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Comprehensive View (comprehensive + view)
Selected AbstractsThe Brain of the Dog in Section: a Comprehensive View for Veterinary StudentsANATOMIA, HISTOLOGIA, EMBRYOLOGIA, Issue 2005I. Salazar Transversal, horizontal and sagittal sections of the brain were stained by the ancient but efficient Mulligan method, a procedure that establishes a clear macroscopic difference between the white and grey substances. Different structures of each section were studied and most of the details were identified and named according to the NAV. All sections were projected onto the whole brain. By means of this easy and basic procedure the students increase their understanding of (1) the size and/or the form and/or the topography of several prominent structures of the brain, (2) the general distribution of the substancia alba and grisea, and they begin to understand the complexity of the brain. [source] DNA sequence-based analysis of the Pseudomonas speciesENVIRONMENTAL MICROBIOLOGY, Issue 6 2010Magdalena Mulet Summary Partial sequences of four core ,housekeeping' genes (16S rRNA, gyrB, rpoB and rpoD) of the type strains of 107 Pseudomonas species were analysed in order to obtain a comprehensive view regarding the phylogenetic relationships within the Pseudomonas genus. Gene trees allowed the discrimination of two lineages or intrageneric groups (IG), called IG P. aeruginosa and IG P. fluorescens. The first IG P. aeruginosa, was divided into three main groups, represented by the species P. aeruginosa, P. stutzeri and P. oleovorans. The second IG was divided into six groups, represented by the species P. fluorescens, P. syringae, P. lutea, P. putida, P. anguilliseptica and P. straminea. The P. fluorescens group was the most complex and included nine subgroups, represented by the species P. fluorescens, P. gessardi, P. fragi, P. mandelii, P. jesseni, P. koreensis, P. corrugata, P. chlororaphis and P. asplenii. Pseudomonas rhizospherae was affiliated with the P. fluorescens IG in the phylogenetic analysis but was independent of any group. Some species were located on phylogenetic branches that were distant from defined clusters, such as those represented by the P. oryzihabitans group and the type strains P. pachastrellae, P. pertucinogena and P. luteola. Additionally, 17 strains of P. aeruginosa, ,P. entomophila', P. fluorescens, P. putida, P. syringae and P. stutzeri, for which genome sequences have been determined, have been included to compare the results obtained in the analysis of four housekeeping genes with those obtained from whole genome analyses. [source] Developmental, metabolic and immunological costs of flea infestation in the common voleFUNCTIONAL ECOLOGY, Issue 6 2008Godefroy Devevey Summary 1Parasites use resources from their hosts, which can indirectly affect a number of host functions because of trade-offs in resource allocation. In order to get a comprehensive view of the costs imposed by blood sucking parasites to their hosts, it is important to monitor multiple components of the development and physiology of parasitized hosts over long time periods. 2The effect of infestation by fleas on body mass, body length growth, haematocrit, resistance to oxidative stress, resting metabolic rate and humoral immune response were experimentally evaluated. During a 3-month period, male common voles, Microtus arvalis, were either parasitized by rat fleas (Nosopsyllus fasciatus), which are naturally occurring generalist ectoparasites of voles, or reared without fleas. Then voles were challenged twice by injecting Keyhole Limpet Haemocyanin (KLH) to assess whether the presence of fleas affects the ability of voles to produce antibodies against a novel antigen. During the immune challenge we measured the evolution of body mass, haematocrit, resistance to oxidative stress and antibody production. 3Flea infestation negatively influenced the growth of voles. Moreover, parasitized voles had reduced haematocrit, higher resting metabolic rate and lower production of antibodies against the KLH. Resistance to oxidative stress was not influenced by the presence of fleas. 4During the immune challenge with KLH, body mass decreased in both groups, while the resistance to oxidative stress remained stable. In contrast, the haematocrit decreased only in parasitized voles. 