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Selected AbstractsParasitism by the mite Trombidium breei on four U.K. butterfly speciesECOLOGICAL ENTOMOLOGY, Issue 6 2002L. Conradt Abstract 1. The incidence of parasitism by larvae of the mite species Trombidium breei was reported in one population of the lycaenid butterfly Polyommatus icarus, four populations of the satyrine butterfly Maniola jurtina, one population of the satyrine butterfly Aphantopus hyperanthus, and two populations of the satyrine butterfly Pyronia tithonus, as well as on one specimen of the dipteran Alophorus hemiptera. A considerable proportion of butterflies (11-50%) was infested in all study populations. 2. The pattern of infestation was examined in detail in M. jurtina. Males had a significantly higher incidence of infestation than females, and middle-aged butterflies had a higher incidence of infestation than old or young butterflies. The incidence of infestation peaked in the middle of the flight season, and this seasonal effect was independent of the effect of butterfly age. 3. Using a model based on capture-recapture data, it was estimated that a hypothetical ideal male M. jurtina that lives exactly the mean expected lifespan of 9-10 days has an approximately 75% chance of becoming infested with mites at least once during its lifetime, a mean time to first infestation of 3-4 days, and an average infestation persistence time of 2-3 days. 4. Capture-recapture data failed to show any effect of mite infestation on the lifespan or within-habitat movement rate of M. jurtina. 5. In experiments in which individual butterflies were taken out of their normal habitat and released, M. jurtina and P. tithonus that were infested with mite larvae did not differ from uninfested individuals in the efficiency with which they returned to suitable habitat. Thus, parasitism by T. breei larvae had no detectable effects on flight performance or orientation ability. 6. The results suggest that trombidiid mite larvae have limited potential in the biological control of insect pests. [source] Behaviourally structured populations persist longer under harsh environmental conditionsECOLOGY LETTERS, Issue 5 2003Sergei V. Petrovskii Abstract The factors and mechanisms that enhance population persistence in a fragmented habitat and/or under harsh environmental conditions are of significant current interest. We consider the dynamics of a population in an isolated habitat surrounded by an unfavourable environment subject to different behavioural responses between the individuals. We assume that there are two responses available: one of them is aggression in its extreme form, the other is its contrary when an individual takes flight in order to avoid any contact with its conspecific. We show that a behaviourally structured population consisting of individuals with fixed behavioural responses is intrinsically less prone to extinction under harsh environmental condition than a population where the individuals can ,choose' between the two given behaviours. We also show that, contrary to an intuitively expected negative impact of aggression on population persistence, the optimal conditions for population persistence are reached when a considerable proportion of the individuals exhibit aggressive behaviour. [source] Use and toxicity of complementary and alternative medicines among emergency department patientsEMERGENCY MEDICINE AUSTRALASIA, Issue 5-6 2004David McD Taylor Abstract Objective:, To determine the prevalence and type of complementary and alternative medicines (CAM) used by ED patients, to identify patient subgroups more likely to use CAM, the conditions for which they were taken, and the prevalence of side-effects and toxicity associated with CAM use. Methods:, This was an analytical cross-sectional survey of patients at a large tertiary referral ED. Consenting patients completed a specifically designed study questionnaire, in their preferred language if required. Information was collected on CAM use on the day of presentation and within the previous week and previous year. Results:, Four hundred and four patients were enrolled (participation rate 97.1%). Fifty (12.4%, 95% CI 9.4, 16.1) patients had taken a CAM on the day of presentation, 203 (50.2%, 95% CI 45.3, 55.2) within the previous week and 275 (68.1%, 95% CI 63.2, 72.5) within the previous year. CAM users were significantly younger, better educated and more likely to be female than non-CAM users (P < 0.01). 103 different CAM had been taken for a wide variety of reasons. Side-effects were experienced in 53 of the 1182 CAM courses taken (side-effect rate of 4.5%). One patient presented suffering specifically from CAM toxicity. Conclusion:,, Complementary and alternative medicines are used by a considerable proportion of ED patients. The potential for side-effects, toxicity and interaction with traditional medication indicates the need for consideration of CAM use in patient assessment. [source] Prevalence and impact of pain in diabetic neuropathyEUROPEAN DIABETES NURSING, Issue 2 2009M Geerts M Abstract Background: Diabetic neuropathy (DNP) is a serious and common complication of diabetes mellitus, with a prevalence of around 30-50%. Aims: To describe the prevalence, severity and medical treatment of painful DNP (PDNP) experienced by patients treated in secondary care; to determine quality of life (QoL) impact and the relationship between severity of pain and severity of DNP. Methods: Cross-sectional, two-phase survey. First, a pain interview was conducted by telephone (219 DNP patients), which covered types of pain, location and duration. Secondly, 50 patients were visited at home. Patients completed the Brief Pain Inventory, the Short Form Health Survey (SF-36) and the Hospital Anxiety and Depression Scale. Results: Prevalence of PDNP was 57.5%. Average and worst pain scores were 5.3 ± 2.1 and 6.4 ± 2.2, respectively (0-10 scale, 10 = worst pain imaginable). In 70% of patients, average pain was severe (score ,5). Substantial interference by pain (score ,4) was found in walking ability, sleep and normal activities. PDNP patients had a decreased QoL for all SF-36 domains (p,0.01) except for health change. Moreover, symptoms of anxiety (36%) and depression (34%) were reported frequently. Medical treatment was prescribed in 46% of patients, in whom treatment was ineffective in 39%. Physical functioning scores