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Computer Software (computer + software)
Terms modified by Computer Software Selected AbstractsPatentability of Computer Software under U.S. LawTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 5 2000Mark J. Abate First page of article [source] Utility of software analysis of esophageal manometry studies in patients with aperistalsisDISEASES OF THE ESOPHAGUS, Issue 1 2009P. A. Hart SUMMARY Esophageal manometry is the gold standard for the diagnosis of esophageal aperistalsis. There is computer software that analyzes peristalsis on esophageal manometry, but this automated analysis has not been formally evaluated. Our primary aim was to evaluate the software analysis of esophageal aperistalsis by esophageal manometry in patients diagnosed with aperistalsis by an experienced clinician. Esophageal manometry studies from January 2006 to November 2007 were retrospectively reviewed for evidence of aperistalsis by an experienced clinician. All studies demonstrating aperistalsis were selected for further review. The automated analysis performed by our software program for each study was recorded. Agreement between the automated analysis and the clinician was measured by the proportion of agreement on the absence of peristalsis. Eighty-seven of the 962 esophageal manometry studies reviewed demonstrated aperistalsis. The automated analysis reported esophageal body peristalsis with wet swallows in 66 out of 87 patients (75.9%). In these patients, the software analyzed an average of 34.2% of the wet swallows as peristaltic. The agreement between the clinician's review and software analysis of aperistalsis was 24.1%. These data suggest there is poor agreement between the automated analysis of peristalsis and that of an experienced reviewer. Automated analysis cannot be relied upon in the diagnostic evaluation of esophageal aperistalsis as it overestimates the presence of peristalsis and may lead to incorrect diagnoses and management strategies. [source] A continuing education programme for general practitionersEUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 2 2000Status report after 5 years of function In 1992, following newly issued university regulations, the board of the School of Dental Medicine of the University of Geneva decided to establish a structured continuing education course programme for practising dentists in an effort to better meet the school's continuing education mandate. The programme started in January 1994 and was structured so that regular courses would be offered in each discipline of dentistry. The course contents were aimed at satisfying the demands of practising dentists, but it was also established that basic science issues and theoretical concepts should be included. Possible course formats were ,conference', ,hands-on', ,clinical' and ,seminar'. The courses were meant as a form of knowledge transfer from the school to the practising community, but also as a means to generate revenue for research and teaching programmes. Operative aspects were supervised by a small staff which was assisted by computer software designed to handle all procedural steps of course administration, participant registration, accounting, communication. The dentists' responses were rewarding in that attendance was very satisfactory. Closer scrutiny of our data, however, indicates that our impact is still low since at best only 20% of the course-hours required by the Swiss dental association are actually taken. Both course and programme evaluations were satisfactory and are discussed using the Harden and Laidlaw CRISIS criteria. [source] Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' viewsHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 3 2007Mark Avis BA(Hons) MSc RN RNT Cert Ed Abstract The objectives of the present study were to examine the factors that parents identify as promoting or hindering participation in Sure Start programmes, and to identify methods for enhancing parents' engagement with Sure Start. A qualitative, in-depth interview study was conducted with parents registered with two local Sure Start programmes based in the East Midlands, UK, and located in inner city areas with a range of health and social problems associated with social exclusion and disadvantage. Sixty parents, guardians or carers of children living in both Sure Start areas were recruited during autumn of 2004 on the basis of whether they were identified as a ,frequent user' or ,non-frequent user' of Sure Start services. The data were analysed using a thematic approach supported by NVivo computer software, and explanatory themes were subsequently tested for completeness and adequacy. The results of the study indicated that parents who used Sure Start services were positive about the benefits that they obtained for themselves and their children, in particular in overcoming a sense of isolation. Parents who were non-frequent users identified a number of practical reasons that prevented them using Sure Start services, although parents also recognised a loss of confidence and trust in the local communities summarised in the phrase ,keeping myself to myself'. Parents' awareness of the targeted nature of Sure Start can also lead to stigma and reluctance to use services. It is concluded that continued investment of time