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Selected AbstractsFunctions of glutamate transporters in cerebellar Purkinje cell synapsesACTA PHYSIOLOGICA, Issue 1 2009Y. Takayasu Abstract Glutamate transporters play a critical role in the maintenance of low extracellular concentrations of glutamate, which prevents the overactivation of post-synaptic glutamate receptors. Four distinct glutamate transporters, GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3 and EAAT4, are distributed in the molecular layer of the cerebellum, especially near glutamatergic synapses in Purkinje cells (PCs). This review summarizes the current knowledge about the differential roles of these transporters at excitatory synapses of PCs. Data come predominantly from electrophysiological experiments in mutant mice that are deficient in each of these transporter genes. GLAST expressed in Bergmann glia contributes to the clearing of the majority of glutamate that floods out of the synaptic cleft immediately after transmitter release from the climbing fibre (CF) and parallel fibre (PF) terminals. It is indispensable to maintain a one-to-one relationship in synaptic transmission at the CF synapses by preventing transcellular glutamate spillover. GLT-1 plays a similar but minor role in the uptake of glutamate as GLAST. Although the loss of neither GLAST nor GLT-1 affects cerebellar morphology, the deletion of both GLAST and GLT-1 genes causes the death of the mutant animal and hinders the folium formation of the cerebellum. EAAT4 removes the low concentrations of glutamate that escape from uptake by glial transporters, preventing the transmitter from spilling over into neighbouring synapses. It also regulates the activation of metabotropic glutamate receptor 1 (mGluR1) in perisynaptic regions at PF synapses, which in turn affects mGluR1-mediated events including slow EPSCs and long-term depression. No change in synaptic function is detected in mice that are deficient in EAAC1. [source] Social integration in young adulthood and the subsequent onset of substance use and disorders among a community population of urban African AmericansADDICTION, Issue 3 2010Kerry M. Green ABSTRACT Aims This paper examines the association between social integration in young adulthood and the later onset of substance use and disorders through mid-adulthood. Design Data come from a community cohort of African Americans followed longitudinally from age 6,42 years with four assessment periods. Setting The cohort all lived in the Woodlawn neighborhood of Chicago in 1966, an urban disadvantaged setting. Participants All Woodlawn first graders in 1966 were asked to participate; 13 families declined (n = 1242). Measurement Substance use was measured via interview at age 42 and includes the onset of alcohol and drug use disorders and the onset of cocaine/heroin use between ages 32 and 42 years. Social integration measures were assessed via interview at age 32 and include social roles (employee, spouse, parent), participation in religious and social organizations and a measure of overall social integration. Control variables were measured in childhood and later in the life course. Findings Multivariate regression analyses suggest that unemployment, being unmarried, infrequent religious service attendance and lower overall social integration in young adulthood predict later adult-onset drug use disorders, but not alcohol use disorders once confounders are taken into consideration. Unemployment and lower overall social integration predict onset of cocaine/heroin use later in adulthood. Conclusions Results show meaningful onset of drug use and substance use disorders during mid-adulthood and that social integration in young adulthood seems to play a role in later onset of drug use and drug disorders, but not alcohol disorders. [source] Comparison of calibration methods for the reconstruction of space-time rainfall fields during a rain enhancement experiment in Southern ItalyENVIRONMETRICS, Issue 7 2009Arianna Orasi Abstract The role of rainfall raingauge observations in calibration of radar derived rainfall estimates is investigated. The final goal is the reconstruction of the rainfall fields over the observed area using both information during a rainfall enhancement experiment. Furthermore, we propose a simple protocol to assess the experiment efficacy. A space-time approach and the use of kriging with external drift are applied and compared. Results are again compared with those one obtained through an ordinary kriging (OK). Data come from a dense raingauge network and a weather radar installed in 1992 for the evaluation of a rain enhancement experiment carried out in Southern Italy. In this paper we report detailed results from one seeding operation carried out on 11 April 1992. The procedure to assess the efficacy of rain enhancement experiment is illustrated for 11 seeding operations. Copyright © 2008 John Wiley & Sons, Ltd. [source] Reduction of quantity smoked predicts future cessation among older smokersADDICTION, Issue 1 2004Tracy Falba ABSTRACT Aim To examine whether smokers who reduce their quantity of cigarettes smoked between two periods are more or less