were lower in patients with severe versus moderate DNP (p,0.01). Conclusions: The prevalence of severe PDNP was high. Severity of DNP was not related to pain severity. PDNP was associated with loss of QoL and with symptoms of anxiety and depression. A considerable proportion of patients did not have medical treatment and, if treatment was given, its impact was disappointing. Medical treatment of PDNP was unsatisfactory and clearly needs to be improved. Copyright © 2009 FEND [source] Effects of M-current modulators on the excitability of immature rat spinal sensory and motor neuronesEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 12 2005I. Rivera-Arconada Abstract M-currents have been shown to control neuronal excitability in a variety of central and peripheral neurones. Here we studied the effects of specific M-current modulators on the excitability of spinal neurones and their response to synaptic activation. Experiments were performed in vitro using the hemisected spinal cord from 7- to 11-day-old rats. Intracellular recordings were obtained from lumbar deep dorsal horn and motor neurones. Neuronal excitability was assessed by applying outward current pulses and synaptic responses were elicited by activation of a lumbar dorsal root. The M-current antagonist 10,10- bis(4-pyridinylmethyl)-9(10H)-anthracenone (XE-991) and the agonist retigabine were superfused at 10 µm. Retigabine produced hyperpolarization and a large decrease in the excitability of motor (7/7) and dorsal horn neurones (11/12). The effects of retigabine were fully reversed by XE-991. XE-991 induced depolarization of most neurones tested and a large increase in the excitability of motor neurones (7/7) but only a weak increase in the excitability of a proportion of dorsal horn neurones (4/10). The effects of XE-991 were partly reversed by retigabine. Consistent with their effects on neuronal excitability, retigabine showed a general depressant effect on synaptic transmission, whereas XE-991 showed the opposite tendency to potentiate responses to dorsal root stimulation, particularly in motor neurones. The results show that retigabine can depress spinal excitability and the transmission of nociceptive information. Results also indicate a post-synaptic expression of functional M-currents in most motor neurones and a considerable proportion of deep dorsal horn neurones. [source] PERSPECTIVE: TEACHING EVOLUTION IN HIGHER EDUCATIONEVOLUTION, Issue 10 2002Brian J. Alters Abstract., In the past decade, the academic community has increased considerably its activity concerning the teaching and learning of evolution. Despite such beneficial activity, the state of public understanding of evolution is considered woefully lacking by most researchers and educators. This lack of understanding affects evolution/science literacy, research, and academia in general. Not only does the general public lack an understanding of evolution but so does a considerable proportion of college graduates. However, it is not just evolutionary concepts that students do not retain. In general, college students retain little of what they supposedly have learned. Worse yet, it is not just students who have avoided science and math who fail to retain fundamental science concepts. Students who have had extensive secondary-level and college courses in science have similar deficits. We examine these issues and explore what distinguishes effective pedagogy from ineffective pedagogy in higher education in general and evolution education in particular. The fundamental problem of students' prior conceptions is considered and why prior conceptions often underpin students' misunderstanding of the evolutionary concepts being taught. These conceptions can often be discovered and addressed. We also attend to concerns about coverage of course content and the influence of religious beliefs, and provide helpful strategies to improve college-level teaching of evolution. [source] Functional biodiversity of macroinvertebrate assemblages along major ecological gradients of boreal headwater streamsFRESHWATER BIOLOGY, Issue 9 2005JANI HEINOArticle first published online: 3 AUG 200 Summary 1. Biodiversity,environment relationships are increasingly well-understood in the context of species richness and species composition, whereas other aspects of biodiversity, including variability in functional diversity (FD), have received rather little rigorous attention. For streams, most studies to date have examined either taxonomic assemblage patterns or have experimentally addressed the importance of species richness for ecosystem functioning. 2. I examined the relationships of the functional biodiversity of stream macroinvertebrates to major environmental and spatial gradients across 111 boreal headwater streams in Finland. Functional biodiversity encompassed functional richness (FR , the number of functional groups derived from a combination of functional feeding groups and habit trait groups), FD , the number of functional groups and division of individuals among these groups, and functional evenness (FE , the division of individuals among functional groups). Furthermore, functional structure (FS) comprised the composition and abundance of functional groups at each site. 3. FR increased with increasing pH, with additional variation related to moss cover, total nitrogen, water colour and substratum particle size. FD similarly increased with increasing pH and decreased with increasing canopy cover. FE decreased with increasing canopy cover and water colour. Significant variation in FS was attributable to pH, stream width, moss cover, substratum particle size, nitrogen, water colour with the dominant pattern in FS being related to the increase of shredder-sprawlers and the decrease of scraper-swimmers in acidic conditions. 4. In regression analysis and redundancy analysis, variation in functional biodiversity was not only related to local environmental factors, but a considerable proportion of variability was also attributable to spatial patterning of environmental variables and pure spatial gradients. For FR, 23.4% was related to pure environmental effects, 15.0% to shared environmental and spatial effects and 8.0% to spatial trends. For FD, 13.8% was attributable to environmental effects, 15.2% to shared environmental and spatial effects and 5% to spatial trends. For FE, 9.0% was related to environmental variables, 12.7% to shared effects of environmental and spatial variables and 4.5% to spatial variables. For FS, 13.5% was related to environmental effects, 16.9% to shared environmental and spatial effects and 15.4% to spatial trends. 