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Current Research (current + research)
Terms modified by Current Research Selected AbstractsBotulinum Toxin Type A: Myths, Facts, and Current ResearchHEADACHE, Issue 2003Stephen D. Silberstein MD No abstract is available for this article. [source] A Commentary on Current Research at the Marketing and Entrepreneurship Interface,JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 1 2008Morgan P. Miles First page of article [source] Health-Related Hardiness and Chronic Illness: A Synthesis of Current ResearchNURSING FORUM, Issue 3 2003Mirella Vasquez Brooks APRN, PhD(C) TOPIC A critical analysis of the relationship between health-related hardiness and chronic illnesses based on a review of the literature. PURPOSE To synthesize the current literature in order to provide an understanding of the state of knowledge and the implications for nursing regarding health-related hardiness and chronic illness. SOURCES Three computerized databases, which yielded 125 articles published from 1966 to 2002. CONCLUSIONS The presence of the health-related hardiness characteristic was significantly related to psychological, psychosocial, and physiologic adaptation. Higher levels of hardiness had positive outcomes in patients with chronic illness. The implications are that the current knowledge base regarding health-related hardiness and chronic illness could be used to assist patients who have to manage not only one but also multiple chronic illnesses. [source] Current Research on Paleoentomology , A PrefaceACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 4 2010REN Dong First page of article [source] Buchbesprechung: Adhesion , Current Research and Applications.CHEMIE-INGENIEUR-TECHNIK (CIT), Issue 1-2 2008Von W. Possart. No abstract is available for this article. [source] Life Stress as a Risk Factor for Postpartum Depression: Current Research and Methodological IssuesCLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 1 2000Joel D. Swendsen There is compelling evidence to suggest that acute adverse life events and certain stressors specific to motherhood increase the risk of maternity blues and diagnoses of postpartum depression. Other psychosocial factors that are likely to explain vulnerability to postpartum depression include previous history of depression and the stress-moderating effects of social support and coping responses. This article reviews the emerging empirical literature on stress and postpartum depression and presents a discussion of methodological issues relevant to advancing this area of research. Multivariate models that examine the interplay of these variables are now required to further our understanding of these syndromes. [source] New concepts in antimalarial use and mode of action in dermatologyDERMATOLOGIC THERAPY, Issue 4 2007Sunil Kalia ABSTRACT: Although chloroquine, hydroxychloroquine and quinacrine were originally developed for the treatment of malaria, these medications have been used to treat skin disease for over 50 years. Recent clinical data have confirmed the usefulness of these medications for the treatment of lupus erythematosus. Current research has further enhanced our understanding of the pharmacologic mechanisms of action of these drugs involving inhibition of endosomal toll-like receptor (TLR) signaling limiting B cell and dendritic cell activation. With this understanding, the use of these medications in dermatology is broadening. This article highlights the different antimalarials used within dermatology through their pharmacologic properties and mechanism of action, as well as indicating their clinical uses. In addition, contraindications, adverse effects, and possible drug interactions of antimalarials are reviewed. [source] Monetary Policy, Credit and Aggregate Supply: The Evidence from ItalyECONOMIC NOTES, Issue 3 2002Riccardo Fiorentini This paper concerns theory and evidence of the monetary transmission mechanisms. Current research has deeply investigated factors, such as dependence of firms on bank credit, that amplify the impact of monetary policy impulses on aggregate demand exerting strong but temporary effects on output and employment. We present an intertemporal macroeconomic equilibrium model of a competitive economy where current production is financed by bank credit, and then we use it to identify supply,side effects of the credit transmission mechanism in data drawn from the Italian economy. We find evidence that the ,credit variables' identified by the model , the overnight rate as a proxy of monetary policy and a measure of credit risk , have permanent effects on employment and output by altering credit supply conditions to firms. To save on space, mathematical