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Comprehensive Survey (comprehensive + survey)
Selected AbstractsComprehensive survey of carapacial ridge-specific genes in turtle implies co-option of some regulatory genes in carapace evolutionEVOLUTION AND DEVELOPMENT, Issue 1 2005Shigehiro Kuraku Summary The turtle shell is an evolutionary novelty in which the developmental pattern of the ribs is radically modified. In contrast to those of other amniotes, turtle ribs grow laterally into the dorsal dermis to form a carapace. The lateral margin of carapacial primordium is called the carapacial ridge (CR), and is thought to play an essential role in carapace patterning. To reveal the developmental mechanisms underlying this structure, we systematically screened for genes expressed specifically in the CR of the Chinese soft-shelled turtle, Pelodiscus sinensis, using microbead-based differential cDNA analysis and real-time reverse transcription-polymerase chain reaction. We identified orthologs of Sp5, cellular retinoic acid-binding protein-I (CRABP-I), adenomatous polyposis coli down-regulated 1 (APCDD1), and lymphoid enhancer-binding factor-1 (LEF-1). Although these genes are conserved throughout the major vertebrate lineages, comparison of their expression patterns with those in chicken and mouse indicated that these genes have acquired de novo expression in the CR in the turtle lineage. In association with the expression of LEF-1, the nuclear localization of ,-catenin protein was detected in the CR ectoderm, suggesting that the canonical Wnt signaling triggers carapace development. These findings indicate that the acquisition of the turtle shell did not involve the creation of novel genes, but was based on the co-option of pre-existing genes. [source] Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype,phenotype correlations and impact on genetic counseling,,HUMAN MUTATION, Issue 1 2007Valérie Pelletier Abstract X-linked forms of retinitis pigmentosa (RP) (XLRP) account for 10 to 20% of families with RP and are mainly accounted for by mutations in the RP2 or RP GTPase regulator (RPGR) genes. We report the screening of these genes in a cohort of 127 French family comprising: 1) 93 familial cases of RP suggesting X-linked inheritance, including 48 out of 93 families with expression in females but no male to male transmission; 2) seven male sibships of RP; 3) 25 sporadic male cases of RP; and 4) two cone dystrophies (COD). A total of 5 out of the 93 RP families excluded linkage to the RP2 and RP3 loci and were removed form the cohort. A total of 14 RP2 mutations, 12 of which are novel, were identified in 14 out of 88 familial cases of RP and 1 out of 25 sporadic male case (4%). In 13 out of 14 of the familial cases, no expression of the disease was noted in females, while in 1 out of 14 families one woman developed RP in the third decade. A total of 42 RPGR mutations, 26 of which were novel, were identified in 80 families, including: 69 out of 88 familial cases (78.4%); 2 out of 7 male sibship (28.6%); 8 out of 25 sporadic male cases (32.0%); and 1 out of 2 COD. No expression of the disease was noted in females in 41 out of 69 familial cases (59.4%), while at least one severely affected woman was recognized in 28 out of 69 families (40.6%). The frequency of RP2 and RPGR mutations in familial cases of RP suggestive of X-linked transmission are in accordance to that reported elsewhere (RP2: 15.9% vs. 6,20%; RPGR: 78.4% vs. 55,90%). Interestingly, about 30% of male sporadic cases and 30% of male sibships of RP carried RP2 or RPGR mutations, confirming the pertinence of the genetic screening of XLRP genes in male patients affected with RP commencing in the first decade and leading to profound visual impairment before the age of 30 years. Hum Mutat 28(1), 81,91, 2007. © 2006 Wiley-Liss, Inc. [source] Competence Models and the Maintenance ProblemCOMPUTATIONAL INTELLIGENCE, Issue 2 2001Barry Smyth Case-based reasoning (CBR) systems solve problems by retrieving and adapting the solutions to similar problems that have been stored previously as a case base of individual problem solving episodes or cases. The maintenance problem refers to the problem of how to optimize the performance of a CBR system during its operational lifetime. It can have a significant impact on all the knowledge sources associated with a system (the case base, the similarity knowledge, the adaptation knowledge, etc.), and over time, any one, or more, of these knowledge sources may need to be adapted to better fit the current problem-solving environment. For example, many maintenance solutions focus on the maintenance of case knowledge by adding, deleting, or editing cases. This has lead to a renewed interest in the issue of case competence, since many maintenance solutions must ensure that system competence is not adversely affected by the maintenance process. In fact, we argue that ultimately any generic