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Corresponding Amides (corresponding + amide)

Distribution by Scientific Domains

Chemistry	80%

Selected Abstracts

Nitrile hydrolysis activity of Rhodococcus erythropolis NCIMB 11540 whole cells

BIOTECHNOLOGY JOURNAL, Issue 5 2006
Mandy K. S Vink
Abstract The nitrile hydrolyzing properties of the bacterium strain Rhodococcus erythropolis NCIMB 11540 have been investigated. Using whole cells of the microorganism, a wide variety of aromatic and aliphatic cyanide-containing substrates was successfully hydrolyzed to the corresponding amide or acid. In the case of dicyanides, selective monohydrolysis took place, which was further explored in the desymmetrization of malononitriles resulting in the corresponding cyano amides in enantiomeric excesses of up to 98%. [source]

Hydrolytic Deallylation of N -Allyl Amides Catalyzed by PdII Complexes

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 30 2008
Naoya Ohmura
Abstract Hydrolytic deallylation of N -allyl amides to give amides and propanal can be achieved with PdII catalysts. The optimized catalyst consists of Pd(OCOCF3)2 and 1,3-bis(diphenylphosphanyl)propane (DPPP). Several kinds of open-chain N -allyl amides and N -allyl lactams undergo hydrolytic deallylation to give the corresponding amides and lactams in good to high yield. A mechanism which includes isomerization to enamides and subsequent hydrolysis is proposed. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

Oxidative Amidation of Aldehydes and Alcohols with Primary Amines Catalyzed by KI-TBHP

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 21 2008
K. Rajender Reddy
Abstract Oxidative amidation of aldehydes and alcohols with amines to afford the corresponding amides in excellent yields and ee values over 98,% is achieved by using a catalytic amount of KI in combination with TBHP as the external oxidant. This method avoids the use of expensive and/or air-sensitive reagents. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

Synthesis of 2,6-Dioxo-1,2,3,4,5,6-hexahydroindoles by Acid- Catalyzed Cyclization of Acetal-Protected (2,4-Dioxocyclohex-1-yl)acetamides and their Transformation into 5,8,9,10-Tetrahydro-6H -indolo[2,1- a]isoquinolin-9-ones

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 7-8 2009
Benard Juma
Abstract Acetal-protected (2,4-dioxocyclohex-1-yl)acetic acids were prepared by allylation of dilithiated 1,3-cyclohexane-1,3-diones, protection of the carbonyl groups and oxidation of the alkene moiety. Their reaction with amines afforded the corresponding amides which were transformed, by acid-catalyzed cyclization, into various 2,6-dioxo-1,2,3,4,5,6-hexahydroindoles. The reaction of the latter with triflic acid resulted in the formation of novel 5,8,9,10-tetrahydro-6H -indolo[2,1- a]isoquinolin-9-ones. [source]

Graphite-Supported Gold Nanoparticles as Efficient Catalyst for Aerobic Oxidation of Benzylic Amines to Imines and N -Substituted 1,2,3,4-Tetrahydroisoquinolines to Amides: Synthetic Applications and Mechanistic Study

CHEMISTRY - AN ASIAN JOURNAL, Issue 10 2009
Man-Ho So
Abstract Selective oxidation of amines using oxygen as terminal oxidant is an important area in green chemistry. In this work, we describe the use of graphite-supported gold nanoparticles (AuNPs/C) to catalyze aerobic oxidation of cyclic and acyclic benzylic amines to the corresponding imines with moderate-to-excellent substrate conversions (43,100,%) and product yields (66,99,%) (19,examples). Oxidation of N -substituted 1,2,3,4-tetrahydroisoquinolines in the presence of aqueous NaHCO3 solution gave the corresponding amides in good yields (83,93,%) with high selectivity (up to amide/enamide=93:4) (6,examples). The same protocol can be applied to the synthesis of benzimidazoles from the reaction of o -phenylenediamines with benzaldehydes under aerobic conditions (8,examples). By simple centrifugation, AuNPs/C can be recovered and reused for ten consecutive runs for the oxidation of dibenzylamine to N -benzylidene(phenyl)methanamine without significant loss of catalytic activity and selectivity. This protocol "AuNPs/C+O2" can be scaled to the gram scale, and 8.9,g (84,% isolated yield) of 3,4-dihydroisoquinoline can be obtained from the oxidation of 10,g 1,2,3,4-tetrahydroisoquinoline in a one-pot reaction. Based on the results of kinetic studies, radical traps experiment, and Hammett plot, a mechanism involving the hydrogen-transfer reaction from amine to metal and oxidation of M-H is proposed. [source]