proofs, statistical tests and data sources have been gathered in two separate appendices that can be examined on request. (J.E.L.: E2, E5). [source] Differences between European and American IPO MarketsEUROPEAN FINANCIAL MANAGEMENT, Issue 4 2003Jay R. Ritter G24; G32; G14; G15 Abstract This brief survey discusses recent developments in the European initial public offering (IPO) market. The spectacular rise and fall of the Euro NM markets and the growth of bookbuilding as a procedure for pricing and allocating IPOs are two important patterns. Gross spreads are lower and less clustered than in the USA. Unlike the USA, some European IPOs, especially those in Germany, have when-issued trading prior to the final setting of the offer price. Current research includes empirical studies on the valuation of IPOs and both theoretical and empirical work on the determinants of short-run underpricing. [source] New developments in our understanding of acne pathogenesis and treatmentEXPERIMENTAL DERMATOLOGY, Issue 10 2009Ichiro Kurokawa Abstract:, Interest in sebaceous gland physiology and its diseases is rapidly increasing. We provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005,2008). We have tried to answer questions arising from the exploration of sebaceous gland biology, hormonal factors, hyperkeratinization, role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Sebaceous glands play an important role as active participants in the innate immunity of the skin. They produce neuropeptides, excrete antimicrobial peptides and exhibit characteristics of stem cells. Androgens affect sebocytes and infundibular keratinocytes in a complex manner influencing cellular differentiation, proliferation, lipogenesis and comedogenesis. Retention hyperkeratosis in closed comedones and inflammatory papules is attributable to a disorder of terminal keratinocyte differentiation. Propionibacterium acnes, by acting on TLR-2, may stimulate the secretion of cytokines, such as interleukin (IL)-6 and IL-8 by follicular keratinocytes and IL-8 and -12 in macrophages, giving rise to inflammation. Certain P. acnes species may induce an immunological reaction by stimulating the production of sebocyte and keratinocyte antimicrobial peptides, which play an important role in the innate immunity of the follicle. Qualitative changes of sebum lipids induce alteration of keratinocyte differentiation and induce IL-1 secretion, contributing to the development of follicular hyperkeratosis. High glycemic load food and milk may induce increased tissue levels of 5,-dihydrotestosterone. These new aspects of acne pathogenesis lead to the considerations of possible customized therapeutic regimens. Current research is expected to lead to innovative treatments in the near future. [source] Pleiotropic effect of a locus on chromosome 4 influencing alcohol drinking and emotional reactivity in ratsGENES, BRAIN AND BEHAVIOR, Issue 3 2003E. Terenina-Rigaldie A QTL search in a segregating F2 intercross between HEP (High-Ethanol Preferring line) and wistar-kyoto (WKY, a low-alcohol consuming strain) rats identified a locus on chromosome 4 linked to the consumption of a 5% alcohol solution offered as a free choice with water (Terenina-Rigaldie et al. submitted). In order to confirm and analyse the influence of this locus, F2 rats were selected according to their genotype at the markers flanking the QTL and bred in order to obtain two groups of rats homozygous HEP/HEP (,HIGH' line) or WKY/WKY (,LOW' line) at the QTL, the rest of the genome being randomly inherited from one or the other founder strain. These two groups of animals displayed large differences in emotional reactivity (open field, elevated-plus maze), sensitivity to taste reinforcers (saccharin, quinine) and alcohol consumption (either forced or as a free choice with water). These results confirm the influence of this locus on alcohol intake and emotional reactivity traits, and suggest a pleiotropic effect of the gene(s) involved. Current research aims at the identification of this (these) gene(s). [source] Detecting genotype combinations that increase risk for disease: Maternal-Fetal genotype incompatibility testGENETIC EPIDEMIOLOGY, Issue 1 2003Janet S. Sinsheimer Abstract Biological mechanisms that involve gene-by-environment interactions have been hypothesized to explain susceptibility to complex familial disorders. Current research provides compelling evidence that one environmental factor, which acts prenatally to increase susceptibility, arises from a maternal-fetal genotype incompatibility. Because it is genetic in origin, a maternal-fetal incompatibility is one possible source of an adverse environment that can be detected in genetic analyses and precisely studied, even years