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Deaf Patients (deaf + patient)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Absence of deafness-associated connexin-26 (GJB2) gene mutations in the Omani population ,,

HUMAN MUTATION, Issue 6 2001
Mehmet Simsek
Abstract We have investigated the prevalence of mutations in the connexin 26 (GJB2) gene in Omani population using both PCR-RFLP and direct DNA sequencing methods. Two common GJB2 gene mutations (35delG and 167delT) were screened in 280 healthy controls and 95 deaf patients using two different PCR-RFLP methods. To investigate other GJB2 mutations, we have amplified and sequenced DNA from 51 unrelated deaf patients and 17 control subjects. None of the samples studied, either by RFLP or sequencing, revealed any deafness-associated mutations in the coding region of the GJB2 gene. These findings disagree with many reports on the GJB2 gene, describing various mutations as the cause of congenital recessive deafness. Although, an amino acid substitution (S86T) was identified by sequencing, we conclude that this change could not be associated with deafness since it was present in all the control and patient samples sequenced. © 2001 Wiley-Liss, Inc. [source]

Medical students, deaf patients and cancer

MEDICAL EDUCATION, Issue 11 2004
Jacqueline H Farber
No abstract is available for this article. [source]

Bone-anchored hearing aid subjective benefit for unilateral deafness,,

THE LARYNGOSCOPE, Issue 3 2010
John W. House MD
Abstract Objectives/Hypothesis: Determine the benefit of the bone-anchored hearing aid (BAHA) in patients with unilateral deafness. Study Design: Retrospective case series and prospective questionnaire study at a tertiary referral center. Methods: Patients with unilateral deafness of various etiologies who were implanted with a BAHA (n = 126) or not implanted with a BAHA after a translabyrinthine craniotomy (n = 126) were mailed questionnaires. A total of 139 patients (55%) responded to the questionnaires. Patients who were implanted with a BAHA received a general questionnaire concerning BAHA usage, the Abbreviated Profile of Hearing Aid Benefit (APHAB), and the Speech, Spatial, and Qualities of Hearing Questionnaire (SSQ). Patients not implanted with a BAHA received only the SSQ hearing questionnaire. Results: Patients with unilateral deafness demonstrated a benefit with BAHA use on the APHAB. Most improvement with the BAHA was seen in the Background Noise subscale, with a 17.4% improvement. Ease of Communication and Reverberation subscales also demonstrated an 11.6% and 13.2% benefit, respectively. Patients with a BAHA demonstrated better scores in the SSQ Speech subscale when compared to unilaterally deaf patients who did not have a BAHA, although this difference was not significant. Conclusions: The APHAB demonstrated significant benefit with the use of a BAHA in patients with unilateral deafness. Although the SSQ speech subscale showed overall improvement in auditory disability with the use of a BAHA, this difference was not significant. However, the SSQ hearing questionnaire demonstrated specific situations were the BAHA is most useful. Laryngoscope, 2010 [source]