likely to quit subsequently. Study design Data come from the Health and Retirement Study, a nationally representative survey of older Americans aged 51,61 in 1991 followed every 2 years from 1992 to 1998. The 2064 participants smoking at baseline and the first follow-up comprise the main sample. Measurements Smoking cessation by 1996 is examined as the primary outcome. A secondary outcome is relapse by 1998. Spontaneous changes in smoking quantity between the first two waves make up the key predictor variables. Control variables include gender, age, education, race, marital status, alcohol use, psychiatric problems, acute or chronic health problems and smoking quantity. Findings Large (over 50%) and even moderate (25,50%) reductions in quantity smoked between 1992 and 1994 predict prospectively increased likelihood of cessation in 1996 compared to no change in quantity (OR 2.96, P < 0.001 and OR 1.61, P < 0.01, respectively). Additionally, those who reduced and then quit were somewhat less likely to relapse by 1998 than those who did not reduce in the 2 years prior to quitting. Conclusions Reducing successfully the quantity of cigarettes smoked appears to have a beneficial effect on future cessation likelihood, even after controlling for initial smoking level and other variables known to impact smoking cessation. These results indicate that the harm reduction strategy of reduced smoking warrants further study. [source] Growing up Charismatic: Morality and Spirituality among Children in a Religious CommunityETHOS, Issue 4 2009Thomas J. Csordas The first question has to do with the problem of how charisma can be successfully transferred to the second generation of a prophetic community. The second question has to do with how children come to be, and to act as, moral and spiritual beings. These questions converge in a particular way in the ethnographic setting of The Word of God Community: it is founded on a charismatic spirituality closely intertwined with a moral imperative, such that its viability depends on reproduction of that morality and spirituality among children of the founding generation. Data come from interviews with 38 children across three age groups (5,7, 10,12, and 15,17 years), conducted over a four-week period subsequent to a community schism, which left members in a state of reflection, self-examination, and openness. We focus on children's responses to a series of culturally specific vignettes designed to present various dilemmas of moral reasoning. In this highly charged context moral and spiritual life are based on an active engagement characterized by dynamic and contested processes, and it is through these processes that individuals make meaning out of and reconstruct the moral code of their culture. [childhood and adolescence, religion, Catholic Charismatic Renewal, Pentecostalism, morality, spirituality, intentional communities] [source] Prevalence and correlates of eating disorders in Latinos in the United StatesINTERNATIONAL JOURNAL OF EATING DISORDERS, Issue S3 2007Margarita Alegria PhD Abstract Objective: To present national estimates and correlates of lifetime and 12-month DSM-IV eating disorders for Latinos. Method: Data come from the National Latino and Asian American Study (NLAAS), a national epidemiological household survey of Latinos in the United States. Results: Latinos have elevated rates of any binge eating and binge eating disorder but low prevalence of anorexia nervosa and bulimia nervosa. The US born and those living a greater percentage of their lifetime in the US evidenced higher risk for certain eating disorders while severe obesity and low levels of education were significant correlates. Rates of treatment utilization were exceedingly low. Conclusion: Standard eating disorder criteria may not be appropriate for understanding psychological morbidity of eating disorders for Latinos, particularly less acculturated Latinos, due to cultural differences in the presentation of eating disorder symptoms. Criteria for disturbed eating patterns that are more reflective of the illness experience of Latinos should be developed. © 2007 by Wiley Periodicals, Inc. [source] Modern pollen precipitation from an elevational transect in central Jordan and its relationship to vegetationJOURNAL OF BIOGEOGRAPHY, Issue 10 2001Caroline P. Davies Aim To explore the relationship between modern pollen precipitation and vegetation patterns in an arid region of the Middle East. Location Data come from the central Jordan Rift from 1700 m elevation in the highlands to 300 m below sea level in the Dead Sea basin. Methods Modern pollen samples and descriptive vegetation data were collected from twenty-one locations at 100 m elevational intervals from the highest elevations on the eastern side of the rift valley, where woodlands grow, to the lowest elevation desert on earth, characterized by drought and salt tolerant plants. Pollen percentage data from each vegetation zone are compared descriptively and numerically using cluster and Principal Components Analyses (PCA). Results Three major vegetation zones: woodland, shrub steppe, and desert scrub, are identified by their dominant plant species. The widely spaced