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Corpus
Kinds of Corpus Terms modified by Corpus Selected Abstracts"The Surest Home Is Pointless": A Pathless Path through Merton's Poetic CorpusCROSSCURRENTS, Issue 4 2008Patrick F. O'Connell [source] Corpus Meum: Disintegrating Bodies and the Ideal of IntegrityHYPATIA, Issue 3 2005DIANE PERPICH This essay shows that Jean-Luc Nancy's reconceptualization of corporeality in such texts as L'Intrus and Corpus can be an important ally to feminist theories of body. I introduce Nancy's ontology and argue that his rejection of the unified, integrated body of humanist discourses in favor of dis-integrated bodies constituted by multiple alterities and his consequent reinterpretation of body as a "being-exscribed" begin the task of thinking bodies beyond traditional dualisms and their ahistorical and rationalist frameworks. I then address three potential criticisms of Nancy's work and suggest that though there may be reasons to move cautiously in adopting the framework he provides, his work harbors resources directly beneficial to critiques of prevailing forms of gender normativity. Quel étrange moi! ,Jean-Luc Nancy, Corpus [source] Connecting linguistic description and language teaching: native and learner use of existential there1INTERNATIONAL JOURNAL OF APPLIED LINGUISTICS, Issue 2 2006Ignacio Palacios-Martínez construcciones existenciales; corpus de estudiantes; enseñanza de lenguas; lingüística contrastiva; lingüística de corpus This article emerges from the need to connect linguistic theory and language teaching to find concrete solutions to problems Spanish students confront when learning English. This study looks at existential there constructions taken from the following native and non-native written English corpora: the International Corpus of Learner English and the Santiago University Learner of English Cor-pus for the non-native set, and the Louvain Corpus of Native English Essays, Biber et al. (1999) and a subcorpus of the BNC for the native English group. This contrastive study reveals important differences in the use of there constructions as regards their frequency, structural complexity, polarity and pragmatic value. Important implications for the presentation and the pedagogical treatment of the there constructions can be derived from the results. El presente artículo surge de la necesidad de conectar la teoría lingüística y la práctica pedagógica, tratando de encontrar soluciones concretas a problemas con los que se enfrentan alumnos españoles de inglés como lengua extranjera. Este trabajo estudia las construcciones existenciales con there (CTs) a partir de los siguientes corpus de textos escritos de hablantes nativos y no nativos: International Corpus of Learner English y Santiago University Learner of English Corpus para los no nativos, y Louvain Corpus of Native English Essays, Biber et al. (1999) y un subcorpus del BNC para los nativos. Este estudio contrastivo constata diferencias importantes en el uso de las CTs relativas a su frecuencia, complejidad estructural, polaridad y valor pragmático. De todos estos resultados se derivan importantes implicaciones para la presentación y tratamiento pedagógico de las CTs. [source] Idioms and Collocations: Corpus-based Linguistic and Lexicographic Studies edited by Christine FellbaumJOURNAL OF SOCIOLINGUISTICS, Issue 1 2009Benjamin Clarke [source] Corpus-based cross-language information retrieval in retrieval of highly relevant documentsJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 3 2007Tuomas Talvensaari Information retrieval systems' ability to retrieve highly relevant documents has become more and more important in the age of extremely large collections, such as the World Wide Web (WWW). The authors' aim was to find out how corpus-based cross-language information retrieval (CLIR) manages in retrieving highly relevant documents. They created a Finnish,Swedish comparable corpus from two loosely related document collections and used it as a source of knowledge for query translation. Finnish test queries were translated into Swedish and run against a Swedish test collection. Graded relevance assessments were used in evaluating the results and three relevance criterion levels,liberal, regular, and stringent,were applied. The runs were also evaluated with generalized recall and precision, which weight the retrieved documents according to their relevance level. The performance of the Comparable Corpus Translation system (COCOT) was compared to that of a dictionary-based query translation program; the two translation methods were also combined. The results indicate that corpus-based CLIR performs particularly well with highly relevant documents. In average precision, COCOT even matched the monolingual baseline on the highest relevance level. The performance of the different query translation methods was further analyzed by finding out reasons for poor rankings of highly relevant documents. [source] The Church's Guide for Reading Paul: The Canonical Shaping of the Pauline Corpus , By Brevard S. ChildsRELIGIOUS STUDIES REVIEW, Issue 2 2010Ben Blackwell