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Selected AbstractsInpatient substance abuse care and the outcome of subsequent community residential and outpatient careADDICTION, Issue 6 2000Rudolf H. Moos Aim. To compare participation in treatment and 1-year substance use, symptom and functioning outcomes between patients with substance use disorders who did versus those who did not have an episode of inpatient care immediately prior to an episode of community residential and outpatient mental health care. Design. Two matched groups of 257 patients each with substance use disorders were assessed at entry to and discharge from a community residential facility (CRF) and at a 1-year follow-up. Findings. Patients in the two treatment groups received a comparable amount of CRF and outpatient mental health care. Nevertheless, patients who had prior inpatient care were more likely to be employed at 1-year follow-up. In addition, when they entered CRF care directly, patients with co-morbid psychiatric disorders were more likely to continue use of alcohol and drugs in the CRF and less likely to complete the program. These patients also experienced more distress and psychiatric symptoms, and were less likely to be employed at the 1-year follow-up. Conclusions. Among patients who seek treatment at Department of Veterans Affairs (VA) facilities, those who have both substance use and psychiatric disorders and enter CRF care directly have somewhat worse outcomes than those who have an immediately prior episode of inpatient care. [source] Niches of the pre-photosynthetic biosphere and geologic preservation of Earth's earliest ecologyGEOBIOLOGY, Issue 2 2007NORMAN H. SLEEP ABSTRACT The tree of terrestrial life probably roots in non-photosynthetic microbes. Chemoautotrophs were the first primary producers, and the globally dominant niches in terms of primary productivity were determined by availability of carbon dioxide and hydrogen for methanogenesis and sulfite reduction. Methanogen niches were most abundant where CO2 -rich ocean water flowed through serpentinite. Black smoker vents from basalt supplied comparable amount of H2. Hydrogen from arc volcanoes supported a significant methanogenic niche at the Earth's surface. SO2 from arc volcanoes reacted with organic matter and hydrogen, providing a significant surface niche. Methane ascended to the upper atmosphere where photolysis produced C-rich haze and CO, and H escaped into space. The CO and C-rich haze supported secondary surface niches. None of these ecologies were bountiful; less than 1% of the CO2 vented by ridge axes, arcs, and metamorphism became organic matter before it was buried in carbonate. In contrast, a photosynthetic biosphere leaves copious amounts of organic carbon, locally concentrated in sediments. Black shales are a classic geologic biosignature for photosynthesis that can survive subduction and high-grade metamorphism. [source] Prospects for inferring pairwise relationships with single nucleotide polymorphismsMOLECULAR ECOLOGY, Issue 4 2003Jeffrey C. Glaubitz Abstract An extraordinarily large number of single nucleotide polymorphisms (SNPs) are now available in humans as well as in other model organisms. Technological advancements may soon make it feasible to assay hundreds of SNPs in virtually any organism of interest. One potential application of SNPs is the determination of pairwise genetic relationships in populations without known pedigrees. Although microsatellites are currently the marker of choice for this purpose, the number of independently segregating microsatellite markers that can be feasibly assayed is limited. Thus, it can be difficult to distinguish reliably some classes of relationship (e.g. full-sibs from half-sibs) with microsatellite data alone. We assess, via Monte Carlo computer simulation, the potential for using a large panel of independently segregating SNPs to infer genetic relationships, following the analytical approach of Blouin et al. (1996). We have explored a ,best case scenario' in which 100 independently segregating SNPs are available. For discrimination among single-generation relationships or for the identification of parent,offspring pairs, it appears that such a panel of moderately polymorphic SNPs (minor allele frequency of 0.20) will provide discrimination power equivalent to only 16,20 independently segregating microsatellites. Although newly available analytical methods that can account for tight genetic linkage between markers will, in theory, allow improved estimation of relationships using thousands of SNPs in highly dense genomic scans, in practice such studies will only be feasible in a handful of model organisms. Given the comparable amount of effort required for the development of both types of markers, it seems that microsatellites will remain the marker of choice for relationship estimation in nonmodel organisms, at least for the foreseeable future. [source] Delayed X-ray emission from fallback in compact-object mergersMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2009Elena M. Rossi ABSTRACT When double neutron star or neutron star,black