tree, Quercus calliprinos Webb, defines the Quercus L. woodland that grows above 1500 m elevation. The shrub steppe can be divided into two subzones found between about 1500 and 900 m elevation: Artemisia herba-alba Asso shrub steppe and Artemisia L. shrub steppe with Juniperus phoenica L. Desert scrub dominates the lower elevation landscape with Hammada salicornia (Moq.) Iljin the dominant shrub between 900 and 200 m and Haloxylon persicum Bge. found below 200 m elevation. Pollen spectra reflect the elevational vegetation zones. In particular, Quercus L., Juniperus L. and Tamarix L. pollen are abundant where the trees grow. Highly variable amounts of non-arboreal pollen taxa , primarily Artemisia L. and Chenopodiaceae Vent. , differentiate shrub steppe from desert scrub vegetation. Cluster and PCA of pollen data support the qualitative vegetation zonation. Main conclusions The main vegetation zones along the Jordan Rift from 1700 to ,300 m elevation can be distinguished by their modern pollen precipitation. Open vegetation types, in particular, can be recognized by their pollen spectra. High amounts of Artemisia L. pollen distinguish the moister upper elevations where Artemisia L. steppe grows. In contrast, greater amounts of Chenopodiaceae Vent. pollen characterize the drier, lower elevation deserts. [source] Stepfamily Formation: Implications for Adolescent Ties to Mothers, Nonresident Fathers, and StepfathersJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2009Valarie King This study examines how the entrance of a stepfather influences adolescent ties to mothers and nonresident fathers and how prior ties to each biological parent influence the development of stepfather-stepchild ties. Data come from 1,753 adolescents in the National Longitudinal Study of Adolescent Health who lived with a single mother in Wave 1 who remained single, cohabited, or married by Wave 2, approximately 1 year later. Stepfamily formation had little consequence for adolescent-nonresident father ties. Adolescent-mother closeness, however, declined when cohabiting, but not married, stepfathers entered the household. Close ties to married stepfathers were more likely to develop when adolescents were closer to their mothers before stepfather entry. Prior ties to nonresident fathers were unrelated to stepfather-stepchild ties. [source] How American Children Spend Their TimeJOURNAL OF MARRIAGE AND FAMILY, Issue 2 2001Sandra L. Hofferth The purpose of this article is to examine how American children under age 13 spend their time, sources of variation in time use, and associations with achievement and behavior. Data come from the 1997 Child Development Supplement to the Panel Study of Income Dynamics. The results suggest that parents' characteristics and decisions regarding marriage, family size, and employment affect the time children spend in educational, structured, and family activities, which may affect their school achievement. Learning activities such as reading for pleasure are associated with higher achievement, as is structured time spent playing sports and in social activities. Family time spent at meals and time spent sleeping are linked to fewer behavior problems, as measured by the child's score on the Behavior Problems Index. The results support common language and myth about the optimal use of time for child development. [source] Justice Excused: The Deployment of Law in Everyday Political EncountersLAW & SOCIETY REVIEW, Issue 2 2006George I. Lovell This paper examines the use of legal claims by government officials and citizens in everyday political encounters involving civil rights. Data come from 580 letters sent to the federal government between 1939 and 1941, and from the replies sent by the newly formed Civil Rights Section of the Justice Department. In almost every case, the department refused to intervene and explained its refusal by making legal claims about federal jurisdiction. These legal claims masked the department's discretionary choices and thus helped depoliticize the encounters. Surprisingly, however, a substantial number of letter writers challenged the government's legal claims by deploying their own legal and moral arguments. The willingness of these citizens to challenge official legal pronouncements cautions against making broad generalizations about the capacity of ordinary people to respond effectively when government officials deploy legal rhetoric. [source] Secular changes in stature and body mass index for Chinese youth in sixteen major cities, 1950s,2005AMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 5 2008Cheng-Ye Ji Evidence shows a secular trend in physical growth in China in recent years. We analyze the secular trend of stature and body mass index (BMI) for the period 1950s,2005 to provide biological evidence for policy-makers to identify measures for improving Chinese children's health. Data come from the historical records in 1950s and the successive cycles of the Chinese National Survey on Student's Constitution and Health. Subjects were 7- to 18-year-old youth from 16 cities. Sex,age differences in mean stature and BMI values between the surveys were analyzed, and the increments