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Additional Control (additional + control)
Selected AbstractsNeuroanatomical correlates of the near response: voluntary modulation of accommodation/vergence in the human visual systemEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 1 2000Hans O. Richter Abstract This study identifies brain regions participating in the execution of eye movements for voluntary positive accommodation (VPA) during open-loop vergence conditions. Neuronal activity was estimated by measurement of changes in regional cerebral blood flow (rCBF) with positron emission tomography and 15O-water. Thirteen naive volunteers viewed a checkerboard pattern with their dominant right eye, while a lens interrupted the line of gaze during alternate 1.5 s intervals. Three counterbalanced tasks required central fixation and viewing of a stationary checkerboard pattern: (i) through a 0.0 diopter (D) lens; (ii) through a ,5.0-D lens while avoiding volitional accommodation and permitting blur; and (iii) through a ,5.0-D lens while maintaining maximal focus. The latter required large-amplitude, high-frequency VPA. As an additional control, seven of the subjects viewed passively a digitally blurred checkerboard through a 0.0-D lens as above. Optometric measurements confirmed normal visual acuity and ability to perform the focusing task (VPA). Large-amplitude saccadic eye movements, verified absent by electro-oculography, were inhibited by central fixation. Image averaging across subjects demonstrated multifocal changes in rCBF during VPA: striate and extrastriate visual cortices; superior temporal cortices; and cerebellar cortex and vermis. Decreases in rCBF occurred in the lateral intraparietal area, prefrontal and frontal and/or supplementary eye fields. Analysis of regions of interest in the visual cortex showed systematic and appropriate task dependence of rCBF. Activations may reflect sensorimotor processing along the reflex arc of the accommodation system, while deactivations may indicate inhibition of systems participating in visual search. [source] Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin testEXPERIMENTAL DERMATOLOGY, Issue 5 2003M. Caproni Abstract:, In approximately one-third of patients with chronic idiopathic urticaria (CIU), autoantibodies against the high-affinity IgE receptor and/or against IgE can be detected and a wheal-and-flare response can be provoked by the intradermal injection of autologous serum (ASST). In this study we aimed to further characterize the inflammatory response observed in the subgroup of CIU patients with positive ASST and serum-evoked histamine-release in vitro from basophils in comparison with unaffected skin and healthy donors. An immunohistochemical analysis of infiltrating cells (CD4, MPO, EG1, EG2, tryptase), cytokines (IL-4, IL-5, IFN-,), chemokines and chemokine receptors (IL-8, CCR3, CXCR3), and adhesion molecules (ICAM-1, VCAM-1, ELAM-1) was performed on seven selected patients (four males and three females; median age: 45 years; range: 22,57) and five healthy donors. Cytokine evaluation was also performed in five psoriatic patients to obtain an additional control. In spontaneous wheals we observed an increased number of CD4+ T lymphocytes when compared with the controls, and an increased number of neutrophils and eosinophils, whereas mast cells did not show a significant variation. A significant expression for IL-4 and IL-5 could only be observed in lesional skin, while IFN-, showed a slight expression in the same site. Chemokine receptors CCR3 and CXCR3 did not show a defined polarized response in either lesional or unaffected skin. An increased expression of all cellular adhesion molecules (CAMs) studied was detected in spontaneous wheals. The lack of a significant difference in the expression of tryptase + mast cells, T lymphocytes, IL-8, CXCR3 and CCR3, a few CAMs between the lesional and unaffected skin of CIU patients suggests a wide immunological activation that involves not only lesional tissues, but possibly extends to the whole of the skin's immune system. [source] c-Type method of unified CAMG and FEA.INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 9 20032D non-linear, 3D linear, Part 1: Beam, arch mega-elements Abstract Computer-aided mesh generation (CAMG) dictated solely by the minimal key set of requirements of geometry, material, loading and support condition can produce ,mega-sized', arbitrary-shaped distorted elements. However, this may result in substantial cost saving and reduced bookkeeping for the subsequent finite element analysis (FEA) and reduced engineering manpower requirement for final quality assurance. A method, denoted as c-type, has been proposed by constructively defining a finite element space whereby the above hurdles may be overcome with a minimal number of hyper-sized elements. Bezier (and de Boor) control vectors are used as the generalized displacements and the Bernstein polynomials (and B-splines) as the elemental basis functions. A concomitant idea of coerced parametry and inter-element continuity on demand unifies modelling and finite element method. The c-type method may introduce additional control, namely, an inter-element continuity condition to the existing h-type and p-type methods. Adaptation of the c-type method to existing commercial and general-purpose computer programs based on a conventional displacement-based finite element method is straightforward. The c-type method with associated subdivision technique can be easily made into a hierarchic adaptive computer method with a suitable a posteriori error analysis. In this context, a summary of a geometrically exact non-linear formulation for the two-dimensional curved beams/arches is presented. Several beam problems ranging from truly three-dimensional tortuous linear curved beams to geometrically extremely non-linear