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Data Base Search (data + base_search)
Selected AbstractsAbstracts of QSAR-related Publications: Data Base Search & Virtual ScreeningMOLECULAR INFORMATICS, Issue 11 2006Article first published online: 8 NOV 200 First page of article [source] Abstracts of QSAR-related Publications: Data Base Search & Virtual ScreeningMOLECULAR INFORMATICS, Issue 10 2006Article first published online: 9 OCT 200 First page of article [source] Abstracts of QSAR-related Publications: Data Base Search & Virtual ScreeningMOLECULAR INFORMATICS, Issue 7 2006Article first published online: 11 JUL 200 No abstract is available for this article. [source] 4254: Infectious and non infectious triggers in non-infectious uveitisACTA OPHTHALMOLOGICA, Issue 2010G WILDNER Purpose The induction of autoimmune uveitis is difficult to explain with respect to the immune privileged status of the eye. The intact BRB can only be passed by already activated leukocytes, which should normally be ignorant to the sequestered intraocular antigens. Antigenic mimicry of retinal autoantigens by environmental proteins could explain extraocular activation of effector T cells. Methods We have previously demonstrated antigenic mimicry of a peptide from retinal S-Antigen and peptides from rotavirus (Rota) and bovine milk casein (Cas). Both, Rota and Cas, induce T cell lines cross-reactive with retinal S-Ag peptide as well as experimental autoimmune uveitis in rats. Patients with uveitis have increased antibody and T cell responses to the mimicry peptides as well as to the S-Ag peptide compared to healthy donors. Accordingly, Infection with rotavirus or any gastrointestinal pathogen with concomitant ingestion of bovine milk products could induce an immune response in the gastrointestinal tract that is cross-reactive with ocular autoantigens and lead to induction of autoimmunity in the eye. Results Uveitis as a well known adverse effect after BCG (Bacille Calmette Guerin) treatment might also be the result of antigenic mimicry. We have shown T cell responses to PPD from M. tuberculosis and the retinal autoantigens S-Ag, IRBP and CRALBP from a patient who had developed granulomatous uveitis after BCG application for bladder carcinoma. Data base searches revealed a number of amino acid sequence homologies between proteins from mycobacteria and retinal autoantigens, suggesting antigenic mimicry. These findings might as well be an explanation for the occurrence of uveitis in connection with M. tuberculosis infection, even when no mycobacteria are detectable in the eye. [source] Apnea testing for the diagnosis of brain deathACTA NEUROLOGICA SCANDINAVICA, Issue 6 2005C. J. G. Lang Objectives,,, A review is given on various methods, preconditions and pitfalls of apnea testing for the diagnosis of brain death. Materials and methods,,, An extensive medical data base search was implemented by information gathered from books and our own experience with more than 2000 apnea tests. Results,,, While testing for apnea (AT) is considered indispensable worldwide, recommendations and handling differ. Rather than relying on elapsed time, a specific target value for the partial arterial pressure of carbon dioxide (PaCO2) should be aimed at being the maximum physiological stimulus for respiration. Methodological points are elaborated upon in detail for apneic oxygenation and hypoventilation. Conclusion,,, AT is an indispensable element of diagnosing brain death. Although with proper handling and adequate precautions AT is safe, it should be performed as a last resort. An international agreement on target values for the PaCO2 is desirable. [source] | ||||||||||