5Our experiment shows that infestation by a haematophageous parasite negatively affects multiple traits like growth, energy consumption and immune response. Fleas may severely reduce the survival probability and reproductive success of their host in natural conditions. [source] Age-Dependent Taxation and the Optimal Retirement Benefit FormulaGERMAN ECONOMIC REVIEW, Issue 1 2008Mathias Kifmann Optimal taxation; pay-as-you-go pension systems; implicit taxation; intra- and intergenerational equity; financial stability Abstract. This paper presents a comprehensive view of lifetime taxation including both explicit taxation through the general tax system and implicit taxation via the retirement benefit formula. Differences in productivity between individuals are unobservable, which provides a rationale for the use of distortionary taxes. It is shown that the optimal structure of age-dependent taxation can be characterized by a generalized Ramsey formula. Furthermore, the paper derives the optimal retirement benefit formula in the presence of the general tax system and examines the compatibility with the financial stability of the pension system. [source] Long-term study of a portable field robot in urban terrainJOURNAL OF FIELD ROBOTICS (FORMERLY JOURNAL OF ROBOTIC SYSTEMS), Issue 8-9 2007Carl Lundberg The armed forces have a considerable amount of experience in using robots for bomb removal and mine clearing. Emerging technology also enables the targeting of other applications. To evaluate if real deployment of new technology is justified, tactical advantages gained have to be compared to drawbacks imposed. Evaluation calls for realistic tests which in turn require methods dictating how to deploy the new features. The present study has had two objectives: first, to gain a comprehensive view of a potential user of man-portable robots; second, to embed a robot system with users for assessment of present technology in real deployment. In this project we investigated an army company specialized in urban operations performing their tasks with the support of the iRobot Packbot Scout. The robot was integrated and deployed as an ordinary piece of equipment which required modifying and retraining a number of standard behaviors. The reported results were acquired through a long-term test ranging over a period of six months. This paper focuses on the characteristics of the users and their current ways of operation; how the robot was implemented and deployed. Additionally, this paper describes benefits and drawbacks from the users' perspective. A number of limitations in current robot technology are also identified. The findings show that the military relies on precise and thoroughly trained actions that can be executed with a minimum of ambiguity. To make use of robots, new behavioral schemes, which call for tactical optimization over several years, are needed. The most common application during the trials was reconnaissance inside buildings with uncertain enemy presence when time was not critical. Deploying the robot took more time than completing the task by traditional means, but in return kept the soldiers out of harm's way and enabled them to decrease weapon deployment. The range of the radio link, limited video feedback, and the bulky operator control unit were the features constraining the system's overall performance the most. On the other hand, did properties of the system, such as ruggedness, size, weight, terrain ability, and endurance, prove to match the application. The users were of the opinion that robots such as the Packbot Scout would be a valuable standard feature in urban intervention. © 2007 Wiley Periodicals, Inc. [source] Analysis of clinical features of acute pancreatitis in Shandong Province, ChinaJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 3 2007Yan Jing Gao Abstract Aim:, To investigate and obtain a more comprehensive view of the etiology and clinical features of acute pancreatitis in China. Method:, The study comprised 1471 patients in 10 cites of China who were admitted to hospitals for acute pancreatitis from January 1992 to December 2002. Data for each patient were collected on a standardized form. Results:, Of the 1471 patients (854 men, 617 women; mean age 43.3 years; range 13,82 years), 1280 had mild pancreatitis and 191 had the severe form. Cholelithiasis (20.2%), alcohol (17.3%) and diet-induced (12.4%) were the most frequent etiological factors, followed by biliary tract infections (5.6%), hyperlipidemia (2.3%) and other factors (5.1%). However, in about 36.1% of cases, the etiology of acute pancreatitis still remained unexplained. In coastal regions, cholelithiasis was the most frequent factor but alcohol ranked first in interior regions. In males, a small predominance of alcohol over cholelithiasis was seen (27.4%vs 14.3%) and there was a clear predominance of cholelithiasis over alcohol (28.4%vs 3.2%) in females. The differences in the frequency of cholelithiasis and alcohol between coastal regions and interior regions and males and females were statistically significant (P < 0.01). According to their frequency, complications of acute pancreatitis were pancreatic pseudocyst, pancreatic ascities and bacterial peritonitis, pulmonary infections, multiple organ failure, diabetes mellitus type 2 and shock. Conclusion:, Cholelithiasis, alcohol and diet-induced factors were the main etiological factors seen in China, whereas