two-dimensional arches are solved to establish numerical efficiency of the method. Incremental Lagrangian curvilinear formulation may be extended to overcome rotational singularity in 3D geometric non-linearity and to treat general material non-linearity. Copyright © 2003 John Wiley & Sons, Ltd. [source] A new controller for the inverted pendulum on a cartINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 17 2008F. Gordillo Abstract This paper presents a complete solution to the problem of swinging-up and stabilization of the inverted pendulum on a cart, with a single control law. The resulting law has two parts: first, an energy-shaping law is able to swing and maintain the pendulum up. Then, the second part introduces additional control to stop the cart and it is based on forwarding control with bounded input. The resulting control law is the sum of both parts and does not commute between different laws although there exist switches inside the controller. Copyright © 2008 John Wiley & Sons, Ltd. [source] Herbivory influences tree linesJOURNAL OF ECOLOGY, Issue 6 2004DAVID M. CAIRNS Summary 1Transitions between major vegetation types, such as the tree line, are useful systems for monitoring the response of vegetation to climate change. Tree lines have, however, shown equivocal responses to such change. 2Tree lines are considered to be primarily thermally controlled, although recent work has highlighted the importance of biotic factors. Dispersal limitation and the invasibility of the tundra matrix have been implicated and here we propose herbivory as an additional control at some tree lines. 3We propose a conceptual model in which differing relative impacts of foliage consumption, availability of establishment sites, trampling, dispersal and seed predation can lead to very different tree-line responses. 4The presence of large numbers of small trees above the current tree line at a site in northern Sweden that experiences limited reindeer (Rangifer tarandus) herbivory suggests range expansion. Other locations in the same region with higher reindeer populations have considerably fewer small trees, suggesting that range expansion is occurring much more slowly, if at all. 5The use of tree lines as indicators of climate change is confounded by the activity of herbivores, which may either strengthen or nullify the impacts of a changed climate. Similar arguments are likely to be applicable to other ecotones. [source] Auditor Quality and the Accuracy of Management Earnings Forecasts,CONTEMPORARY ACCOUNTING RESEARCH, Issue 4 2000PETER M. CLARKSON Abstract In this study, we appeal to insights and results from Davidson and Neu 1993 and McConomy 1998 to motivate empirical analyses designed to gain a better understanding of the relationship between auditor quality and forecast accuracy. We extend and refine Davidson and Neu's analysis of this relationship by introducing additional controls for business risk and by considering data from two distinct time periods: one in which the audit firm's responsibility respecting the earnings forecast was to provide review-level assurance, and one in which its responsibility was to provide audit-level assurance. Our sample data consist of Toronto Stock Exchange (TSE) initial public offerings (IPOs). The earnings forecast we consider is the one-year-ahead management earnings forecast included in the IPO offering prospectus. The results suggest that after the additional controls for business risk are introduced, the relationship between forecast accuracy and auditor quality for the review-level assurance period is no longer significant. The results also indicate that the shift in regimes alters the fundamental nature of the relationship. Using data from the audit-level assurance regime, we find a negative and significant relationship between forecast accuracy and auditor quality (i.e., we find Big 6 auditors to be associated with smaller absolute forecast errors than non-Big 6 auditors), and further, that the difference in the relationship between the two regimes is statistically significant. [source] ORIGINAL ARTICLE: PD-1 but not CTLA-4 Blockage Abrogates the Protective Effect of Regulatory T Cells in a Pregnancy Murine ModelAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 5 2009Paul Ojiambo Wafula Problem, Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal pregnancy and protect paternal/fetal antigens from rejection by maternal effector cells. Accordingly, the transfer of Treg obtained from BALB/c-mated CBA/J females prevents abortion in DBA/2J-mated animals. The actual mechanism through which Treg mediate their protective effect is still inconclusive. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and Programmed cell death 1 (PD-1) are some of known Treg-associated molecules; however, their role in Treg-mediated fetal protection in murine model has not been investigated. Method of study, Treg obtained from normal pregnant animals (NP; CBA/J × BALB/c) on day 14 were adoptively transferred into abortion-prone mice (AP; CBA/J × DBA/2J) intravenously on day 2 of pregnancy. An amount of 250 ,g of either anti-PD-1 or anti-CTLA-4 mAb were injected intraperitoneally on days 0, 3, 6 and 9 of pregnancy. Controls received Treg + IgG or Treg + PBS. NP or AP treated with PBS served as additional controls. Results, Blocking PD-1 abrogated the protective effect of Treg, resulting in a higher median abortion rate in comparison with the Treg/isotype-treated control while CTLA-4 blockage did not interfere with the protective effect of Treg. This was associated with a diminished number of vascular endothelial growth factor-A+ cells, previously reported as stimulators of lymphocyte extravasation in preterm labor. Conclusion, Our data suggest PD-1 as an important mediator in Treg-induced fetal protection in the CBA/J × DBA/2J murine model. [source] | ||||||||||||||||