5. Given that functional biodiversity should portray variability in ecosystem functioning, one might expect to find functionally rather differing ecosystems at the opposite ends of major environmental gradients (e.g. acidity, stream size). However, the degree to which variation in the functional biodiversity of stream macroinvertebrates truly portrays variability in ecosystem functioning is difficult to judge because species traits, such as feeding roles and habit traits, are themselves strongly affected by the habitat template. 6. If functional characteristics show strong responses to natural environmental gradients, they also are likely to do so to anthropogenic environmental changes, including changes in habitat structure, organic inputs and acidifying elements. However, given the considerable degree of spatial structure in functional biodiversity, one should not expect that only the local environment and anthropogenic changes therein are responsible for this variability. Rather, the spatial context, as well as natural variability along environmental gradients, should also be explicitly considered in applied research. [source] Clinical outcome of moderate haemophilia compared with severe and mild haemophiliaHAEMOPHILIA, Issue 1 2009I. E. M. DEN UIJL Summary., Information on outcome and treatment of patients with moderate haemophilia is scarce. In this study, we compared self-reported burden of disease in moderate haemophilia to severe and mild haemophilia. A nationwide questionnaire on bleeding pattern, treatment, impairment and quality of life was sent to 1567 Dutch patients with haemophilia. Out of 1066 respondents (response rate: 68%), 16% had moderate, 44% severe and 39% mild haemophilia. Median age was 36 years. Although overall outcome in moderate haemophilia was in between severe and mild haemophilia, moderate haemophilia patients did report a substantial burden of disease. The majority of patients with moderate haemophilia (73%) reported bleeds in the previous year; and a considerable proportion of moderate patients reported joint impairment (43%), chronic pain (15%), needed orthopaedic aids (24%) or were unemployed because of disability (27%). Within the group of moderate haemophilia patients, a large variation in bleeding pattern and outcome was observed. A quarter of patients with moderate haemophilia reported a more severe phenotype and intermittent use of prophylaxis. These patients reported frequent bleeding, with a median of eight bleeds per year, including two joint bleeds, and 68% reported joint impairment. In conclusion: Although outcome in moderate haemophilia is generally in between severe and mild haemophilia, moderate haemophilia patients reported a substantial burden of disease, and for more than 25% of patients with moderate haemophilia long term prophylaxis was implemented because of frequent bleeds. [source] Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held deviceHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 1 2007Catherine F. Poh DDS Abstract Background A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. Methods Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand-held device that permits the direct visualization of alterations to autofluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied. Results We present 3 representative cases in which occult lesions were identified with fluorescence visualization during longitudinal follow-up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3. Conclusions This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high-risk changes not apparent with white-light visualization. © 2006 Wiley Periodicals, Inc. Head Neck, 2006 [source] Detection of Enterohepatic and Gastric Helicobacter Species in Fecal Specimens of Children with Crohn's DiseaseHELICOBACTER, Issue 4 2008Si Ming Man Abstract Background: Although there is compelling evidence to support the role of bacteria in Crohn's disease (CD), there is currently no solid evidence to support the role of any one specific bacterial causative agent. Recent studies have suggested that members of the Helicobacteraceae may play a role in the development of CD. The aim of this study was to further investigate the presence of members of the Helicobacteraceae in children with and without CD. Materials and methods: Fecal specimens from 29 children with CD, 11 healthy, normal controls, and 26 symptomatic controls with non-inflammatory bowel disease (IBD) pathology were obtained for DNA extraction and subjected to Helicobacteraceae -specific polymerase chain reaction (PCR). All PCR-positive samples were sequenced. The association between the presence of members of the Helicobacteraceae and each study group was statistically analysed using the Fisher's exact test. Results: Based on Helicobacteraceae -specific PCR analysis, 59% (17 of 29) of the children with CD were positive, which was significantly higher than that in asymptomatic healthy children [9% (1 of 11); p = .01] and that in symptomatic children with non-IBD pathology [0% (0/26); p < .0001]. Sequencing of the 16S rRNA gene of positive samples revealed the presence of both enterohepatic Helicobacter species and Helicobacter pylori in fecal specimens. Conclusions: For the first time, enterohepatic and gastric Helicobacter species have been identified in fecal specimens from children diagnosed with CD using PCR. Our data suggest that Helicobacter species may have a pathogenic role in the development of CD in a considerable proportion of children. [source] Predictors of anemia in patients on hemodialysisHEMODIALYSIS INTERNATIONAL, Issue 3 2009Willy AASEBŘ Abstract Even though the use of erythropoietin and intravenous iron has improved the treatment of anemia in hemodialysis patients, a considerable proportion of these patients still have anemia. The aim of this study was to identify predictors of anemia in a hemodialysis population. In a single-center hemodialysis unit, all patients were studied with blood tests and their medication recorded during a period of 22 months. Correlations with hemoglobin (Hb) were performed with a simple regression or a t test. Variables that reached 5% significance were entered in a