hole binaries merge, the final remnant may comprise a central solar-mass black hole surrounded by a ,0.01,0.1 M, torus. The subsequent evolution of this disc may be responsible for short ,-ray bursts (SGRBs). A comparable amount of mass is ejected into eccentric orbits and will eventually fallback to the merger site after ,0.01 s. In this paper, we investigate analytically the fate of the fallback matter, which may provide a luminous signal long after the disc is exhausted. We find that matter in the eccentric tail returns at a super-Eddington rate and eventually (,0.1 s) is unable to cool via neutrino emission and accrete all the way to the black hole. Therefore, contrary to previous claims, our analysis suggests that fallback matter is not an efficient source of late-time accretion power and unlikely to cause the late-flaring activity observed in SGRB afterglows. The fallback matter rather forms a radiation-driven wind or a bound atmosphere. In both the cases, the emitting plasma is very opaque and photons are released with a degraded energy in the X-ray band. We therefore suggest that compact binary mergers could be followed by an ,X-ray renaissance', as late as several days to weeks after the merger. This might be observed by the next generation of X-ray detectors. [source] Biochemical changes during larval development in the short neck clam, Paphia malabarica ChemnitzAQUACULTURE RESEARCH, Issue 13 2009Raghavan Gireesh Abstract Biochemical compositions were determined for eggs, D-shaped larvae, umbo larvae and pediveliger of the short neck clam Paphia malabarica Chemnitz. Spawned eggs were composed of 63.2% protein, 25.4% lipid and 11.4% carbohydrate. After 48 h of embryogenesis, 2.6% of the protein, 11.8% of the lipid and 3.2% of carbohydrate mass had been lost, providing 20.5%, 75.4% and 4.1% of the total energy expenditure of 0.2147 mJ embryo,1. During 48 h of metamorphosis, lipid was utilized first, followed by a heavy consumption of protein; protein, lipid and carbohydrate lost 23.8%, 50.2% and 32.5% of their mass respectively. Protein and lipid supplied a comparable amount of energy for metamorphosis, 34.2% and 55.2%, respectively, whereas, carbohydrate contributed only 10.6% to the 2.733 mJ larva,l metamorphic energy expenditure. [source] Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patientsEXPERIMENTAL DERMATOLOGY, Issue 1 2005Karsten Dieckhoff Abstract:, Decreased production of T helper type 1 (Th1) cytokines, such as interferon-, (IFN-,) or interleukin-2 (IL-2), is a hallmark of atopic diseases. While accessory signals from antigen-presenting cells may be missing, T cells themselves may be suppressed in their ability to produce substantial amounts of Th1 cytokines. We show, in this study, that T cell receptor (TCR)-activated T cells from atopic dermatitis (AD) patients proliferate less than control T cells and produce lower amounts of IFN-, and IL-2, but comparable amounts of IL-4. Because mice lacking the nuclear factor kappa B (NF-,B) transcription factors , p65 or c-Rel , show reduced Th1, but undisturbed Th2 responses, we investigated the role of c-Rel and p65 for Th1 cytokine production in T cells from healthy and severe AD patients. TCR-activated primary T cells from healthy donors treated with c-Rel antisense oligonucleotides produced lower levels of IL-2 and IFN-, and proliferated less efficiently than the corresponding control T cells. Moreover, transfection of primary T cells with c-Rel or p65 enhanced proliferation and production of IL-2 and IFN-,. Nuclear extracts of activated primary T cells from AD donors bound weakly to NF-,B-specific oligonucleotides, compared to extracts from healthy control T cells. Western blotting studies revealed that nuclear, but not cytosolic, extracts from T cells of AD patients lacked significant amounts of c-Rel and p65. T cell clones derived from AD patients failed to sufficiently translocate c-Rel and p65 into the nucleus following activation. Thus, impaired nuclear translocation of c-Rel and p65 may determine an impaired Th1 cytokine response in AD. [source] The professionalism of practising law: A comparison across work contextsJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 8 2008Jean E. Wallace Traditionally, the literature assumed that solo practitice best exemplifies the ideal professional work arrangement and that when professionals become salaried employees their professionalism is seriously threatened. The primary goal of this paper is to examine lawyers' sense of professionalism across two work contexts: solo practitioner offices and law firm settings. We also examine status distinctions within law firms, between associates and partners, and compare both to independent practitioners. Solo practitioners and law firm partners are similar on most key dimensions of professionalism, whereas the greatest contrasts occur between partners and associates within law firms. Partners and solo practitioners share similar experiences of autonomy and service as owner-managers, whereas partners and associates share greater collegiality among professionals, perhaps fostered through law firm