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Core Members (core + member)
Selected Abstractsoleed, a medaka Polycomb group gene, regulates ciliogenesis and left,right patterningGENES TO CELLS, Issue 12 2009Daisuke Arai Left-right (LR) patterning is an essential part of the animal body plan. Primary cilia are known to play a pivotal role in this process. In humans, genetic disorders of ciliogenesis cause serious congenital diseases. A comprehensive mechanism that regulates ciliogenesis has not been proposed so far. Here, we show that EED, a core member of the Polycomb group (PcG) genes and a presumed player in many epigenetic processes, is required for ciliogenesis and subsequent LR patterning in the medaka fish, Oryzias latipes. Moderate knockdown of oleed, a medaka homolog of EED, preferentially caused situs inversus. In the affected embryo, the cilia in Kupffer's vesicle showed various defects in their structure, position and motility. Furthermore, we demonstrated that oleed maintains the expression of Noto, which, in mice, regulates ciliogenesis and LR patterning. This study provides the first evidence for the involvement of epigenetic plasticity in LR patterning through ciliogenesis. [source] Detection and identification of rumen bacteria constituting a fibrolytic consortium dominated by Fibrobacter succinogenesANIMAL SCIENCE JOURNAL, Issue 1 2010Takumi SHINKAI ABSTRACT A fibrolytic consortium, dominated by the rumen cellulolytic bacterium Fibrobacter succinogenes, was artificially constructed on hay stems to detect and identify rumen bacteria that can potentially interact with F. succinogenes. Consortium-bacterial members were determined by DGGE and sequencing analysis targeted bacterial 16S rDNA. An artificial consortium was formed in a 2-step incubation of hay stems; the first step with group 1, 2 or 3 F. succinogenes strains, the second step with rumen fluid. After consortium formation, morphologically different bacteria were observed in association with F. succinogenes. DGGE exhibited more than 30 bands, the pattern of which depended on the F. succinogenes group. Sequencing suggested that Butyrivibrio fibrisolvens, Pseudobutyrivibrio ruminis, Clostridium sp., F. succinogenes group 2, Prevotella ruminicola and unclassified Bacteroides were prominent in the group 1 consortium and that Treponema bryantii, B. fibrisolvens, Acinetobacter sp, and Wolinella succinogenes were prominent in the group 2 consortium. However, in the group 3 consortium, F. succinogenes -like bacteria were microscopically undetectable, whereas cellulolytic Ruminococcus albus and F. succinogenes group 1 were prominent, suggesting that the group 3 cannot be a core member of this consortium. This study is the first attempt to identify bacterial members of a fibrolytic consortium dominated by a specific bacterium. [source] Celebrating Ourselves: The Family Reunion Rituals of African-Caribbean Transnational FamiliesGLOBAL NETWORKS, Issue 3 2004Constance R. Sutton In the past decade, family reunions have become an important ritualized event among Afro-Caribbean transnational migrants. Dispersed across a large number of North Atlantic countries, Afro-Caribbeans have turned to organizing events specifically designed to reunite kinfolk. The rituals constitute a celebration of family as a distinct social group with a kin-based, lineage-like identity. Re-creating kin ties among those spread across different nations and transmitting kin-based connections to their offspring are the main incentives for holding these rituals. In this article I describe three different recent family reunions, one held in Barbados, one in Grenada, and one in Trinidad and Barbados. I analyse the specific forms these rituals take, relate their differences from the social positioning of the core members of the kin groups and discuss the signifying practices of the reunions for maintaining Caribbean family connections in the diaspora. Finally, I raise questions about how the kin-based identities constructed in the reunion rituals intersect with race/class, ethnic and national identities. [source] Universities and Industry: Does the Lambert Code of Governance Meet the Requirements of Good Governance?HIGHER EDUCATION QUARTERLY, Issue 4 2004Roger Buckland The Lambert Model Code of Governance proposes to institutionalise the dominance of governors from commercial and industrial organisations as core members of compact and effective boards controlling UK universities. It is the latest expression of a fashion for viewing university governance as an overly-simple example of an obsolete system, where overweening and obstructive committee systems inhibit universities from achieving more significant and business-relevant activity. In this paper university governance is analysed in terms of classic agency analysis, in the Jensen and Meckling tradition. This suggests that governance of and in the system is complex and that, although inherited structures may indeed be deficient, the prescription of the Lambert Review is profoundly flawed and would be unlikely to achieve improvement in UK universities' competitiveness or attainment of mission. [source] The Development of Advanced Nursing Practice GloballyJOURNAL OF NURSING SCHOLARSHIP, Issue 3 2008Barbara Sheer Purpose: To examine the development of advanced nursing practice globally. Methods: Data were collected from documentary resources available in the International Nurse Practitioners/Advanced Practice Nurse Network (INP/APNN) of the International Council of Nurses. The areas examined were guided by the "key informant survey on advanced nursing practice self-administered questionnaire." Two core members of the INP/APNN who have rich experience in global advanced nursing development analyzed the data. A total of 14 countries and three regions from five continents were included in the analyses. The development of advanced nursing practice in these areas is facilitated by a need for better access to care in a cost-containment era and the enhancement of nursing education to postgraduate level. The mechanism for regulation of practice is in place in some countries. Conclusions: Confirms the development of advanced practice in nursing is a global trend. Clinical Relevance: APNs can improve global health with points to enhanced education in nursing and regulation of advanced practice. [source] | ||||||||||