per decade were compared. An overall positive secular trend was found in 1950s,2005. Mean stature of the 18-year olds increased from 166.6 to 173.4 cm for males and from 155.8 to 161.2 cm for females, yielding rates of 1.3 and 1.1 cm/decade; the overall increments of BMI values were 2.6 for males and 1.8 for females, yielding rates of 0.8 and 0.6/decade, respectively. The most significant changes occurred during puberty. The overall positive secular trend is closely associated with the socioeconomic progress and the improvement of livelihood. Strong evidence suggests that in China this trend will be continued for many years. Further studies are needed to explore how to ensure healthy changes for poorer rural youth. Effective preventive strategies and measures should be taken to prevent the progressive increase in the prevalence of childhood obesity accompanying this trend. Am. J. Hum. Biol., 2008. © 2008 Wiley-Liss, Inc. [source] Estimation of Rates of Births, Deaths, and Immigration from Mark,Recapture DataBIOMETRICS, Issue 1 2009R. B. O'Hara Summary The analysis of mark,recapture data is undergoing a period of development and expansion. Here we contribute to that by presenting a model which includes both births and immigration, as well as the usual deaths. Data come from a long-term study of the willow tit (Parus montanus), where we can assume that all births are recorded, and hence immigrants can also be identified as birds captured as adults for the first time. We model the rates of immigration, birth rate per parent, and death rates of juveniles and adults. Using a hierarchical model allows us to incorporate annual variation in these parameters. The model is fitted to the data using Markov chain Monte Carlo, as a Bayesian analysis. In addition to the model fitting, we also check several aspects of the model fit, in particular whether survival varies with age or immigrant status, and whether capture probability is affected by previous capture history. The latter check is important, as independence of capture histories is a key assumption that simplifies the model considerably. Here we find that the capture probability depends strongly on whether the individual was captured in the previous year. [source] Mass-independent fractionation of sulfur isotopes in sulfides from the pre-3770 Ma Isua Supracrustal Belt, West GreenlandGEOBIOLOGY, Issue 4 2006D. PAPINEAU ABSTRACT Redox chemistry of the coupled atmosphere,hydrosphere system has coevolved with the biosphere, from global anoxia in the Archean to an oxygenated Proterozoic surface environment. However, to trace these changes to the very beginning of the rock record presents special challenges. All known Eoarchean (c. 3850,3600 Ma) volcanosedimentary successions (i.e. supracrustal rocks) are restricted to high-grade gneissic terranes that seldom preserve original sedimentary structures and lack primary organic biomarkers. Although complicated by metamorphic overprinting, sulfur isotopes from Archean supracrustal rocks have the potential to preserve signatures of both atmospheric chemistry and metabolic fractionation from the original sediments. We present a synthesis of multiple sulfur isotope measurements (32S, 33S and 34S) performed on sulfides from amphibolite facies banded iron-formations (BIFs) and ferruginous garnet-biotite (metapelitic) schists from the pre-3770 Ma Isua Supracrustal Belt (ISB) in West Greenland. Because these data come from some of the oldest rocks of interpretable marine sedimentary origin, they provide the opportunity to (i) explore for possible biosignatures of sulfur metabolisms in early life; (ii) assess changes in atmospheric redox chemistry from ,3.8 Ga; and (iii) lay the groundwork to elucidate sulfur biogeochemical cycles on the early Earth. We find that sulfur isotope results from Isua do not unambiguously indicate microbially induced sulfur isotopic fractionation at that time. A significantly expanded data set of ,33S analyses for Isua dictates that the atmosphere was devoid of free oxygen at time of deposition and also shows that the effects of post-depositional metamorphic remobilization and/or dilution can be traced in mass-independently fractionated sulfur isotopes. [source] Evidence that dingoes limit abundance of a mesopredator in eastern Australian forestsJOURNAL OF APPLIED ECOLOGY, Issue 3 2009Chris N. Johnson Summary 1Aggressive behaviour of top predators may have strong effects on the distribution and abundance of mesopredator species. Such interactions between predator species can reduce the intensity of predation on vulnerable prey. Suppression of mesopredators by top predators is a potentially important process that could protect small prey species from unsustainable predation. 2There is some evidence that in Australia, the dingo Canis lupus suppresses populations of the red fox Vulpes vulpes. This interaction could be significant to biodiversity conservation because while dingoes have been in Australia for several thousand years and coexist with a wide range of small mammals, the fox is a recent arrival which has caused declines and extinctions, and continues to threaten many prey species. 