cultures. All three groups report comparable amounts of variety in their work and are equally committed to the practice of law. The key factors that account for gaps in professionalism reflect the nature of law practices, primarily through time spent with corporate clients and pressure to generate profits. We conclude that different versions of lawyers' professionalism are influenced by the everyday aspects of their work and one version is not necessarily more professional than the other. Copyright © 2008 John Wiley & Sons, Ltd. [source] Synthesis of biodegradable copolymers with low-toxicity zirconium compounds.JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 1 2006Abstract The results of the copolymerization of glycolide with cyclic trimethylene carbonate and 2,2-dimethyltrimethylene carbonate are described. The copolymerization was conducted in the presence of low-toxicity zirconium(IV) acetylacetonate as an initiator. With this kind of initiator, the composition of the comonomer units in the copolymer chains was assumed to be obtained with high efficiency. Despite significant differences in the comonomer reactivity, in copolymers containing comparable amounts of glycolidyl and carbonate sequences, highly randomized chain structures were observed. This effect resulted from strong intermolecular transesterification that proceeded during the studied copolymerization and caused glycolidyl microblock randomization. The assignment of the spectral NMR lines to appropriate comonomer sequences of polymeric chains was performed in the region of methylene protons of glycolidyl units in 1H NMR spectra of the copolymers and in the carbonyl region of carbon spectra. The equations were formulated for a detailed characterization of the obtained copolymer chains, the average lengths of the blocks, and the transesterification and randomization coefficients. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 98,114, 2006 [source] Calanus oil as a natural source for flesh pigmentation in Atlantic salmon (Salmo salar L.)AQUACULTURE NUTRITION, Issue 2 2009N. HYNES Abstract The present study was to understand how efficiently the astaxanthin in Calanus oil is utilized for flesh colouration in Atlantic salmon (Salmo salar). Postsmolts of the fish (309 g) were held at 7.9 °C and they were fed diets containing 20 or 60 mg astaxanthin per kilogram feed derived from a synthetic source or from Calanus oil for 181 days. Besides growth and feed intake assessments, at day 81 and 181, fish flesh were subjected to colour analysis and astaxanthin determination. Growth and feed performance did not vary between the groups. There were significant differences in the amount of astaxanthin in muscle between almost all groups both at day 81 (P < 0.05) and at day 181 (P < 0.001). However, a notable similarity between fish receiving 20 mg astaxanthin from the synthetic source and those receiving 60 mg astaxanthin from Calanus oil (P > 0.05) at day 181 indicated that comparable amounts were deposited only with the greater level of the natural source. Tristimuli colorimeter a* values support the analytical results at day 181. Although Calanus oil did serve as a natural dietary pigment source for farmed salmon, its inclusion level should provide more than 60 mg astaxanthin per kilogram feed to achieve colouration preferred by the market. [source] Determination of uric acid concentrations in human tear fluid, aqueous humour and serumACTA OPHTHALMOLOGICA, Issue 2 2009Jutta Horwath-Winter Abstract. Purpose:, The aim of this investigation was to assess and compare levels of uric acid in human tear fluid, aqueous humour and serum in cataract patients in order to obtain information about uric acid-dependent antioxidative status. Methods:, Reflex tear fluid, aqueous humour and serum were obtained from 103 cataract patients (52 women, 51 men). Uric acid was determined by a reversed phase chromatographic method with electrochemical detection. The Randox test was used to measure the contribution of uric acid to the total antioxidative status (TAS) of these body fluids. Results:, Mean concentrations of uric acid were 20 ± 8 ,g/ml in tear fluid, 18 ± 6 ,g/ml in aqueous humour and 58 ± 15 ,g/ml in serum. Significantly less uric acid was found in tear fluid (p < 0.01) and aqueous humour (p < 0.01) in female cataract patients compared with male cataract patients. There was a significant positive correlation between uric acid content in tear fluid, aqueous humour and serum, respectively (p < 0.01). The contribution of uric acid to TAS (Randox test) amounted to 38% in tear fluid, 10% in aqueous humour and 37% in serum. Conclusions:, Uric acid was found in comparable amounts in tear fluid and aqueous humour, but these were two- to threefold lower than in serum. Female cataract patients had lower uric acid values in tear fluid and aqueous humour compared with male cataract patients. Uric acid is an important antioxidant, as proven by its contribution to TAS as determined by the Randox test. The precise role of uric acid in the antioxidative reactions in tear fluid and aqueous humour is still under debate. [source] |