Home About us Contact
|
Home About us Contact | ||
|
|
||
Deep
Kinds of Deep Terms modified by Deep Selected AbstractsIsolation of epithelial stem cells from dermis by a three-dimensional culture system,JOURNAL OF CELLULAR BIOCHEMISTRY, Issue 1 2006Reinhold J. Medina Abstract Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mouse embryonic skin using a simple selection method based on an assumption that stem cells may grow in an anchorage-independent manner. We inoculated single cell suspensions prepared from mouse embryonic dermis into a temperature-sensitive gel and propagated the resulting colonies in a monolayer culture. The cells named dermis-derived epithelial progenitor-1 (DEEP) showed epithelial morphology and grew rapidly to a more than 200 population doubling level over a period of 250 days. When the cells were kept confluent, they spontaneously formed spheroids and continuously grew even in spheroids. Immunostaining revealed that all of the clones were positive for the expression of cytokeratin-8, ,18, ,19, and E-cadherin and negative for the expression of cytokeratin-1, ,5, ,6, ,14, ,20, vimentin, nestin, a ckit. Furthermore, they expressed epithelial stem cell markers such as p63, integrin ,1, and S100A6. On exposure to TGF, in culture, some of DEEP-1 cells expressed ,-smooth muscle actin. When the cells were transplanted into various organs of adult SCID mice, a part of the inoculated cell population acquired neural, hepatic, and renal cell properties. These results indicate that the cells we isolated were of epithelial stem cell origin and that our new approach is useful for isolation of multipotent stem cells from skin tissues. J. Cell. Biochem. 98: 174,184, 2006. © 2006 Wiley-Liss, Inc. [source] SHALLOW, DEEPER, DEEP: A FEW THOUGHTS ON A SMALL PIECE OF WALTER SINNOTT-ARMSTRONG'S MORAL SKEPTICISMSANALYTIC PHILOSOPHY, Issue 3 2008Jamie Dreier First page of article [source] Branding Deep in the Russian FederationDESIGN MANAGEMENT REVIEW, Issue 2 2006Tim Robertson Principal First page of article [source] Geomorphology of the onset area of a paleo-ice stream, Marguerite Bay, Antarctic PeninsulaEARTH SURFACE PROCESSES AND LANDFORMS, Issue 4 2008John B. Anderson Abstract Geomorphic features indicate that both glacial and melt-water erosion characterize the onset area of the ancestral Marguerite Ice Stream. The large size of these features indicates that they formed over repeated glacial cycles, most recently during the Last Glacial Maximum. Ice drainage within the bay and on the inner continental shelf was strongly influenced by tectonic fabric. Deep, isolated basins surrounded by rugged bedrock bathymetry characterize the innermost part of the bay. Drumlins and other streamlined features occur in the floors of these basins at depths of up to 900 m. The outer bay has three large interconnected basins. Drumlins and megaflutings within these basins indicate ice was grounded at water depths up to 1000 m. The orientations of these features show convergence of drainage from the northeast, east and south into the Marguerite paleo-ice stream. On the inner continental shelf, the ice converged into a single, wide trough dominated by mega-scale glacial lineations. This transition in geomorphic features from drumlins and megaflutings to mega-scale glacial lineations occurs at the location on the continental shelf where sedimentary strata blanket bedrock, and marks a zone of acceleration of the ice stream. The glacially sculptured geomorphic features within Marguerite Bay co-exist with anastomosing, radial and relatively straight channels, which become increasingly focused in a seaward direction. This implies that a well organized subglacial drainage system existed within the bay at some point in the past. Copyright © 2008 John Wiley & Sons, Ltd. [source] Laparoscopic management of benign liver diseases: where are we?HPB, Issue 4 2004Jean-François Gigot Background The role of laparoscopic surgery in the management of benign cystic and solid liver tumours appears to differ according to each tumour type. As regards congenital liver cysts, laparoscopic treatment is now the gold standard for treating selected, huge, accessible, highly symptomatic or complicated cysts. In contrast, the laparoscopic approach is not useful for patients suffering from adult polycystic liver disease (PLD), except for type I PLD with large multiple hepatic cysts. For benign hepatocellular tumours, the surgical management has recently benefited from a better knowledge of the natural history of each type of tumour and from the improvement of imaging techniques in assuring a precise diagnosis of tumour nature. Thus the general tendency has led to a progressive restriction and tailoring of indications for resection in benign liver tumours, selecting only patients with huge, specifically symptomatic or compressive benign tumours or patients suffering from liver cell adenoma. Despite the enthusiastic use of the laparoscopic approach, selective indications for resection of benign liver tumours should indeed remain unchanged. For all types of benign liver tumours, the best indication remains small, superficial lesions, located in the anterior or the lateral segments of the liver. Deep, centrally located lesions or tumours in contact with major vascular or biliary trunks are not ideal candidates for laparoscopic liver resections. When performed by expert