cholelithiasis alone predominated in females and alcohol ranked first in males. In about 36.1% of cases, the etiology of acute pancreatitis remained unknown. More attention should be paid to studying the etiologies of acute pancreatitis that remain unknown. [source] Properties modification of PET vascular prosthesesJOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 5 2009W. Chaouch Abstract Aging mechanisms have been investigated on polyethylene terephthalate (PET) fibres extracted from various vascular prostheses in order to identify the different modifications of the material's degradation. NMR spectroscopy provides a comprehensive view of chemical structures of macromolecules. Examination of a series of PET fibres showed significant chemical differences between the virgin prostheses and the explants, especially for diethylene glycol (DEG) and cyclic oligomeric groups. These analyses revealed that PET failures in vascular prostheses are susceptible to hydrolysis during in vivo stay. We also extended this 1H NMR technique to determine the hydroxyl and carboxyl end-group concentrations. In order to validate the 1H NMR results, complementary techniques , chemical titration and classical viscosimetry , were used. The obtained results showed an increase in end-group concentrations and a decrease of the viscosity averaged macromolecular weight (M,) for the explants. Copyright © 2009 John Wiley & Sons, Ltd. [source] A Resource-Process Framework of New Service DevelopmentPRODUCTION AND OPERATIONS MANAGEMENT, Issue 2 2007Craig M. Froehle Motivated by the increasing attention given to the operational importance of developing new services, this paper offers a theoretical framework that integrates both process- and resource-oriented perspectives of new service development (NSD) by defining and organizing 45 practice constructs for NSD-related practices and activities that occur in contemporary service firms. We employ a rigorous procedure whereby both quantitative and qualitative data were gathered through multiple rounds of interviews and card-sorting exercises with senior service managers. This iterative refinement process helps ensure that the construct domains and definitions are consistent and that they are applicable across multiple service sectors. A primary contribution of this research is to provide precise operational definitions of theoretically important NSD practice constructs. Importantly, this study expands on the NSD literature by including both resource- and process-centric perspectives within a single framework. A second contribution is to illustrate a general methodology for developing clear, concise, and consistent construct definitions that may be generally useful for production and operations management scholars interested in new construct development for emerging areas. Empirical results suggest that the resource-process framework can help guide and organize future research on, and provide insight into, a more comprehensive view of new service development. [source] Proteomics analysis of serous fluids and effusions: Pleural, pericardial, and peritonealPROTEOMICS - CLINICAL APPLICATIONS, Issue 8 2007Yu-Chang Tyan Abstract Serous body fluids are normally present in small amounts in the cavities lined by serous membranes, and effusions are the term usually used to represent an excess of these fluids. Thus, any changes in the effusions may accurately reflect various pathological processes. In this review, we will introduce the present status of effusion analysis. Proteomics allows the global study of protein expression and offers a comprehensive view to analyze effusion proteins at a system level. It deals with the study of proteins, their structures, localizations, PTM, functions, and interactions with other proteins. This paper reviews the variety of analytical methods that have been used for the analysis of effusions. The proteins expressed in effusions, which have been identified by proteomics methods are discussed. [source] Modulation of aggressive behaviour by fighting experience: mechanisms and contest outcomesBIOLOGICAL REVIEWS, Issue 1 2006Yuying Hsu ABSTRACT Experience in aggressive contests often affects behaviour during, and the outcome of, later contests. This review discusses evidence for, variations in, and consequences of such effects. Generally, prior winning experiences increase, and prior losing experiences decrease, the probability of winning in later contests, reflecting modifications of expected fighting ability. We examine differences in the methodologies used to study experience effects, and the relative importance and persistence of winning and losing experiences within and across taxa. We review the voluminous, but somewhat disconnected, literature on the neuroendocrine mechanisms that mediate experience effects. Most studies focus on only one of a number of possible mechanisms without