and effort in maintaining communication networks between Sure Start staff and local parents is vital if parents and children are to make the best use of Sure Start services. [source] Toward a hybrid model for usability resource allocation in industrial software product developmentHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 3 2007Colleen M. Duffy The organizational aspects of user-centered software development in a financial services company are presented. The financial services industry sector is one of the industrial sectors to embark on the development of computer software as a consumer product. The nature of business in the service sector predisposes it to encounter difficulties in developing software aimed at meeting customer demands. Lack of familiarity and experience with the product design and implementation processes, as well as reliance on usability for acceptance, are major obstacles encountered. Difficulties, insights, and lessons learned regarding organizational ergonomics issues faced by a user-centered design group are provided, and a hybrid resource distribution model is proposed to guide other service sector companies in their future software development efforts. © 2007 Wiley Periodicals, Inc. Hum Factors Man 17: 245,262, 2007. [source] Can a long-term continuing education course in patient counselling promote a change in the practice of Finnish community pharmacists?INTERNATIONAL JOURNAL OF PHARMACY PRACTICE, Issue 3 2003Heli Kansanaho assistant in social pharmacy ABSTRACT Objective To assess community pharmacists' perceptions of the impact of a long-term continuing education (CE) course on their patient counselling skills. Methods Three focus groups were conducted with the course participants (n = 17) during the last module of the CE course. Data were analysed using computer software for qualitative analysis. Key findings The focus groups revealed eight preliminary categories that were further categorised into four themes related to the learning process in patient counselling skills. The first theme related to achieving the learning objectives. The second related to personal development, understanding principles of two-way communication, and problems in their implementation in practice. The third theme related to actions taken by the participants in their work place, and the fourth involved the potential conflict between the new skills gained and the traditional communication culture in the participant's pharmacy. Conclusion The CE course provided the community pharmacists with new skills and knowledge in patient counselling and collective in-house training. The findings show that the greatest challenge is to change the communication culture of the pharmacy. To achieve this, it may be necessary for more than one pharmacist from the same pharmacy to participate in the training process at the same time. [source] Learning statistics by computer software is cheatingJOURNAL OF COMPUTER ASSISTED LEARNING, Issue 3 2001J. Maltby No abstract is available for this article. [source] On the evolution of statistical methods as applied to clinical trialsJOURNAL OF INTERNAL MEDICINE, Issue 5 2004D. Machin Abstract. This paper describes how statistical methods have evolved in parallel with activities associated with randomized control trials. In particular we emphasize the pivotal role of two papers published in British Journal of Cancer, and the paper describing the Cox proportional hazards model. In addition, the importance of early papers on estimating the sample size required for trials is highlighted. Later developments including the increasing roles for competing risks, multilevel modelling and Bayesian methodologies are described. The interplay between computer software and statistical methodological developments is stressed. Finally some future directions are indicated. [source] Nursing Research and HIV Infection: State-of-the-ScienceJOURNAL OF NURSING SCHOLARSHIP, Issue 3 2000Barbara A. Goldrick Purpose: To provide an update of the nursing research literature on HIV infection and to develop an HIV/AIDS database using arcs© computer software. Methods: Nursing research literature from 1986 through 1997 on human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) was reviewed. With an emphasis on client-focused research, 246 studies were entered into the arcs© HIV/AIDS database. Findings: Analysis of over 1,000 citations in the HIV/AIDS nursing research literature over the past decade indicated that 22% (n = 219) of the nursing studies were client- or patient-focused; 29% (n = 292) were risk-group focused; and 49% (n = 492) were provider-focused. Of the 246 studies entered into the arcs© HIV/AIDS database, 88 (35.7%) were classified in the psychologic domain, 65 (26.4%) in the physiologic domain, 24 (9.7%) in the behavioral domain, and 25 (10%) in the social domain. In addition, 17 (6.9%) of the studies were classified in the quality of life domain, and 27 (10.9%) in the stage of HIV disease domain. The majority (53%) of the 246 studies (n = 131) were correlational, 86 (35%) were descriptive, and 29 (12%) had experimental or quasi-experimental designs. Conclusions: Although nursing studies have described some of the problems that affect HIV-infected people, further research is needed, particularly related to clinical interventions. [source] Effects