liver and laparoscopic surgeons using an adequate surgical technique, the laparoscopic approach is safe for performing minor liver resections and is accompanied by the usual postoperative benefits of laparoscopic surgery. When applied in selected patients and tumours, laparoscopic management of benign liver diseases appears to be a promising technique for hepatobiliary surgeons. [source] Deep and Shallow Integration in Asia: Towards a Holistic AccountIDS BULLETIN, Issue 1 2006David Evans First page of article [source] Is Agency Skin Deep?INFANCY, Issue 3 2004Surface Attributes Influence Infants' Sensitivity to Goal-Directed Action Three studies investigated the role of surface attributes in infants' identification of agents, using a habituation paradigm designed to tap infants' interpretation of grasping as goal directed (Woodward, 1998). When they viewed a bare human hand grasping objects, 7- and 12-month-old infants focused on the relation between the hand and its goal. When the surface properties of the hand were obscured by a glove, however, neither 7- nor 12-month-old infants represented its actions as goal directed (Study 1). Next, infants were shown that the gloved hands were part of a person either prior to (Study 2) or during (Study 3) the habituation procedure. Infants who actively monitored the gloved person in Study 2 and older infants in Study 3 interpreted the gloved reaches as goal directed. Thus, varying the extent to which an entity is identifiable as a person impacts infants' interpretation of the entity as an agent. [source] Deep into the Shinnyo Spiritual WorldINTERNATIONAL JOURNAL OF JAPANESE SOCIOLOGY, Issue 1 2001Akira Kawabata "Shinnyo-en" (Garden of the Truth) is one of the most famous religious groups in Japan today. But outside Shinnyo-en it is difficult to understand Shinnyo teaching. By focusing on the words from interviews, this article depicts its spiritual world and analyzes the function of its spiritual power on interviewees. The believers' narrative is interpreted from a sociological perspective using computer-aided qualitative data analysis and a life history approach. The computer-aided coding method is found to be an effectual means to discover significant factors in Shinnyo teachings. This method has four steps: (1) interview transcripts are input in ASCII format in several groups according to the time we interviewed; (2) KT2 system, a set of programs for computerized content analysis, disaggregates the transcripts into words to which I assign codes; (3) the codes are integrated into several meaningful categories for a cross-tabular examination of two variables, times and categories; (4) a contour map made from the cross-table helps to grasp the significance of the categories and their relations in a life history. This procedure enables us to understand the significance of the "self", and the transformation of the "self" according to the time flows. The contour map of the belief commands a panoramic view of Shinnyo teaching. From this point of view we can scrutinize the interview data and describe the Shinnyo spiritual world as it is understood. [source] Ultrastructure of the embryonic snake skin and putative role of histidine in the differentiation of the shedding complexJOURNAL OF MORPHOLOGY, Issue 2 2002Lorenzo Alibardi Abstract The morphogenesis and ultrastructure of the epidermis of snake embryos were studied at progressive stages of development through hatching to determine the time and modality of differentiation of the shedding complex. Scales form as symmetric epidermal bumps that become slanted and eventually very overlapped. During the asymmetrization of the bumps, the basal cells of the forming outer surface of the scale become columnar, as in an epidermal placode, and accumulate glycogen. Small dermal condensations are sometimes seen and probably represent primordia of the axial dense dermis of the growing tip of scales. Deep, dense, and superficial loose dermal regions are formed when the epidermis is bilayered (periderm and basal epidermis) and undifferentiated. Glycogen and lipids decrease from basal cells to differentiating suprabasal cells. On the outer scale surface, beneath the peridermis, a layer containing dense granules and sparse 25,30-nm thick coarse filaments is formed. The underlying clear layer does not contain keratohyalin-like granules but has a rich cytoskeleton of intermediate filaments. Small denticles are formed and they interdigitate with the oberhautchen spinulae formed underneath. On the inner scale surface the clear layer contains dense granules, coarse filaments, and does not form denticles with the aspinulated oberhautchen. On the inner side surface the oberhautchen only forms occasional spinulae. The sloughing of the periderm and embryonic epidermis takes place in ovo 5,6 days before hatching. There follow beta-, mesos-, and alpha-layers, not yet mature before hatching. No resting period is present but a new generation is immediately produced so that at 6,10 h posthatching an inner generation and a new shedding complex are forming beneath the outer generation. The first shedding complex differentiates 10,11 days before hatching. In hatchlings 6,10 h old, tritiated histidine is taken up in the epidermis 4 h after injection and is found mainly in the shedding complex, especially in the apposed membranes of the clear layer and oberhautchen cells. This indicates that a histidine-rich protein is produced in preparation for shedding, as previously seen in lizard epidermis. The second shedding (first posthatching) takes place at 7,9 days posthatching. It is suggested that the shedding complex in lepidosaurian reptiles has evolved after the production of a histidine-rich protein and of a beta-keratin layer beneath the former alpha-layer. J. Morphol. 