multiple regression analysis. Selected variables were presented in quartiles with levels of Hb. Mean Hb was 11.3 g/dL, and 53 patients (40%) had Hb<11.0 g/dL. In the simple regression analysis Hb correlated positively with s-iron, CHr, s-albumin, and doses of sevelamer, and negatively with sedimentation rate (SR), ferritin, base excess, and doses of erythropoietin. In the multiple regression analysis erythrocytes SR was the only variable that remained significant. Elevated SR is the strongest predictor of anemia in hemodialysis patients receiving adequate treatment with erythropoietin and intravenous iron. Patients using high doses of sevelamer had higher Hb levels than patients using low doses. [source] Atmospheric conditions associated with the exceptional fire season of 2003 in PortugalINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 13 2006Ricardo M. Trigo Abstract The summer of 2003 was characterised by exceptional warm weather in Europe, particularly during the first two weeks of August, when a devastating sequence of large fires was observed, reaching an amount of circa 450 000 ha, the largest figure ever recorded in Portugal in modern times. They were concentrated in two relatively confined regions of Portugal and a considerable proportion of burnt area was due to fires started on the 2nd and 3rd of August. It is shown that the 850 hPa temperature values observed over Portugal for the 1st and 2nd of August 2003 were the highest recorded since 1958. Using data from synoptic stations covering the entire Portuguese territory, the event was characterised in fine detail, including the evolution of both maximum and minimum temperatures, surface relative humidity, and wind anomaly fields. The different spatial extent of maximum and minimum temperatures is analysed leading to the new all-time Portuguese records of 47.3 °C for maximum and 30.6 °C for minimum temperatures that were recorded on the 1st of August near the main area of occurrence of the largest fire. Finally, it is shown that the summer of 2003 was preceded by a wet winter followed by a very dry month of May, a precipitation anomalous regime that contributed to a climatic background that favoured the role played by the early August heatwave and the associated meteorological surface conditions. Copyright © 2006 Royal Meteorological Society [source] Spatial population structure of a specialist leaf-mining mothJOURNAL OF ANIMAL ECOLOGY, Issue 4 2008Sofia Gripenberg Summary 1The spatial structure of natural populations may profoundly influence their dynamics. Depending on the frequency of movements among local populations and the consequent balance between local and regional population processes, earlier work has attempted to classify metapopulations into clear-cut categories, ranging from patchy populations to sets of remnant populations. In an alternative, dichotomous scheme, local populations have been classified as self-sustaining populations generating a surplus of individuals (sources) and those depending on immigration for persistence (sinks). 2In this paper, we describe the spatial population structure of the leaf-mining moth Tischeria ekebladella, a specialist herbivore of the pedunculate oak Quercus robur. We relate moth dispersal to the distribution of oaks on Wattkast, a small island (5 km2) off the south-western coast of Finland. 3We build a spatially realistic metapopulation model derived from assumptions concerning the behaviour of individual moths, and show that the model is able to explain part of the variation in observed patterns of occurrence and colonization. 4While the species was always present on large trees, a considerable proportion of the local populations associated with small oaks showed extinction,recolonization dynamics. The vast majority of moth individuals occur on large trees. 5According to model predictions, the dominance of local vs. regional processes in tree-specific moth dynamics varies drastically across the landscape. Most local populations may be defined broadly as ,sinks', as model simulations suggest that in the absence of immigration, only the largest oaks will sustain viable moth populations. Large trees in areas of high oak density will contribute most to the overall persistence of the metapopulation by acting as sources of moths colonizing other trees. 6No single ,metapopulation type' will suffice to describe the oak,moth system. Instead, our study supports the notion that real populations are often a mix of earlier identified categories. The level to which local populations may persist after landscape modification will vary across the landscape, and sweeping classifications of metapopulations into single categories will contribute little to understanding how individual local populations contribute to the overall persistence of the system. [source] Contemporary Immigration Policy Orientations Among Dominant-Group Members in Western EuropeJOURNAL OF SOCIAL ISSUES, Issue 3 2001James S. Jackson Predictors of immigration policy attitudes were investigated among members of receiving societies in large national probability samples in 15 Western European countries. We found that a considerable proportion of the variation in immigration policy orientations toward outgroups could be explained by self- and group interests and independent measures of perceived threat. Self-reported racism also contributed independently and significantly to these policy positions. It was concluded that a general framework of proximal self- and group-position indicators (Allport, 1954), perceived threat, and prejudice/racism was useful in predicting the immigrant policy orientations of dominant members of receiving societies across Western Europe. The meaning of these findings for future research on immigration policy orientations across, and especially within, European countries is discussed. [source] The prevalence of melanocytic naevi among schoolchildren in South HungaryJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 12 2008Z Csoma Abstract Background, Malignant melanoma is an increasing public health problem worldwide; accordingly, identification of the constitutional and environmental factors which contribute to the development of the disease, and hence identification of the individuals at high risk of melanoma, is an indispensable step in all primary prevention efforts. Objectives, This paper aims to assess the prevalence