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Debris Particles (debris + particle)

Distribution by Scientific Domains
Polymers and Materials Science40%

Kinds of Debris Particles

  • wear debris particle
    		•

    Selected Abstracts

    Wear Mechanisms of TiB2 and TiB2,TiSi2 at Fretting Contacts with Steel and WC,6 wt% Co

    INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, Issue 1 2010
    Golla Brahma Raju
    Unlubricated fretting wear tests on TiB2 and TiB2,5 wt% TiSi2 ceramics against two different mating materials (bearing grade steel and WC,6 wt% Co balls) were performed with a view to understand the counterbody-dependent difference in friction and wear properties. The fretting experiments were conducted systematically by varying load (2,10 N) at an oscillating frequency of 4 Hz and 100 ,m linear stroke, for a duration of 100,000 cycles. Adhesion, abrasion, and three-body wear have been observed as mechanisms of material damage for both the TiB2/steel and TiB2/WC,Co tribosystems. The third body is predominantly characterized as tribochemical layer for TiB2/steel and loose wear debris particles for TiB2/WC,Co tribocouple. An explanation on differences in tribological properties has been provided in reference to the counterbody material as well as microstructure and mechanical properties of flat materials. [source]

    Standardized analysis of UHMWPE wear particles from failed total joint arthroplasties

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 5 2002
    Jay D. Mabrey
    Abstract Periprosthetic tissue obtained at revision surgery from eight total hip replacement cases was hydrolyzed, and polyethylene debris particles were isolated from each case. Individual particles were analyzed by scanning electron microscopy (SEM) and computerized image analysis in accordance with ASTM F1877-98, a standard for quantitative description of wear debris. For comparison, periprosthetic tissues from eight total knee revision and four total shoulder revision cases were processed and analyzed with identical methods. A total of 2599 hip, 4345 knee, and 1200 shoulder particles were analyzed. The morphologies of the isolated polyethylene particles from the total hip specimens were distinctly different from the total knee and total shoulder particles. The mean equivalent circle diameter (ECD) for hip particles was 0.694 ,m ± 0.005; knee particles measured 1.190 ,m ±0.009; and shoulder particles 1.183 ,m ± 0.017. The ECD was significantly different between hip particles and those from the shoulder and knee. The mean aspect ratio (AR) for the hip particles was 1.626 ± 0.015, compared to the knee particles at 1.935 ± 0.015 and shoulder particles at 2.082 ± 0.033. The AR was statistically different among all three groups. Other descriptors from the ASTM standard, elongation (E), form factor (FF), and roundness (R) were all significantly different among the three groups of joints. This study demonstrates the utility of ASTM F1877-98 in differentiating wear debris particles from different sources. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 475,483, 2002 [source]

    Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-,B

    JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 6 2005
    Elizabeth A. Fritz
    Abstract Chemokines, or chemotactic cytokines, are major regulators of the inflammatory response and have been identified as pathogenic factors in the periprosthetic soft tissue. Particulate wear debris induced NF-kB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate-stimulated human osteoblasts. Here, we demonstrate that phagocytosed particles activate the IL-8 gene promoter via a NF-kB-mediated mechanism. Transfection of a dominant negative mutant IkB, protein that cannot be serine phosphorylated led to suppression of IL-8 promoter activity. The p65/RelA NF-kB subunit activity was affected in both a time- and titanium particle concentration-dependent fashion. Titanium particles led to increased ERK, JNK, and p38 activation in MG-63 osteoblast cells, and IL-8 protein release was suppressed by specific inhibitors of the ERK and p38 MAPK pathways. Together, our results suggest that wear debris particles induce chemokine expression in osteoblasts via NF-kB-mediated transcriptional activation, which is controlled by the MAPK signal transduction pathway. © 2005 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. [source]

    PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway

    JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 1 2004
    Susan V. Bukata
    Aseptic loosening of orthopaedic implants is precipitated by wear debris-induced osteolysis. Central to this process are the pro-inflammatory mediators that are produced in response to wear by the fibroblastic cells, which comprise the majority of periprosthetic membranes. Since this pro-inflammatory cascade is mediated by a plethora of factors with redundant functions, it is imperative to establish a hierarchy. Two well-known fibroblast derived pro-inflammatory factors that stimulate wear debris-induced osteoclastic resorption are prostaglandin E2 (PGE2) and IL-6. However, their relationship to each other in this process is poorly defined. Here we show immunohistochemistry of retrieval membranes indicating that COX-2 is the principal cyclooxygenase responsible for PGE2 production in fibroblasts around failed implants. We also performed in vitro experiments with fibroblasts derived from wild-type (WT), COX-1 (,/,) and COX-2 (,/,) mice, which demonstrated that COX-2 is required for Ti wear debris-induced PGE2 production. Interestingly, COX-2 was also required for IL-6 production in these assays, which could be rescued by the addition of exogenous PGE2 (10,6 M). Pharmacology studies that utilized the COX-1 selective inhibitor SC 560, the COX-2 selective inhibitor celecoxib, and the nonselective COX inhibitor indomethacin confirmed these results. Taken together, these results indicate that selective inhibition of prostaglandin signaling could favorably impact aseptic loosening beyond its direct effects on PGE2 synthesis, in that it inhibits downstream pro-inflammatory/pro-osteoclastic cytokine production. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. [source]

    PMMA particles and pressure,a study of the osteolytic properties of two agents proposed to cause prosthetic loosening

    JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 2 2003
    Björn Skoglund
    Amongst the wear debris particles implicated in the particle hypothesis for prosthetic loosening are polymethylmethacrylate (PMMA), and particularly PMMA with barium sulphate contrast agent. Another suggested cause for loosening is hydrostatic pressure. PMMA particles were combined with hydrostatic pressure in a study to investigate whether there could be a synergistic or additive effect between these two factors. Titanium plates were fastened onto tibiae of 59 rats. After osseointegration, PMMA particles with barium sulphate were administered to the bone-implant interface. Further, PMMA particles were introduced into a previously published model for hydrostatic pressure induced osteolysis. There was measurable resorption in response to the PMMA particles but no additive or synergistic effect from introducing particles to the pressure model, and the effect of pressure was far greater than that of particles. These results suggest that, whereas particles can be shown to elicit an osteolytic response, the much less studied osteolytic effects of pressure could be far more important. © 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved. [source]