after the adverse environment was present. Existing statistical models and tests for gene detection are not optimal or even appropriate for identifying maternal-fetal genotype incompatibility loci that may increase the risk for complex disorders. We describe a new test, the maternal-fetal genotype incompatibility (MFG) test, that can be used with case-parent triad data (affected individuals and their parents) to identify loci for which a maternal-fetal genotype incompatibility increases the risk for disease. The MFG test adapts a log-linear approach for case-parent triads in order to detect maternal-fetal genotype incompatibility at a candidate locus, and allows the incompatibility effects to be estimated separately from direct effects of either the maternal or the child's genotype. Through simulations of two biologically plausible maternal-fetal genotype incompatibility scenarios, we show that the type-I error rate of the MFG test is appropriate, that the estimated parameters are accurate, and that the test is powerful enough to detect a maternal-fetal genotype incompatibility of moderate effect size. Genet Epidemiol 24:1,13, 2003. © 2003 Wiley-Liss, Inc. [source] SWAT2000: current capabilities and research opportunities in applied watershed modellingHYDROLOGICAL PROCESSES, Issue 3 2005J. G. Arnold Abstract SWAT (Soil and Water Assessment Tool) is a conceptual, continuous time model that was developed in the early 1990s to assist water resource managers in assessing the impact of management and climate on water supplies and non-point source pollution in watersheds and large river basins. SWAT is the continuation of over 30 years of model development within the US Department of Agriculture's Agricultural Research Service and was developed to ,scale up' past field-scale models to large river basins. Model components include weather, hydrology, erosion/sedimentation, plant growth, nutrients, pesticides, agricultural management, stream routing and pond/reservoir routing. The latest version, SWAT2000, has several significant enhancements that include: bacteria transport routines; urban routines; Green and Ampt infiltration equation; improved weather generator; ability to read in daily solar radiation, relative humidity, wind speed and potential ET; Muskingum channel routing; and modified dormancy calculations for tropical areas. A complete set of model documentation for equations and algorithms, a user manual describing model inputs and outputs, and an ArcView interface manual are now complete for SWAT2000. The model has been recoded into Fortran 90 with a complete data dictionary, dynamic allocation of arrays and modular subroutines. Current research is focusing on bacteria, riparian zones, pothole topography, forest growth, channel downcutting and widening, and input uncertainty analysis. The model SWAT is meanwhile used in many countries all over the world. Recent developments in European Environmental Policy, such as the adoption of the European Water Framework directive in December 2000, demand tools for integrative river basin management. The model SWAT is applicable for this purpose. It is a flexible model that can be used under a wide range of different environmental conditions, as this special issue will show. The papers compiled here are the result of the first International SWAT Conference held in August 2001 in Rauischholzhausen, Germany. More than 50 participants from 14 countries discussed their modelling experiences with the model development team from the USA. Nineteen selected papers with issues reaching from the newest developments, the evaluation of river basin management, interdisciplinary approaches for river basin management, the impact of land use change, methodical aspects and models derived from SWAT are published in this special issue. Copyright © 2005 John Wiley & Sons, Ltd. [source] A revised Canadian perspective: progress in glacier hydrologyHYDROLOGICAL PROCESSES, Issue 1 2005D. Scott Munro Abstract Current research into glacier hydrology is occurring at a time when glaciers around the world, particularly those whose hydrological regimes affect populated areas, are shrinking as they go through a state of perpetual negative annual mass balance. Small glaciers alone are likely to contribute 0·5 to 1 mm year,1 to global sea-level rise, with associated reductions in local freshwater resources, impacts upon freshwater ecosystems and increased risk of hazard due to outburst floods. Changes to the accumulation regimes of glaciers and ice sheets may be partly responsible, so the measurement and distribution of snowfall in glacierized basins, a topic long represented in non-glacierized basin research, is now beginning to receive more attention than it did