251:149,168, 2002. © 2002 Wiley-Liss, Inc. [source] Deglacial seasonal and sub-seasonal diatom record from Palmer Deep, Antarctica,JOURNAL OF QUATERNARY SCIENCE, Issue 5 2005Eleanor J. Maddison Abstract The Antarctic Peninsula is one of the most sensitive regions of Antarctica to climate change. Here, ecological and cryospheric systems respond rapidly to climate fluctuations. A 4.4,m thick laminated diatom ooze deposited during the last deglaciation is examined from a marine sediment core (ODP Site 1098) recovered from Basin I, Palmer Deep, western Antarctic Peninsula. This deglacial laminated interval was deposited directly over a glaciomarine diamict, hence during a globally recognised period of rapid climate change. The ultra-high-resolution deglacial record is analysed using SEM backscattered electron imagery and secondary electron imagery. Laminated to thinly bedded orange-brown diatom ooze (near monogeneric Hyalochaete Chaetoceros spp. resting spores) alternates with blue-grey terrigenous sediments (open water diatom species). These discrete laminae are interpreted as austral spring and summer signals respectively, with negligible winter deposition. Sub-seasonal sub-laminae are observed repeatedly through the summer laminae, suggesting variations in shelf waters throughout the summer. Tidal cycles, high storm intensities and/or intrusion of Circumpolar Deep Water onto the continental shelf introduced conditions which enhanced specific species productivity through the season. Copyright © 2005 John Wiley & Sons, Ltd. [source] Phylogeographic analysis of the red seaweed Palmaria palmata reveals a Pleistocene marine glacial refugium in the English ChannelMOLECULAR ECOLOGY, Issue 3 2005JIM PROVAN Abstract Phylogeography has provided a new approach to the analysis of the postglacial history of a wide range of taxa but, to date, little is known about the effect of glacial periods on the marine biota of Europe. We have utilized a combination of nuclear, plastid and mitochondrial genetic markers to study the biogeographic history of the red seaweed Palmaria palmata in the North Atlantic. Analysis of the nuclear rDNA operon (ITS1-5.8S-ITS2), the plastid 16S- trnI- trnA-23S-5S, rbcL- rbcS and rpl12- rps31- rpl9 regions and the mitochondrial cox2,3 spacer has revealed the existence of a previously unidentified marine refugium in the English Channel, along with possible secondary refugia off the southwest coast of Ireland and in northeast North America and/or Iceland. Coalescent and mismatch analyses date the expansion of European populations from approximately 128 000 bp and suggest a continued period of exponential growth since then. Consequently, we postulate that the penultimate (Saale) glacial maximum was the main event in shaping the biogeographic history of European P. palmata populations which persisted throughout the last (Weichselian) glacial maximum (c. 20 000 bp) in the Hurd Deep, an enigmatic trench in the English Channel. [source] Discovery of new nearby L and late-M dwarfs at low Galactic latitude from the DENIS data baseMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2008N. Phan-Bao ABSTRACT We report on new nearby L and late-M dwarfs (dphot, 30 pc) discovered in our search for nearby ultracool dwarfs (I,J, 3.0, later than M8.0) at low Galactic latitude (|b| < 15°) over 4800 deg2 in the Deep Near Infrared Survey of the Southern Sky (DENIS) data base. We used late-M (, M8.0), L and T dwarfs with accurate trigonometric parallaxes to calibrate the MJ versus I,J colour,luminosity relation. The resulting photometric distances have standard errors of ,15 per cent, which we used to select candidates dphot, 30 pc. We measured proper motions from multi-epoch images found in the public archives ALADIN, DSS, 2MASS and DENIS, with at least three distinct epochs and time baselines of 10,21 yr. We then used a maximum reduced proper motion cut-off to select 28 candidates as ultracool dwarfs (M8.0,L8.0) and to reject one as a distant red star. No T dwarf candidates were found in this search, which required an object to be detected in all three DENIS bands. Our low-resolution optical spectra confirmed that 26 were indeed ultracool dwarfs, with spectral types from M8.0 to L5.5. Two contaminants and one rejected by the maximum reduced proper motion cut-off were all reddened F,K main sequence stars. 20 of these 26 ultracool dwarfs are new nearby ultracool dwarf members, three L dwarfs within 15 pc with one L3.5 at only ,10 pc. We determine a stellar density of dwarfs pc,3 mag,1 over 11.1 ,MJ, 13.1 based on this sample of M8,L3.5 ultracool dwarfs. Our ultracool dwarf density value is in good agreement with the measurement by Cruz et al. of the ultracool dwarf density at high Galactic latitude. [source] Toward a Unified Paradigm of RaceAMERICAN ANTHROPOLOGIST, Issue 3 2006ENOCH H. PAGE Racism in Mind. Michael Levine and Tamas Pataki, eds. Ithaca, NY: Cornell University Press, 2004. 