of rotation on measurement of lower limb alignment for knee osteotomyJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 6 2004Hideo Kawakami Abstract The purposes of this study were to clarify the effects of rotation on two-dimensional measurement of lower limb alignment for knee osteotomy using a three-dimensional method and to determine whether this 3-D simulation method could help with planning of knee osteotomy. We developed computer software to calculate femorotibial angle (FTA) and hip,knee,ankle angle (HKA) and simulate knee osteotomy from a CT-based 3-D bone model of the lower limb. Lower limb rotation on anteroposterior long-standing radiographs was measured by superimposing the 3-D bone models. Changes in alignment with limb rotation were calculated using the software. FTA after virtual closed-wedged osteotomy was measured for a hypothetical case of a rotation error of the osteotomy plane in reattaching the proximal cutting surface to the distal cutting surface. For 31 varus knees in 20 patients with medial compartment arthritis, the mean rotation angle, relative to the epicondylar axis, with variable limb position was 7.4 ± 3.9° of internal rotation (mean ± SD), ranging from 8° of external rotation to 14° of internal rotation; the mean changes in FTA and HKA were 3.5 ± 2.2° (range, 0.4,8.6) and 1.6 ± 1.3° (range, 0.2,4.9), respectively. The FTA "flexion angle" (lateral view alignment from neutral AP) and the absolute HKA "flexion angle" correlated with the change in FTA and HKA with limb rotation, respectively (FTA, R = 0.999; HKA, R = 0.993). The mean change in FTA after virtual closed-wedged osteotomy was 3.2° for internal and external 10° rotation errors in reattaching the osteotomy plane. Rotation may affect measurement of lower limb alignment for knee osteotomy, and 3-D methods are preferable for surgical planning. © 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. [source] The Effect of a Constant Electrical Field on Osseointegration after Immediate Implantation in Dog Mandibles: A Preliminary StudyJOURNAL OF PROSTHODONTICS, Issue 5 2007Yadollah Soleymani Shayesteh DDS Purpose: The long time span between insertion of implants and functional rehabilitation often inconveniences patients. Accelerating bone growth around dental implants can shorten this time span. This in vivo study evaluated the effect of a constant electrical field on bone growth around dental implants. Materials and Methods: Four mongrel dogs were used in this study. Sixteen dental implants were placed immediately after extraction of the first premolar and molar teeth. A constant electrical field (CEF) generator was placed in the mucoperiostal pouch created from the subperiostral dissection under the inferior border of the dog's mandible and connected to the experiment side fixtures. CEF provided 3 V of electrical potential during osseointegration. Histologic sections were stained with hematoxylin,eosin and observed under light microscopy. The sections were analyzed histomorphometrically to calculate the amount of newly formed bone. Statistical analysis was performed with SPSS 11.0 computer software (,= 0.05). Results: At the end of the first stage of the osseointegration (90 days) CEF group sections showed enhanced growth of the trabeculae compared with the control group. Statistical analysis revealed significant differences between experimental and control groups. Bone contact ratio was statistically significant in the experimental group (p= 0.001). An increase in the local bone formation and bone contact ratio was observed with direct electrical stimulation of the implant and the bone area around the implant. Conclusion: Minimal direct electrical current, which can produce an electrical field around the implant, can increase the amount of bone formation and decrease the time of osseointegration. [source] The lipophilicity indices of flavonoids estimated by reversed-phase liquid chromatography using different computation methodsJOURNAL OF SEPARATION SCIENCE, JSS, Issue 12 2009Rodica Domnica Briciu Abstract The chromatographic behavior of some flavonoids was established by RP-HPLC on RP-18 (LiChroCART, LiChrosphere RP-18e), RP-8 (Zorbax, Eclipse XDB-C8), CN (Säulentechnik, LiChrosphere CN100) columns. The mobile phases were mixtures of methanol-water in different volume proportions from 70 to 80% v/v for RP-18 and RP-8, while for the CN column the proportions were between 66 and 70% v/v. The lipophilicity was expressed through different lipophilicity descriptors such as mean of k (mk), mean of log k (mlog k), log kW, S, f0, and scores of k and log k corresponding to the first principal component. The experimental lipophilicity indices are directly correlated with the computed values, via computer software and internet module, at a high analytical level. Furthermore, the results obtained applying principal component analysis to k and/or log k values allow the prediction and explanation of the interaction involved in the retention mechanism which takes place between the compounds and the employed stationary phases during the development. [source] Accounting for co-extractable compounds (blank correction) in spectrophotometric measurement of extractable and total-bound proanthocyanidin in Leucaena sppJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 8 