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Corneal Erosions (corneal + erosion)
Selected AbstractsAlcohol vs. mechanical delamination in the treatment of corneal erosion: an electron microscopic studyACTA OPHTHALMOLOGICA, Issue 2009I PALADINI Purpose To performed an electron microscopy study to investigate the cleavage plane and the efficacy of alcohol delamination in recurrent corneal erosion (RCE). Methods By electron microscopy we analysed the epithelium of: seven controls treated with mechanical debridment, seven controls treated with alcohol delamination, ten cases of traumatic RCE and seven RCE due to MDFP treated with alcohol delamination, with special regard to the epithelial cells and the cleavage plane. Moreover we analysed four corneas from penetrating keratoplastys that were treated by alcohol delamination on the bench and both the epithelium and stroma were studied. Results In traumatic RCE the basement membrane remained in situ, a precondition for quick epithelial healing . In MDFP the whole basement membrane was detached from the stroma and remained adherent to the epithelium, therefore after alcohol delamination the healing process should be different between MDFP and traumatic RCE. Conclusion The present findings give strenght to alcohol delamination as a promising treatment for RCE [source] Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome treated with acitretinJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 6 2005S Khandpur ABSTRACT We describe a 3-year-old male patient with the ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome, who developed cutaneous and ocular involvement in infancy. In addition, he had growth retardation and borderline intelligence; no other systemic involvement was found on detailed investigation. A moderate response to acitretin therapy (1 mg/kg) administered for 6 months was observed, with improvement in cutaneous features and corneal erosions and no change in alopecia or photophobia. [source] Dystrophia Smolandiensis: a novel morphological picture of recurrent corneal erosionsACTA OPHTHALMOLOGICA, Issue 4 2010Björn Hammar Abstract. Purpose:, The aim of this study was to describe morphological changes in Dystrophia Smolandiensis, a corneal disease that is characterized by recurrent corneal erosive episodes and the formation of central corneal keloid-like opacities in approximately half of those affected. Methods:, The corneas of seven affected individuals were examined using in-vivo confocal microscopy. Specimens of one primary corneal graft, one regraft and one biopsied keloid-like region , all obtained from members of a large family with the disease , were re-examined with a light microscope. Sections were stained with Congo red and analysed immunohistochemically for fibronectin and S100A4. Results:, Light microscopic examination revealed epithelial hyperplasia, absence of Bowman's layer and subepithelial fibrosis. Fibronectin was expressed in the area of subepithelial fibrosis, and the keratocytes in this area generally expressed S100A4. The biopsy specimen stained positive for Congo red, suggesting an amyloid deposit. In-vivo confocal microscopy confirmed epithelial abnormalities, loss of Bowman's layer and significant alterations of the subbasal nerve plexus in affected individuals. Conclusion:, The morphological picture in Dystrophia Smolandiensis is novel for a condition dominated by recurrent corneal erosions at the clinical level. Although no single morphological feature unique to the disease could be found, the general morphological pattern of pathology (true keloid formation, absence of Bowman's layer, subepithelial fibrosis and abnormal subbasal nerves) probably reflects a novel phenotypic expression of the healing response to recurrent erosion of the corneal epithelium. However, the pathogenesis of Dystrophia Smolandiensis remains to be elucidated fully. [source] Dystrophia Helsinglandica: a new type of hereditary corneal recurrent erosions with late subepithelial fibrosisACTA OPHTHALMOLOGICA, Issue 6 2009Björn Hammar Abstract. Purpose:, To describe the phenotype of an autosomal-dominant corneal dystrophy with an early onset of recurrent corneal erosions and development of subepithelial fibrosis in the cornea, and also to exclude genetic linkage to known corneal dystrophies with autosomal-dominant inheritance and clinical resemblance. Methods:, We describe the medical history and clinical findings in individuals from a seven-generation family with recurrent corneal erosions. A total of 43 individuals were evaluated by ophthalmological examination. Genomic DNA was prepared from peripheral blood and polymorphic microsatellite markers were analysed to study haplotypes surrounding genes causing corneal dystrophies with similar phenotypes. Results:, Erosive symptoms usually lasted for between 1 and 10 days. By the age of 7 almost all of the affected individuals suffered from recurrent corneal erosions. The attacks generally declined in frequency and intensity from the late 20s, but all examined individuals had developed subepithelial fibrosis by the age of 37. The fibrosis generally started in the mid periphery and was followed in some family members by central fibrosis and the development of gelatinous superficial elevations. Only a marginal reduction of visual acuity was seen in a few individuals. The affected individuals did not share haplotypes for genetic microsatellite markers surrounding genes that are known to cause autosomal-dominant corneal dystrophies. Conclusion:, We describe a new type of autosomal-dominant corneal disorder with recurrent corneal erosions and subepithelial fibrosis not significantly affecting visual acuity. [source] | ||||||||||