of different pigmented lesions among schoolchildren and to investigate their relationship with phenotypic pigmentary characteristics, sun exposure and other factors. Patients/methods, A cross-sectional study was performed in two secondary schools in Szeged, Hungary. A total of 1320 schoolchildren, aged 14 to 18 years, underwent a whole-body skin examination. A standardized questionnaire was used to collect data on phenotypic, sun exposure and other variables. Results, One to 10 common melanocytic naevi were found in 27% of the participants, and the naevus numbers were in the range of 10,100 in 67%; 5.4% of them had more than 100 common melanocytic naevi. The prevalence of clinically atypical naevi was 24.3%. Statistically significant associations were found between the number of pigmented lesions and gender, hair colour, eye colour, skin phototype, a history of severe painful sunburns and a family history of a large number of melanocytic naevi. Conclusion, Our study population displayed a markedly high prevalence of clinically atypical melanocytic naevi. Moreover, a considerable proportion of the investigated individuals had multiple common melanocytic naevi. Since the presence of a large number of melanocytic naevi is a strong predictor for future melanoma development, health educational programmes on melanoma prevention should be aimed at young age groups. [source] Frequency of renal impairment, advanced age, obesity and cancer in venous thromboembolism patients in clinical practiceJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 5 2007L. M. COOK Summary.,Background:,Low-molecular-weight heparin (LMWH) dosed by weight is recommended as first-line therapy for the initial treatment of venous thromboembolism (VTE) and as monotherapy for long-term treatment of cancer-related VTE. In ,special populations' such as those with renal impairment or the elderly, weight-based dosing may be excessive, and capping the dose in obese patients may lead to inadequate dosing. Objectives:,We determined the frequency of ,special population' characteristics (renal impairment, advanced age, obesity) and cancer among VTE patients in clinical practice, and assessed whether these characteristics appeared to influence the type and dose of anticoagulants prescribed. Methods:,During 2004,2005, among consecutive patients with VTE at two large Canadian hospitals, the proportions with the above characteristics were calculated and treatments prescribed were determined. Results:,Of 524 VTE patients, 31% were aged > 75 years. Moderate renal impairment [creatinine clearance (CrCl) 30,59 mL min,1] was present in 20% of patients, and severe renal impairment (CrCl < 30 mL min,1) in 5% of patients. LMWH was prescribed to 67% of patients with severe renal impairment and to 83% of patients with moderate renal impairment. Body weight was > 100 kg in 15% of patients. Underdosing of LMWH by > 10% was documented in 36% of such patients compared with 8% of patients < 100 kg (P < 0.001). Among 26% of patients with active cancer, only one-third were prescribed LMWH monotherapy. Conclusions:,In clinical practice, renal impairment, advanced age, obesity and cancer are frequently present in patients with VTE. A considerable proportion of these patients may not receive the optimal type or dose of medication to treat VTE. [source] Effects of temporal and spatial variations in food supply on the space and habitat use of red squirrels (Sciurus vulgaris L.)JOURNAL OF ZOOLOGY, Issue 2 2000Peter W. W. Lurz Abstract In non-native conifer plantations characterized by strong spatial and temporal variations in the availability of tree seeds in Spadeadam Forest, northern England, the home range and habitat use of red squirrels Sciurus vulgaris was very flexible. Males tended to have much larger home ranges than females and core-areas of most breeding females seemed mutually exclusive. Adult female red squirrels were found to increase their home range and core-area size in forest patches where food was less abundant. Home-range size was significantly related to home-range quality and the extent of overlap by other females. In contrast with high-quality continuous conifer forests: (1) a considerable proportion of adult males and females at Spadeadam shifted home range, (2) both sexes had much larger home ranges than reported from other habitats in Britain or Belgium. Many ranges were multinuclear, particularly from January onwards, when supplies of seeds become depleted through consumption and seed shed. Squirrels tracked the availability of conifer seeds (lodgepole pine cones throughout the study, Norway spruce cones in spring 1992 and Sitka spruce cones in autumn 1993) and intensively used several non-adjacent activity centres in temporally food-rich patches. Consequently, habitat preference changed markedly with time. The squirrels seemed to maximize nitrogen intake and to avoid the smaller seeds when possible. This resulted in an overall preference for a mixed diet of lodgepole pine and spruce seeds and avoidance of Sitka spruce seeds when Norway spruce seeds were available. These results lend support to the hypothesis of Ostfeld (1985) that when food is sparse and patchily distributed, females should develop intrasexual territoriality, concentrating their activity in food-rich patches, while males should be non-territorial and adapt their space use to the distribution of females. [source] Allocation of resources within mountain birch canopy after simulated winter browsingOIKOS, Issue 1 2000Kari Lehtilä As a response to browsing, birches are known to produce fewer but larger, more nutritious leaves, with enhanced palatability for herbivores. We simulated winter browsing in ramets of mountain birch (Betula pubescens ssp. czerepanovii) to find out whether it decreases subsequent foliage biomass and alters the number and type of shoots. After removal of a considerable proportion of buds (up to 35%) in late winter, the birches were able to compensate for the lost leaf biomass in the following summer; there were no differences in total leaf biomass between winter-clipped and control ramets. This indicates that foliage growth was limited by the total amount of stored resources, not by the number of buds. Depending on the position of the buds removed, different mechanisms were responsible for the compensation. After removal of apical buds, the number of leaves decreased significantly