No abstract is available for this article. [source] Strudel: A Corpus-Based Semantic Model Based on Properties and TypesCOGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 2 2010Marco Baroni Abstract Computational models of meaning trained on naturally occurring text successfully model human performance on tasks involving simple similarity measures, but they characterize meaning in terms of undifferentiated bags of words or topical dimensions. This has led some to question their psychological plausibility (Murphy, 2002;Schunn, 1999). We present here a fully automatic method for extracting a structured and comprehensive set of concept descriptions directly from an English part-of-speech-tagged corpus. Concepts are characterized by weighted properties, enriched with concept,property types that approximate classical relations such as hypernymy and function. Our model outperforms comparable algorithms in cognitive tasks pertaining not only to concept-internal structures (discovering properties of concepts, grouping properties by property type) but also to inter-concept relations (clustering into superordinates), suggesting the empirical validity of the property-based approach. [source] HIGH-DIMENSIONAL LEARNING FRAMEWORK FOR ADAPTIVE DOCUMENT FILTERING,COMPUTATIONAL INTELLIGENCE, Issue 1 2003Wai Lam We investigate the unique requirements of the adaptive textual document filtering problem and propose a new high-dimensional on-line learning framework, known as the REPGER (relevant feature pool with good training example retrieval rule) algorithm to tackle this problem. Our algorithm possesses three characteristics. First, it maintains a pool of selective features with potentially high predictive power to predict document relevance. Second, besides retrieving documents according to their predicted relevance, it also retrieves incoming documents that are considered good training examples. Third, it can dynamically adjust the dissemination threshold throughout the filtering process so as to maintain a good filtering performance in a fully interactive environment. We have conducted experiments on three document corpora, namely, Associated Press, Foreign Broadcast Information Service, and Wall Street Journal to compare the performance of our REPGER algorithm with two existing on-line learning algorithms. The results demonstrate that our REPGER algorithm gives better performance most of the time. Comparison with the TREC (Text Retrieval Conference) adaptive text filtering track participants was also made. The result shows that our REPGER algorithm is comparable to them. [source] Connecting linguistic description and language teaching: native and learner use of existential there1INTERNATIONAL JOURNAL OF APPLIED LINGUISTICS, Issue 2 2006Ignacio Palacios-Martínez construcciones existenciales; corpus de estudiantes; enseñanza de lenguas; lingüística contrastiva; lingüística de corpus This article emerges from the need to connect linguistic theory and language teaching to find concrete solutions to problems Spanish students confront when learning English. This study looks at existential there constructions taken from the following native and non-native written English corpora: the International Corpus of Learner English and the Santiago University Learner of English Cor-pus for the non-native set, and the Louvain Corpus of Native English Essays, Biber et al. (1999) and a subcorpus of the BNC for the native English group. This contrastive study reveals important differences in the use of there constructions as regards their frequency, structural complexity, polarity and pragmatic value. Important implications for the presentation and the pedagogical treatment of the there constructions can be derived from the results. El presente artículo surge de la necesidad de conectar la teoría lingüística y la práctica pedagógica, tratando de encontrar soluciones concretas a problemas con los que se enfrentan alumnos españoles de inglés como lengua extranjera. Este trabajo estudia las construcciones existenciales con there (CTs) a partir de los siguientes corpus de textos escritos de hablantes nativos y no nativos: International Corpus of Learner English y Santiago University Learner of English Corpus para los no nativos, y Louvain Corpus of Native English Essays, Biber et al. (1999) y un subcorpus del BNC para los nativos. Este estudio contrastivo constata diferencias importantes en el uso de las CTs relativas a su frecuencia, complejidad estructural, polaridad y valor pragmático. De todos estos resultados se derivan importantes implicaciones para la presentación y tratamiento pedagógico de las CTs. [source] Current usage of the epicene pronoun in written EnglishJOURNAL OF SOCIOLINGUISTICS, Issue 3 2002Maciej Baranowski This paper deals with current epicenepronominal usage in written English. The first part focuses on the prescription of the so,called generic he and includes a short review of research into epicene pronominal usage in the last three decades. The results of previous research serve as a background to the present study, which, based on two corpora of written English, aims