before, aided by the advent of reliable automatic weather stations that provide data throughout the year. Satellite data continue to be an important information source for summer meltwater estimation, as distributed models, and their need for albedo maps, continue to develop. This further entails the need for simplifications to energy balance components, sacrificing point detail so that spatial calculation may proceed more quickly. The understanding of surface meltwater routing through the glacier to produce stream outflow continues to be a stimulating area of research, as demonstrated by activity at the Trapridge Glacier, Canada, and Canadian involvement in the Haut Glacier d'Arolla, Switzerland. As Canadian glacier monitoring continues to evolve, effort must be directed toward developing situations where mass balance, meltwater generation and flow routing studies can be done together at selected sites. Copyright © 2005 John Wiley & Sons, Ltd. [source] New Patterns of Youth Transition in EducationINTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 164 2000Johanna Wyn Current research provides evidence that new relationships are being forged between youth people and education. Increased participation in post-compulsory education, combinations of work and study and uncertain career outcomes havebecome common experiences. There is an emerging disparity between the stated goals of education and the changing priorities and choices of young people. In particular, the linear notion of transitions, expressed in the metaphorsof pathways used in policy documents, is increasingly at odds with the patterns of life experienced by young people in many nations. Three themes stand out in the research on young people in the 1990s. First, an awareness of foreclosed options in educational outcomes is a consistent thread across a range of studies. Secondly, there is a discernible shift by the end of the 1990s toward more complex life-patterns and a blending or balancing of a range of personal priorities and interests. Thirdly, the need to give ,active voice' to young people about the dramatic social and economic changes they have been subjected to, is unmistakable in the light of the increasing disparity between the rhetoric of youth and education policy and their own experience of its out-comes. [source] Oligomeric alpha-synuclein and its role in neuronal deathIUBMB LIFE, Issue 5 2010David R. Brown Abstract Alpha-synuclein is a natively unfolded protein associated with a number of neurodegenerative disorders that include Parkinson's disease. In the past, research has focused on the fibrillar form of the protein. Current research now indicates that oligomeric alpha-synuclein is the form of the protein most likely to causes neuronal death. Recent research has suggested that a unique oligomer associated with the copper binding capacity of the protein is the neurotoxic form of the protein. This review looks at the evidence for this possibility. © 2010 IUBMB IUBMB Life, 62(5): 334,339, 2010 [source] Treatment of Trauma- and Abuse-Related Dissociative Symptom Disorders in Children and AdolescentsJOURNAL OF CHILD AND ADOLESCENT PSYCHIATRIC NURSING, Issue 1 2009Scott Weber EdD TOPIC:,Dissociation is believed to be one of the most common underlying psychological processes among children and adolescents receiving mental health treatment, but most of the dissemination of information about dissociation has occurred among psychiatrists and psychologists. PURPOSE:,Modes of treatment for dissociation as it affects children and adolescents are described. SOURCES USED:,Current research and practice scholarly articles on treatment of children and adolescents for dissociation and dissociative symptom disorders were accessed and critically reviewed. CONCLUSIONS:,Prognosis in children and adolescents can vary widely among patients and between the specific types of dissociation disorder; however, expert clinicians and researchers agree that early, intense treatment offers the greatest possibility of full recovery. [source] Effectiveness of maternity support belts in reducing low back pain during pregnancy: a reviewJOURNAL OF CLINICAL NURSING, Issue 11 2009Simone SM Ho Aims., This article aims to review the literature published to date on the types, current use, the biomechanical effects and adverse effects of maternity support belts for low back pain during pregnancy, to identify future research directions. Background., Lumbar/pelvic support belts are frequently recommended for the prevention and treatment of low back pain during pregnancy. Design., Systematic review. Methods., MEDLINE, CINAHL, the Cochrane Library and patents databases were electronically searched. Results., Maternity support belts belong to one of