but leaves were larger than in control ramets. Removal of the same mass of basal buds , containing similar amount of carbohydrates and proteins as in the treatment removing apical buds , activated dormant buds, especially in apical locations, so that leaf number was similar as in the controls; consequently, size of individual leaves increased only slightly. Thus, while the total leaf biomass in a tree seems to be limited by resources from source organs, the distribution of resources among different canopy sections is controlled by their relative sink strengths. In terms of leaf biomass, apical parts are able to compensate for bud loss by increasing shoot number, basal parts only by increasing leaf size. [source] Thyroid function abnormalities among first-degree relatives of Iranian congenital hypothyroidism neonatesPEDIATRICS INTERNATIONAL, Issue 3 2010Mahin Hashemipour Abstract Background:, Congenital hypothyroidism (CH) is a relatively common metabolic disease in neonates. Until recent years the disorder was usually regarded as occurring in a sporadic manner. Over the past few years, however, a considerable proportion of familial cases have been identified, and possible roles of autoimmune factors suggested. The aim of the present study was to evaluate abnormality of thyroid function tests in first-degree relatives of CH neonates and compared this to the normal population. Methods:, From 2002 until 2007 thyroid function tests (T4 and thyroid-stimulating hormone [TSH]) were done in randomly selected CH and normal neonates (n= 194 and n= 350, respectively) and their first-degree relatives. Most mothers of the CH neonates and control groups were also evaluated for thyroid peroxidase antibody (TPOAb). Results:, Thyroid function test in first-degree relative of neonates with CH (361 parents, 136 siblings) were compared with those in control groups (665 parents, 478 siblings). Abnormal thyroid function tests were found in 85 patients in the CH group versus 96 patients in the control group; hypothyroidism was found in 75 (15.1%) and 57 subjects (5%) person in the CH and control groups, respectively (P < 0.05). Positive TPO antibody was found in 22 mothers (17.3%) of CH neonates in comparison with 65 mothers (32.5%) of control groups (P < 0.05). Frequency of hyperthyroidism in parents of control group had trend to be higher than parents of CH neonates (P= 0.05) Conclusion:, Familial and genetic components play a role in inheritance of CH, but maternal thyroid autoimmunity may not play an important role in the development of CH in Iran. [source] The use of prescription medicines and self-medication among children,a population-based study in Finland,PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 10 2010Sanna Ylinen Abstract Purpose The aim of this study was to investigate the prevalence and concomitant use of prescription medicines and self-medication, including over-the-counter (OTC) medicines, vitamins, and complementary and alternative medicines (CAMs) among Finnish children aged under 12 years. Methods We carried out a nationwide postal survey of the use of medicines by a representative sample (n,=,6000) of Finnish children aged under 12 years in spring 2007. A response rate of 67% (n,=,4032) was achieved. The current use of prescription medicines and the use of OTC medicines, vitamins, and CAMs in the preceding 2 days were the main outcome measures. Results In total, 17% of children had used prescription medicines and 50% some self-medication. The corresponding figures for OTC medicines, vitamins, and CAMs use were 17, 37, and 11%, respectively. Drugs for obstructive airway diseases were the most common prescription medicines, whereas analgesics and antipyretics, including non-steroidal-anti-inflammatory-medicines (NSAID), were the most common OTC medicines reported. Vitamin D was the most common vitamin, while fish oils and fatty acids were the most common CAMs used. Ten percent of the children had used prescription medicines and self-medication concomitantly. Conclusions Most of the children's medication consists of self-medication, and especially of vitamin use. However, also a considerable proportion had used prescription medicines, and a minority prescription medicines and self-medication concomitantly. In three of the cases, a combination of prescription and OTC medicine with a potential risk for interactions were found. Physicians should be aware of this wide use of self-medication when prescribing medicines. Copyright © 2010 John Wiley & Sons, Ltd. [source] Estimates of spatial and interchannel observation-error characteristics for current sounder radiances for numerical weather prediction.THE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 649 2010I: Methods, application to ATOVS data Abstract This is the first part of a two-part article that uses three methods to estimate observation errors and their correlations for clear-sky sounder radiances used in the European Centre for Medium-Range Weather Forecasts (ECMWF) assimilation system. The analysis is based on covariances derived from pairs of first-guess and analysis departures. The methods used are the so-called Hollingsworth/Lönnberg method, a method based on subtracting a scaled version of mapped assumed background errors from first-guess departure covariances and the Desroziers diagnostic. The present article reports the results for the three Advanced TIROS Operational Vertical Sounder (ATOVS) instruments: the Advanced Microwave Sounding Unit (AMSU)-A, High-Resolution Infrared Radiation Sounder (HIRS) and Microwave Humidity Sounder (MHS). The findings suggest that all AMSU-A sounding channels show little or no interchannel or spatial observation-error correlations, except for surface-sensitive channels over land. Estimates for the observation error are mostly close to the instrument noise. In contrast, HIRS temperature-sounding channels exhibit some interchannel error correlations, and these are stronger for surface-sensitive channels. There are also indications for stronger spatial-error correlations for the HIRS short-wave channels. There is good agreement between the estimates from the three methods for temperature-sounding channels. Estimating observation errors for humidity-sounding channels of MHS and HIRS appears more difficult. A considerable proportion of the observation error for humidity-sounding channels appears correlated spatially