maintenance solution must explicitly incorporate competence factors into its maintenance policies. For this reason, in our work we have focused on developing explanatory and predictive models of case competence that can provide a sound foundation for future maintenance solutions. In this article we provide a comprehensive survey of this research, and we show how these models have been used to develop a number of innovative and successful maintenance solutions to a variety of different maintenance problems. [source] Incidence of and Risk Factors for Medical Malpractice Lawsuits among Mohs SurgeonsDERMATOLOGIC SURGERY, Issue 1 2006CLIFFORD S. PERLIS MD BACKGROUND Despite rising medical malpractice costs, little is known about the factors associated with claims filed against Mohs surgeons. OBJECTIVE We sought to define the scope of medical malpractice claims filed against Mohs surgeons and to identify salient factors associated with the filing and disposition of those claims. METHODS A comprehensive survey was mailed to 599 physicians with US addresses listed in the 2003 directory of the American College of Mohs Micrographic Surgery and Cutaneous Oncology. RESULTS Of the 300 completed surveys returned, 33 (11%) reported ever having been sued. Physicians who practiced Mohs surgery for a longer period of time were more likely to have been sued for malpractice. Physicians reported the wrong site and functional outcome as the most frequent causes of malpractice lawsuits. [source] Electric field-enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysisELECTROPHORESIS, Issue 5 2010Pavel Kubá Abstract Separation techniques, such as electrodialysis, electroextraction, electro-membrane extraction and extraction across phase interfaces, are reviewed and discussed as methods for sample cleanup and preconcentration. This survey clearly shows that electromigration of ionic species across phase interfaces, especially across supported liquid membranes, may be very selective and is strongly dependent on the chemical composition of these interfaces. Thus, electric field-enhanced transport across chemically tailored liquid membranes may open new perspectives in preparative analytical chemistry. This review offers comprehensive survey of related literature and discussion of the topic, which may stimulate interest of experts and practitioners in bioanalysis. [source] Recent developments in CE and CEC of peptidesELECTROPHORESIS, Issue 1 2008Václav Ka, ka Dr. Abstract The article brings a comprehensive survey of recent developments and applications of high-performance capillary electromigration methods, zone electrophoresis, ITP, IEF, affinity electrophoresis, EKC, and electrochromatography, to analysis, preparation, and physicochemical characterization of peptides. New approaches to the theoretical description and experimental verification of electromigration behavior of peptides and to methodology of their separations, such as sample preparation, adsorption suppression, and detection, are presented. Novel developments in individual CE and CEC modes are shown and several types of their applications to peptide analysis are presented: conventional qualitative and quantitative analysis, purity control, determination in biomatrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid and sequence analysis, and peptide mapping of proteins. Some examples of micropreparative peptide separations are given and capabilities of CE and CEC techniques to provide important physicochemical characteristics of peptides are demonstrated. [source] On-line dynamic security assessment to mitigate the risk of blackout in the Italian power systemEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 8 2008Diego Cirio Abstract This paper provides a comprehensive survey of the major initiatives and research projects recently carried out by the Italian system operator, Cesi Ricerca, and Universities on power system monitoring, defense, and security assessment. The technological and methodological features of an advanced wide area measurement system (WAMS) are described and the main aspects of an adaptive system for event-based automatic load shedding are presented. Then preventive and corrective security assessment, with particular emphasis to dynamic security assessment,DSA, is introduced. Results from an EU project, where the Italian power system served as a test site for on-line experimentation, are reported. Considering the need for very fast assessment by stability indices, a complementary approach to the above "conventional" DSA, currently under way, is described in further detail. The methodology relies on a correlation model relating significant power system measurements with local loadability margins. Results of some tests on the Italian power system are presented and discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source] THE LOCI OF EVOLUTION: HOW PREDICTABLE IS GENETIC EVOLUTION?EVOLUTION, Issue 9 2008David