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Selected AbstractsVitamin A, Mastitis, and Mother-to-Child Transmission of HIV-1 through Breast-feeding: Current Information and Gaps in KnowledgeNUTRITION REVIEWS, Issue 10 2005Stephanie M. Dorosko DVM Mastitis has been implicated as a risk factor for mother-to-child transmission (MTCT) of HIV-1 through breast-feeding. Maternal vitamin A deficiency is also associated with increased MTCT, as well as with episodes of mastitis in lactating animals. This review describes the complex interrelationship between vitamin A, mastitis, and MTCT of HIV-1 via mothers' milk. Current gaps in knowledge, as well as recommendations for future research efforts, are also discussed. [source] Derivation of the mammalian skull vaultJOURNAL OF ANATOMY, Issue 1-2 2001GILLIAN M. MORRISS-KAY abstract This review describes the evolutionary history of the mammalian skull vault as a basis for understanding its complex structure. Current information on the developmental tissue origins of the skull vault bones (mesoderm and neural crest) is assessed for mammals and other tetrapods. This information is discussed in the context of evolutionary changes in the proportions of the skull vault bones at the sarcopterygiantetrapod transition. The dual tissue origin of the skull vault is considered in relation to the molecular mechanisms underlying osteogenic cell proliferation and differentiation in the sutural growth centres and in the proportionate contributions of different sutures to skull growth. [source] Brief communication: Noninvasive measuring of operational tongue length in callitrichidsAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009Eckhard W. Heymann Abstract Callitrichids use their tongue in various social, ecological, and hygienic contexts. Using a noninvasive measuring device, we obtained data on the operational tongue length (OTL) in seven species from the family Callitrichidae. OTL (defined as the maximum tongue extension into the device) varied significantly between species and the width of the device, but did not correlate with mandible length; it is smaller in relation to mandible length in Leontopithecus chrysomelas compared to species from the genera Saguinus and Callithrix. Current information does not allow concluding which of the various functions of the tongue is selecting for tongue length. Am J Phys Anthropol 2009. © 2009 Wiley-Liss, Inc. [source] Conodont affinity and chordate phylogenyBIOLOGICAL REVIEWS, Issue 2 2000PHILIP C. J. DONOGHUE ABSTRACT Current information on the conodonts Clydagnathus windsorensis (Globensky) and Promissum pulchrum Kovács- Endrödy, together with the latest interpretations of conodont hard tissues, are reviewed and it is concluded that sufficient evidence exists to justify interpretation of the conodonts on a chordate model. A new phylogenetic analysis is undertaken, consisting of 17 chordate taxa and 103 morphological, physiological and biochemical characters; conodonts are included as a primary taxon. Various experiments with character coding, taxon deletion and the use of constraint trees are carried out. We conclude that conodonts are cladistically more derived than either hagfishes or lampreys because they possess a mineralised dermal skeleton and that they are the most plesiomorphic member of the total group Gnathostomata. We discuss the evolution of the nervous and sensory systems and the skeleton in the context of our optimal phylogenetic tree. There appears to be no simple evolution of free to canal-enclosed neuromasts; organised neuromasts within canals appear to have arisen at least three times from free neuromasts or neuromasts arranged within grooves. The mineralised vertebrate skeleton first appeared as odontodes of dentine or dentine plus enamel in the paraconodont/euconodont feeding apparatus. Bone appeared later, co-ordinate with the development of a dermal skeleton, and it appears to have been primitively acellular. Atubular dentine is more primitive than tubular dentine. However, the subsequent distribution of the different types of dentine (e.g. mesodentine, orthodentine), suggests that these tissue types are homoplastic. The topology of relationships and known stratigraphic ranges of taxa in our phylogeny predict the existence of myxinoids and petromyzontids in the Cambrian. [source] Genetic study of alcoholism and novel gene expression in the alcoholic brainADDICTION BIOLOGY, Issue 1 2004Li Fan Alcohol dependence may result from neuroadaptation involving alteration of gene expression after long-term alcohol exposure. The systematic study of gene expression profiles of the human alcoholic brain was initiated using the method of polymerase chain reaction (PCR)-differential display and was followed by DNA microarray. To date, more than 100 alcohol-responsive genes have been identified from the frontal cortex, motor cortex and nucleus accumbens of the human brain. These genes have a wide range of functions in