irradiated at 58,kGy and six at 72,kGy) left knee inserts were wear tested for 5.5 million cycles (Mc) under loads and motions that mimic activities of daily living, such as walking, chair rise, stair ascent, and deep squatting. Another six HXPE (72,kGy) and six CPE inserts were also tested under conditions that could produce severe delamination for 8 Mc. Ten other knees (five 72,kGy HXPE and five CPE) were subjected to posterior edge loading fatigue testing for 5 Mc. The HXPE inserts had an average wear rate reduction of about 80% relative to their CPE counterparts during all activities. All of the CPE inserts delaminated and fractured during high cycle deep squat (152° flexion) motions, while all the HXPE remained intact. None of the HXPE inserts delaminated after 8 Mc, while all of the CPE inserts developed delamination damage within 1.5,5.8 Mc of delamination testing. All CPE inserts developed subsurface cracks and delamination within 2.8 Mc during posterior edge loading fatigue studies, while none of the HXPE inserts showed cracking or delamination after 5 Mc. These results show that aged HXPE has higher wear and fatigue resistance than aged CPE, and offers potential long-term advantages for young active patients with sustained activities of daily living. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1120,1126, 2010 [source] Effect of crosslinking, remelting, and aging on UHMWPE damage in a linear experimental wear modelJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 7 2007Suzanne A. Maher Abstract The objective of this study was to establish the effect of postirradiation melting as a function of irradiation dose on the wear behavior and material characteristics of ultrahigh molecular weight polyethylene. Our hypothesis was that a low dose of irradiation followed by melting would have the same improved wear performance as is found with higher doses of irradiation, but without the disadvantages associated with reduced fracture toughness. The hypothesis was tested by measuring the wear performance (wear track area, incidence of pitting and delamination) in a linear doubly curved-on-flat cyclic test, material behavior (elastic modulus, fracture toughness), and aging response (density changes through the thickness) of the following materials: elevated crosslinked groups,radiated at 25, 65, and 120 kGy, melted, sterilized and aged; a melted group,melted, sterilized, and aged; and a control group,sterilized and aged. Our findings suggest that postirradiation melting, not the irradiation dose, dominates the material property changes and wear response. Melting ensured reduced modulus and therefore decreased contact stresses, superior wear performance, and good resistance to aging, even after low levels of irradiation (25 kGy). The low modulus of the 25 kGy elevated crosslinked group, coupled with increased fracture toughness compared to samples irradiated at higher doses and a resistance to aging not found in the melted group, support our hypothesis. A low dose of irradiation followed by heat treatment has the same beneficial effects in terms of improved wear performance, but without the disadvantages of reduced fracture toughness found with higher doses of irradiation. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:849,857, 2007 [source] Noncontact photo-acoustic defect detection in drug tabletsJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 8 2007Ivin Varghese Abstract Quality assurance monitoring is of great importance in the pharmaceutical industry for the reason that if defects such as coating layer irregularities, internal cracks, and delamination are present in a drug tablet, the desired dose delivery and bioavailability can be compromised. The U.S. Food and Drug Administration (FDA) established the Process Analytical Technology (PAT) initiative, in order to ensure efficient quality monitoring at each stage of the manufacturing process by the integration of analysis systems into the evaluation procedure. Improving consistency and predictability of tablet action by improving quality and uniformity of tablet coatings as well as ensuring core integrity is required. An ideal technique for quality monitoring would be noninvasive, nondestructive, have a short measurement time, intrinsically safe, and relatively inexpensive. In the proposed acoustic system, a pulsed laser is utilized to generate noncontact mechanical excitations and interferometric detection of transient vibrations of the drug tablets is employed for sensing. Two novel methods to excite vibrational modes in drug tablets are developed and employed: (i) a vibration plate excited by a pulsed-laser and (ii) pulsed laser-induced plasma generated shockwave expansion. Damage in coat and/or core of a tablet weakens its mechanical stiffness and, consequently, affects its acoustic response to an external dynamic force field. From the analysis of frequency spectra and the time,frequency spectrograms obtained under both mechanisms, it can be concluded that defective tablets can be effectively differentiated from the defect-free ones and the proposed proof-of-concept techniques have potential to provide a technology platform to be used in the greater PAT effort. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:2125,2133, 2007 [source] Microtensile Bond Strength and Impact Energy of Fracture of CAD-Veneered Zirconia RestorationsJOURNAL OF PROSTHODONTICS, Issue 3 2009Moustafa N. Aboushelib DDS Abstract Purpose: With state-of-the-art CAD/CAM technology, the fabrication of large and complex zirconia frameworks is just a click away. On the other hand, veneering of the frameworks is still operator-dependent. The aim of this work was to evaluate CAD veneering of zirconia restorations in terms of zirconia veneer bond strength and impact energy of fracture in a step towards complete automation of the fabrication process. Materials and Methods: A new CAD/CAM system was used to fabricate a resin replica of the esthetic ceramic required to veneer a zirconia framework. The replica was seated on the zirconia framework and further processed using press-on technology. The bond strength between zirconia and the CAD veneer was evaluated using microtensile bond strength test. The impact energy of fracture of the specimens was also investigated. Manually layered zirconia specimens served as a control (,= 0.05). Results: There was no significant difference in the microtensile bond strength between zirconia and either of the used veneers (39 MPa). Even though the impact energy of fracture of the CAD-veneered and manually layered specimens was almost identical (0.13 J), the former demonstrated a cohesive fracture of the veneer, while the latter failed by delamination of the veneer ceramic. Conclusion: CAD veneering is a reliable method for veneering zirconia restorations. [source] | ||||||||||||||||||||||||||||||||||