L. Stern Is genetic evolution predictable? Evolutionary developmental biologists have argued that, at least for morphological traits, the answer is a resounding yes. Most mutations causing morphological variation are expected to reside in the cis -regulatory, rather than the coding, regions of developmental genes. This "cis -regulatory hypothesis" has recently come under attack. In this review, we first describe and critique the arguments that have been proposed in support of the cis -regulatory hypothesis. We then test the empirical support for the cis -regulatory hypothesis with a comprehensive survey of mutations responsible for phenotypic evolution in multicellular organisms. Cis -regulatory mutations currently represent approximately 22% of 331 identified genetic changes although the number of cis -regulatory changes published annually is rapidly increasing. Above the species level, cis -regulatory mutations altering morphology are more common than coding changes. Also, above the species level cis -regulatory mutations predominate for genes not involved in terminal differentiation. These patterns imply that the simple question "Do coding or cis -regulatory mutations cause more phenotypic evolution?" hides more interesting phenomena. Evolution in different kinds of populations and over different durations may result in selection of different kinds of mutations. Predicting the genetic basis of evolution requires a comprehensive synthesis of molecular developmental biology and population genetics. [source] Candidate glioblastoma development gene identification using concordance between copy number abnormalities and gene expression level changesGENES, CHROMOSOMES AND CANCER, Issue 10 2007Ken C. Lo Copy number abnormalities (CNAs) in tumor cells are presumed to affect expression levels of genes located in region of abnormality. To investigate this relationship we have surveyed the losses, gains and amplifications in 30 glioblastomas using array comparative genome hybridization and compared these data with gene expression changes in the same tumors using the Affymetrix U133Plus2.0 oligonucleotide arrays. The two datasets were overlaid using our in-house overlay tool which highlights concordance between CNAs and expression level changes for the same tumors. In this survey we have highlighted genes frequently overexpressed in amplified regions on chromosomes 1, 4, 11, and 12 and have identified novel amplicons on these chromosomes. Deletions of specific regions on chromosomes 9, 10, 11, 14, and 15 have also been correlated with reduced gene expression in the regions of minimal overlap. In addition we describe a novel approach for comparing gene expression levels between tumors based on the presence or absence of chromosome CNAs. This genome wide screen provides an efficient and comprehensive survey of genes which potentially serve as the drivers for the CNAs in GBM. © 2007 Wiley-Liss, Inc. [source] Inherited coagulation disorders in southern IranHAEMOPHILIA, Issue 6 2002M. Karimi Summary., A comprehensive survey concerning the Shiraz Hemophilia Society and the associated haemophilia treatment centre was undertaken in April 2002 to collect data on demographics, signs and symptoms in the southern Iranian population with haemophilia and allied disorders. The total number of patients with coagulation disorders was 367. Haemophilia A (factor [F] VIII deficiency) was found in 271, 39 had haemophilia B (FIX deficiency) and 24 had von Willebrand disease. The rare coagulation disorders (n = 33) included 11 patients with FX deficiency; 10 with FVII; six with FXIII; two with afibrinogenaemia; two with FXI; one with combined FVIII and FV; and one with combined FVII, FVIII and FIX deficiency. The prevalence was 6.64 per 100 000 inhabitants. The most common symptoms were haemarthrosis, haematomas and epistaxis. None of the patients were human immunodeficiency virus positive but 47 (15%) were hepatitis C virus positive and two (0.7%) were hepatitis B positive, so that the rate of transfusion-transmitted infections was lower compared with other populations. [source] Teaching & Learning Guide for: The Origins of the Civil WarHISTORY COMPASS (ELECTRONIC), Issue 4 2007Nicole Etcheson Author's Introduction The author argues that slavery is the root cause of the Civil War even though historians have often posited other explanations. Some other interpretations have been ideological (i.e., about the morality of slavery), others have been economic, political, or cultural. Focus Questions 1If you were to make an argument for the causes of the Civil War, what evidence or types of evidence would you want to examine? 