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Complementary Fashion (complementary + fashion)
Selected AbstractsEffect of spatial inhibition on saccade trajectory depends on location-based mechanismsJAPANESE PSYCHOLOGICAL RESEARCH, Issue 1 2009HIROYUKI SOGO Abstract:, Saccade trajectory often curves away from a previously attended, inhibited location. A recent study of curved saccades showed that an inhibitory effect prevents ineffective reexamination during serial visual search. The time course of this effect differs from that of a similar inhibitory effect, known as inhibition of return (IOR). In the present study, we examined whether this saccade-related inhibitory effect can operate in an object-based manner (similar to IOR). Using a spatial cueing paradigm, we demonstrated that if a cue is presented on a placeholder that is then shifted from its original location, the saccade trajectory curves away from the original (cued) location (Experiment 1), yet the IOR effect is observed on the cued placeholder (Experiment 2). The inhibitory mechanism that causes curved saccades appears to operate in a location-based manner, whereas the mechanism underlying IOR appears to operate in an object-based manner. We propose that these inhibitory mechanisms work in a complementary fashion to guide eye movements efficiently under conditions of a dynamic visual environment. [source] Pharmaceutical impurity identification: A case study using a multidisciplinary approachJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 9 2004Karen M. Alsante Abstract A multidisciplinary team approach to identify pharmaceutical impurities is presented in this article. It includes a representative example of the methodology. The first step is to analyze the sample by LC-MS. If the structure of the unknown impurity cannot be conclusively determined by LC-MS, LC-NMR is employed. If the sample is unsuitable for LC-NMR, the impurity needs to be isolated for conventional NMR characterization. Although the technique of choice for isolation is preparative HPLC, enrichment is often necessary to improve preparative efficiency. One such technique is solid-phase extraction. For complete verification, synthesis may be necessary to compare spectroscopic characteristics to those observed in the original sample. Although not widely practiced, an effective means of getting valuable structural information is to conduct a degradation study on the purified impurity itself. This systematic strategy was successfully applied to the identification of an impurity in the active pharmaceutical ingredient 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulphonylurea. Identification required the use of all of the previously mentioned techniques. The instability of the impurity under acidic chromatographic conditions presented an additional challenge to purification and identification. However, we turned this acidic instability to an advantage, conducting a degradation study of the impurity, which provided extensive and useful information about its structure. The following discussion describes how the information gained from each analytical technique was brought together in a complementary fashion to elucidate a final structure. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:2296,2309, 2004 [source] PKS1 plays a role in red-light-based positive phototropism in rootsPLANT CELL & ENVIRONMENT, Issue 6 2008MARIA LIA MOLAS ABSTRACT Aerial parts of plants curve towards the light (i.e. positive phototropism), and roots typically grow away from the light (i.e. negative phototropism). In addition, Arabidopsis roots exhibit positive phototropism relative to red light (RL), and this response is mediated by phytochromes A and B (phyA and phyB). Upon light stimulation, phyA and phyB interact with the phytochrome kinase substrate (PKS1) in the cytoplasm. In this study, we investigated the role of PKS1, along with phyA and phyB, in the positive phototropic responses to RL in roots. Using a high-resolution feedback system, we studied the phenotypic responses of roots of phyA, phyB, pks1, phyA pks1 and phyB pks1 null mutants as well as the PKS1- overexpressing line in response to RL. PKS1 emerged as an intermediary in the signalling pathways and appears to promote a negative curvature to RL in roots. In addition, phyA and phyB were both essential for a positive response to RL and act in a complementary fashion. However, either photoreceptor acting without the other results in negative curvature in response to red illumination so that the mode of action differs depending on whether phyA and phyB act independently or together. Our results suggest that PKS1 is part of a signalling pathway independent of phyA and phyB and that PKS1 modulates RL-based root phototropism. [source] Clinical Implications of Advances in the Basic Science of Liver Repair and RegenerationAMERICAN JOURNAL OF TRANSPLANTATION, Issue 9 2009S. J. Karp Recent advances in our understanding of the basic mechanisms that control liver regeneration and repair will produce the next generation of therapies for human liver disease. Insights gained from large-scale genetic analysis are producing a new framework within which to plan interventions. Identification of specific molecules that drive regeneration will increase the options for live-donor liver transplantation, and help treat patients with small-for-size syndrome or large tumors who would otherwise have inadequate residual mass after resection. In a complementary fashion, breakthroughs in the ability to manipulate various cell types to adopt the hepatocyte or cholangiocyte phenotype promise to revolutionize therapy for acute liver failure and metabolic liver disease. Finally, elucidating the complex interactions of liver cells with each other and various matrix components during the response to injury is essential for fabricating a liver replacement device. This focused review will discuss how a variety of important scientific advances are likely to impact the treatment of specific types of liver disease. [source] The Wnt/,-catenin pathway: master regulator of liver zonation?BIOESSAYS, Issue 11 2006Zoë D. Burke The liver contains two systems for the removal of ammonia,the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/,-catenin pathway. BioEssays 28: 1072,1077, 2006. © 2006 Wiley Periodicals, Inc. [source] | ||||||||||