the brain and indicate diverse actions of alcohol on neuronal function. This review discusses the current information on the genetic basis of alcoholism and the induction and characterization of these alcohol-responsive genes. [source] Shrinking baseline: the growth in juvenile fisheries, with the Hong Kong grouper fishery as a case studyFISH AND FISHERIES, Issue 4 2009Allen W L To Abstract Historic and current information on the grouper fishery from Hong Kong and adjacent waters reveals significant changes in species composition and fish sizes over the past 50 years in this important Asian centre for seafood consumption. Once dominant, large groupers are now rare and small species and sizes prevail in the present-day fishery. Juveniles comprise over 80% of marketed fish by number among the most commonly retailed groupers, and reproductive-sized fish are absent among larger species. Current fishery practices and the lack of management in Hong Kong and adjacent waters pose a significant threat to large species with limited geographic distribution such as Epinephelus akaara and Epinephelus bruneus, both now listed as threatened by the IUCN. The heavy reliance on juveniles, not only for groupers, but for an increasing diversity of desired fishes within Asia, potentially reduces stock spawning potential. The ,shrinking baseline' in terms of a progressive reduction in fish sizes being marketed in the region can seriously undermine fishery sustainability and recoverability of depleted fish stocks. Fishing pressure on groupers and other valuable food fishes within the Asia-Pacific is intensifying, the declining long-term trend of grouper landings in Hong Kong and the increasing focus on juveniles for immediate sale or for mariculture ,grow-out' signal a worrying direction for regional fisheries. Moreover, the common appearance of small groupers for sale will influence public perception regarding what are ,normal-sized' fish. Management attention is needed if these fisheries are to remain viable. [source] CD4+ T-regulatory cells: toward therapy for human diseasesIMMUNOLOGICAL REVIEWS, Issue 1 2008Sarah E. Allan Summary T-regulatory cells (Tregs) have a fundamental role in the establishment and maintenance of peripheral tolerance. There is now compelling evidence that deficits in the numbers and/or function of different types of Tregs can lead to autoimmunity, allergy, and graft rejection, whereas an over-abundance of Tregs can inhibit anti-tumor and anti-pathogen immunity. Experimental models in mice have demonstrated that manipulating the numbers and/or function of Tregs can decrease pathology in a wide range of contexts, including transplantation, autoimmunity, and cancer, and it is widely assumed that similar approaches will be possible in humans. Research into how Tregs can be manipulated therapeutically in humans is most advanced for two main types of CD4+ Tregs: forkhead box protein 3 (FOXP3)+ Tregs and interleukin-10-producing type 1 Tregs (Tr1 cells). The aim of this review is to highlight current information on the characteristics of human FOXP3+ Tregs and Tr1 cells that make them an attractive therapeutic target. We discuss the progress and limitations that must be overcome to develop methods to enhance Tregs in vivo, expand or induce them in vitro for adoptive transfer, and/or inhibit their function in vivo. Although many technical and theoretical challenges remain, the next decade will see the first clinical trials testing whether Treg-based therapies are effective in humans. [source] A robust approach to the UAV task assignment problemINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 2 2008Mehdi Alighanbari Abstract This paper presents a new robust approach to the task assignment of unmanned aerial vehicles (UAVs) operating in uncertain dynamic environments for which the optimization data, such as target cost and target,UAV distances, are time varying and uncertain. The impact of this uncertainty in the data is mitigated by tightly integrating two approaches for improving the robustness of the assignment algorithm. One approach is to design task assignment plans that are robust to the uncertainty in the data, which reduces the sensitivity to errors in the situational awareness (SA), but can be overly conservative for long duration plans. A second approach is to replan as the SA is updated, which results in the best plan given the current information, but can lead to a churning type of instability if the updates are performed too rapidly. The strategy proposed in this paper combines robust planning with the techniques developed to eliminate churning. This combination results in the robust filter-embedded task assignment algorithm that uses both proactive techniques that hedge against the uncertainty, and reactive approaches that limit churning behavior by the vehicles. Numerous simulations are shown to demonstrate the performance benefits of this new algorithm. Copyright © 2007 John Wiley & Sons, Ltd. [source] Shifting Paradigms of Globalization: The Twenty-first Century Transition Towards Generics in Skilled Migration from IndiaINTERNATIONAL MIGRATION, Issue 5 2001Binod Khadria Globalization of human capital through international migration is no longer about global physical presence only; it is also about global applicability of skills across various fields of specialization. This marks the main characteristics of skilled migration from India to developed countries in the twenty-first century. The focus is shifting away from professionals in specific occupations, like doctors, engineers, scientists, architects, bankers, to information technology (IT) professionals embodying, in a way, more generic skills. In other words, it is the generic applicability of information and communications technology (ICT) which has led to large-scale migration of Indians skilled in IT. Moreover, the exodus comprises not only the fully trained and educated workers going abroad for employment, but also students - the semi-finished human capital - pursuing higher education in onshore as well as offshore universities of the developed countries. The new emigration is directed towards traditional host countries in the West such as the UK, Canada, and the US, but also towards newly emerging destinations in continental Europe (Germany, France, Belgium, Italy, Denmark), Australasia (Australia, New Zealand), East Asia (Japan, Republic of Korea), and South-East Asia (Singapore, Malaysia). By using mainly current information and informal data as reported in the media, this article perceives emerging trends and changes in the context of the global labour market for skills, and suggests a possible framework towards evolving strategies of remedial development. [source] Nitric oxide and pain: ,Something old, something new'ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 9 2009A. MICLESCU Challenges have emerged following the revival of nitric oxide (NO) from ,something old', a simple gas derived from nitrogen and oxygen with a role in the early stages of evolution, into ,something new', an endogenously formed biological mediator regulating a wide variety of physiological functions. Although pain is a common sensation, it encompasses multiple neurobiologic components, of which NO is only one. In pain research, the study of NO is complicated by convoluted problems related mostly to the effects of NO, which are pro- or anti-nociceptive depending on the circumstances. This dual function reflects the multi-faceted roles of the NO molecule described in physiology. This review covers current information about NO and its implications in pain mechanisms. In addition, it follows the pain pathways, demonstrating the role of NO in peripheral nociceptive transmission as well in central sensitization. This knowledge may provide the scientific basis for developing new drugs that are indicated for different types of pain, drugs that may be related to the chemical links of NO. A comprehensive approach to understanding the effects of NO will help clinicians identify novel agents that combine the pharmacological profile of native drugs with a controllable manner of NO release. Inhibitors of NO synthesis may have analgesic effects and would be of interest for treating inflammatory and neuropathic pain. Unfortunately, only a few of these compounds have reached the stage of clinical pain trials. [source] The life, death, and replacement of oligodendrocytes in the adult CNSJOURNAL OF NEUROCHEMISTRY, Issue 1 2008Dana M. McTigue Abstract Oligodendrocytes (OLs) are mature glial cells that myelinate axons in the brain and spinal cord. As such, they are integral to functional and efficient neuronal signaling. The embryonic lineage and postnatal development of OLs have been well-studied and many features of the process have been described, including the origin, migration, proliferation, and differentiation of precursor cells. Less clear is the extent to which OLs and damaged/dysfunctional myelin are replaced following injury to the adult CNS. OLs and their precursors are very vulnerable to conditions common to CNS injury and disease sites, such as inflammation, oxidative stress, and elevated glutamate levels leading to excitotoxicity. Thus, these cells become dysfunctional or die in multiple pathologies, including Alzheimer's disease, spinal cord injury, Parkinson's disease, ischemia, and hypoxia. However, studies of certain conditions to date have detected spontaneous OL replacement. This review will summarize current information on adult OL progenitors, mechanisms that contribute to OL death, the consequences of their loss and the pathological conditions in which spontaneous oligodendrogenesis from endogenous precursors has been observed in the adult CNS. [source] Reproductive Options for Individuals at Risk for Transmission of a Genetic DisorderJOURNAL OF OBSTETRIC, GYNECOLOGIC & NEONATAL NURSING, Issue 2 2002Shirley L. Jones RNC The basis of human growth