2In what ways can the different types of arguments (ideological, economic, political, and cultural), be combined to explain the causes of the Civil War? Do such arguments exclude or reinforce each other? In what ways? Author Recommends * E. L. Ayres, In the Presence of Mine Enemies: War in the Heart of America, 1859,1863 (New York, NY: Norton, 2003). A study of two counties, one north and one south, during the end of the sectional crisis and the early Civil War. While Potter, Walther, and Wilentz offer sweeping, often political, histories, Ayres offers a microhistory approach to the sectional conflict. Although Ayres writes within the tradition of seeing cultural differences between North and South, he concludes that slavery was the issue that drove the two sections apart. * M. A. Morrison, Slavery and the American West: The Eclipse of Manifest Destiny and the Coming of the Civil War (Chapel Hill, NC: University of North Carolina Press, 1997). Views the development of the sectional crisis through the lens of Manifest Destiny. Territorial expansion drove hostility between the sections. Morrison concentrates on the political developments of the period connected to the acquisition and organization of the territories to show how the issue of slavery in the territories polarized the sections. * D. M. Potter, The Impending Crisis, 1848,1861 (New York, NY: Harper & Row, 1976). The most comprehensive survey of the decade before the war. Potter traces the development of slavery as a political issue that North and South could not resolve. While it is a masterly and nuanced treatment of the political history, it does not incorporate social history and is more detailed than is useful for most undergraduates. E. H. Walther, The Shattering of the Union: America in the 1850s (Wilmington, Scholarly Resources, 2004) has recently supplanted Potter as a survey of the decade. It is an easier read for undergraduates and incorporates the new literature than has emerged since Potter wrote. * S. Wilentz, The Rise of American Democracy: Jefferson to Lincoln (New York, NY: Norton, 2005). A sweeping history of the United States from the constitutional era to the outbreak of the Civil War. Wilentz attempts to update Arthur M. Schlesinger Jr.'s synthesis The Age of Jackson by returning to a focus on the evolution of democracy while at the same time incorporating the social history that emerged after Schlesinger wrote. Only the last third of this very long book covers the 1850s, but Wilentz argues that democracy had taken differing sectional forms by that period: a free-labor version in the North and a plantation version in the South. Online Materials 1. The Valley of the Shadow: Two Communities in the American Civil War (http://valley.vcdh.virginia.edu/) A prize-winning website that profiles Augusta County, Virginia and Franklin County, Pennsylvania. Material from this website formed the basis of Ayres, In the Presence of Mine Enemies. Although the website primarily concentrates on the Civil War itself, it provides access to newspapers and letters and diaries from the 1850s that show the development of, and reaction to, the sectional crisis in those counties. It also shows students the types of materials (census, tax, and church records as well as newspapers and letters and diaries) with which historians work to build an argument. 2. American Memory from the Library of Congress (http://memory.loc.gov/ammem/index.html) Although not specifically devoted to the origins of the Civil War, the American Memory site provides access to the collections of the Library of Congress which contain massive amounts of primary materials for students and scholars. From the website, one can gain access to congressional documents, periodicals from the 1850s, nineteenth-century books, music, legal documents, memoirs by white and black southerners as well as slave narratives. Sample Syllabus Nicole Etcheson's ,Origins of the Civil War,' History Compass, 3/1 (2005), doi:10.1111/j.1478-0542.2005.00166.x can be used as a reading in any Civil War course. [source] A standardized, comprehensive magnetic resonance imaging protocol for rapid and precise quantification of HIV-1-associated lipodystrophyHIV MEDICINE, Issue 7 2007M Bickel Objectives Although multiple methods have been proposed, there is no current gold standard for assessing HIV-1-associated lipodystrophy. Methods HIV-1-infected participants were randomly enrolled and surveyed about changes in the abdomen, thigh, cheek and neck areas. Magnetic resonance imaging (MRI) sequences of these sites were obtained. Participants were grouped according to survey results, and the MRI measurements were compared between groups. Results One hundred participants were included in the study, of whom 79% reported any body fat changes. Persons reporting increased abdominal girth had higher visceral ([mean±standard deviation] 142±75 vs. 59±48 cm2; P<0.0001) and total abdominal adipose tissue than those reporting no change (344±119 vs. 201±95 cm2; P<0.0001). The amount of localized fat was less for persons reporting sunken cheeks and reduced diameter of the legs compared with those who noted no changes (5.9±3.6 vs. 9.3±3.8 cm2; P<0.0001, and 35±28 vs. 112±56 cm2; P<0.0001). Participants