2002Scott A Dalzell Abstract Methods to account for the spectral interference of co-extractable compounds (blank correction) in the spectrophotometric analysis of both extractable and bound proanthocyanidin (PA) using the proanthocyanidin (butanol/HCl) assay were evaluated. Crude extractable and bound PA sample matrices of PA-free Leucaena magnifica were used. Extractable PA blanks generated in heated 95% butanol/5% H2O reagent underestimated the optical density (absorbance) of co-extractable compounds by 24% (P,<,0.01), whereas unheated 95% butanol/5% HCl blanks, incubated at room temperature, accurately measured the absorbance of the background matrix (P,<,0.01). Current procedures that estimate bound PA concentrations using the proanthocyanidin assay produce intensely coloured background matrices. Recovery measurements from total-bound PA extracts spiked with 1071 and 2142,µg anthocyanidin per tube indicated that existing analytical procedures that do not account for the spectral interference of co-extractable compounds overestimated (P,<,0.01) bound PA concentrations by 69 and 38% respectively. An innovative technique that generated an internal correction factor for each sample, using wavelength-scanning spectrophotometry and non-linear curve-fitting computer software, was developed. This procedure recovered 100% of added anthocyanidins from bound PA matrices. © 2002 Society of Chemical Industry [source] Quantification of Video-Taped Images in Microcirculation Research Using Inexpensive Imaging Software (Adobe Photoshop)MICROCIRCULATION, Issue 2 2000Joachim Brunner ABSTRACT Background: Study end-points in microcirculation research are usually videotaped images rather than numeric computer print-outs. Analysis of these videotaped images for the quantification of microcirculatory parameters usually requires computer-based image analysis systems. Most software programs for image analysis are custom-made, expensive, and limited in their applicability to selected parameters and study end-points. Methods and Result: We demonstrate herein that an inexpensive, commercially available computer software (Adobe Photoshop), run on a Macintosh G3 computer with inbuilt graphic capture board provides versatile, easy to use tools for the quantification of digitized video images. Using images obtained by intravital fluorescence microscopy from the pre- and postischemic muscle microcirculation in the skinfold chamber model in hamsters, Photoshop allows simple and rapid quantification (i) of microvessel diameters, (ii) of the functional capillary density and (iii) of postischemic leakage of FITC-labeled high molecular weight dextran from postcapillary venules. We present evidence of the technical accuracy of the software tools and of a high degree of interobserver reliability. Conclusions: Inexpensive commercially available imaging programs (i.e., Adobe Photoshop) provide versatile tools for image analysis with a wide range of potential applications in microcirculation research. [source] Genomic repertoire of human mesangial cells: comprehensive analysis of gene expression by cDNA array hybridizationNEPHROLOGY, Issue 4 2000Naohiro Yano SUMMARY: Knowing when and where a gene is expressed in a cell often provides a strong clue as to its physiological role. It is estimated the human genome contains 80 000,100 000 genes. Assessment of gene activity on a global genome-wide scale is a fundamental and newly developed experimental strategy to expand the scope of biological investigation from a single gene to studying all genes at once in a systematic way. Capitalizing on the recently developed methodology of cDNA array hybridization, we monitored the simultaneous expression of thousands of genes in primary human mesangial cells. Complex ,- 33P-labelled cDNA probes were prepared from cultured mesangial cells. The probe was hybridized to a high-density array of 18 326 paired target genes. The radioactive hybridization signals were analysed by phosphorimager. Bioinformatics from public genomic databases was utilized to assign a chromosomal location of each expressed transcript. Approximately 7460 different gene transcripts were detected in mesangial cells. Close to 13% (957 genes) were full-length mRNA human transcripts (HTs), the remainder 6503 being expressed sequence tags (ESTs). Using special imaging computer software, the transcriptional level of the 957 HTs was compared with the expression of the ribosomal protein S28 (housekeeping gene). The HTs were also classified by function of the gene product and listed with information on their chromosomal loci. To allow comparison between clinical and experimental studies of gene expression, the detected human gene transcripts were cross-referenced to orthologous mouse genes. Thus, the presented data constitute a quantitative preliminary blueprint of the transcriptional map of the human mesangial cell. The information may serve as a resource for speeding up the discovery of genes underlying human glomerular diseases. The complete listing of the full-length expressed genes is available upon request via E-mail: (Abdalla_Rifai@Brown.edu). [source] The effect of mosapride citrate on proximal and distal colonic motor function in the guinea-pig in vitroNEUROGASTROENTEROLOGY & MOTILITY, Issue 2 2008H. S. Kim Abstract, Mosapride citrate (mosapride), a