320 pp. Only Skin Deep: Changing Visions of the American Self. Coco Fusco and Brian Wallis, eds. New York: Harry N. Abrams, 2003. 416 pp. [source] Flow over a hill covered with a plant canopyTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 596 2004J. J. Finnigan Abstract We develop an analytical model for atmospheric boundary-layer flow over a hill that is covered with a vegetation canopy. The slope of the hill is assumed to be small enough that the flow above the canopy can be treated within the linear framework of Hunt. Perturbations to the flow within the canopy are driven by the pressure gradient associated with the flow over the hill. In the upper canopy this pressure gradient is balanced by downwards turbulent transport of momentum and the canopy drag. The flow there can be calculated from linearized dynamics, which show that the maximum streamwise winds are where the perturbation pressure is at a minimum, i.e. near the crest of the hill. Deep within the canopy the pressure gradient associated with the flow over the hill is balanced by the canopy drag, here the nonlinear canopy drag. This nonlinear balance shows how the streamwise winds are largest where the perturbation pressure gradient is largest, i.e. on the upwind slope of the hill. In the lee of the hill this nonlinear solution shows how the pressure gradient decelerates the wind deep within the canopy, leading to separation with a region of reversed flow when the canopy is sufficiently deep. Coupling between the out-of-phase flows within and above the canopy means that the maximum velocity is further upwind of the hill crest than in flow over a rough hill, while the extra turbulent mixing caused by the canopy significantly reduces the magnitude of the velocity speed-up over the hill. Finally, we find that there is no formal limit process where the solutions with a canopy yield the well-known solutions for flow over a rough hill. This finding calls into question the very use of a roughness length in accelerating or decelerating turbulent boundary layers. Copyright © 2004 Royal Meteorological Society [source] From Shallow to Deep: Toward a Thorough Cultural Analysis of School Achievement PatternsANTHROPOLOGY & EDUCATION QUARTERLY, Issue 4 2008Mica Pollock What do anthropologists of education do? Many observers think that we provide quick glosses on what various "cultures",typically racialized, ethnic, and national-origin groups,"do" in schools. Hervé Varenne and I each name an alternative form of analysis that we think should be central to the subfield. Varenne argues that anthropologists of education should expand analysis of teaching and learning beyond (American) schools and classrooms and examine everyday life in various places as containing countless moments of teaching and learning that are worth understanding. Varenne reminds us that teaching and learning occur nonstop in everyday life, not just in classrooms. "Education" is about far more than what we typically call "achievement," which usually translates into grades, graduation, or test scores.1 This long-standing way of thinking anthropologically about "education" is essential to exploding simplistic notions of what, when, how, and from whom people "learn." In my essay, I contend that U.S. anthropologists of education also need to analyze thoroughly how U.S. school achievement patterns take shape in real time. I argue that it is our particular responsibility to counteract "shallow" analyses of "culture" in schools, which purport to explain "achievement gaps" by making quick claims about how parents and children from various racial, ethnic, national-origin, or class groups react to schools. Such shallow analyses dangerously oversimplify the social processes, interactions, and practices that create disparate outcomes for children. Shallow cultural analyses are common in both journalism and popular discourse,and in schools of education as well (see Ladson-Billings 2006 for a related critique). They are explanatory claims that name a group as having a "cultural" set of behaviors and then name that "cultural" behavior as the cause of the group's school achievement outcomes. (E.g., some argue that "group x"[e.g., "Asians"] employs a "group x behavior"[e.g., "push their children"] that causes "high" or "low" achievement.) Such claims allow people to explain achievement outcomes too simply as the production of parents and children without ever actually examining the real-life experiences of specific parents and children in specific opportunity contexts. Going deeper requires pressing for actual, accurate information about the everyday interactions among real-life parents, children, and other actors that add up to school achievement patterns (graduation rates, dropout rates, skill-test scores, suspension lists, and the like). When anthropologists of education say that we study culture, we mean that we are studying the organization of people's everyday interactions in concrete contexts. Shallow analyses of "culture" that purport to describe only how a "group's" parents train its children blame a reduced set of actors, behaviors, and processes for educational outcomes, and they include a reduced set of actors and actions in a reduced set of projects for educational improvement. Anthropologists of education should make clear that we examine children's experiences both in context and in appropriate detail; we study interactional processes that other