for short separation distances, as well as between channels. Observation error estimates for humidity channels are generally considerably larger than the instrument noise. Observation error estimates from this study are consistently lower than those assumed in the ECMWF assimilation system. As error correlations are small for AMSU-A, the study suggests that the current use of AMSU-A data in the ECMWF system in terms of observation-error or thinning-scale choices is fairly conservative. Copyright © 2010 Royal Meteorological Society [source] Visualisation of needle position using ultrasonographyANAESTHESIA, Issue 2 2006G. A. Chapman Summary Anaesthetists and intensivists spend a considerable proportion of their working time inserting needles and catheters into patients. In order to access deeper structures like central veins and nerves, they have traditionally relied on surface markings to guide the needle into the correct position. However, patients may present challenges due to anatomical abnormalities and size. Irrespective of the skill of the operator, there is the ever-present risk of needle misplacement with the potential of damage to structures like arteries, nerve bundles and pleura. Repeated attempts, even if ultimately successful, cause patient suffering and probably increase the risk of infection and other long term complications. Portable and affordable, high-resolution ultrasound scanners, has accelerated the interest in the use of ultrasound guidance for interventional procedures. Ultrasound guidance offers several advantages including a greater likelihood of success, fewer complications and less time spent on the procedure. Even if the target structure is identified correctly there is still the challenge to place the needle or other devices in the optimum site. The smaller and deeper the target, the greater the challenge and potential usefulness of ultrasound guidance. As a result of limited training in the use of ultrasound we believe that many clinicians fail to use it to its full potential. A lack of understanding, with regard to imaging the location of the needle tip remains a major obstacle. Needle visualisation and related topics form the basis for this review. [source] THE STUDY OF NABATAEAN ORGANIC RESIDUES FROM MADÂ'IN SÂLIH, ANCIENT HEGRA, BY GAS CHROMATOGRAPHY , MASS SPECTROMETRY,ARCHAEOMETRY, Issue 4 2009C. MATHE Four Nabataean samples collected in some of the monumental tombs of Madâ'in Sâlih, ancient Hegra, in Saudi Arabia, have been studied by gas chromatography coupled with mass spectrometry. These samples are textile fragments that are either covered with a black layer or bound together with some black amorphous substance. Fatty acids and triterpenoic compounds were detected. Eight triterpenic compounds were identified: ursa-9(11),12-dien-3-ol, ursa-9(11),12-dien-3-one, olean-9(11),12-dien-3,-ol, ,-amyrone, ,-amyrin, ,-amyrone, ,-amyrin and lupeol. The resinous chemical composition and these pentacyclic alcohols, in considerable proportion, indicate a resin of the Burseraceae family, possibly of the genus Canarium. [source] Social Welfare in Vietnam: A Curse or Blessing for Poor Children?ASIAN SOCIAL WORK AND POLICY REVIEW, Issue 2 2010Keetie Roelen Despite a rapid increase in economic growth accompanied by the rise of living standards over the last two decades in Vietnam, there is still a considerable proportion of the population that lives in poor and vulnerable conditions. Children in particular are disproportionately affected by poverty. The country employs a broad range of social protection programs that tend to be regressive in effect rather than supportive of the poor. The present paper evaluates the social welfare scheme in Vietnam in terms of child poverty. We use the Vietnam Household Living Standards Survey (VHLSS) 2006 and identify and quantify child poverty in monetary as well as multidimensional terms. We consider the link between social welfare receipt and poverty and evaluate coverage, exclusion, and inclusion errors. Furthermore, we use benefit incidence analysis to evaluate the impact of social welfare on monetary child poverty. Findings suggest that coverage of the social welfare scheme is limited and that the scheme suffers from considerable exclusion and inclusion errors. Furthermore, we find that social welfare only slightly reduces the incidence and depth of monetary poverty. [source] Kaposi's sarcoma-like lesions and other nodules as cutaneous involvement in AIDS-related visceral leishmaniasisBRITISH JOURNAL OF DERMATOLOGY, Issue 6 2000M.J. González-Beato A 40-year-old human immunodeficiency virus (HIV)-positive man had three relapses of visceral leishmaniasis (VL). In the third he developed nodular skin lesions of three types, some reminiscent of Kaposi's sarcoma. Biopsy of each type disclosed abundant dermal macrophages with a huge number of intracellular and extracellular Leishman,Donovan bodies. Rapid improvement of lesions was achieved after antiparasitic treatment. AIDS leads to atypical forms of leishmaniasis. Leishmania has been detected both in normal and pathological skin of these patients due to dissemination during VL. It is suspected that a considerable proportion of the population may be infected in endemic areas, Leishmania being opportunistic in immunosuppressed individuals. It is important to recognize the range of lesions that may occur in patients with HIV and VL, many of which are non-specific and may cause diagnostic difficulty. [source] Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatmentCANCER, Issue 13 2010A prospective study Abstract BACKGROUND: The incidence of chemotherapy-induced amenorrhea (CIA) and the time to subsequent menstrual bleeding in premenopausal breast cancer patients treated with current standard chemotherapy regimens was examined. METHODS: Four hundred sixty-six women ages 20 to 45 years at the time of diagnosis of a stage I to III breast cancer were recruited between January 1998 and July 2002. Patients completed monthly bleeding calendars from the time of study recruitment. Updated medical history data were obtained at 6-month intervals. RESULTS: Most women received doxorubicin and cyclophosphamide (AC); doxorubicin, cyclophosphamide, and paclitaxel (ACT); or cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). Approximately 41% of women experienced an initial 6 months of CIA, and an additional 29% had at