3However the strength of the effect of dingoes on foxes is unclear, and some published data have been interpreted as demonstrating no relationship between abundance of the two species. These data come from forested habitats in eastern Australia, and may suggest that negative relationships of dingoes and foxes do not occur in complex habitats. 4We re-analyse published data on fox vs. wild dog (i.e. dingoes plus, potentially, feral dogs and hybrids) abundance in eastern forests. These data reveal a triangular relationship of fox to wild dog density: when wild dogs are abundant, foxes are consistently rare, while when wild dogs are rare, foxes may be abundant but are not always so. This suggests that the abundance of wild dogs sets an upper limit on the abundance of foxes, but does not fully determine fox abundance. 5Standard regression and correlation methods are not appropriate for analysing such triangular relationships. We apply two statistical methods that can be used to characterize the edges of data distributions, and use these to demonstrate a negative relationship of maximum fox abundance to the abundance of wild dogs. 6Synthesis and applications. Our analysis adds to evidence that dingoes may have negative effects on red foxes in a wide range of habitats, and therefore, that dingoes may be significant to conservation of mammal biodiversity in Australia. It also illustrates problems and solutions in the statistical analysis of abundance of one species as a function of the abundance of another species with which it has a strong interaction. [source] Rarity, specialization and extinction in primatesJOURNAL OF BIOGEOGRAPHY, Issue 4 2002A. H. Harcourt Aim To determine and explain biological traits that distinguish rare from common primate taxa. Location Africa, Americas, Asia, Madagascar. Methods We compare the biology of rare primate taxa with the biology of common taxa. Rarity is defined by (1) small size of geographic range; (2) small geographic range plus low local population density; and (3) small geographic range plus low local density plus narrow habitat specificity. After a linear comparison of size of geographic range with various biological traits, globally and by realm, extremes of rarity and commonness per realm are identified, and then combined for a global analysis. Tests are done both with genera treated as independent data points (n=62), and also with phylogenetic control by use of an independent contrasts test. Extinction risk in vertebrates, including primates, often correlates with high resource requirements, slow population recovery rate, and specialization. The three indices of rarity are therefore compared with these three general traits. Measures of resource use are body mass, local density, annual range size, and group size; of recovery rate, interbirth interval, and maximum intrinsic rate of natural population increase; and of degree of specialization, variety of diet, of habitats, maximum latitude, and morphological variety. All data come from the literature. Because several measures are compared, probabilities are Bonferroni corrected. Results If rarity in primates correlates with any biological attribute, it consistently correlates with only measures of specialization, and not with measures of high resource use, or slow population recovery rate. Without phylogenetic correction, the first two indices of rarity associate significantly with all four measures of specialization, and the third with maximum latitude. With phylogenetic correction, the first index still associates with all four, the second with two (maximum latitude, number of species per genus), and the third shows no significant associations. While the four measures of specialization are strongly interrelated, stepwise regressions on geographic range indicate that maximum latitude has the strongest effect, followed by dietary variety and number of species per genus and, finally, habitat variety. Main conclusions The most commonly demonstrated traits of susceptibility to extinction are those of high resource use, slow recovery rate, and specialization. Yet, while rarity (almost however, it is defined) is an inevitable precursor to extinction, specialization is the only trait found to correlate with rarity in this study. We cannot explain this apparent contradiction. [source] Migrant Interactions With Elderly Parents in Rural Cambodia and ThailandJOURNAL OF MARRIAGE AND FAMILY, Issue 3 2008Zachary Zimmer This paper examines interactions between older adults living in rural areas of Thailand and Cambodia and their adult children. Thai data come from the Survey of the Welfare of the Elderly (N= 3,202 older adults and 17,517 adult children). Cambodia data are from the Survey of the Elderly in Cambodia (N= 777 older adults and 3,751 adult children). Results indicate that older adults in rural areas are not being abandoned, and supportive expressions such as visits and provision of material goods depend on living proximity, characteristics that relate to the needs and dependency of the older adult, and the life circumstances of adult children. These findings support an extension of an altruistic perspective that incorporates notions of vulnerability of older