observers might describe too quickly or with insufficient information.2 I think that if anthropologists of education explicitly, publicly, and colloquially name what counts as deep, thorough cultural analysis of American school achievement patterns, we will make ourselves far better prepared to respond to harmfully shallow claims made by journalists, colleagues, and educators alike. We will also support other stakeholders in children's lives (including teachers and teacher educators) to think more thoroughly about which actions, by whom, and in what situations produce children's achievement. This short essay suggests four key ways that anthropologists of education can, do, and should get "deep" in analyzing American achievement patterns. I invite colleagues to edit and extend this list in future editions of AEQ. [source] Digging Deep for Justice: A Radical Re-imagination of the Artisanal Gold Mining Sector in GhanaANTIPODE, Issue 4 2009Petra Tschakert Abstract:, This article explores the concept of "contact zones" to counteract misrecognition and exclusion in the artisanal gold mining sector of Ghana. The large majority of the 300,000,500,000 Ghanaian artisanal miners work without an official license, illegally. Due to their encroachment on corporate concession lands, the use of toxic mercury in the gold extraction process, and the social disruption caused by their migratory activities, these miners are often marginalized and criminalized. Yet, devaluation and misrecognition hamper environmental stewardship and participation in political decision-making. Through parity-fostering participatory research, I propose a radical re-imagination of the sector that encourages agency and flourishing among these ostracized men and women diggers. [source] More than Skin Deep: A Remarkable Life Story.ANZ JOURNAL OF SURGERY, Issue 5 2004Marius Fahrer No abstract is available for this article. [source] Deep, hierarchical divergence of mitochondrial DNA in Amplirhagada land snails (Gastropoda: Camaenidae) from the Bonaparte Archipelago, Western AustraliaBIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 1 2010MICHAEL S. JOHNSON Continental islands have experienced cycles of isolation and connection. Although complex genetic patterns have been described for mainland species affected by glacial cycles of isolation, island biotas have received little attention. We examined mitochondrial DNA in Amplirhagada land snails from 16 islands and two adjacent mainland areas of the Bonaparte Archipelago, in the Kimberley region of northern Western Australia. Four major clades, with sequence divergence of 16,27% in the 16S ribosomal RNA gene, correspond to the major geographic groupings, separated by 10,160 km. Distinct lineages also characterize islands that are only a few kilometres apart. The large differences indicate that the lineages are much older than the islands themselves, and show no evidence of geologically recent connection. Three of the major clades match the morphological description of Amplirhagada alta. Either this named species comprises several morphologically cryptic species, or it is a single, genetically very diverse species, distributed over much of the Bonaparte Archipelago. © 2010 The Linnean Society of London, Biological Journal of the Linnean Society, 2010, 100, 141,153. [source] Outsourcing and Audit Risk for Internal Audit Services,CONTEMPORARY ACCOUNTING RESEARCH, Issue 3 2000DENNIS H. CAPLAN Abstract Some companies now outsource their internal audit function to public accountants. Internal auditors and accounting firms disagree about the merits of outsourcing. Each type of auditor claims to provide more cost-effective services and appears to claim superior expertise. This paper uses agency theory to examine outsourcing and reconciles the outsourcing debate without resorting to differential auditor expertise. Under the assumptions that public accountants' "deep pockets" provide incentives to outsource and their higher opportunity cost provides a disincentive, we characterize the optimal employment contract with each auditor. We find that public accountants provide higher levels of testing, but possibly for a higher expected fee. This result supports both the internal auditor's claim as the lower cost provider, and the public accountant's claim of higher quality. We also find that incentives to outsource generally increase in various measures of risk, including the risk that a control weakness exists and the size of the loss that can result from an undetected control weakness. [source] Underwriting and Calls of Convertible Bonds,DECISION SCIENCES, Issue 1 2000Arnold R. Cowan We model convertible bond calls under asymmetric information where, unlike Harris and Raviv (1985), we consider a nonzero call price and a call notice period. In the model, the use of underwriters conveys negative information. Consequently, the stock price decline is greater for underwritten calls than for nonunderwritten calls. Furthermore, underwritten calls are made earlier and when the conversion option is less deep in the money. Underwriting commissions and the stock price decline associated with a call are negatively related to the extent that the conversion option is in the money before the call. Empirical evidence in this paper and Singh, Cowan, and Nayar (1991) are consistent with the model's predictions. [source] pH changes in external