reporting increased neck girth had a thicker fat layer in the dorsocervical region compared with those reporting no change (4.0±1.8 vs. 2.3±1.4 cm; P<0.0002). Conclusions MRI is a precise method for rapidly surveying body regions affected by HIV-1-associated lipodystrophy. Our proposed protocol provides a rapid, comprehensive survey of these areas, without the need to combine multiple modalities or to expose subjects to radiation. [source] The Blalock-Taussig ShuntJOURNAL OF CARDIAC SURGERY, Issue 2 2009Shi-Min Yuan M.D. This warrants us a zest in making a comprehensive survey on this subject. Methods: Articles were extensively retrieved from the MEDLINE database of National Library of Medicine USA if the abstract contained information relevant to the B-T shunt in terms of the conduit options, modified surgical techniques, surgical indications, short- and long-term results, complications, and prognosis. Further retrieval was undertaken by manually searching the reference list of relevant papers. Results: Classical or modified B-T shunts, either on ipsilateral or contralateral side to the aortic arch, can be performed on patients of any age with minimum postoperative complications and low operative mortality. Expended polytetrafluoroethylene has gained satisfactory long-term patency rate in the construction of the modified B-T shunt. Excellent pulmonary artery growth was observed in the patients with a modified B-T shunt, and it has shown superb prognosis over the classic with regard to hemodynamics, patency rate, and survival. Conclusions: The modified B-T shunt that was developed on basis of the classic fashion remains the preferable palliative procedure aiming at enhancing pulmonary blood flow for neonates and infants with complicated cyanotic congenital heart defects. The modified B-T shunt is technically simpler with less dissection, and blood flow to the respective arm is not jeopardized. It has been proved to be of low risk, excellent palliation, and is associated with excellent pulmonary artery growth, has become the most effective palliative shunt procedure of today. [source] Insulin pumps: from inception to the present and toward the futureJOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 2 2010F. M. Alsaleh BPharm MSc Summary As an alternative to the usual insulin injections, insulin pumps have been introduced as an advanced method of insulin delivery for managing type 1 diabetes mellitus patients. This review documents the history of insulin pump development and the production of ,smart pumps' that offer patients greater dosing accuracy, flexibility, and ease of use. This has resulted in an increase in the number of insulin pump users around the world. This paper also provides a comprehensive survey of the pumps currently available on the market and their specifications. Unique features of each product and the drawbacks are addressed in the review. The future direction of insulin pump development is targeted toward closing the loop, to allow feedback control between an insulin pump and a glucose sensor, and hence finer adjustment of insulin delivery rates as required. [source] PRODUCTIVE GOVERNMENT EXPENDITURE AND ECONOMIC GROWTHJOURNAL OF ECONOMIC SURVEYS, Issue 4 2009Andreas Irmen Abstract We provide a comprehensive survey of the recent literature on the link between productive government expenditure and economic growth. We show that an understanding of the core results and the ensuing contributions can be gained from the study of their respective Euler equations. We argue that the existing literature incorporates many relevant aspects; however, policy recommendations tend to hinge on several knife-edge assumptions. Therefore, future research ought to focus more on idea-based endogenous growth models to check the robustness of policy recommendations. Moreover, the inclusion of hitherto unexplored types of government expenditure, e.g. on the ,rule of law', would be desirable. [source] An Economist's Perspective on Probability MatchingJOURNAL OF ECONOMIC SURVEYS, Issue 1 2000Nir Vulkan The experimental phenomenon known as ,probability matching' is often offered as evidence in support of adaptive learning models and against the idea that people maximise their expected utility. Recent interest in dynamic-based equilibrium theories means the term re-appears in Economics. However, there seems to be conflicting views on what is actually meant by the term and about the validity of the data. The purpose of this paper is therefore threefold: First, to introduce today's readers to what is meant by probability matching, and in particular to clarify which aspects of this phenomenon challenge the utility-maximisation hypothesis. Second, to familiarise the reader with the different theoretical approaches to behaviour in such circumstances, and to focus on the differences in predictions between these theories in light of recent advances. Third, to provide a comprehensive