substituted benzamide, is a selective 5-HT4 receptor agonist, and is known to have prokinetic properties on the stomach. However, it is unclear whether mosapride also has a prokinetic effect on the colon. We previously found that mosapride significantly shortened colonic transit time in the guinea-pig, an animal with a distribution of colonic 5-HT4 receptors similar to that of a human. So, we aimed to separately evaluate the effect of mosapride on proximal and distal colonic motor function in the guinea-pig. Proximal (approximately 8 cm from the ileocolic junction) and distal colon (approximately 8 cm from the anus) were removed. Both ends of the colon were connected to a chamber containing a Krebs-Henseleit solution. To measure colonic transit time, artificial faeces were inserted into the oral side of the lumen and moved towards the anal side by intraluminal perfusion via a peristaltic pump. A total of 6 cm of transit was observed and time was measured in 2 cm increments. A tissue bath study, using electrical stimulation, was performed to estimate the contractile activity of the circular musculature of the colon. Immunohistochemical staining for 5-HT4 receptors was performed in the myenteric plexus and circular muscle in both proximal and distal colon, and the stained area was measured using a microscope and computer software. Mosapride enhanced contraction at 10,9 to 10,7 mol L,1, coinciding with rapid transit both in proximal and distal colon. This pattern was more prominent in proximal colon. At the high dose (10,6 mol L,1) mosapride had little or no effect on colonic contraction. This stimulatory effect was attenuated by GR113808, atropine and tetrodotoxin. In the myenteric plexus, the density of 5-HT4 receptors was significantly greater in the proximal colon than in the distal colon, but in circular muscle the density was greater in the distal colon. Thus, mosapride accelerates transit through increased contraction in the proximal colon more than distal colon. The different distribution of neuronal and muscular 5-HT4 receptors may support these findings. Therefore, mosapride may be a useful alternative to tegaserod and cisapride for constipation. [source] Evaluating the efficacy of tele-cognitive rehabilitation for functional performance in three case studiesOCCUPATIONAL THERAPY INTERNATIONAL, Issue 1 2003Dr Sing-Fai Tam PhD Associate Professor Abstract Traumatic brain injury (TBI) is one of the main causes of long-term disability, and its rehabilitation is a challenge to the healthcare team. Tele-rehabilitation, through using advancements in networking and tailor-made software, has been developed and applied to the cognitive rehabilitation of persons with brain injury in the present study. Tele-cognitive rehabilitation uses customized online computer software as a treatment mode. The online treatment software is operated on an interactive tele-communication platform , for example, video conferencing with screen sharing. Through implementing the tele-cognitive rehabilitation activities, therapists can help clients to practise and thus improve their cognitive skills through using the treatment software successfully. Moreover, hypermedia programming techniques allow the therapist to adjust the software to meet the client's treatment needs, so that the treatment is appropriate to his/her functional levels and living environment. Also the software can customize immediate visual, auditory and personalized feedback to motivate the client and training can be set at the right pace for the client's needs. The present study aimed to evaluate the effectiveness and perceived efficacy of the newly developed customized tele-cognitive rehabilitation programme for three subjects with traumatic brain injury through using single-case and qualitative research design. The cognitive factors investigated in this pilot study were, respectively, Chinese word recognition, prospective memory and semantic memory. The subjects had undergone a recruitment process with stipulated screening criteria. A single case experimental design (ABA reversal/withdrawal design) consisted of a no-intervention baseline phase (A), an intervention phase (B) and a no-intervention withdrawal phase (A). There were six sessions in each phase, making a total of 18 sessions. Tele-cognitive rehabilitation software was tailor-made according to each subject's cognitive functional needs. To monitor the change in cognitive functions, variables were tapped by tailor-made assessment and qualitative questionnaires through interviews, and they were then used to explore subjects' opinions of the programme and to test the treatment efficacy of the tele-cognitive rehabilitation programme. Finally, the relationships among the three phases were analysed through visual analysis and trend line analysis by means of the split-middle method. The three persons with brain injury showed improving trends and levels of specific cognitive performance during the treatment phase. Qualitative findings were analysed and confirmed the efficacy of the treatment module. The tele-cognitive rehabilitation approach was well received by subjects. The authors suggest that further replication studies of this kind should be conducted in the future and that more subjects should be recruited to improve the generalizability of the results. Copyright © 2003 Whurr Publishers Ltd. [source] Comparing indirect methods of digit ratio (2D:4D) measurementAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 2 2009Christoph J. Kemper The ratio of the lengths of the second and fourth finger (2D:4D) has been proposed to index prenatal exposure to androgens. Different methods have been utilized to measure digit ratio, however, their measurement precision and economy have not been systematically compared yet. Using different indirect methods (plastic ruler, caliper, computer software), three independent raters measured finger lengths of 60 participants. Generally, measurement precision (intraclass correlation coefficient, technical error of measurement, and relative technical error of measurement) was acceptable for each method. However, precision estimates were highest for the computer software, indicating excellent measurement precision. Estimates for the caliper method were somewhat lower followed by ruler which had the lowest precision. On the contrary, the software-based measurements took somewhat longer to complete than the other methods. Nonetheless, we would favor the use of these tools in digit ratio research because of their relative superior reliability which could be crucial when associations with other variables are expected to be low to moderate or sample size is limited. Software offers several promising opportunities that may contribute to an accurate identification of the proximal finger crease (e.g., zooming, adjusting contrast, etc.). Am. J. Hum. Biol., 2009. © 2008 Wiley-Liss, Inc. [source] Carbon starvation survival of Listeria monocytogenes in planktonic state and in biofilm: A proteomic studyPROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 10 2003Emmanuelle Helloin Abstract The proteomes of Listeria monocytogenes expressed in suspension and biofilm state, in the presence and absence of a caron source, were analysed by two-dimensional electrophoresis with the help of computer software. The up-regulated proteins in each case were identified by peptide sequencing using electrospray ionisation tandem mass spectrometry and a database search against the Listeria genome was performed. Relevant functions could be attributed to a number of the induced proteins which contibute to the understanding of the mechanisms of starvation survival of L. monocytogenes in planktonic state and in biofilm. [source] Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrixRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 13 2008Zhengyin Yan In addition to matrix effects, common interferences observed in liquid chromatography/tandem mass spectrometry (LC/MS/MS) analyses can be caused by the response of drug-related metabolites to the multiple reaction monitoring (MRM) channel of a given drug, as a result of in-source reactions or decomposition of either phase I or II metabolites. However, it has been largely ignored that, for some drugs, metabolism can lead to the formation of isobaric or isomeric metabolites that exhibit the same MRM transitions as parent drugs. The present study describes two examples demonstrating that interference caused by isobaric or isomeric metabolites is a practical issue in analyzing biological samples by LC/MS/MS. In the first case, two sequential metabolic reactions, demethylation followed by oxidation of a primary alcohol moiety to a carboxylic acid, produced an isobaric metabolite that exhibits a MRM transition identical to the parent drug. Because the drug compound was rapidly metabolized in rats and completely disappeared in plasma samples, the isobaric metabolite appeared as a single peak in the total ion current (TIC) trace and could easily be quantified as the drug since it was eluted at a retention time very close to that of the drug in a 12-min LC run. In the second example, metabolism via the ring-opening of a substituted isoxazole moiety led to the formation of an isomeric product that showed an almost identical collision-induced dissociation (CID) MS spectrum as the original drug. Because two components were co-eluted, the isomeric product could be mistakenly quantified and reported by data processing software as the parent drug if the TIC trace was not carefully inspected. Nowadays, all LC/MS data are processed by computer software in a highly automated fashion, and some analysts may spend much less time to visually examine raw TIC traces than they used to do. Two examples described in this article remind us that quality data require both adequate chromatographic separations and close examination of raw data in LC/MS/MS analyses of drugs in biological matrix. Copyright © 2008 John Wiley & Sons, Ltd. [source] Copyright Protection for Computer Programs in South Africa: Aspects of Sui Generis CategorizationTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 4 2009Lee-Ann Tong This article considers the protection of computer software in South Africa. It deals specifically with copyright of computer programs as provided for in the Copyright Act 98 of 1978 which makes provision for the categorization of computer programs as a sui generis category of works distinct from literary works. It explores the level of copyright protection under this regime with reference to aspects like the subsistence of copyright, authorship, ownership, duration, moral rights and