the four main types of maternity support garments, which are widely commercially-available. Current research showed limited evidence in support of the commercial maternity products regarding the effectiveness in the prevention and/or treatment of low back pain during pregnancy, other than that from the manufacturers. However, potential stabilisation effect of maternity support belt was demonstrated in some studies. Adverse effects reported include increased pain, fetal heart rate changes, skin irritation and discomfort. Conclusions., There is insufficient scientific evidence to conclude that wearing maternity support belts reduces pregnancy-related low back pain and/or pelvic girdle pain. Future research directions in the area of biomechanics and physiology are recommended. Relevance to clinical practice., This review provides comprehensive understanding of the effectiveness of maternity support belts for the relief of low back pain during pregnancy which will facilitate healthcare professionals in providing evidence-based advice to their patients. [source] Cognitive,behavior therapy for PTSD in rape survivorsJOURNAL OF CLINICAL PSYCHOLOGY, Issue 8 2002Lisa H. Jaycox In recent years, new data have appeared, further suggesting the utility of cognitive,behavioral interventions for posttraumatic stress disorder (PTSD) subsequent to sexual assault. In this article, we present a model of cognitive,behavioral treatment (CBT) for PTSD in rape survivors. Emotional-processing theory, which proposes mechanisms that underlie the development of disturbances following rape, is reviewed. A CBT-based therapy (Prolonged Exposure) is presented that entails education about common reactions to trauma, relaxation training, imaginal reliving of the rape memory, exposure to trauma reminders, and cognitive restructuring. Current research regarding the use of prolonged exposure is discussed. The case example of a young female rape survivor is described in detail, and her prior substance dependence and intense shame are highlighted. The therapy was successful in reducing the client's symptoms of PTSD, as well as her depressive symptoms, and these gains were maintained at a one-year follow-up assessment. © 2002 Wiley Periodicals, Inc. J Clin Psychol/In Session 58: 891,906, 2002. [source] Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sampleJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 7 2010A. Lachiewicz Abstract Background Current research suggests that depression and anxiety may be common problems in women with the fragile X (FMR1) premutation. Methods To learn more about this in a clinical setting, we asked 33 women with the FMR1 premutation and 20 women without the FMR1 premutation to complete the Brief Carroll Depression Scale (Brief CDS) and the Multidimensional Anxiety Questionnaire (MAQ) and to provide information about mental health medication use. Questionnaire findings were compared between groups and with normative samples. Trinucleotide (CGG) repeat counts were also correlated to checklist findings. Results Both women with the FMR1 premutation and the comparison group had high current mental health medication use (33% vs. 35%). Approximately 1/3 of the women from both groups had high Brief CDS Total T-scores (33% vs. 30%). More women with the FMR1 premutation had at least one elevated MAQ Total or sub-scale T-score than the comparison group (39% vs. 10%, P = 0.03). Twenty-one per cent of women with the FMR1 premutation had all three of the indicators of distress targeted in this study vs. none of the women in the comparison samples (P < 0.05). There was no statistically significant correlation between CGG repeat size and abnormal checklist findings using the Spearman rank correlation, although a higher percentage of women with >100 CGG repeats (57%) had an elevated Brief CDS Total T-score than women with ,100 CGG repeats (16%) (P = 0.02). More women with >100 CGG repeats also had all three indicators of anxiety and depression (P = 0.03). Conclusions Women with the FMR1 premutation appear to have a high incidence of depression and increased symptoms of anxiety. Screening tools like the Brief CDS and the MAQ may be useful to identify these women in the clinic setting. Positive identification could lead to increased mental health care and treatment. [source] Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?JOURNAL OF INTERNAL MEDICINE, Issue 3 2006C. SÖDERBERG-NAUCLÉR Abstract. Human cytomegalovirus (HCMV) is a herpes virus that infects and is carried by 70,100% of the world's population. During its evolution, this virus has developed mechanisms that allow it to survive in an immunocompetent host. For many years, HCMV was not considered to be a major human pathogen, as it