and development has long been considered to be one of the great mysteries of science and mankind. The portal to understanding this mystery was achieved by the Human Genome Project and Celera Genomics in 2001, with their joint announcement of the sequencing of 99% of the human genome map. Current reproductive options, however, remain restricted to the prevention of transmitting an at-risk gene or genes, but do not include treatment or cure. It is anticipated that this state of "halfway technology" will continue for years to come. As such, the scientific and ethical issues associated with each of these reproductive options will continue to affect the decision making of at-risk individuals. As the omnipresent health care provider, nurses have a duty to know and disseminate accurate and current information about reproductive options for individuals at risk for transmission of a genetic disorder. Nurses also have a duty to advocate for and ensure the privacy and confidentiality of genetic information. [source] New insights into the nature of Warthin's tumourJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 1 2009Iain David O'Neill Warthin's tumour is considered heterogeneous as to its pathogenesis with some data supporting a polyclonal origin for the epithelium, implying a non-neoplastic nature. After inconsistent reports, current information from molecular studies suggests that a recurrent t(11;19) and associated CRTC1-MAML2 fusion oncogene characterizes a subset of Warthin's tumours and supports a clonal origin in such cases. CRTC1-MAML2 is also a frequent feature of mucoepidermoid carcinoma. These findings, and the recent reports of Warthin's tumour and co-existent mucoepidermoid carcinoma with common CRTC1-MAML2 expression, provide a morphological and molecular framework for future studies as a basis for a fresh appraisal of the pathogenesis of Warthin's tumour. The underlying molecular basis and the pivotal studies defining such events are discussed. [source] Sense-making of employment: on whether and why people read employment advertisingJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 6 2006Anat Rafaeli This paper suggests a process of sense-making of "employment" and identifies employment ads to be useful agents in this process. It is suggested that individuals read ads in surveillance of the employment market in addition to reading them to search for employment vacancies. Employment ads are suggested to be a forum for organizational self-presentation that offers current information about the employment exchange as it is viewed by employers. Two exploratory studies are presented to support the thesis. Study 1 is an inductive survey of people's reading of employment ads, showing that people read ads even if they are not looking for a job because they view ads as a source of insight about the employment environment. Study 2 reviews the content of employment ads, showing them to convey prevailing elements of the idea of employment, namely that employment is an exchange of employee skills and responsibilities for organizational intrinsic and extrinsic rewards. Recognizing the individual need for sense-making of employment, and identifying employment ads as a source of information about employment, opens up a new area for research and practice on recruiting, organizational self-presentation, and sense-making. Copyright © 2006 John Wiley & Sons, Ltd. [source] Acute pancreatitis in dogsJOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Issue 4 2003Jennifer L. Holm DVM Abstract Objective: To summarize current information regarding severity assessment, diagnostic imaging, and treatment of human and canine acute pancreatitis (AP). Human-based studies: In humans, scoring systems, advanced imaging methods, and serum markers are used to assess the severity of disease, which allows for optimization of patient management. The extent of pancreatic necrosis and the presence of infected pancreatic necrosis are the most important factors determining the development of multiple organ failure (MOF) and subsequent mortality. Considerable research efforts have focused on the development of inexpensive, easy, and reliable laboratory markers to assess disease severity as early as possible in the course of the disease. The use of prophylactic antibiotics, enteral nutrition, and surgery have been shown to be beneficial in certain patient populations. Veterinary-based studies: The majority of what is currently known about naturally occurring canine AP has been derived from retrospective evaluations. The identification and development of inexpensive and reliable detection kits of key laboratory markers in dogs with AP could dramatically improve our ability to prognosticate and identify patient populations likely to benefit from treatment interventions. Treatment remains largely supportive and future studies evaluating the efficacy of surgery, nutritional support and other treatment modalities are warranted. Data