at elucidating singular epicene pronominal choices in the writing of British and American writers. The study shows that the traditional form he is no longer predominant, while singular they is the pronoun most likely to be used. He or she is shown to be used rather rarely. It is argued that the choice of singular epicene pronoun is considerably influenced by the semanto,syntactic type of the antecedent and by the social roles stereotypically associated with the referent. Also, differences between British and American writers are discussed. It is shown that American writers are more conservative in their choice of singular epicene pronoun and an explanation of the difference is suggested. [source] English-Arabic proper-noun transliteration-pairs creationJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 10 2008Mohamed Abdel Fattah Proper nouns may be considered the most important query words in information retrieval. If the two languages use the same alphabet, the same proper nouns can be found in either language. However, if the two languages use different alphabets, the names must be transliterated. Short vowels are not usually marked on Arabic words in almost all Arabic documents (except very important documents like the Muslim and Christian holy books). Moreover, most Arabic words have a syllable consisting of a consonant-vowel combination (CV), which means that most Arabic words contain a short or long vowel between two successive consonant letters. That makes it difficult to create English-Arabic transliteration pairs, since some English letters may not be matched with any romanized Arabic letter. In the present study, we present different approaches for extraction of transliteration proper-noun pairs from parallel corpora based on different similarity measures between the English and romanized Arabic proper nouns under consideration. The strength of our new system is that it works well for low-frequency proper noun pairs. We evaluate the new approaches presented using two different English-Arabic parallel corpora. Most of our results outperform previously published results in terms of precision, recall, and F -Measure. [source] Unraveling the Dyad: Using Recurrence Analysis to Explore Patterns of Syntactic Coordination Between Children and Caregivers in ConversationLANGUAGE LEARNING, Issue 3 2006Rick Dale Recurrence analysis is introduced as a means to investigate syntactic coordination between child and caregiver. Three CHILDES (MacWhinney, 2000) corpora are analyzed and demonstrate coordination between children and their caregivers in terms of word-class n -gram sequences. Results further indicate that trade-offs in leading or following this coordination reflect individual differences between children at varying levels of development. Further analyses characterize the syntactic patterns that are coordinated, and results are consistent with recent language acquisition research on syntax acquisition. Overall, recurrence analysis reveals that there is a process of child-caregiver coordination taking place in ongoing conversation at the level of syntactic description. [source] Chinese medicine Banxia-houpu decoction regulates c-fos expression in the brain regions in chronic mild stress model in ratsPHYTOTHERAPY RESEARCH, Issue 3 2004Weiyun Zhang Abstract Banxia-houpu decoction is a safe and effective traditional Chinese medicinal formula used in the treatment of mild and manic-depressive disorders for centuries. There has been increasing interest in its therapeutic application in depression. However, the mechanisms behind behavioural changes are still poorly understood. Chronic mild stress (CMS)-induced preference behaviour change has been used as a model to predict the clinical ef,cacy of many types of antidepressant treatment. Both EtOH and water extracts (AE and WE) of Banxia-houpu decoction exhibited a signi,cantly increased sucrose intake in the CMS model in rats, but there was no effect in unstressed animals. In the present study, it was found that the c-fos expression in cerebral cortex, hippocampus and striatum corpora were very high in the CMS model in rats. WE and AE at a dose of 130 mg/kg exhibited a signi,cantly decreased c-fos expression in the cerebral regions in CMS model in rats, respectively. The former was more potent than the latter. However, no signi,cant changes in the c-fos expression were observed in unstressed rats treated with the decoction. Fluoxetine not only signi,cantly reduced c-fos expression in all regions in the CMS model in rats, but only showed a marked decrease in c-fos expression in the hippocampus in unstressed animals. A different molecular mechanism of Banxia-houpu decoction and ,uoxetine may be implied. The cerebral cortex, hippocampus and striatum conpora might be important structural substrates in the central nervous system mediating the section of the Banxia-houpu decoction on preference behaviour in CMS-induced rats, and fos protein might be the common substrate of the signal transduction process of the decoction. Copyright © 2004 John Wiley & Sons, Ltd. [source] Size variation in early human mandibles and