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Current Insights (current + insight)
Selected AbstractsNatural killer cell-based immunotherapy in cancer: current insights and future prospectsJOURNAL OF INTERNAL MEDICINE, Issue 2 2009T. Sutlu Abstract. As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell-based immunotherapeutic approaches in cancer starting from a historical background and an overview of molecular mechanisms taking part in NK cell responses. The status of NK cells in cancer patients, currently investigated clinical applications such as in vivo modulation of NK cell activity, ex vivo purification/expansion and adoptive transfer as well as future possibilities such as genetic modifications are discussed in detail. [source] Dermatofibroma: a possible model of local fibrosis with epithelial/mesenchymal cell interactionJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 4 2009T Yamamoto Abstract Dermatofibromas are benign dermal nodules usually seen on the extremities; however, whether a dermatofibroma is a reactive fibrous hyperplasia or a true neoplasm is still unclear. Fibrous type dermatofibromas might be regarded as the symptom of local fibrotic processes and thus present a possible model of local fibrosis. Interaction between proliferated dermatofibroma fibroblasts and overlying elongated epidermis suggests a relationship between keratinocytes and mesenchymal cells. We herein describe current insights into the pathogenesis of dermatofibromas and explore the possible involvement of immunocytes around fibroblasts and effector cells which play an important role in the development of dermatofibromas. Conflicts of interest None declared [source] Teil 1: Entwicklungsstand und FlankenpegeldifferenzBAUPHYSIK, Issue 1 2004Elmar Sälzer Dipl.-Ing. Nach mehr als 20 Jahren wird zusammenfassend über den gegenwärtigen Stand der Erkenntnisse zum Schallschutz von Hohlraumböden berichtet, aufbauend auf über 500 Messungen im akustischen Laboratorium und mehreren hundert Messungen am Bau, letztere immer im Zusammenklang von Wänden, Decken, Hohlraumböden und sonstigen Bauteilen. Sound protection of cavity floors Part 1: State of the development and difference in flanking transmission level After more than 20 years of development, a summary of current insights regarding the sound protection of cavity floors is provided, based on more than 500 measurements in an acoustics laboratory and several hundred measurements on site, with the latter invariably taking account of the combined effect of walls, ceilings, cavity floors and other components. [source] Cell fate transitions during stomatal developmentBIOESSAYS, Issue 8 2009Laura Serna Abstract Stomata, the most influential components in gas exchange with the atmosphere, represent a revealing system for studying cell fate determination. Studies in Arabidopsis thaliana have demonstrated that many of the components, functioning in a signaling cascade, guide numerous cell fate transitions that occur during stomatal development. The signaling cascade is initiated at the cell surface through the activation of the membrane receptors TOO MANY MOUTHS (TMM) and/or ERECTA (ER) family members by the secretory peptide EPIDERMAL PATTERNING FACTOR1 (EPF1) and/or a substrate processed proteolytically by the subtilase STOMATAL DENSITY AND DISTRIBUTION1 (SDD1) and transduced through cytoplasmic MAP kinases (YODA (YDA), MKK4/MKK5, and MPK3/MPK6) towards the nucleus. In the nucleus, these MAP kinases regulate the activity of the basic helix-loop-helix (bHLH) proteins SPEECHLESS (SPCH), MUTE, and FAMA, which act in concert with the bHLH-Leu zipper protein SCREAM (SCRM) (and/or its closely related paralog, SCREAM2). This article reviews current insights into the role of this signaling cascade during stomatal development. [source] 2213: Herpetic keratitis: Herpes simplex virus versus hostACTA OPHTHALMOLOGICA, Issue 2010G VERJANS Herpes simplex virus type 1 (HSV-1) is an endemic virus worldwide that causes ocular disease in a limited but significant number of infected persons. Corneal HSV-1 infection is clinically classified into herpetic epithelial keratitis (HEK) and herpetic stromal keratitis (HSK). HEK is an acute inflammation and results from viral toxicity of infected corneal epithelial cells. In contrast, HSK is characterized as a chronic immunopathogenic disease in which tissue injury and eventually blindness is due to the complex interplay between cells of the innate and adoptive immune response to viral antigens expressed in the corneal tissue. Studies performed on the experimental HSK mouse model greatly improved our understanding of the pathogenesis of HSK. This talk will recapitulate current insights on the virus-host interactions involved in the initiation and perpetuation of herpetic keratitis in mice and men. [source] | ||||||||||