sources: Current human and veterinary literature. Conclusions: Pancreatitis can lead to a life-threatening severe systemic inflammatory condition, resulting in MOF and death in both humans and dogs. Given the similarities in the pathophysiology of AP in both humans and dogs, novel concepts used to assess severity and treat people with AP may be applicable to dogs. [source] Distribution, status and conservation problems of the Spanish Ibex, Capra pyrenaica (Mammalia: Artiodactyla),MAMMAL REVIEW, Issue 1 2002Jesús M. Pérez ABSTRACT In this paper, the distribution and status of the Spanish Ibex, Capra pyrenaica (Mammalia: Artiodactyla), are revised. The whole Iberian population numbers nearly 50 000, distributed in more than 50 nuclei, and has generally increased during the last decades. Nevertheless, within this wider context, different conditions apply to different populations, including recent extinction (the Pyrenean population), recovery from recent severe epizooty of sarcoptic mange (e.g. the Sierras de Cazorla and Segura y Las Villas range population) and populations at high densities (e.g. Gredos mountain range and Sierra de Grazalema Natural Park, among others). The main factors affecting the conservation of this species are also reported and discussed. On the basis of current information we propose the status of ,vulnerable' for the Spanish Ibex. [source] The cell cycle of SulfolobusMOLECULAR MICROBIOLOGY, Issue 3 2007Rolf Bernander Summary Much of the current information about the archaeal cell cycle has been generated through studies of the genus Sulfolobus. The overall organization of the cell cycle in these species is well understood, and information about the regulatory principles that govern cell cycle progression is rapidly accumulating. Exciting progress regarding the control and molecular details of the chromosome replication process is evident, and the first insights into the elusive crenarchaeal mitosis and cytokinesis machineries are within reach. [source] Impact of apoE genotype on oxidative stress, inflammation and disease riskMOLECULAR NUTRITION & FOOD RESEARCH (FORMERLY NAHRUNG/FOOD), Issue 1 2008Laia Jofre-Monseny Abstract Although in developing countries an apolipoprotein E4 (apoE4) genotype may offer an evolutionary advantage, as it has been shown to offer protection against certain infectious disease, in Westernised societies it is associated with increased morbidity and mortality, and represents a significant risk factor for cardiovascular disease, late-onset Alzheimer's disease and other chronic disorders. ApoE is an important modulator of many stages of lipoprotein metabolism and traditionally the increased risk was attributed to higher lipid levels in E4 carriers. However, more recent evidence demonstrates the multifunctional nature of the apoE protein and the fact that the impact of genotype on disease risk may be in large part due to an impact on oxidative status or the immunomodulatory/anti-inflammatory properties of apoE. An increasing number of studies in cell lines, targeted replacement rodents and human volunteers indicate higher oxidative stress and a more pro-inflammatory state associated with the ,4 allele. The impact of genotype on the antioxidant and immunomodulatory/anti-inflammatory properties of apoE is the focus of the current review. Furthermore, current information on the impact of environment (diet, exercise, smoking status, alcohol) on apoE genotype-phenotype associations are discussed with a view to identifying particular lifestyle strategies that could be adapted to counteract the ,at-risk' E4 genotype. [source] Structural and functional changes in spastic skeletal muscle,MUSCLE AND NERVE, Issue 5 2004Richard L. Lieber PhD Abstract This review summarizes current information regarding the changes in structure or function that occur in skeletal muscle secondary to spasticity. Most published studies have reported an increase in fiber size variability in spastic muscle. There is no general agreement regarding any shift in fiber type distribution secondary to spasticity. Mechanical studies in whole limbs as well as in isolated single cells support the notion of an intrinsic change in the passive mechanical properties of muscle after spasticity in addition to the more widely reported neural changes that occur. Evidence is presented for changes within both the muscle cell and extracellular matrix that contribute to the overall changes in the tissue. Taken together, the literature supports the notion that, although spasticity is multifactorial and neural in origin, significant structural alterations in muscle also occur. An understanding of the specific changes that occur in the muscle and extracellular matrix may facilitate the development of new conservative or surgical therapies for this problem. Muscle Nerve 29: 615,627, 2004 [source] Evolution of obligate pollination mutualism in the tribe Phyllantheae (Phyllanthaceae)PLANT SPECIES BIOLOGY, Issue 1 2010ATSUSHI