molars from Klasies River, South Africa: Comparison with other middle and late Pleistocene assemblages and with modern humans,AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 2 2009Danielle F. Royer Abstract Previous studies of the Middle Stone Age human remains from Klasies River have concluded that they exhibited more sexual dimorphism than extant populations, but these claims have not been assessed statistically. We evaluate these claims by comparing size variation in the best-represented elements at the site, namely the mandibular corpora and M2s, to that in samples from three recent human populations using resampling methods. We also examine size variation in these same elements from seven additional middle and late Pleistocene sites: Skh,l, Dolní V,stonice, Sima de los Huesos, Arago, Krapina, Shanidar, and Vindija. Our results demonstrate that size variation in the Klasies assemblage was greater than in recent humans, consistent with arguments that the Klasies people were more dimorphic than living humans. Variation in the Skh,l, Dolní V,stonice, and Sima de los Huesos mandibular samples is also higher than in the recent human samples, indicating that the Klasies sample was not unusual among middle and late Pleistocene hominins. In contrast, the Neandertal samples (Krapina, Shanidar, and Vindija) do not evince relatively high mandibular and molar variation, which may indicate that the level of dimorphism in Neandertals was similar to that observed in extant humans. These results suggest that the reduced levels of dimorphism in Neandertals and living humans may have developed independently, though larger fossil samples are needed to test this hypothesis. Am J Phys Anthropol, 2009. © 2009 Wiley-Liss, Inc. [source] Masticatory stress and the mechanics of "wishboning" in colobine jawsAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009David J. Daegling Abstract Cercopithecoid monkeys experience relatively high strains along the lingual aspect of the mandibular symphysis because of lateral transverse bending of the mandibular corpora ("wishboning") during mastication. Hylander (Am J Phys Anthropol 64 (1984) 1,46; Am Zool 25 (1985) 315,330) demonstrated that the distribution of strains arising from wishboning loads is comprehensible with reference to the mechanics of curved beams. Theory of curved beams suggests that lingual tensile strains are some multiple of labial compressive strains, yet limitations of experimental methods and uncertainty in estimating parameters needed for theoretical calculations have confounded attempts to characterize the magnitude of this disparity of normal strains. We evaluate the theoretical disparity of normal strains in wishboning in comparison to in vitro strains collected under controlled loads for a sample of mandibles representing two colobine species (N = 6). These data suggest that in colobine monkeys, maximum normal lingual strains should be at least twice maximum labial strains. In addition, we reexamine the distribution of symphyseal stress under an assumption of asymmetric bending, a general approach for calculation of stress appropriate for members that lack a plane of symmetry and are bent along an axis that is not coincident with the member's principal axes. Under asymmetric bending in colobine mandibles, the effect of symphyseal inclination on lingual strain is mitigating at the superior transverse torus and exacerbating at the inferior transverse torus. Relative compliance of colobine mandibular bone further supports the hypothesis that the structural and material properties of the colobine mandibular symphysis do not represent a morphological strategy for minimizing masticatory strain. Am J Phys Anthropol, 2009. © 2008 Wiley-Liss, Inc. [source] A Method of Automated Nonparametric Content Analysis for Social ScienceAMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 1 2010Daniel J. Hopkins The increasing availability of digitized text presents enormous opportunities for social scientists. Yet hand coding many blogs, speeches, government records, newspapers, or other sources of unstructured text is infeasible. Although computer scientists have methods for automated content analysis, most are optimized to classify individual documents, whereas social scientists instead want generalizations about the population of documents, such as the proportion in a given category. Unfortunately, even a method with a high percent of individual documents correctly classified can be hugely biased when estimating category proportions. By directly optimizing for this social science goal, we develop a method that gives approximately unbiased estimates of category proportions even when the optimal classifier performs poorly. We illustrate with diverse data sets, including the daily expressed opinions of thousands of people about the U.S. presidency. We also make available software that implements our methods and large corpora of text for further analysis. [source] The Role of Opiorphins (Endogenous Neutral Endopeptidase Inhibitors) in Urogenital Smooth Muscle BiologyTHE JOURNAL OF SEXUAL MEDICINE, Issue S3 2009Kelvin