adults. [source] Normalizing bilingualism:The effects of the Catalonian linguistic normalization policy one generation after1JOURNAL OF SOCIOLINGUISTICS, Issue 3 2008Michael Newman This study examines the evolution of language attitudes of linguistically diverse adolescents in urban Catalonia a generation after the instauration of Linguistic Normalization, official language policies favoring Catalan. Woolard (1984, 1989) and Woolard and Gahng's (1990) classic Catalan/Spanish matched guise studies are used as a baseline. Current data come from a modified and expanded replication of those original studies. Findings show: (1) differences in attitudes between youths of Spanish and Catalan background have softened; (2) disparities in Status and Solidarity have evened out; (3) language choice can be highly gendered; and (4) bilingual proficiency is now valued by and for both communities. The support for bilingualism and the easing of divisions are understood as signs of increased ,linguistic cosmopolitanism,' a stance that looks beyond parochial own-group communities and favors bridging linguistic boundaries. The significance is that minority languages can be valued when they take on such symbolic roles. [source] Trends in the consumption of antidepressants in Castilla y León (Spain).PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 9 2010Association between suicide rates, antidepressant drug consumption Abstract Objective To learn the evolution of antidepressant and lithium use in Castilla y León (Central Spain) and its relationship with suicide rates. Methods A search in the ECOM (Especialidades Consumo de Medicamentos) database of the Spanish Ministry of Health for antidepressants and lithium was carried out for the period 1992,2005. Defined daily doses (DDD) per 1000 inhabitants per day were obtained as consumption data. Population and suicide rates data come from the Spanish National Statistics Institute. Results Antidepressant consumption increased 7-fold, from 6.9 DDD per 1000 inhabitants per day in 1992 to 47.3 in 2005; the corresponding increase in cost was more than 10-fold. Selective serotonin reuptake inhibitors (SSRIs) comprised 77% of the total consumption. Venlafaxine consumption multiplied by 2.2. The consumption of monoamine oxidase inhibitors (MAOIs) decreased after venlafaxine and mirtazapine were marketed. Lithium consumption increased by 76% during the period studied, but it plateaued in 2000. Conclusions The consumption of antidepressants in Castilla y León has increased remarkably and the pattern has changed; there is an increase in the consumption of the new and more expensive antidepressants such as venlafaxine and escitalopram. No association was observed between suicide rates and antidepressant consumption. Copyright © 2010 John Wiley & Sons, Ltd. [source] Smoking and the Asian American workforce in the National Latino and Asian American StudyAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 2 2010A.B. de Castro PhD, MSN/MPH Abstract Background Smoking among the Asian American workforce has not been extensively researched. This study examines smoking prevalence among a nationally representative sample of Asian Americans with an emphasis on occupational classification. Methods Cross-sectional data come from the National Latino and Asian American Study. Multivariate logistic regression analyses were used to determine smoking prevalence by occupation, gender, and nativity, among 1,528 participants self-identifying as in the labor force. Results Blue collar workers reported the highest smoking prevalence (32%) followed by unemployed (19%), other (17%), service (14%), and white collar (10%). Among both employed males and females, blue collar workers had the highest prevalence (45% and 18%, respectively). By nativity, smoking was highest among blue collar workers for immigrants (25%) and highest among the unemployed for U.S. born (16%). Blue collar employment was significantly associated with being a current smoker (OR,=,2.52; 95% CI: 1.23,5.16; P,<,0.05) controlling for demographics (e.g., age, gender, ethnic group, nativity, etc.). Conclusions Findings reveal that smoking differs by occupation among Asian Americans. Future research should examine factors explaining differences while considering gender and nativity. Am. J. Ind. Med. 53:171,178 2010. © 2009 Wiley-Liss, Inc. [source] Competing interests: Toronto's Chinese immigrant associations and the politics of multiculturalismPOPULATION, SPACE AND PLACE (PREVIOUSLY:-INT JOURNAL OF POPULATION GEOGRAPHY), Issue 2 2007J. Salaff Abstract Social service agencies and advocacy groups have played an integral role in mediating between the Asian ethnic populations. In the Canadian institutional setting, associations become a means of political expression. Canada incorporates new immigrants into its national institutions. However, these neo-liberal institutions and policies have not redressed major problems arising in the settlement process. Under Canada's discourse of enlightened multiculturalism, social service agencies are funded to help to integrate diverse peoples. The policy of multiculturalism meshes well with the liberal ideology underlying loose