root surface cavities after calcium hydroxide is placed at 1, 3 and 5 mm short of the radiographic apexDENTAL TRAUMATOLOGY, Issue 5 2009Thaddeus M. Chamberlain The root canals of single-rooted anterior human teeth were cleaned and shaped after decoronation. Cavities about 0.50 mm deep and 1.0 mm wide located at 1, 3 and 5 mm from the radiographic apex were prepared on the external root surface and the teeth were randomly divided into four groups. The roots were filled with calcium hydroxide at 1, 3 and 5 mm from the radiographic apex, and the control group was left empty. pH readings were obtained at intervals over a 28-day study. The roots which were filled within 1 mm of the radiographic apex had the greatest increase in pH in each of the cavities. These results demonstrate that the greatest pH change on the external root surface near the apex is obtained when the canal is more completely filled with calcium hydroxide. [source] Nonablative Acne Scar Reduction after a Series of Treatments with a Short-Pulsed 1,064-nm Neodymium:YAG LaserDERMATOLOGIC SURGERY, Issue 8 2006GRAEME M. LIPPER MD BACKGROUND Effective treatment of facial acne scarring presents a major challenge. Nonablative lasers and radiofrequency devices work by thermally stimulating dermal collagen remodeling, thereby softening acne scars in a minimally invasive fashion. One such laser, a 1,064-nm short-pulsed Nd:YAG, uses rapidly scanned low-energy infrared pulses to heat the dermis selectively through the normal dermal microvasculature. OBJECTIVE In this pilot study, the safety and efficacy of a novel short-pulsed Nd:YAG laser were investigated for the treatment of moderate to severe facial acne scarring. MATERIALS AND METHODS Nine of 10 enrolled patients with moderate to severe facial acne scarring received eight sequential 1,064-nm Nd:YAG treatments (laser parameters 14 J/cm2, 0.3 milliseconds, 5-mm spot size, 7-Hz pulse rate, 2,000 pulses per side of face). Patients were graded for the presence and severity of three scar morphologies: superficial (rolling), medium-depth (boxcar), and deep (ice pick). Outcome measures included blinded evaluation of before and after photographs by three physician observers (scar severity score) and patient self-assessment. RESULTS Acne scarring improved in 100% of the nine patients completing the study. Scar severity scores improved by a mean of 29.36% (95% confidence interval, 16.93%,41.79%; p=.006); 89% of patients noted greater than 10% scar improvement. No treatment-related adverse events were seen. CONCLUSION Our findings support the use of a short-pulsed, low-fluence 1,064-nm Nd:YAG laser as a safe, effective treatment for facial acne scarring. Scar improvement was noted in all treated subjects with minimal discomfort and no downtime. This protocol appears to be most effective at reducing scar depth and softening scar contours. [source] Deep Plane Fixation in Integumental SurgeryDERMATOLOGIC SURGERY, Issue 2 2004Gerard E. Seery MD Background. Standard wound closure techniques are prone to complication in the presence of tension. Objective. To show that deep plane fixation (DPF), a surgical modality based on limited undermining and strategic placement of DPF sutures, affects tension-reduced closure in wounds that would otherwise require skin grafts/flaps or tissue expansion. Methods. The study is based on an analysis of over 2000 scalp operations. Results. Two groupings of identical sagittal scalp reductions were done. DPF was used in one and not the other. In the series with DPF, reduced tension closure was consistently possible, as was significantly increased excision, relative to the series without DPF. Conclusions. DPF narrows the wound base and channels tension forces from superficial to deep and/or nonundermined tissues (where they harmlessly dissipate). This allows relatively increased tissue excision and tension-reduced closure. [source] Treatment of "Cyrano" Angioma with Pulsed Dye LaserDERMATOLOGIC SURGERY, Issue 7 2001Soyun Cho MD Background. Hemangiomas of the nasal tip, the so-called Cyrano nose, are often deep, disfiguring, and persistent. Objective. To evaluate the effect of treatment with pulsed dye laser on Cyrano nose. Methods. A 3-month-old boy with hemangioma of the nasal tip of 1-months duration underwent six sessions of pulsed dye laser treatment with a 7 mm collimated beam at fluences of 5.75,6.5 J/cm2, 6 weeks apart. Results. Initial improvement was noted after two treatments, and the lesion showed a marked reduction in size and improvement in color over a total treatment period of 9 months. Conclusion. Treatment with the 585 nm pulsed dye laser should be considered in the management of infants with mild to moderate degrees of nasal tip hemangiomas since it effectively reduces the lesions with minimal adverse effects. [source] Wildlife and Politics: CAMPFIRE in ZimbabweDEVELOPMENT AND CHANGE, Issue 3 2000Jocelyn Alexander CAMPFIRE programmes have been hailed internationally for the innovative ways in which they have sought to confront the challenges of some of Africa's most marginal regions through the promotion of local control over wildlife management. In Zimbabwe, CAMPFIRE has been cast as an antidote to the colonial legacy of technocratic and authoritarian development which had undermined people's control over their environment and criminalized their use of game. This article explores