Paul Davies BSc ABSTRACT Introduction., The opiorphins are a newly characterized class of peptides that act as potent endogenous neutral endopeptidase (NEP) inhibitors. Recent reports have suggested that they play an important role in erectile physiology. Aim., This article reviews recent developments that increase our understanding of the role of the opiorphin family of peptides in erectile physiology. Methods., During a microarray screen of gene changes that occur in a rat diabetic model of erectile dysfunction (ED), Vcsa1 was one of the most down-regulated genes in the rat corpora. Quantitative real-time polymerase chain reaction demonstrated that in at least three models of diseases that result in ED (diabetes, aging, and cavernous nerve [CN] transection), Vcsa1 was down-regulated in the rat corpora. The human opiorphin family of genes (hSMR3A/B and ProL1) also acts as markers of erectile function in patients with ED. Main Outcome Measures., The reader will be informed of the most current research regarding the role of opiorphins in urogenital smooth muscle biology. Results., These observations led to the suggestion that genes encoding opiorphins (and potentially their peptide products) can act as markers of ED. Gene transfer of plasmids overexpressing Vcsa1 in aging rats, as well as intracorporal injection of sialorphin, led to an improvement in erectile function. In organ bath studies, we demonstrated that sialorphin can cause increased rates of relaxation of corporal smooth muscle (CSM). We have also demonstrated that in vitro, Vcsa1 causes changes in the expression of G-protein-coupled receptors (GPCRs). This has led us to suggest that the action of Vcsa1 on erectile physiology may act through relaxation of CSM by its ability to act as an inhibitor of NEP, therefore prolonging the action of peptide agonists at their GPCRs. Conclusions., Overall, there is a growing body of evidence that the opiorphins play a role in regulating CSM tone and thereby erectile function. Davies KP. The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology. J Sex Med 2009;6(suppl 3):286,291. [source] Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseasesBJU INTERNATIONAL, Issue 2 2007Jason D. Hipp OBJECTIVE To identify early diabetes-related alterations in gene expression in bladder and erectile tissue that would provide novel diagnostic and therapeutic treatment targets to prevent, delay or ameliorate the ensuing bladder and erectile dysfunction. MATERIALS AND METHODS The RG-U34A rat GeneChip® (Affymetrix Inc., Sunnyvale, CA, USA) oligonucleotide microarray (containing ,8799 genes) was used to evaluate gene expression in corporal and male bladder tissue excised from rats 1 week after confirmation of a diabetic state, but before demonstrable changes in organ function in vivo. A conservative analytical approach was used to detect alterations in gene expression, and gene ontology (GO) classifications were used to identify biological themes/pathways involved in the aetiology of the organ dysfunction. RESULTS In all, 320 and 313 genes were differentially expressed in bladder and corporal tissue, respectively. GO analysis in bladder tissue showed prominent increases in biological pathways involved in cell proliferation, metabolism, actin cytoskeleton and myosin, as well as decreases in cell motility, and regulation of muscle contraction. GO analysis in corpora showed increases in pathways related to ion channel transport and ion channel activity, while there were decreases in collagen I and actin genes. CONCLUSIONS The changes in gene expression in these initial experiments are consistent with the pathophysiological characteristics of the bladder and erectile dysfunction seen later in the diabetic disease process. Thus, the observed changes in gene expression might be harbingers or biomarkers of impending organ dysfunction, and could provide useful diagnostic and therapeutic targets for a variety of progressive urological diseases/conditions (i.e. lower urinary tract symptoms related to benign prostatic hyperplasia, erectile dysfunction, etc.). [source] Preventive Effects of Isoflavones, Genistein and Daidzein, on Estradiol-17,-related Endometrial Carcinogenesis in MiceCANCER SCIENCE, Issue 7 2001Zenglin Lian The effects of isoflavones (genistein and daidzein) on endometrial carcinogenesis in mice were investigated in two experiments. In the short-term experiment (2 weeks), single subcutaneous (s.c.) administration of genistein [1 mg/30 g body weight (b.w.)] significantly decreased the levels of estradiol-l7, (E2) (5 ppm in diet)-induced expression of c-jun, interleukin-l, (IL-l,) and tumor necrosis factor-a (TNF-a) mRNAs in the uteri of ovariectomized mice (P<0.005, P<0.05 and P<0.01, respectively). Daidzein significantly inhibited E2-induced expression of c-fos and IL-l, (P<0.01, P<0.01 respectively). In the long-term experiment (30 weeks), 140 female ICR mice were given N-methyl-N-nitrosourea-containing solution (1 mg/100 g b.w.) and normal saline (as controls) into their left and right uterine corpora, respectively. They were divided into six groups; group 1 was given E2 (in diet) alone. Group 2 was given E2 and genistein (1 mg/30 g b.w., s.c., every four weeks). Group 3 was exposed to E2 and daidzein (1 mg/30 g b.w., s.c., every four weeks). Groups 4 and 5 respectively received genistein and daidzein, and were kept on the basal diet. Group 6 was kept on the basal diet and served as a control. At the termination of the experiment, incidences of endometrial adenocarcinoma and atypical endometrial hyperplasia of the group given E2 and genistein or daidzein were significantly lower than of the group with E2 alone (P<0.01 and P<0.05, respectively). It is suggested that both genistein and daidzein have an inhibitory effect on estrogen-related endometrial carcinogenesis in mice, possibly by suppressing expression of estrogen-induced estrogen-related genes c-fos and c-jun, and internal cytokines IL-l, and TNF-, through a cytokine and estrogen receptor-mediated pathway. [source] SENTIMENT CLASSIFICATION of MOVIE REVIEWS USING CONTEXTUAL VALENCE SHIFTERSCOMPUTATIONAL INTELLIGENCE, Issue 2 2006Alistair Kennedy We present two methods for determining the sentiment expressed by a movie review. The semantic orientation of a review can be positive, negative, or neutral. We examine the effect of valence shifters on classifying the reviews. We examine three types of valence shifters: negations, intensifiers, and diminishers. Negations are used to reverse the semantic polarity of a particular term, while intensifiers and diminishers are used to increase and decrease, respectively, the degree to which a term is positive or negative. The first method classifies reviews based on the number of positive and negative terms they contain. We use the General Inquirer to identify positive and negative terms, as well as negation terms, intensifiers, and diminishers. We also use positive and negative terms from other sources, including a dictionary of synonym differences and a very large Web corpus. To compute corpus-based semantic orientation values of terms, we use their association scores with a small group of positive and negative terms. We show that extending the term-counting method with contextual valence shifters improves the accuracy of the classification. The second method uses a Machine Learning algorithm, Support Vector Machines. We start with unigram features and then add bigrams that consist of a valence shifter and another word. The accuracy of classification is very high, and the valence shifter bigrams slightly improve it. The features that contribute to the high accuracy are the words in the lists of positive and negative terms. Previous work focused on either the term-counting method or the Machine Learning method. We show that combining the two methods achieves better results than either method alone. [source] Natural head motion synthesis driven by acoustic prosodic featuresCOMPUTER ANIMATION AND VIRTUAL WORLDS (PREV: JNL OF VISUALISATION & COMPUTER ANIMATION), Issue 3-4 2005Carlos Busso Abstract Natural head motion is important to realistic facial animation and engaging human,computer interactions. In this paper, we present a novel data-driven approach to synthesize appropriate head motion by sampling from trained hidden markov models (HMMs). First, while an actress recited a corpus specifically designed to elicit various emotions, her 3D head motion was captured and further processed to construct a head motion database that included synchronized speech information. Then, an HMM for each discrete head motion representation (derived directly from data using vector quantization) was created by using acoustic prosodic features derived from speech. Finally, first-order Markov models and interpolation techniques were used to smooth the synthesized sequence. Our comparison experiments and novel synthesis results show that synthesized head motions follow the temporal dynamic behavior of real human subjects. Copyright © 2005 John Wiley & Sons, Ltd. [source] Checking ownership and confinementCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 7 2004Alex Potanin Abstract A number of proposals to manage aliasing in Java-like programming languages have been advanced over the last five years. It is not clear how practical these proposals are, that is, how well they relate to the kinds of programs currently written in Java-like languages. To address this problem, we analysed heap snapshots from a corpus of Java programs. Our results indicate that object-oriented programs do in fact exhibit symptoms of encapsulation in practice, and that proposed models of uniqueness, ownership, and confinement can usefully describe the aliasing structures of object-oriented programs. Understanding the kinds of aliasing present in programs should help us to design formalisms to make explicit the kinds of aliasing implicit in object-oriented programs. Copyright © 2004 John Wiley & Sons, Ltd. [source] A MAGE/NDN-like gene in zebrafishDEVELOPMENTAL DYNAMICS, Issue 3 2003Jocelyn M. Bischof Abstract The human necdin/MAGE gene family has over 50 members, but most of the proteins encoded by these genes are of unknown function. We have now identified a single locus in