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Cytotoxic Studies (cytotoxic + studies)
Selected AbstractsSynthesis, in-vitro Antimicrobial and Cytotoxic Studies of Novel Azetidinone DerivativesARCHIV DER PHARMAZIE, Issue 4 2010Rangappa S. Keri Abstract Developing novel antimicrobial drugs is increasingly important in the modern pharmaceutical industry. A series of novel 3-chloro-4-[4-(2-oxo-2H -chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-ones 5a,o have been synthesized from 4-bromomethylcoumarins 1a,e and 4-aryliminomethyl-phenols 3a,c. These compounds were screened for their in-vitro antibacterial activity against two Gram-positive (Staphylococcus aureus and Vancomycin resistant enteroccoccus) and two Gram-negative (Escherichia coli and Shigella dysentery) bacterial strains and antifungal activity against Aspergillus fumigatus, Candida albicans, and Penicillium. Results revealed that compounds 5c, 5f, 5h, 5j, and 5m showed excellent activity against a panel of microorganisms. The brine-shrimp bioassay was also carried out to study their in-vitro cytotoxic properties and two compounds, 5h and 5m, possessing LD50 = 7.154×10,4 M and 5.782×10,4 M, respectively, displayed potent cytotoxic activity against Artemia salina. The presence of a chlorine group in the coumarin moiety, its effect on their antibacterial, antifungal, and cytotoxic activities is discussed. All newly synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and MS. [source] Synthesis, in-vitro Microbial and Cytotoxic Studies of New Benzimidazole DerivativesARCHIV DER PHARMAZIE, Issue 7 2009Reddy S. Harisha Abstract Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD50) at the concentration 1×10,3 M against Artemia salina. [source] Synthesis and Cytotoxic Studies of Hydroximino Derivatives of Some 16E-Arylidenosteroids.CHEMINFORM, Issue 52 2004Raja Chattopadhaya No abstract is available for this article. [source] Tailored carbon nanotubes for tissue engineering applicationsBIOTECHNOLOGY PROGRESS, Issue 3 2009Jithesh V. Veetil Abstract A decade of aggressive researches on carbon nanotubes (CNTs) has paved way for extending these unique nanomaterials into a wide range of applications. In the relatively new arena of nanobiotechnology, a vast majority of applications are based on CNTs, ranging from miniaturized biosensors to organ regeneration. Nevertheless, the complexity of biological systems poses a significant challenge in developing CNT-based tissue engineering applications. This review focuses on the recent developments of CNT-based tissue engineering, where the interaction between living cells/tissues and the nanotubes have been transformed into a variety of novel techniques. This integration has already resulted in a revaluation of tissue engineering and organ regeneration techniques. Some of the new treatments that were not possible previously become reachable now. Because of the advent of surface chemistry, the CNT's biocompatibility has been significantly improved, making it possible to serve as tissue scaffolding materials to enhance the organ regeneration. The superior mechanic strength and chemical inert also makes it ideal for blood compatible applications, especially for cardiopulmonary bypass surgery. The applications of CNTs in these cardiovascular surgeries led to a remarkable improvement in mechanical strength of implanted catheters and reduced thrombogenecity after surgery. Moreover, the functionalized CNTs have been extensively explored for in vivo targeted drug or gene delivery, which could potentially improve the efficiency of many cancer treatments. However, just like other nanomaterials, the cytotoxicity of CNTs has not been well established. Hence, more extensive cytotoxic studies are warranted while converting the hydrophobic CNTs into biocompatible nanomaterials. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 [source] | ||||||||||