infringement. It also considers the effect of the sui generis categorization on compliance with the Agreement on Trade-Related Aspects of Intellectual Property Rights and the anomalies that arise in the protection of preparatory work and computer programs. The focus is primarily on South African law. [source] Evaluation of software for introducing protein structureBIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, Issue 5 2010Visualization, simulation Abstract Communicating an understanding of the forces and factors that determine a protein's structure is an important goal of many biology and biochemistry courses at a variety of levels. Many educators use computer software that allows visualization of these complex molecules for this purpose. Although visualization is in wide use and has been associated with student learning, it is quite challenging to develop visualizations that allow students to interactively observe the effects of altered amino acid sequence on protein structure. A software simulation, the protein investigator (PI), has been developed to specifically facilitate this type of exploration. When using the PI, students enter or edit an amino acid sequence; the software then simulates its folding in two dimensions using the major forces involved in protein structure. This study explores freshman undergraduate students' use of visualization and simulation when learning about protein structure. It also evaluates some of the learning outcomes from these two approaches. Our results show that simulation leads to similar learning outcomes as visualization. Because simulation allows a more interactive exploration, a combination of the two approaches may be an effective approach to introducing the basic principles of protein structure. [source] Relationships between ocular dimensions and adult stature among participants in the Reykjavik Eye StudyACTA OPHTHALMOLOGICA, Issue 6 2005Thor Eysteinsson Abstract. Purpose:,To examine the relationships between adult stature, age and ocular dimensions in a large homogenous, white population. Methods:,We used the national population census for Reykjavik to select a random sample of adults aged 50 years or older. A total of 846 persons were examined. Scheimpflug images were used to measure anterior chamber depth. Ultrasound was used to measure axial length, lens thickness and vitreous chamber depth. An autorefracto-keratometer was used to measure autorefractive and keratometric values, including the radius of the corneal curvature. Stereo fundus photographs were taken of the optic disc and measurements of the disc diameters were made using computer software. Results:,Height correlated positively with axial length in the multivariate model (B = 0.020, 95% CI 0.006,0.034, p < 0.01). Both age and height showed significant correlations with vitreous chamber depth, where the correlation with age was negative (B = , 0.016, 95% CI , 0.006 to , 0.025, p < 0.005) and the correlation with height was positive (B = 0.019, 95% CI 0.005,0.034, p < 0.01). Height also showed a positive correlation with the radius of the corneal curvature (B = 0.008, 95% CI 0.004,0.011, p < 0.001). Anterior chamber depth had a negative correlation with age (B = , 0.013, 95% CI , 0.010 to , 0.016, p < 0.001), whereas lens thickness had a significant positive correlation with age (B = 0.019, 95% CI 0.016,0.023, p < 0.001). We found a significant negative correlation between axial length and refraction/spherical equivalent (r = , 0.595, p < 0.0001). Discussion:,Our results indicate that there is a significant relationship between height and several ocular dimensions in this adult population and confirms a negative correlation between axial length and refraction. [source] A morphometric study of the inferior orbital fissure using three-dimensional anatomical landmarks: Application to orbital surgeryCLINICAL ANATOMY, Issue 6 2009Mehmet Asim Ozer Abstract The inferior orbital fissure (IOF) is an important structure during orbital surgery, however, neither its anatomical features nor the procedures necessary to expose the IOF have been examined in detail. A morphometric analysis of the IOF was performed on 232 orbits using computer software. The longest and shortest borders of the IOF were 18.2 ± 4.9 and 1.9 ± 1.3 mm, respectively. The outer and the inner angles were 138.9 ± 32.7° and 38.4 ± 24.7°, respectively. The perimeter of the IOF was 50.6 ± 13.5 mm and its area was 61.3 ± 39.1 mm2. Eight types of IOF were observed. Type 1 IOF was observed in 42.2% and the Type 2 IOF was identified in 15.9%. A statistically significant relation was found between the longest edge and area and the widest edge and area of the IOF. The findings of our study suggest that the removal of the lateral wall should begin inferiorly, just lateral to the IOF and extended superolaterally. These data may be useful during surgical approaches to the orbit. Clin. Anat. 22:649,654, 2009. © 2009 Wiley-Liss, Inc. [source] An in vitro study of non-axial forces upon the retention of an O-ring attachmentCLINICAL ORAL IMPLANTS RESEARCH, Issue 12 2009Renata Cristina Silveira Rodrigues Abstract: Objective: The purpose of this study was to evaluate the retention force of an O-ring attachment system in different inclinations to the ideal path of insertion, using devices to compensate angulations. Material