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Selected AbstractsDirect toxicity assessment of wastewater: Baroxymeter, a portable rapid toxicity device and the industry perspectiveENVIRONMENTAL TOXICOLOGY, Issue 3 2002Achilles Tzoris Abstract Direct toxicity assessment of wastewater is becoming necessary, and new legislation may render it compulsory for the water industry. At present such assessment is performed at a laboratory away from a site, at considerable cost, and results often come too late, after a toxic event has occurred and the toxin has been released into the environment. Some of the rapid toxicity tests available today require certain conditions to function properly, or their results do not always correlate with other methods. The objective of this study was to assess a portable device, the Baroxymeter, for its suitability as an instrument to test wastewater toxicity. The way the device works is based on monitoring respiration of a bacterial culture by pressure measurements and using respiration inhibition as a toxicity alert. It has been shown that it is possible to detect toxic substances such as 3,5-dichlorophenol and bronopol within 5 min from a 1-mL sample. The benefits and future applications of the Baroxymeter as a high-throughput, cost-effective alternative for toxicity screening are discussed in this article. © 2002 Wiley Periodicals, Inc. Environ Toxicol 17: 284,290, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/tox.10059 [source] Short-term harvest planning including scheduling of harvest crewsINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 5 2003J. Karlsson Abstract The problem we consider is short-term harvesting planning for a total planning period of 4,6 weeks where we want to decide the harvest sequences or schedules for harvest crews. A schedule is an order or sequence of harvest areas assigned to each crew. The harvesting of areas is planned in order to meet industrial demand. The total cost includes harvesting, transportation, and storage. One considerable cost is due to the quality reduction of logs stored at harvest areas. There are a number of restrictions to be considered. Areas are of varying size and the composition of assortments in each area is different. Each harvest team has different skills, a different home base, and different production capacity. Another aspect is the road network. There is a cost related to road opening (restoring, snow removal). In this paper, we develop a mixed integer programming (MIP) model for the problem. The schedules are represented by 0/1 variables. With a limited number of schedules, the problem can be solved by a commercial MIP solver. We have also developed a heuristic solution approach that provides high-quality integer solutions within a distinct time limit to be used when more schedules are used. Computational results from a major Swedish forest company are presented. [source] Diagnosis and Management of the Painful Ankle/Foot.PAIN PRACTICE, Issue 4 2003Interpretation, Management, Part 2: Examination ,,Abstract: Diagnosis, interpretation, and subsequent management of ankle/foot pathology can be challenging to clinicians. A sensitive and specific physical examination is the strategy of choice for diagnosing selected ankle/foot injuries and additional diagnostic procedures, at considerable cost, may not provide additional information for clinical diagnosis and management. Because of a distal location in the sclerotome and the reduced convergence of afferent signals from this region to the dorsal horn of the spinal cord, pain reference patterns are low and the localization of symptoms is trustworthy. Effective management of the painful ankle/foot is closely linked to a tissue-specific clinical examination. The examination of the ankle/foot should include passive and resistive tests that provide information regarding movement limitations and pain provocation. Special tests can augment the findings from the examination, suggesting compromises in the structural and functional integrity of the ankle/foot complex. The weight bearing function of the ankle/foot compounds the clinician's diagnostic picture, as limits and pain provocation are frequently produced only when the patient attempts to function in weight bearing. As a consequence, clinicians should consider this feature by implementing numerous weightbearing components in the diagnosis and management of ankle/foot afflictions. Limits in passive motion can be classified as either capsular or non-capsular patterns. Conversely, patients can present with ankle/foot pain that demonstrates no limitation of motion. Bursitis, tendopathy, compression neuropathy, and instability can produce ankle/foot pain that is challenging to diagnose, especially when they are the consequence of functional weight bearing. Numerous non-surgical measures can be implemented in treating the painful ankle/foot, reserving surgical interventions for those patients who are resistant to conservative care.,, [source] Can early extubation and intensive physiotherapy decrease length of stay of acute quadriplegic patients in intensive care?PHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 1 2002A retrospective case control study Abstract Background and Purpose Respiratory complications remain a major cause of morbidity and mortality in the acute quadriplegic patient population. The literature has suggested that early insertion of a tracheostomy facilitated pulmonary management and an earlier discharge from the intensive care unit (ICU). Recently, a change in practice has meant that these patients are considered for extubation and intensive physiotherapy treatment, including an overnight on-call service, rather than tracheostomy. The aim of the present retrospective, case-controlled study was to determine if either practice resulted in a difference in length of stay in intensive care and if an on-call physiotherapy service for these patients was cost effective. Method A case control design was used. Between April 1997 and November 1999, seven patients who did not require a tracheostomy were identified; case control subjects were matched for severity with seven patients who did receive a tracheostomy. Length of stay in intensive care and on the acute ward, days from injury to fixation and the overall number of respiratory physiotherapy and night physiotherapy treatments were recorded. Results Five of the seven patients in the non-tracheostomy group received on-call overnight physiotherapy treatment, with an average of five sessions over a total of three nights. This group's length of stay in an ICU was significantly less than patients who were tracheostomized (p = 0.02). The overall number of physiotherapy treatments between the two groups was not significantly different. Conclusions The results of this study suggest that if extubation and intensive physiotherapy is undertaken for suitable patients, the length of stay in intensive care can be significantly reduced. This represents a considerable cost saving for ICUs and more than covers the added cost of providing an after hours on-call physiotherapy treatment service. A prospective evaluation is required to confirm these findings. Copyright © 2002 Whurr Publishers Ltd. [source] The Effect on Elderly Parents in Cambodia of Losing an Adult Child to AIDSPOPULATION AND DEVELOPMENT REVIEW, Issue 3 2007John Knodel Little systematic quantitative research is available on the parents