why such a potentially positive programme went so badly wrong in the case of Nkayi and Lupane districts, raising points of wider significance for comparable initiatives. Local histories and institutional politics need careful examination. The first part of the article thus investigates the historical forces which shaped attitudes to game, while the second part considers the powerful institutional and economic forces which conspired to sideline these historically formed local views. CAMPFIRE in Nkayi and Lupane was further shaped by the legacies of post-independence state violence in this region, and the failure of earlier wildlife projects. This range of factors combined to create deep distrust of CAMPFIRE, and quickly led to open confrontation. [source] An in vivo comparison of photoactivatable fluorescent proteins in an avian embryo modelDEVELOPMENTAL DYNAMICS, Issue 6 2007Danny A. Stark Abstract Tracing the lineage or neighbor relationships of cells in a migratory population or deep within an embryo is difficult with current methods. The recent explosion of photoactivatable fluorescent proteins (PAFPs) offers a unique cell labeling tool kit, yet their in vivo performance in intact embryos and applicability have not been thoroughly explored. We report a comparison study of PAGFP, PSCFP2, KikGR, and Kaede analyzed in the avian embryo using confocal and 2-photon microscopy. PAFPs were introduced into the chick neural tube by electroporation and each photoconverted in the neural crest or cells in the neural tube with exposure to 405 nm light, but showed dramatic differences in photoefficiency and photostability when compared at the same 2% laser power. KikGR and Kaede photoconverted with ratios only slightly lower than in vitro results, but cells rapidly photobleached after reaching maximal photoefficiency. PSCFP2 had the lowest photoefficiency and photoconverted nearly 70 times slower than the other dual-color PAFPs tested, but was effective at single-cell marking, especially with 2-photon excitation at 760 nm. The dual-color PAFPs were more effective to monitor cell migratory behaviors, since non-photoconverted neighboring cells were fluorescently marked with a separate color. However, photoconverted cells were limited in all cases to be visually distinguishable for long periods, with PSCFP2 visible from background the longest (48 hr). Thus, photoactivation in embryos has the potential to selectively mark less accessible cells with laser accuracy and may provide an effective means to study cell,cell interactions and short-term cell lineage in developmental and stem cell biology. Developmental Dynamics 236:1583,1594, 2007. © 2007 Wiley-Liss, Inc. [source] On the tail of Errivaspis and the condition of the caudal fin in heterostracansACTA ZOOLOGICA, Issue 2009Elga Mark-Kurik Abstract Articulated caudal fins of heterostracans are preserved in very rare cases. Their morphology and internal structure are completely unknown for the majority of species. One of the few preserved caudal fins belongs to the Early Devonian pteraspidid Errivaspis waynensis from the Welsh Borderland, UK. There are two different reconstructions of the tail: (1) strongly asymmetric, with a considerably longer ventral lobe, and a rather concave posterior margin (e.g. White 1935); and (2) almost symmetrical with an only slightly longer ventral lobe and a small notch in the posterior margin (e.g. Blieck 1984). A new reconstruction of the Errivaspis caudal fin, based on a detailed study of White's specimens is presented here. The ventral lobe is longer than the dorsal one but not so much as in White's reconstruction, and the notch in the posterior margin of the fin is less deep. The comparatively massive ventral lobe and ,en echelon' arrangement of three digitations, supporting the fin web and branching off from this lobe, indicate the hypocercal condition of the asymmetrical tail. The same internal structure is present in other heterostracans with nearly symmetrical caudal fins (e.g. Doryaspis, Nahanniaspis, Dinaspidella and Athenaegis) where all, or most, of the intermediate digitations branch off from the ventral lobe. [source] Stream geomorphology in a mountain lake district: hydraulic geometry, sediment sources and sinks, and downstream lake effectsEARTH SURFACE PROCESSES AND LANDFORMS, Issue 4 2007C. D. Arp Abstract Lakes are common in glaciated mountain regions and geomorphic principles suggest that lake modifications to water and sediment fluxes should affect downstream channels. Lakes in the Sawtooth Mountains, Idaho, USA, were created during glaciation and we sought to understand how and to what extent glacial morphology and lake disruption of fluxes control stream physical form and functions. First, we described downstream patterns in channel form including analyses of sediment entrainment and hydraulic geometry in one catchment with a lake. To expand on these observations and understand the role of glacial legacy, we collected data from 33 stream reaches throughout the region to compare channel form and functions among catchments with lakes, meadows (filled lakes), and no past or present lakes. Downstream hydraulic geometry relationships were weak for both the single catchment and regionally. Our data show that downstream patterns in sediment size, channel shape, sediment entrainment and channel hydraulic adjustment are explained by locations