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Adult Chinese Population (adult + chinese_population)
Selected AbstractsPrevalence of Actinobacillus actinomycetemcomitans in an ethnic adult Chinese populationJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 9 2001Kai Soo Tan Abstract Aim: The aim of this study was to determine the prevalence and the structure of the leukotoxin promoter region of Actinobacillus actinomycetemcomitans in an ethnic Chinese population. Method: Subgingival plaque samples were collected from 42 patients with moderate to advanced periodontitis and 50 periodontally healthy patients. A. actinomycetemcomitans was detected directly from the crude subgingival plaque by PCR using leukotoxin gene specific primers. The presence of A. actinomycetemcomitans was determined by a single 285 bp PCR amplicon. Results:A. actinomycetemcomitans was found to be present in the subgingival plaque of 68 out of a total of 92 patients examined (74%). 29 out of the 42 periodontitis patients tested were carriers of A. actinomycetemcomitans (69%). Among the periodontally healthy patients studied, 39 out of 50 subjects possessed the bacteria (78%). PCR analysis of the promoter region of the ltx operon revealed that none of the 42 moderate to advanced periodontitis patients examined harboured A.actinomycetemcomitans strains with the JP2-like promoter of the ltx operon, known to enhance leukotoxin expression. 2 out of the 27 advanced periodontitis patients clinically diagnosed as suffering from rapidly progressive periodontitis were found to be carriers of the mildly toxic strain of A. actinomycetemcomitans with the characteristic 652-like promoter. Conclusions: The high prevalence of A. actinomycetemcomitans, regardless of whether the subgingival samples were analysed from patients with healthy or diseased periodontium suggests that this bacterial species is part of the normal oral flora of ethnic Chinese. Our preliminary results also suggested that subjects who harboured the mildly toxic strain of A. actinomycetemcomitans were potentially susceptible to aggressive forms of periodontitis. Zusammenfassung Das Ziel dieser Studie war es, in einer ethnischen Population von Chinesen die Prävalenz von Actinobacillus actinomycetemcomitans und die Struktur der Leukotoxin-Promoterregion zu bestimmen. Von 42 Patienten mit moderater bis fortgeschrittener Parodontitis und 50 parodontal gesunden Patienten wurden subgingivale Plaqueproben entnommen. A. actinomycetemcomitans wurde direkt in der unbehandelten subgingivalen Plaque durch PCR unter Verwendung eines Leukotoxingen-spezifischen Primers nachgewiesen. Das Vorhandensein von A. actinomycetemcomitans wurde mittels eines einzigen 285 bp-PCR-Amplikons bestimmt. Es wurde A. actinomycetemcomitans bei 68 von 92 untersuchten Patienten (74%) vorgefunden. 29 von 42 getesteten Parodontitispatienten waren Träger von A. actinomycetemcomitans (69%). Unter den Studierten parodontal gesunden Patienten besaßen 39 von 50 Personen das Bakterium (78%). Die PCR-Analyse der Promoterregion des ltx -Operons zeigte, dass keiner der 42 untersuchten Patienten mit moderater bis fortgeschrittener Parodontitis den A. actinomycetemcomitans mit dem JP2-ähnlichen Promoter des ltx -Operons, welches die Leukotoxinexpression verstärkt, besaß. Bei 2 der 27 Patienten mit fortgeschrittener Parodontitis wurde klinisch eine rasch fortschreitende Parodontitis diagnostiziert und es wurde der mit geringer Toxizität versehene Stamm des A. actinomycetemcomitans mit dem charakteristischen 652-ähnlichen Promoter vorgefunden. Bedingt durch die hohe Prävalenz von A. actinomycetemcomitans unabhängig davon, ob die Proben von Patienten mit gesundem oder erkranktem Parodontium stammen, lässt sich annehmen, dass diese Bakterienspezies bei ethnischen Chinesen ein Teil normalen Mundflora ist. Unsere vorläufigen Resultate lassen auch annehmen, dass Personen, die den mit geringer Toxizität versehenen Stamm des A. actinomycetemcomitans tragen eine potentielle Anfälligkeit für aggressive Formen der Parodontitis besitzen. Résumé Le but de l'étude présente a été de déterminer la fréquence globale et la structure de la région promoteur de leukotoxine de l'Actinobacillus actinomycetemcomitans (A.a.) dans une population chinoise. Des échantillons de plaque dentaire sous-gingivale ont été prélevés chez 42 patients avec parodontite modérée à avancée et chez 50 patients sains. L'A.a. a été détecté directement dans la plaque sous-gingivale par PCR en utilisant les sites spécifiques de gènes leukotoxines. La présence de l'A.a. a été déterminée par un amplicon PCR de 285 bp. L'A.a. a été décelé dans la plaque sous-gingivale de 68 des 92 patients examinés (74%). 29 des 42 patients avec parodontite ont été reconnus comme porteurs d'A.a. (69%). Parmi les patients sains étudiés, 39 des 50 sujets étaient porteurs de la bactérie (78%). L'analyse PCR de la région promoteur de operon ltx a révélé que des 42 patients avec parodontite modéréà avancée aucun n'avaient de souche A.a. avec le promoteur ressemblant au JP2 de l'operon ltx, reconnu pour acroître la leukotoxine. 