Danio rerio that encodes a putative protein with significant coding sequence similarity to the mammalian NDN/MAGE genes. Analysis of the complete Fugu ribripes genome sequence also suggests that there is only a single MAGE-like gene in teleost fish. mage is expressed in the larval and adult brain, specifically the retina, the medial region of the telencephalon, periventricular gray zone of the optic tectum, and most highly in the cerebellar corpus. The discovery of a zebrafish NDN/MAGE gene expressed the developing brain facilitates studies of the MAGE homology domain in vertebrate development. Developmental Dynamics, 2003. © 2003 Wiley-Liss, Inc. [source] Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterusDIAGNOSTIC CYTOPATHOLOGY, Issue 7 2010Ayako Horita M.D. Abstract We report a case of atypical polypoid adenomyoma (APA) concomitantly identified with complex atypical endometrial hyperplasia (CAH) in the uterus. Since an initial endometrial smear revealed atypical endometrial cells, a diagnosis of CAH was made. Even though a concomitantly performed uterine cervical smear contained both atypical epithelial and stromal cells, the diagnosis of APA was not initially made because the cytological criteria for APA had not been established. Histologically, we recognized both CAH in the uterine corpus and APA in the lower uterine segment in the hysterectomy material. Retrospectively, the cells in the first cervical smear were interpreted as part of APA because the same types of cells were observed in the intraoperative cytology sample. Although the APA and CAH lesions were interposed by normal endometrium, estrogen was suspected to be the common etiological factor. Reports regarding the cytology of APA are currently scarce. To our knowledge, this is the first report showing cytological presentation of association of APA with CAH in addition to the first cervical smear of APA containing both epithelial and stromal components. Identification of abnormal proliferation of epithelium and stromal cells of smooth muscle origin is useful in the cytological diagnosis of APA. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. [source] Primary relapse of acute lymphoblastic leukemia in a cervical smear: A case reportDIAGNOSTIC CYTOPATHOLOGY, Issue 7 2006Akiko Ikuta M.D. Abstract Uterine cervix and corpus are rarely the initial site of relapse in leukemia or lymphoma. We report herein a case of uterine cervical relapse with B-cell acute lymphoblastic leukemia (ALL). The patient, a 60-yr-old woman, had a history of ALL that had been in remission for 2 yr after chemotherapy. She presented with a chief complaint of genital bleeding. In a routine cervico-vaginal Papanicolau smear, abundant atypical lymphoid cells with round-to-oval nuclei, scant cytoplasm, and high nuclear to cytoplasmic ratios was observed. The nuclei of these cells had fine and dark chromatin and thickened nuclear membranes, with one or several nucleoli being visible. Biopsy under colposcope was performed, and a diagnosis of relapse of ALL was confirmed. The ongoing genital bleeding presented a problem with clinical management of the patient. It was decided to proceed with hysterectomy to end that problem and thereafter proceed with therapy directed against the leukemia. Our results suggest that in patients with known extrauterine cancer, the presence of malignancy in uterine cellular samples provides information regarding the extent of the neoplasm. Diagn. Cytopathol. 2006;34:499,502. © 2006 Wiley-Liss, Inc. [source] ENDOSCOPIC IDENTIFICATION OF HELICOBACTER PYLORI GASTRITIS IN CHILDRENDIGESTIVE ENDOSCOPY, Issue 2 2010Nao Hidaka Aim:, The role of endoscopic findings in deciding whether to biopsy the gastric mucosa of children remains unclear. The present study attempted, for the first time, to identify the value of endoscopic features for diagnosis of Helicobacter pylori (Hp) infection in children. Methods:, Hp status of consecutive children receiving esophagogastroduodenoscopy (EGD) was established by combinations of histology, 13C-urea breath test, and serum Hp immunoglobulin (Ig)G antibody. After routine EGD using a conventional endoscope, the presence of RAC (regular arrangement of collecting venules) was scored by close observation, which was carried out at two sites of lower corpus lesser curvature and upper corpus greater curvature. RAC-positive was defined as the presence of minute red points in a regular pattern. Antral nodularity was also scored as present/absent. Results:, Eighty-seven consecutive children (38 boys, median age 13 years, range 9,15 years) were evaluated; 25 (29%) were Hp positive. Antral nodularity was seen in 21 (84%) all of whom were Hp positive. The RAC-negative pattern based on examination of the upper and lower corpus yielded a sensitivity, specificity, positive predictive value and negative predictive value for the presence of Hp infection of 100%, 90%, 81%, and 100%. Magnifying endoscopy confirmed that the RAC pattern corresponded to collecting venules in the gastric corpus. Conclusions:, The absence of RAC pattern suggests that gastric mucosa biopsies should be taken