of sediment sources (hillslopes and tributaries) and sediment sinks (lakes). Stream reaches throughout the region are best differentiated by landscape position relative to lakes and meadows according to channel shape and sediment size, where outlets are wide and shallow with coarse sediment, and inlets are narrow and deep with finer sediment. Meadow outlets and lake outlets show similarities in the coarse-sediment fraction and channel capacity, but meadow outlets have a smaller fine-sediment fraction and nearly mobile sediment. Estimates of downstream recovery from lake effects on streams suggest 50 per cent recovery within 2,4 km downstream, but full recovery may not be reached within 20 km downstream. These results suggest that sediment sinks, such as lakes, in addition to sources, such as tributaries, are important local controls on mountain drainage networks. Copyright © 2006 John Wiley & Sons, Ltd. [source] Controlling factors of gullying in the Maracujá Catchment, southeastern BrazilEARTH SURFACE PROCESSES AND LANDFORMS, Issue 11 2005L. de A. P. Bacellar Abstract Hundreds of gullies (,voçorocas') of huge dimensions (up to 400,500 m long, 150 m wide and 50 m deep) are very common in the small Maracujá Catchment in southeastern Brazil. These erosional features, which occur with an uneven intensity throughout the area, started due to bad soil management practices at the beginning of European settlement, at the end of the 17th century, and nowadays are still evolving, but at a slower rate. As surface soils are usually very resistant to erosion, the outcrop of the more erodible basement saprolites seems to be an essential condition for their beginning. An analysis of well known erosion controlling factors was performed, aiming to explain the beginning and evolution of these gullies and to understand the reasons for their spatial distribution. Data shows that geology and, mainly, geomorphology are the main controlling factors, since gullies tend to be concentrated in basement rock areas with lower relief (domain 2) of Maracujá Catchment, mainly at the fringes of broad and flat interfluves. At the detailed scale (1:10 000), gullies are more common in amphitheatre-like headwater hollows that frequently represent upper Quaternary gullies (paleogullies), which demonstrate the recurrence of channel erosion. So, gullies occur in areas of thicker saprolites (domain 2), in places with a natural concentration of surface and underground water (hollows). Saprolites of the preserved, non-eroded hollows are usually pressurized (confined aquifer) due to a thick seal of Quaternary clay layer, in a similar configuration to the ones found in hollows of mass movement (mudflow) sites in southeastern Brazil. Therefore, the erosion of the resistant soils by human activities, such as road cuts and trenches (,valos'), or their mobilization by mudflow movements, seem to be likely mechanisms of gullying initiation. Afterwards, gullies evolve by a combination of surface and underground processes, such as wash and tunnel erosion and falls and slumps of gully walls. Copyright © 2005 John Wiley & Sons, Ltd. [source] Hydrological connectivity of soil pipes determined by ground-penetrating radar tracer detectionEARTH SURFACE PROCESSES AND LANDFORMS, Issue 4 2004Joseph Holden Abstract Soil pipes are common and important features of many catchments, particularly in semi-arid and humid areas, and can contribute a large proportion of runoff to river systems. They may also signi,cantly in,uence catchment sediment and solute yield. However, there are often problems in ,nding and de,ning soil pipe networks which are located deep below the surface. Ground-penetrating radar (GPR) has been used for non-destructive identi,cation and mapping of soil pipes in blanket peat catchments. While GPR can identify subsurface cavities, it cannot alone determine hydrological connectivity between one cavity and another. This paper presents results from an experiment to test the ability of GPR to establish hydrological connectivity between pipes through use of a tracer solution. Sodium chloride was injected into pipe cavities previously detected by the radar. The GPR was placed downslope of the injection points and positioned on the ground directly above detected soil pipes. The resultant radargrams showed signi,cant changes in re,ectance from some cavities and no change from others. Pipe waters were sampled in order to check the radar results. Changes in electrical conductivity of the pipe water could be detected by the GPR, without data post-processing, when background levels were increased by more than approximately twofold. It was thus possible to rapidly determine hydrological connectivity of soil pipes within dense pipe networks across hillslopes without ground disturbance. It was also possible to remotely measure travel times through pipe systems; the passing of the salt wave below the GPR produced an easily detectable signal on the radargram which required no post-processing. The technique should allow remote sensing of water sources and sinks for soil pipes below the surface. The improved understanding of ,owpath connectivity will be important for understanding water delivery, solutional and particulate denudation, and hydrological and geomorphological model development. Copyright © 2004 John Wiley & Sons, Ltd. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||