2 des 27 patients avec parodontit avancée souffraient d'une parodontite progressant rapidement et étaient porteurs d'une souche moyennement toxique d'A.a. avec la caractéristique du promoteur ressemblant au 652. La fréquence globale importante d'A.a., sans tenir compte si les échantillons sous-gingivaux ont été analysés de patients avec un parodonte sain ou malade, suggère que ces espèces bactériennes font partie de la flore buccale normale de l'ethnie chinoise. Ces résultats indiquent également que les porteurs de la souche peu toxique d'A.a. seraient potentiellement susceptibles à des formes de parodontite agressive. [source] Epidemiological study of symptomatic gastroesophageal reflux disease in China: Beijing and ShanghaiJOURNAL OF DIGESTIVE DISEASES, Issue 1 2000Pan Guozong OBJECTIVE: To explore the 1-year point prevalences (July,September 1996) of symptomatic gastroesophageal reflux (GER), gastroesophageal reflux disease (GERD) and reflux esophagitis (RE) in the adult population of two Chinese city-regions (Beijing and Shanghai) and to identify the conditions that predispose patients to GERD. METHODS: Phase I: 5000 residents of the two regions aged between 18 and 70 years were studied via a questionnaire. The study was carried out by cluster sampling from city, suburban and rural areas by using simple random sampling. Symptom scores (Sc) of the intensity and frequency of heartburn, acid reflux and regurgitation within 1 year of the time of study were taken as indices of acid reflux (highest score, Sc = 18) and Sc , 6 indicated the presence of symptomatic GER. Phase II: a small number of patients who were identified as having symptomatic GER in the survey were enrolled in a case, control study using gastroscopy and 24-h pH monitoring to obtain correct diagnostic rates of GERD and RE. Estimates of the prevalence of GERD and RE were then adjusted according to the rates of correct diagnosis. RESULTS: A total of 4992 subjects completed the survey, 2.5% had heartburn once daily, 8.97% had symptomatic GER (Sc , 6) and the male to female ratio was 1:1.11. Point prevalences for the year for GERD and RE were 5.77 and 1.92%, respectively. Stratified analysis indicated that the prevalence of symptomatic GER in Beijing (10.19%) was higher than that in Shanghai (7.76%) and there was also a higher prevalence of GER in males, manual laborers, people from rural areas and people older than 40 years of age in Beijing as compared with Shanghai. Stepwise logistic analysis indicated that GER had a close relationship with dental, pharyngolaryngeal disorders and respiratory diseases. The conditions that predispose patients to GERD are (OR, odds ratio): age > 40 (OR = 1.01), eating greasy/oily food (OR = 6.56), overeating (OR = 1.99), tiredness (OR = 2.35), emotional stress (OR = 2.22), pregnancy (OR = 6.80) and constipation (OR = 1.65). CONCLUSIONS: Gastroesophageal reflux disease is a common disease in the adult Chinese population and it is more common in Beijing than in Shanghai. [source] Prevalence of optic disc drusen in an adult Chinese population: the Beijing Eye StudyACTA OPHTHALMOLOGICA, Issue 2 2009Qi Sheng You Abstract. Purpose:, This study aimed to determine the prevalence of optic disc drusen and their associations with ocular and general parameters. Methods:, The Beijing Eye Study included 4439 of 5324 subjects invited to participate (response rate 83.4%). All subjects were aged , 40 years. The present investigation involved 8594 (96.8%) eyes of 4324 (97.4%) subjects from whom readable fundus photographs of at least one eye were available. The main outcome parameter was the presence of optic disc drusen defined as round, whitish bodies. Results:, Optic disc drusen were detected in nine (0.1 ± 0.05%) eyes of eight subjects (five women). The prevalence rate was 0.2 ± 0.07% (95% confidence interval 0.07,0.33%) per subject. Optic disc drusen were significantly associated with small optic discs (p < 0.001). They were not statistically associated with age (p = 0.90), gender (p = 0.73), intraocular pressure (p = 0.97), refractive error (p = 0.71), visual field defects (p = 0.47) or corrected visual acuity (p = 0.84). Conclusions:, Optic disc drusen are present in about two in 1000 adult Chinese people in Northern China. The main associated factor is a small optic disc. [source] Major eye diseases and risk factors associated with systemic hypertension in an adult chinese population: the Beijing Eye StudyACTA OPHTHALMOLOGICA, Issue 2009T LIBONDI Purpose To assess the relationship of hypertension with major eye diseases and other ocular parameters. Methods The Beijing Eye Study is a population-based study. Examination at baseline in 2001; follow-up examination in 2006; 3222 subjects had blood pressure measurements. All participants underwent a thourough ophthalmic examination and blood pressure measurement. Hypertension was defined as a systolic blood pressure ,140 mm Hg and/or a diastolic blood pressure ,90 mm Hg, and/or self-reported current treatment for hypertension with antihypertensive medication. Results Mean age of participants in the present study was 60.4±10.0 years. Hypertension was present in 1500 (46.6%) of the 3222 subjects who had their blood pressure measured. In multiple regression analysis, hypertension was associated with higher intraocular pressure (P = 0.005), arterio-venous nicking (P = 0.009),retinal vein occlusions (P = 0.02), and diabetic retinopathy (P = 0.02). Hypertension was not significantly associated with the prevalence of open-angle glaucoma (P = 0.19) or angle-closure glaucoma (P = 0.15), age-related macular degeneration (P = 0.73), nuclear cataract (P = 0.88), posterior subcapsular cataract (P = 0.30), cortical cataract (P = 0.10), or area of alpha zone (P=0.05) or beta zone of parapapillary atrophy (P = 0.95). Conclusion In Chinese persons, while controlling for other systemic parameters, hypertension was associated with increased intraocular pressure, retinal microvascular abnormalities, and prevalence of retinal vein occlusion and diabetic retinopathy. Hypertension was not associated significantly with age-related macular degeneration, age-related cataract, or glaucoma [source] | ||||||||||