of adults who become ill and die of AIDS despite their large number and the wide range of adverse consequences. This study, based on survey data from Cambodia, explores economic and social effects on parents in a country characterized by extreme poverty and a substantial AIDS epidemic. Results indicate that parents play a major role during the illness of an adult son or daughter, often sharing living quarters, providing care, and paying for illness-related expenses. These contributions to the societal response to AIDS come at considerable cost to parents at advanced ages. Multivariate analysis suggests lasting negative consequences for parents'economic well-being, and the consequences are more substantial if the adult child's death was from AIDS rather than from other causes. The study found little evidence of stigma associated with losing a grown child to AIDS: reactions from local community members are more likely to be sympathetic and supportive than negative. These results underscore the need for organizations dealing with AIDS to recognize the contributions older persons make in coping with the epidemic and to address the burden it imposes on them. [source] Phase II study of neoadjuvant chemotherapy and extended surgery for locally advanced gastric cancer,BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 9 2009T. Yoshikawa Background: Locally advanced gastric cancer with extensive lymph node metastasis is usually considered unresectable and so treated by chemotherapy. This trial explored the safety and efficacy of preoperative chemotherapy followed by extended surgery in the management of locally advanced gastric adenocarcinoma. Methods: Patients with gastric cancer with extensive lymph node metastasis received two or three 28-day cycles of induction chemotherapy with irinotecan (70 mg/m2 on days 1 and 15) and cisplatin (80 mg/m2 on day 1), and then underwent gastrectomy with curative intent with D2 plus para-aortic lymphadenectomy. Primary endpoints were 3-year overall survival and incidence of treatment-related death. Results: The study was terminated because of three treatment-related deaths when 55 patients had been enrolled (mortality rate above 5 per cent). Two deaths were due to myelosuppression and one to postoperative complications. Clinical response and R0 resection rates were 55 and 65 per cent respectively. The pathological response rate was 15 per cent. Median overall survival was 14·6 months and the 3-year survival rate 27 per cent. Conclusion: This multimodal treatment of locally advanced gastric cancer provides reasonable 3-year survival compared with historical data, but at a considerable cost in terms of morbidity and mortality. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. [source] Drug misuse and acquisitive crime among clients recruited to the National Treatment Outcome Research Study (NTORS)CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2000Duncan Stewart Background Criminal activity among drug-misusing populations can result in considerable costs. This paper examines the relationship between acquisitive criminal behaviour and drug use among a cohort of 1075 clients recruited to the National Treatment Outcome Research Study (NTORS). Method Clients were recruited from 54 drug misuse treatment programmes in England. A structured interview was administered by clinical staff. The majority of clients were opiate-dependent poly-drug users. Results 27 000 acquisitive criminal offences were reported by the cohort in the three months prior to starting treatment, of which shoplifting was the most common offence. There was marked variation in the amount of acquisitive crime reported; just 10% of the sample were responsible for three-quarters of the crimes committed. Two other groups were identified: low-rate offenders, and those who did not commit an acquisitive crime. Multivariate analyses revealed that frequency of illicit drug use was associated with increased levels of criminal behaviour. Compared with the no-crime group, the high-rate offenders were 11 times more likely to be regular users of heroin, and three times more likely to have used cocaine regularly. Discussion These findings suggest that the most dependent and problematic drug misusers present treatment services with the greatest challenge in terms of reducing levels of criminality. Copyright © 2000 Whurr Publishers Ltd. [source] Experimental reduction of incubation temperature affects both nestling and adult blue tits Cyanistes caeruleusJOURNAL OF AVIAN BIOLOGY, Issue 5 2008Johan F. Nilsson Incubation was for a long time considered to be a period of decreased activity and low cost for parents. It was therefore ignored as a potential factor affecting life-history trade-offs in birds. Lately this view has started to change, and studies now show that there might be considerable costs connected to incubation. We experimentally reduced the nest temperature during incubation in blue tits Cyanistes caeruleus, thus increasing the energetic cost of incubation, to test the importance of incubation as a component of reproductive costs and for nestling quality. While most other studies use brood size manipulation to manipulate reproductive costs, we were able to separate treatment effects acting during the incubation period from those acting on later reproductive performance by applying a cross-foster design. We were also able to isolate the effects of decreased incubation temperature on the nestlings from treatment effects acting on incubating females. We found no experimental effect on the length of the incubation period or on hatching success. The lower temperature during incubation, however, caused lower growth rates in nestlings and reduced chick rearing capacity in adults. We conclude that incubation is a costly period, with the potential to affect both the trade-off between current and future reproduction and the one between parental effort and offspring quality within the current breeding attempt. [source] Transition pathways for young people with complex disabilities: exploring the economic consequencesCHILD: CARE, HEALTH AND DEVELOPMENT, Issue 4 2008M. Knapp Abstract Background Disabled young people with complex needs face particular challenges when they reach adulthood and seek to move from school to employment or further education. There are potentially substantial personal and social costs arising from these challenges. Methods We sought evidence from recent UK research, policy and related literatures; undertook exploratory statistical analyses of birth cohort data; and analysed information provided by 30 disabled young people requiring high levels of practical and communication support. Results The personal, family and social costs that result from unsuccessful transition are substantial and wide-ranging. Health service and local authority expenditure are important elements, but do not allow young people to achieve the educational or employment goals to which they aspire, resulting in considerable costs for the state, whether through missing opportunities to contribute to the economy or through dependence on welfare benefits. Conclusions The considerable sums currently spent on disabled children and young people are clearly not enough, or not deployed appropriately, to enable those who reach adulthood to fulfil their ambitions, or to meet government policy intentions for young people to achieve economic well-being. [source] | |||||||||||||