appeared to cause only rare cases of HCMV inclusion disease in neonates. However, HCMV is poorly adapted for survival in the immunosuppressed host and has emerged as an important human pathogen in AIDS patients and in patients undergoing immunosuppressive therapy following organ or bone marrow transplantation. HCMV-mediated disease in such patients has highlighted the possible role of this virus in the development of other diseases, in particular inflammatory diseases such as vascular diseases, autoimmune diseases and, more recently, with certain forms of cancers. Current research is focused on determining whether HCMV plays a causative role in these diseases or is merely an epiphenomenon of inflammation. Inflammation plays a central role in the pathogenesis of HCMV. This virus has developed a number of mechanisms that enable it to hide from the cells of the immune system and, at the same time, reactivation of a latent infection requires immune activation. Numerous products of the HCMV genome are devoted to control central functions of the innate and adaptive immune responses. By influencing the regulation of various cellular processes including the cell cycle, apoptosis and migration as well as tumour invasiveness and angiogenesis, HCMV may participate in disease development. Thus, the various drugs now available for treatment of HCMV disease (e.g. ganciclovir, acyclovir and foscarnet), may also prove to be useful in the treatment of other, more widespread diseases. [source] Modifying Women's Risk for Cardiovascular DiseaseJOURNAL OF OBSTETRIC, GYNECOLOGIC & NEONATAL NURSING, Issue 2 2007Kathleen M. McCauley Objective:, To present current recommendations for cardiovascular disease risk reduction in women. Data Sources:, Medline databases were searched from 1990 to 2006 using keywords women and cardiovascular risk, hypertension, cholesterol, and hormone replacement therapy, as well as Web sites from scientific associations such as the American Heart Association, American College of Cardiology, Agency for Health Research and Quality, and the Centers for Disease Control for relevant scientific statements and guidelines. Study Selection:, Randomized controlled trials, particularly those that have influenced current practice recommendations, scientific statements, and clinical practice guidelines were selected. Data Extraction and Synthesis:, Factors contributing to women's particular risk and current practice recommendations. Conclusions:, Current research has clarified the importance of regular exercise (at least 30 minutes/day most days of the week); abstinence from smoking; a diet focused on whole grains, fruits, vegetables, and low-fat protein sources; and maintenance of normal weight. This lifestyle combined with a partnership with a health care provider to maintain a normal blood pressure (115/75 mm Hg) and optimal lipoproteins through pharmacotherapy when indicated can prevent 82% of cardiovascular disease events in women. JOGNN, 36, 116-124; 2007. DOI: 10.1111/J.1552-6909.2007.00125.x [source] Neurodevelopmental outcomes and surgery in neonatesJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 12 2006Karen Walker Abstract: A neonate requiring major surgery in 2006 has a greater prospect of survival than ever before. Increasingly, however, there is awareness that critical illness may affect later neurodevelopment. Pre-existing conditions in addition to the physiologic stresses associated with cardiac and general surgery are implicated but remain unavoidable in the case of significant structural abnormalities such as transposition of the great arteries or congenital diaphragmatic hernia. For those affected by neurodevelopmental impairment, there is a significant cost to the child, family and society. Current research focuses on the preventable causes of brain injury, before, during and after the intervention, and the rate of impairment in apparently uncomplicated procedures. In contrast to the quantity of neurodevelopmental outcome data following cardiac surgery, there remain few outcome studies dealing with non-cardiac surgery despite such intervention being two to three times more common. There appear to be compelling clinical and economic arguments for the instigation of formalised population-based developmental assessments for all infants undergoing major surgery. [source] Addressing nutritional issues in the college-aged client: Strategies for the nurse practitionerJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 1 2008FNP Family Nurse PractitionerArticle first published online: 2 JAN 200, Sarah E. Gores RN Abstract Purpose: To educate nurse practitioners (NPs) on the nutritional risks specific to the college-aged client and provide recommendations for interventions