KAWAKITA Abstract The landmark discovery of obligate pollination mutualism between Glochidion plants and Epicephala moths has sparked increased interest in the pollination systems of Phyllantheae plants. In this paper I review current information on the natural history and evolutionary history of obligate pollination mutualism in Phyllantheae. Currently, an estimated >500 species are mutualistic with Epicephala moths that actively pollinate flowers and whose progeny feed on the resulting seeds. The Phyllantheae also includes species that are not mutualistic with Epicephala moths and are instead pollinated by bees and/or flies or ants. Phylogenetic analyses indicate that the mutualism evolved independently five times within Phyllantheae, whereas active pollination behavior, a key innovation in this mutualism, evolved once in Epicephala. Reversal of mutualism has occurred at least once in both partner lineages, involving a Breynia species that evolved an alternative pollination system and a derived clade of Epicephala that colonized ant-pollinated Phyllantheae hosts and thereby lost the pollinating habit. The plant,moth association is highly species specific, although a strict one-to-one assumption is not perfectly met. A comparison of plant and moth phylogenies suggests signs of parallel speciation, but partner switches have occurred repeatedly at a range of taxonomic levels. Overall, the remarkable species diversity and multiple originations of the mutualism provide excellent opportunities to address many important questions on mutualism and the coevolutionary process. Although research on the biology of the mutualism is still in its infancy, the Phyllantheae,Epicephala association holds promise as a new model system in ecology and evolutionary biology. [source] Integrating maintenance activities and Quality Assurance in a research and development (R&D) systemQUALITY ASSURANCE JOURNAL, Issue 4 2006Debasish Basak Abstract A well-balanced maintenance program furnishes information and instructions to personnel involved in maintaining existing equipment, provides current information on the availability and location of maintenance materials, improves utilization of labor forces and increases equipment reliability. Planned and preventive maintenance procedures where components are serviced and changed when they approach the end of their useful lives can be augmented by suitable means, which continuously check vital machine functions. Quality Assurance can be seen as a management system that brings maintenance activities undertaken by all parties under control with the aim of preventing things from going wrong and costing time, effort and money to put them right. An attempt has been made to highlight the integration of maintenance activities with Quality Assurance as a whole in a research and development (R&D) system. Copyright © 2006 John Wiley & Sons, Ltd. [source] Labor Market Transitions of Immigrant-Born, Refugee-Born, and Canadian-Born YouthCANADIAN REVIEW OF SOCIOLOGY/REVUE CANADIENNE DE SOCIOLOGIE, Issue 2 2008LORI WILKINSON Cet article a pour but d'analyser les expériences du marché du travail des jeunes nés de parents immigrants, réfugiés et canadiens en utilisant deux ensembles de données de 1998, l'Enquête sur la dynamique du travail et du revenu, et L'enquête sur le rétablissement des réfugiés en Alberta. Son ambition première est de comprendre leurs expériences de travail, étant donné qu'elles sont essentielles à leur intégration et à leur passage à l'âge adulte. D'un point de vue pratique, les résultats aident les fournisseurs de services de première ligne en procurant de l'information supplémentaire sur les besoins liés à l'emploi des jeunes nouveaux arrivants. Théoriquement, cette étude a pour objectif de mieux comprendre un des aspects de l'intégration , l'emploi ,, étant donné que l'information actuelle ne décrit pas adéquatement les expériences de ces jeunes. Dans l'ensemble, cette recherche augmente les connaissances sur l'intégration des jeunes nés de parents immigrants et réfugiés sur le marché canadien du travail. This paper examines the labor market experiences of immigrant-born, refugee-born, and Canadian-born youth using two data sets, the 1998 Survey on Labour and Income Dynamics and the 1998 Refugee Resettlement to Alberta Survey. Its main objective is to understand their job experiences as they are crucial to their integration and transition to adulthood. On a practical level, the findings help front-line service providers by providing additional information about the employment-related needs of newcomer youth. Theoretically, this research aims to develop a better understanding of one aspect of the integration, employment, as current information does not adequately describe the experiences of newcomer youth. Taken together, this research increases knowledge about the integration of immigrant-born and refugee-born youth in the Canadian labor market. [source] | ||||||||||||||||||||||