and methods: Two implants were inserted into an aluminum base, and ball attachments were screwed to implants. Cylinders with O-rings were placed on ball attachments and connected to the test device using positioners to compensate implant angulations (0°, 7°, and 14°). Plexiglass bases were used to simulate implant angulations. The base and the test device were positioned in a testing apparatus, which simulated insertion/removal of an overdenture. A total of 2900 cycles, simulating 2 years of overdenture use, were performed and 36 O-rings were tested. The force required for each cycle was recorded with computer software. Longitudinal sections of ball attachment,positioner,cylinder with O-rings of each angulation were obtained to analyze the relationship among them, and O-ring sections tested in each angulation were compared with an unused counterpart. A mixed linear model was used to analyze the data, and the comparison was performed by orthogonal contrasts (,=0.05). Results: At 0°, the retention force decreased significantly over time, and the retention force was significantly different in all comparisons, except from 12 to 18 months. When the implants were positioned at 7°, the retention force was statistically different at 0 and 24 months. At 14°, significant differences were found from 6 and 12 to 24 months. Conclusions: Within the limitations of this study, it was concluded that O-rings for implant/attachments perpendicular to the occlusal plane were adequately retentive over the first year and that the retentive capacity of O-ring was affected by implant inclinations despite the proposed positioners. [source] Computer-assisted calculation of myocardial infarct size shortens the evaluation time of contrast-enhanced cardiac MRICLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, Issue 1 2008Lene Rosendahl Summary Background:, Delayed enhancement magnetic resonance imaging depicts scar in the left ventricle which can be quantitatively measured. Manual segmentation and scar determination is time consuming. The purpose of this study was to evaluate a software for infarct quantification, to compare with manual scar determination, and to measure the time saved. Methods:, Delayed enhancement magnetic resonance imaging was performed in 40 patients where myocardial perfusion single photon emission computed tomography imaging showed irreversible uptake reduction suggesting a myocardial scar. After segmentation, the semi-automatic software was applied. A scar area was displayed, which could be corrected and compared with manual delineation. The different time steps were recorded with both methods. Results:, The software shortened the average evaluation time by 12·4 min per cardiac exam, compared with manual delineation. There was good correlation of myocardial volume, infarct volume and infarct percentage (%) between the two methods, r = 0·95, r = 0·92 and r = 0·91 respectively. Conclusion:, A computer software for myocardial volume and infarct size determination cut the evaluation time by more than 50% compared with manual assessment, with maintained clinical accuracy. [source] Four correlates of complex behavioral networks: Differentiation, behavior, connectivity, and compartmentalization: Carving networks at their jointsCOMPLEXITY, Issue 6 2005Mark A. Changizi Abstract Some of the most complex networks are those that (i) have been engineered under selective pressure (either economic or evolutionary), and (ii) are capable of eliciting network-level behaviors. Some examples are nervous systems, ant colonies, electronic circuits and computer software. Here we provide evidence that many such selected, behavioral networks are similar in at least four respects. (1) Differentiation: Nodes of different types are used in a combinatorial fashion to build network structures through local connections, and networks accommodate more structure types via increasing the number of node types in the network (i.e., increasing differentiation), not via increasing the length of structures. (2) Behavior: Structures are themselves combined globally to implement behaviors, and networks accommodate a greater behavioral repertoire via increasing the number of lower-level behavior types (including structures), not via increasing the length of behaviors. (3) Connectivity: In order for structures in behavioral networks to combine with other structures within a fixed behavior length, the network must maintain an invariant network diameter, and this is accomplished via increasing network connectivity in larger networks. (4) Compartmentalization: Finally, for re sons of economical wiring, behavioral networks become increasingly parcellated. Special attention is given to nervous systems and computer software, but data from a variety of other behavioral selected networks are also provided, including ant colonies, electronic circuits, web sites and businesses. A general framework is introduced illuminating why behavioral selected networks share these four correlates. Because the four above features appear to apply to computer software as well as to biological networks, computer software provides a useful framework for comprehending the large-scale function and organization of biological networks. © 2005 Wiley Periodicals, Inc. Complexity 10: 13,40, 2005 [source] | ||||||||||||||||||||||