for this group. Data sources: Information was gathered through a literature search as well as the author's own experience. Conclusions: As young adults move into an independent living situation, there is a high risk for unhealthy eating habits. While this may not translate into the weight gain known as the "Freshman 15," this is the time period when young adults begin to cement their eating habits. Current research has found that students who gain weight during this period tend to continue a slow, steady gain in weight. Implications for practice: NPs must take every opportunity to provide guidance toward healthy eating habits. Most clients of this age group are seen infrequently by a primary care practitioner. Thus, each visit should be used to explore the topic with clients to minimize adverse outcomes in the future. [source] Physiology and Treatment of Retained Fetal Membranes in CattleJOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 2 2010J.C. Beagley Retained fetal membranes (RFM) in cattle have adverse effects on fertility and production. Understanding the pathophysiology and causes of RFM is important for managing this disease. The hormonal processes that lead to normal placental separation are multifactorial and begin before parturition. A variety of risk factors, including early or induced parturition, dystocia, hormonal imbalances, and immunosuppression, can interrupt these normal processes and result in retention of the placenta. Current research does not support the efficacy of many commonly practiced treatments for RFM. Systemic administration of antibiotics can be beneficial for treating metritis after RFM, but antibiotic administration has not been shown to significantly improve future reproduction in cows with RFM. Collagenase injected into the umbilical arteries of retained placentas specifically targets the lack of placentome proteolysis and might enhance placental release. However, such therapy is costly and its benefits in terms of improving subsequent reproductive function have not been evaluated. [source] Nutritional status in pregnant adolescents: a systematic review of biochemical markersMATERNAL & CHILD NUTRITION, Issue 2 2007Victoria Hall Moran Abstract Adolescent pregnancy is a major public health challenge for many industrialized countries and is associated with significant medical, nutritional, social and economic risk for mothers and their infants. Despite this, relatively little is known about the nutritional status of this population. The aim of this paper was to conduct a systematic review of the current evidence relating to the biochemical markers of nutritional status of pregnant adolescents living in industrialized countries. Six papers were identified that fulfilled the inclusion criteria, the majority of which were conducted in the United States. The studies were of variable quality and most failed to control for potential confounders which may have strongly influenced the findings. Due to limited research, conclusions cannot be drawn about the zinc and calcium status of pregnant adolescents, and data on folate and vitamin B12 status appeared conflicting. There was some consensus among studies, however, to suggest that indicators of anaemia and iron status were compromised in pregnant adolescents, particularly during the third trimester of pregnancy. Chronological age did not appear to influence nutritional status, although there was some evidence to suggest that increasing gynaecologic age may positively influence plasma ferritin levels. Current research is limited by sampling and measurement bias, and research is urgently required to address these limitations. Further consideration should also be made of the influence of the role of socio-economic support on pregnant adolescents' nutritional status. The achievement of improved nutrition in pregnancy among adolescents requires multidisciplinary collaborations of adolescent healthcare providers, academics, professional organizations, policymakers, industry and service users. Only once this is achieved can adolescent nutrition, and adolescent nutrition in pregnancy, be significantly and sustainably optimized. [source] Insecticide resistance in the horn fly: alternative control strategiesMEDICAL AND VETERINARY ENTOMOLOGY, Issue 3 2008M. P. OYARZÚN Abstract The horn fly, Haematobia irritans (Linnaeus 1758) (Diptera: Muscidae) is one of the most widespread and economically important pests of cattle. Although insecticides have been used for fly control, success has been limited because of the development of insecticide resistance in all countries where the horn fly is found. This problem, along with public pressure for insecticide-free food and the prohibitive cost of developing new