coupling, encouraging people to retain their cultural identities while settling and participating in national processes. These policies are designed to be sensitive to clients' cultural backgrounds; however, there are unforeseen consequences. In this system, different groups are granted different amounts of social, cultural and economic capital along with differential access to this capital, which affects their position and potential for action in other arenas. In particular, we find that the social service approach treats new Chinese immigrants as similar, thereby fostering competition between subgroups over leadership, funds and representation. Our data come from interviews with key figures in the Chinese-Canadian community and associations, and reviews of press and other media. Copyright © 2006 John Wiley & Sons, Ltd. [source] Assessing ecological changes in and around marine reserves using community perceptions and biological surveysAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 4 2010M. Yasué Abstract 1. Well-enforced partial or total no-fishing zones (collectively known as marine protected areas, or MPAs) can help restore degraded coral reefs and enhance fish populations. 2. A comparison was made of community perceptions of ecological changes in an MPA with concurrent scientific data on these changes in the same MPA. Such analyses are particularly important in community-based MPAs where local support is a key determinant of ecological success. 3. The no-take MPA in question was initially launched in partnership with the community in 1995 and formalized in 1998. The perceptions data come from interviews with community members in 1999 and 2004, the biological data come from underwater visual censuses of the MPA from 1998 to 2004. 4. Community members perceived more fish within the MPA and slight increases in catch outside the MPA. In contrast, fish censuses showed a high degree of stochastic variation and only minor increases in fish abundance, size and diversity in and around the MPA between 1998 and 2004. 5. Possible explanations for these discrepancies include different temporal, spatial or species frames of reference and/or limitations to the biological survey technique. Other options include wishful thinking, external influences, a desire to please, or confounding with other benefits. 6. This study demonstrates some of the strengths and weaknesses of community perceptions and biological data. In order to improve our understanding about the changes that occur over time in an MPA and engender community support for the long-term viability of MPAs, it is important to develop diverse and efficient monitoring schemes. Copyright © 2010 John Wiley & Sons, Ltd. [source] Variability in non-nucleoside reverse transcriptase and protease inhibitor concentrations among HIV-infected adults in routine clinical practiceBRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Issue 5 2006José Moltó What is already known about this subject ,,The concentration of protease and non-nucleoside reverse transcriptase inhibtors in plasma has been related to both efficacy and toxicity. ,,Most antiretroviral concentration data come from selected populations of patients undergoing therapeutic drug monitoring programmes, which may overestimate interindividual variability. What this study adds ,,Our study has demonstrated the large interindividual variability in antiretroviral drug concentrations in an unselected population of patients during routine clinical practice. ,,These results may provide interesting information to clinicians for the management of antiretroviral therapy in HIV-infected patients. Aims The objective of this study was to assess interindividual variability in trough concentrations of plasma of non-nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) among HIV-infected adults in a routine outpatient setting. Methods One hundred and seventeen patients who attended our clinic for routine blood tests, and who were receiving antiretroviral therapy which included NNRTI or PI were studied. Patients were not informed that drug concentrations were going to be measured until blood sampling. The times of the last antiretroviral dose and of blood sampling were recorded. Drug concentrations were considered optimal if they were above the proposed minimum effective value. In addition, efavirenz, nevirapine and atazanavir concentrations were considered potentially toxic if they were >,4.0 mg l,1, >,6.0 mg l,1 and >,0.85 mg l,1, respectively. Results Overall, interindividual variability of NNRTI and PI concentrations in plasma was approximately 50%, and only 68.4% of the patients had drug concentrations within the proposed therapeutic range. Poor adherence explained only 35% of subtherapeutic drug concentrations. Conclusion Interindividual variability in trough concentrations of NNRTI and PI among HIV-infected adults is large in routine clinical practice, with drug concentrations being outside the therapeutic window in a significant proportion of patients. These findings provide further evidence that therapeutic drug monitoring may be useful to guide antiretroviral therapy in clinical practice. [source] | ||||||||||||||||||||||