despite otherwise normal-appearing gastric mucosa for the diagnosis of Hp infection in children. [source] SMALL EARLY GASTRIC CANCER OCCURRING IN A YOUNG WOMAN WITH NODULAR GASTRITISDIGESTIVE ENDOSCOPY, Issue 2 2007Shuji Kochi We found a small gastric cancer in a 25-year-old woman with nodular gastritis. Endoscopically, the cancer was identified as a whitish area in the gastric antrum. There was also a miliary pattern in the gastric antrum and corpus. In addition, serology and histology revealed the patient to have been infected by Helicobacter pylori. Histological examination of the resected stomach showed that the cancer was poorly differentiated adenocarcinoma with signet-ring cell restricted to the mucosal layer. In the surrounding mucosa, there were chronic inflammatory cell infiltrates and enlarged lymphoid follicles with germinal centers. Our case suggests that nodular gastritis may be at a high risk for the development of gastric cancer of poorly differentiated type. [source] PEUTZ-JEGHERS SYNDROME ASSOCIATED WITH RENAL AND GASTRIC CANCER THAT DEMONSTRATED AN STK11 MISSENSE MUTATIONDIGESTIVE ENDOSCOPY, Issue 4 2006Hiromi Kataoka A 75-year-old male was admitted to the gastroenterology unit of Nagoya City University Hospital due to epigastralgia after surgical treatment for right renal cancer. Endoscopy revealed advanced type 1 gastric cancer in the corpus of the stomach and multiple polypoid lesions in the stomach and duodenum. X-ray examination of the small intestine using barium showed multiple polyps in the upper jejunum. Faint pigmentation on the palm was also detected. Peutz-Jeghers syndrome (PJS) was diagnosed, despite a lack of family history. Total gastrectomy, resection of part of the upper jejunum and intraoperative endoscopic polypectomy of duodenal polyps was performed. This is the second reported case of PJS associated with renal cancer. We also detected a missense mutation in the tumor suppressor gene STK11 that, when mutated, is causative for PJS. [source] NODULAR GASTRITIS AND GASTRIC CANCERDIGESTIVE ENDOSCOPY, Issue 2 2006Tomoari Kamada Nodular gastritis is defined as antral gastritis usually characterized endoscopically by a miliary pattern resembling gooseflesh and pathologically by prominent lymphoid follicles and infiltration of mononuclear cells. This physiological phenomenon was once considered particular to young women. Recent studies have shown that nodular gastritis is strongly associated with Helicobacter pylori infection and may be associated with gastric cancer. Reported cases of gastric cancer with nodular gastritis showed some features in common: all gastric cancers were diagnosed histologically as the diffuse-type, and all were located in the corpus with Helicobacter pylori infection. Because nodular gastritis may be a risk factor for diffuse-type gastric cancer, Helicobacter pylori may need to be eradicated to prevent gastric cancer in patients with nodular gastritis. [source] Endoscopic classification of chronic gastritis based on a pilot study by the research society for gastritisDIGESTIVE ENDOSCOPY, Issue 4 2002Michio Kaminishi Background:,Various types of classification of gastritis have been proposed, but no plausible classification has been available until now. The Research Society for Gastritis performed a pilot study to establish an endoscopic classification, taking into consideration the following: (i) ease of use; (ii) permitting everyone the common image; and (iii) presence of histopathological evidence. Methods:,One hundred and fifty-five patients were enrolled and underwent gastroscopy. Eight basic endoscopic and histological types of gastritis (superficial, hemorrhagic, erosive, verrucous, atrophic, metaplastic, hyperplastic and special types) were defined. Gastritis was endoscopically diagnosed according to the definition of the endoscopic types of gastritis. Four or more biopsy specimens were obtained from the lesser and the greater curvatures of the antrum and the corpus of each patient, and the histological findings of gastritis and Helicobacter pylori infection were assessed. The histological diagnosis of gastritis was made according to the definition of histology types of gastritis. The endoscopic and the histological diagnoses were then compared in a blinded fashion. Results:,Endoscopic diagnosis was 62% as sensitive as histological diagnosis for erosive gastritis, 67% for verrucous gastritis and 84% for atrophic gastritis in the antrum. In superficial gastritis, sensitivity was approximately 25% in the corpus, but only 8% in the antrum. Metaplastic and hyperplastic gastritis were correctly diagnosed only in severe cases. Conclusion:,Five basic types of gastritis (superficial, erosive, verrucous, atrophic and special types) should be employed for the new endoscopic gastritis classification. Metaplastic and hyperplastic gastritis are considered to be subtypes of atrophic gastritis and they should be excluded from the basic endoscopic classification. A new definition of gastritis in the antrum accompanied by redness still remains to be investigated. [source] | ||||||||||||||||||||||||||||||||||||||||||||||