classes of compounds, has driven the investigation of alternative control methods that minimize or avoid the use of insecticides. This review provides details of the economic impact of horn flies, existing insecticides used for horn fly control and resistance mechanisms. Current research on new methods of horn fly control based on resistant cattle selection, semiochemicals, biological control and vaccines is also discussed. [source] Three-dimensional reconstruction of the remodeling of the systemic vasculature in early pig embryosMICROSCOPY RESEARCH AND TECHNIQUE, Issue 2 2008Pieter Cornillie Abstract Current research on angiogenesis and vascular regression is mainly focused on pathological conditions such as tumor growth and diabetic retinopathy, while a suitable physiological model to study the controlling factors in these processes is still lacking. The remodeling pattern of the embryonic vasculature into the adult configuration, such as the branchial arch arterial system developing into the aorta or the early embryonic veins building the caudal vena cava can potentially serve as a model. However, practical applications of the embryonic vascular patterning are impeded by the current controversy over the exact development of the caudal vena cava in mammals. To elucidate these ambiguities, specific developmental stages of vascular development in pig embryos were mapped by means of computer-assisted 3D reconstructions starting from histological serial sections of Bouin's fixed embryos. Special attention was given to venous segments in the lumbar region, as their origin and fate are equivocally described in literature. Here we demonstrate that these venous segments originate from the caudal cardinal veins which are forced to migrate during development into a more dorsal position due to the expansion of the developing metanephroi and the more dorsal relocation of the umbilical arteries. These findings are in contrast with the generally accepted theory that the venous segments in the lumbar region arise from newly formed veins that are located dorsal to the early caudal cardinal system. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc. [source] Nitric oxide in wound-healingMICROSURGERY, Issue 5 2005Jeff S. Isenberg M.D., M.P.H. Modulation of the complex process of wound-healing remains a surgical challenge. Little improvement beyond controlling infection, gentle tissue handling, and debridement of necrotic tissue has been had in the modern era. However, increasing appreciation of the process from a biomolecular perspective offers the potential for making significant strides in wound modulation. The bioactive molecule nitric oxide was found to have wide-ranging impact on cellular activities, including the cellular responses engendered by wound healing. Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent. © 2005 Wiley-Liss, Inc. Microsurgery 25:442,451, 2005. [source] Recurrent nuclear DNA introgression accompanies chloroplast DNA exchange between two eucalypt speciesMOLECULAR ECOLOGY, Issue 7 2010G. E. MCKINNON Abstract Numerous studies within plant genera have found geographically structured sharing of chloroplast (cp) DNA among sympatric species, consistent with introgressive hybridization. Current research is aimed at understanding the extent, direction and significance of nuclear (nr) DNA exchange that accompanies putative cpDNA exchange. Eucalyptus is a complex tree genus for which cpDNA sharing has been established between multiple species. Prior phylogeographic analysis has indicated cpDNA introgression into the widespread forest species Eucalyptus globulus from its rare congener E. cordata. In this study, we use AFLP markers to characterize corresponding nrDNA introgression, on both a broad and fine spatial scale. Using 388 samples we examine (i) the fine-scale spatial structure of cp and nrDNA introgression from E. cordata into E. globulus at a site in natural forest and (ii) broad-scale patterns of AFLP marker introgression at six additional mixed populations. We show that while E. globulus and E. cordata retain strongly differentiated nuclear gene pools overall, leakage of nrDNA occurs at mixed populations, with some AFLP markers being transferred to E. globulus recurrently at different sites. On the fine scale, different AFLP fragments show varying distances of introgression into E. globulus, while introgression of cpDNA is extensive. The frequency of E. cordata markers in E. globulus is correlated with spatial proximity to E. cordata, but departs from expectations based on AFLP marker frequency in E. cordata, indicating that selection may be governing the persistence of introgressed fragments in E. globulus. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||