survey of repeated, binary choice experiments. [source] Physiological adaptation of Corynebacterium glutamicum to benzoate as alternative carbon source , a membrane proteome-centric viewPROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 14 2009Ute Haußmann Abstract The ability of microorganisms to assimilate aromatic substances as alternative carbon sources is the basis of biodegradation of natural as well as industrial aromatic compounds. In this study, Corynebacterium glutamicum was grown on benzoate as sole carbon and energy source. To extend the scarce knowledge about physiological adaptation processes occurring in this cell compartment, the membrane proteome was investigated under quantitative and qualitative aspects by applying shotgun proteomics to reach a comprehensive survey. Membrane proteins were relatively quantified using an internal standard metabolically labeled with 15N. Altogether, 40 proteins were found to change their abundance during growth on benzoate in comparison to glucose. A global adaptation was observed in the membrane of benzoate-grown cells, characterized by increased abundance of proteins of the respiratory chain, by a starvation response, and by changes in sulfur metabolism involving the regulator McbR. Additional to the relative quantification, stable isotope-labeled synthetic peptides were used for the absolute quantification of the two benzoate transporters of C. glutamicum, BenK and BenE. It was found that both transporters were expressed during growth on benzoate, suggesting that both contribute substantially to benzoate uptake. [source] Samesaying, Propositions and Radical InterpretationRATIO, Issue 2 2001Gary Kemp Davidson's paratactic account of indirect quotation preserves the apparent relational structure of indirect speech but without assuming, in the Fregean manner, that the thing said by a sayer is a proposition. I argue that this is a mistake. As has been recognised by some critics, Davidson's account suffers from analytical shortcomings which can be overcome by redeploying the paratactic strategy as a means of referring to propositions. I offer a quick and comprehensive survey of these difficulties and a concise propositional solution. Further, I argue that Davidson's more general philosophical commitments provide no reason not to embrace the propositional strategy: despite appearances, to invoke propositions in the way suggested is consistent with Davidson's holism and consequent doctrine of semantic indeterminacy. [source] Factors Influencing Housing Equity Withdrawal: Evidence from a Microeconomic Survey,THE ECONOMIC RECORD, Issue 267 2008CARL SCHWARTZ The increase in housing equity withdrawal and coincident decline in aggregate savings rates in a number of countries in recent years is consistent with the consumption-smoothing model of housing equity withdrawal. However, there are a variety of other theoretical models that purport to explain why households withdraw and inject equity. To assess the relative importance of these various theories, we use a comprehensive survey of the equity withdrawal and injection decisions of Australian households. We find support for several theories. Life cycle considerations appear to be most important, with older households accounting for the bulk of equity withdrawn. Portfolio rebalancing considerations also appear important, with financial asset accumulation the primary use of withdrawn funds. Consumption-smoothing motives play an influential role, although primarily for smaller-value transactions. [source] Modified Translabyrinthine Approach and Hearing PreservationTHE LARYNGOSCOPE, Issue 6 2004Giuseppe Magliulo MD Abstract Objectives/Hypothesis: In 1991, the translabyrinthine approach was modified by sealing the vestibule with bone wax, which allowed preservation of the hearing function in one patient. The present study aimed specifically at evaluating the effectiveness of the modified translabyrinthine approach in preserving hearing function in a group of patients with vestibular schwannoma that involved the internal auditory canal. Study Design: Prospective study. Methods: The series consisted of 12 patients with vestibular schwannoma (average age, 49.7 y). The schwannoma was smaller than 2 cm in all patients who had surgery. The patients accepted for the study were required to have preserved hearing function. Results: None of the patients has shown signs of persistence or tumoral relapse on postoperative magnetic resonance imaging. Immediately after surgery, the entire group had excellent facial functionality. Six patients had maintained their hearing function (four in Class 1 and two in Class 2 according to the Gardner-Robertson scale) at the last follow-up after surgery. A patient during follow-up noted fluctuating hearing contemporarily with a tinnitus in the ear that had maintained its hearing, which was attributable to an endolymphatic hydrops. Three of the six patients with