least 1 year of CIA. Approximately half of the women with 6 months of CIA and 29% of those with 1 year of CIA resumed bleeding within the subsequent 3 years, usually in the year after their amenorrheic episode. Resumption of bleeding differed significantly by treatment regimen after 6 months of CIA (P = .002; 68% with AC, 57% with ACT, and 23% with CMF), but not after 1 year of CIA (P = .5). Of the 23% of women who experienced an initial 2-year period of CIA, 10% resumed bleeding within the ensuing 3 years after their amenorrheic episode, but none had regular menses. CONCLUSIONS: A considerable proportion of women treated with chemotherapy will experience periods of CIA, but many will resume bleeding. Newer treatment regimens such as ACT appear to have a higher resumption of bleeding compared with CMF. This finding may have implications for choice of anti-estrogen treatment and for future potential pregnancies/fertility. Cancer 2010. © 2010 American Cancer Society. [source] Social adversity predicts ADHD-medication in school children , a national cohort studyACTA PAEDIATRICA, Issue 6 2010A Hjern Abstract Aims:, To test the hypothesis that psychosocial adversity in the family predicts medicated ADHD in school children. Method:, ADHD-medication during 2006 was identified in the Swedish Prescribed Drug Register in national birth cohorts of 1.1 million 6,19 year olds. Logistic regression models adjusted for parental psychiatric disorders were used to test our hypothesis. Results:, There was a clear gradient for ADHD medication with level of maternal education, with an adjusted odds ratio of 2.20 (2.04,2.38) for the lowest compared with the highest level. Lone parenthood and reception of social welfare also implied higher risks of ADHD-medication with adjusted ORs of 1.45 (1.38,1.52) and 2.06 (1.92,2.21) respectively. Low maternal education predicted 33% of cases with medicated ADHD and single parenthood 14%. Conclusions:, Social adversity in the family predicts a considerable proportion of ADHD-medication in school children in Sweden. [source] Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classificationINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 4 2008U. John Abstract Little is known about psycholeptic and psychoanaleptic medicine (PM) use in the general population. This study presents prevalence data about PM use. The sample included 4310 individuals aged 20,79 from a general population health examination in a northern German area (participation proportion: 68.8%; Study of Health in Pomerania, SHIP). Medicines taken during the past seven days were assessed from the medicine packages or self-reports and classified according to the Anatomical Therapeutic Chemical (ATC) classification developed by the World Health Organization. In total, 6.3% of the sample reported PM intake, 8.7% of the women and 4.7% of the men. During the past 12 months prior to the health examination, 49.2% of the individuals with PM use consulted a general practitioner but not a neurologist or a psychiatrist. Among the study participants with PM use, 88.8% had one or more mental disorders during lifetime according to a screening questionnaire. It is concluded that considerable proportions of individuals with current PM use exist although lower than may be expected on the basis of the number of individuals with mental disorder in the general population. Copyright © 2008 John Wiley & Sons, Ltd. [source] Richness and diversity of helminth communities in tropical freshwater fishes: empirical evidenceJOURNAL OF BIOGEOGRAPHY, Issue 4 2000Anindo Choudhury Abstract Aim Published information on the richness and diversity of helminth parasite communities in tropical freshwater fishes is reviewed in response to expectations of species-rich parasite communities in tropical regions. Location Areas covered include the tropics and some subtropical areas. In addition, the north temperate area of the nearctic zone is included for comparison. Methods Data from 159 communities in 118 species of tropical freshwater fish, summarized from 46 published studies, were used for this review. Parasite community descriptors used in the analyses included component community richness and calculated mean species richness. Data from 130 communities in 47 species of nearctic north temperate freshwater fish were summarized from 31 studies and used for comparison. Results The component helminth communities of many tropical freshwater fish are species-poor, and considerable proportions of fish from certain parts of the tropics, e.g. West African drainages, are uninfected or lightly infected. Mean helminth species richness was low and equaled or exceeded 2.0 in only 22 of 114 communities. No single group of helminths was identified as a dominant component of the fauna and species composition was variable among and within broader geographical areas. The richest enteric helminth assemblages were found in mochokid and clariid catfish with a mixed carnivorous diet, whereas algal feeders, herbivores and detritivores generally had species-poor gut helminth communities. Comparisons indicated that certain areas in the north temperate region had higher helminth species richness in fishes than areas in the tropics. Main conclusions Expectations of high species richness in helminth communities of tropical freshwater fishes are not fulfilled by the data. Direct comparisons of infracommunities and component communities in host species across widely separated phylogenetic and geographical lines are inappropriate. Examination of latitudinal differences in richness of monophyletic parasite groups or of compound communities may uncover patterns different from those found in this study. Richness of helminth communities may be ultimately determined not by the number of host species present but by the degree of divergence of host lineages and by their diversification modes. A phylogenetic framework for hosts and parasites will reveal if increased host species richness within host clades, when host speciation is accompanied by habitat or diet specialization, or both, leads to lower helminth diversity in host species by fragmentation of a core helminth fauna characteristic or specific of the larger host clade. This pattern may be analysed in the context of cospeciation and acquisition from other unrelated hosts (host-sharing or host-switching). 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