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Darier's Sign (darier + sign)

Distribution by Scientific Domains
Medical Sciences100%

Kinds of Darier's Sign

  • positive darier sign
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    Selected Abstracts

    Urticating Hashimoto,Pritzker Langerhans Cell Histiocytosis

    PEDIATRIC DERMATOLOGY, Issue 1 2001
    David F. Butler M.D.
    The Darier sign has been a reliable feature in the diagnosis of mastocytosis. However, the cutaneous infiltrate of Hashimoto,Pritzker Langerhans cell histiocytosis (LCH) may contain a large number of mast cells, leading to confusion both clinically and histologically. We report an infant who developed red-brown papules of Hashimoto,Pritzker LCH during the neonatal period and presented with a positive Darier sign and acute urticaria. [source]

    Linear-agminated juvenile xanthogranulomas

    INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 4 2008
    Despoina Kiorpelidou MD
    An 8-month-old girl presented with an asymptomatic skin lesion on the right popliteal fossa, which had been present for approximately 6 months. The child had a past medical history of a urinary tract infection at the age of 1 month and had been on daily cotrimoxazole since. There was no history of trauma to the site. Examination revealed a solitary, well-demarcated, plaque-like lesion on the right popliteal fossa, with multiple agminated papules in an almost linear distribution (Fig. 1a). The lesion did not follow Blaschko's lines, but was vertical to them. The plaque was slightly indurated, measuring approximately 4 × 1.5 cm, fixed to the overlying skin but movable over the deeper tissue. The papules were yellowish in color and firm to palpation, showing a positive Darier's sign (Fig. 1b,c). There was no regional adenopathy and no other skin lesions were observed. The physical examination and laboratory investigations were otherwise unremarkable. There was no hepatosplenomegaly, and an ocular examination and chest X-ray were normal. Figure 1. Juvenile xanthogranuloma: agminated nodulopapular lesions on the right popliteal fossa (a) showing positive Darier's sign (b and c; arrows) ,A biopsy from the lesion (Fig. 2a) revealed a dermal infiltrate of histiocytes, some of which were foamy, and admixed Touton-type giant cells, lymphocytes, eosinophils, and mast cells. By immunohistochemistry, the predominant cell population was CD68 (KP-1, MIB-1, and PG-M1, all pursued from Dako) positive, but S-100 protein and CD1a negative (Fig. 2b,e). By Giemsa stain, scattered mast cells (< 5% of the total cell number) were detectable within the lesion. The morphology and immunohistochemistry of the lesion were diagnostic for juvenile xanthogranuloma. Eight months later, the lesion was still present but slightly elongated, proportional to the child's growth, and hyperpigmented. Figure 2. Juvenile xanthogranuloma: histomorphology of skin lesion showing a cell-rich histiocytic dermal infiltrate (a) with immunohistochemical characteristics (b,e) of non-Langerhans dendritic cells (a, hematoxylin and eosin; b, anti-S-100 protein; c, anti-CD-1a; d, e, anti-CD68 monocytic markers MIB-1 and KP-1, respectively; a,e, initial magnification ×40) [source]

    Cutaneous mastocytosis: demographic aspects and clinical features of 55 patients

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 8 2006
    G Akoglu
    Abstract Background, Mastocytosis is a rare, heterogeneous group of disorder with abnormal increase of mast cells in one or more organ systems. Objective, To evaluate the demographic and clinical features of cutaneous mastocytosis (CM). Methods, Records of 55 patients with cutaneous mastocytosis were retrospectively analysed. Results, Of the 22 females and 33 males, 80% had urticaria pigmentosa/maculopapular CM and 20% had mastocytoma. Of all cases, 81.8% had first lesions in childhood. The most common presentation was involvement of trunk together with extremities. Thirteen (23.6%) patients had history of bulla; Darier's sign was positive in 34 of 38 patients. Itching was the most common complaint, provocated by hot weather/bath. Conclusion, Clinical presentations of urticaria pigmentosa/maculopapular CM and mastocytoma are similar regarding gender, age of onset, age of diagnosis, and presence of Darier's sign and history of bulla. In contrast to mastocytoma, urticaria pigmentosa/maculopapular CM lesions were frequently located on trunk together with extremities. [source]

    Scabies with Clinical Features and Positive Darier Sign Mimicking Mastocytosis

    PEDIATRIC DERMATOLOGY, Issue 3 2009
    ALICE PHAN M.D.
    But diagnosis pitfalls are frequent in infants, in whom the clinical presentation is usually atypical and different from adults. We report a misleading case of a 5-month-old child, who presented with pruritic brown,red macules of the trunk showing a positive Darier's sign, suggestive of an urticaria pigmentosa. [source]