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Cutaneous Horn (cutaneous + horn)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Cutaneous horn occurring on the lip of a child

INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 5 2003
L. N. Souza
Summary. Cutaneous horn is a relatively uncommon lesion consisting of keratotic material resembling that of an animal horn. This kind of lesion is more common in Caucasians and in older age groups. The primary lesion underlying the horny material may be benign, premalignant or malignant. The treatment of choice is an excisional biopsy with a narrow margin, because of the possibility of malignancy. The material must be submitted for histopathological evaluation. The first reported case of cutaneous horn arising on the vermillion border of the lower lip in a black child is presented. [source]

Expression of stratum corneum chymotryptic enzyme in ichthyoses and squamoproliferative processes

JOURNAL OF CUTANEOUS PATHOLOGY, Issue 6 2003
Brad Johnson
Objective:, Stratum corneum chymotryptic enzyme (SCCE) is a serine protease, which is thought to play a role in the desquamation of skin via the proteolysis of desmosomes in the stratum corneum. The objective of this study was to investigate the expression of SCCE in ichthyoses and squamoproliferative processes, conditions in which the shedding and replacement of epidermal cells is disrupted. Design:, Tissue samples from cases of Netherton's syndrome, congenital ichthyosiform erythroderma, ichthyosis vulgaris, actinic keratosis, squamous cell carcinoma in situ, and invasive squamous cell carcinoma were examined for expression of SCCE using immunohistochemistry. Main outcome measures:, The slides were qualitatively analyzed for the expression of SCCE by a certified dermatopathologist. Results:, In all disease states, we found that the expression of SCCE was absent in areas of parakeratotic stratum corneum of normal thickness. In areas of mixed orthokeratosis and parakeratosis where the stratum corneum was greatly thickened as might correspond clinically to a cutaneous horn, SCCE staining was either absent or focally aggregated without regard to orthokeratosis or parakeratosis. Of note, complete absence of SCCE expression was not observed in any of the cases of ichthyosis examined, nor was there increased expression of SCCE in the atypical cells of the squamoproliferative disorders. Conclusions:, These results suggest that SCCE is abnormally expressed in skin where epidermal cell kinetics are disrupted due to inherited and acquired defects. Further investigation is needed to determine causality between the abnormal expression of SCCE and the altered cell kinetics in these diseases. [source]