providing a comprehensive view of how these mechanisms are integrated into overt behaviour. More carefully controlled work on the mechanisms underlying experience effects is needed before firm conclusions can be drawn. Behavioural changes during contests that relate to prior experience fall into two general categories. Losing experiences decrease willingness to engage in a contest while winning experiences increase willingness to escalate a contest. As expected from the sequential assessment model of contest behaviour, experiences become less important to outcomes of contests that escalate to physical fighting. A limited number of studies indicate that integration of multiple experiences can influence current contest behaviour. Details of multiple experience integration for any species are virtually unknown. We propose a simple additive model for this integration of multiple experiences into an individual's expected fighting ability. The model accounts for different magnitudes of experience effects and the possible decline in experience effects over time. Predicting contest outcomes based on prior experiences requires an algorithm that translates experience differences into contest outcomes. We propose two general types of model, one based solely on individual differences in integrated multiple experiences and the other based on the probability contests reach the escalated phase. The difference models include four algorithms reflecting possible decision rules that convert the perceived fighting abilities of two rivals into their probabilities of winning. The second type of algorithm focuses on how experience influences the probability that a subsequent contest will escalate and the fact that escalated contests may not be influenced by prior experience. Neither type of algorithm has been systematically investigated. Finally, we review models for the formation of dominance hierarchies that assume that prior experience influences contest outcome. Numerous models have reached varied conclusions depending on which factors examined in this review are included. We know relatively little about the importance of and variation in experience effects in nature and how they influence the dynamics of aggressive interactions in social groups and random assemblages of individuals. Researchers should be very active in this area in the next decade. The role of experience must be integrated with other influences on contest outcome, such as prior residency, to arrive at a more complete picture of variations in contest outcomes. We expect that this integrated view will be important in understanding other types of interactions between individuals, such as mating and predator-prey interactions, that also are affected significantly by prior experiences. [source] Measurement of xenobiotics in saliva: is saliva an attractive alternative matrix?BIOMEDICAL CHROMATOGRAPHY, Issue 1 2009Case studies, analytical perspectives Abstract The use of saliva for measuring xenobiotic concentrations has been practiced for a number of years. While the use of saliva has been generally reserved for the analysis of diagnostic and forensic/toxicology samples, attempts have been made to further enhance the value of saliva as an alternate matrix to those of plasma and serum. It is understood that saliva represents a handy tool for therapeutic drug monitoring (TDM) as it offers certain distinctive advantages. This scope of this review encompasses the following: (a) a comprehensive view of saliva as an alternate matrix for either plasma or serum to understand the pharmacokinetic/pharmacodynamic (PK/PD) characteristics; (b) an account of the factors contributing to the observed variability in salivary monitoring; (c) a tabular compilation of diverse case studies of xenobitoics belonging to different therapeutic classes with emphasis on assay methodology and applicable analytical/biopharmaceutical/pharmacokinetic findings; (d) relevant thoughts on assay procedures as they relate to salivary monitoring; and (e) some representative case studies highlighting the new thinking on the use of saliva outside of traditional TDM. Overall, based on the review, saliva represents a valuable TDM tool for a number of xenobiotics. While parent compound and phase I metabolite(s) for many xenobiotics have been generally quantifiable in saliva, phase II metabolites have not generally been detected in saliva. Therefore saliva samples could also be used to answer some specific PK/PD questions during the drug development process, if applicable. However, the development and validation of the assay in saliva needs to be carried out carefully with particular focus on proper sample collection, processing and storage to ensure the stability of the xenobiotics and with the same rigor as applied to plasma, serum and urine matrices. Copyright © 2008 John Wiley & Sons, Ltd. [source] | ||||||||||||||||