preserved hearing complained of persistent tinnitus. None of the patients had any of the complications or consequences of cerebellopontine surgery. Conclusion: In our patients, Class 1 or 2 hearing was preserved in 50% of the patients, with no persistence or tumoral relapse. The follow-up has obviously been short, but the first results are encouraging and deserve to be studied further in a more comprehensive survey. [source] Life, the universe and everything, with GAIAASTRONOMY & GEOPHYSICS, Issue 5 2001Gerry Gilmore Great things are expected of the GAIA Observatory, currently expected to launch in 2011. Gerry Gilmore explains how it will provide accurate measurements that will help us understand the formation of the Milky Way and the distribution of dark matter. The GAIA Observatory, ESA's Cornerstone 6 mission, addresses the origin and evolution of our galaxy, and a host of other scientific challenges. GAIA will provide unprecedented positional and radial velocity measurements with the accuracies needed to produce a stereoscopic and kinematic census of about one billion stars in our galaxy and throughout the Local Group, about 1% of the galactic stellar population. Combined with astrophysical information for each star, provided by on-board multicolour photometry, these data will have the precision and depth necessary to address the three key questions which underlie the GAIA science case: l when did the stars in the Milky Way form? l when and how was the Milky Way assembled? l what is the distribution of dark matter in our galaxy? The accurate stellar data acquired for this purpose will also have an enormous impact on all areas of stellar astrophysics, including luminosity calibrations, structural studies, and the cosmic distance scale. Additional scientific products include detection and orbital classification of tens of thousands of extrasolar planetary systems, a comprehensive survey of objects ranging from huge numbers of minor bodies in our solar system, including near-Earth objects, through galaxies in the nearby universe, to some 500 000 distant quasars. GAIA will also provide several stringent new tests of general relativity and cosmology. [source] Business ethics as academic field in Africa: its current statusBUSINESS ETHICS: A EUROPEAN REVIEW, Issue 4 2000Belinda Barkhuysen Reflection on the state of business ethics as academic field in Africa has been largely neglected, partly because there existed no overall picture of what is happening in this field of study. This paper reports the findings of the first comprehensive survey on the state of business ethics as academic field on the African continent. It has both a descriptive and reflective component. In the descriptive part of the paper the research strategy and methodology used to conduct this survey is outlined as well as the difficulties encountered in the research project. Then the findings with regard to how academics perceived the purpose of this field of study, what academic activity there is within this field, where it is being done, and how it is institutionalised are reported. In the reflective part of the paper, the implications of these findings are considered and some directives for the further development of business ethics as academic field are proposed. [source] Teaching & Learning Guide for: Moral Realism and Moral NonnaturalismPHILOSOPHY COMPASS (ELECTRONIC), Issue 3 2008Stephen Finlay Authors' Introduction Metaethics is a perennially popular subject, but one that can be challenging to study and teach. As it consists in an array of questions about ethics, it is really a mix of (at least) applied metaphysics, epistemology, philosophy of language, and mind. The seminal texts therefore arise out of, and often assume competence with, a variety of different literatures. It can be taught thematically, but this sample syllabus offers a dialectical approach, focused on metaphysical debate over moral realism, which spans the century of debate launched and framed by G. E. Moore's Principia Ethica. The territory and literature are, however, vast. So, this syllabus is highly selective. A thorough metaethics course might also include more topical examination of moral supervenience, moral motivation, moral epistemology, and the rational authority of morality. Authors Recommend: Alexander Miller, An Introduction to Contemporary Metaethics (Cambridge: Polity Press, 2003). This is one of the few clear, accessible, and comprehensive surveys of the subject, written by someone sympathetic with moral naturalism. David Brink, Moral Realism and the Foundations of Ethics (Cambridge: Cambridge University Press, 1989). Brink rehabilitates naturalism about moral facts by employing a causal semantics and natural kinds model of moral thought and discourse. Michael Smith, The Moral Problem (Oxford: Blackwell, 1994). Smith's book frames the debate as driven by a tension between the objectivity of morality and its practical role, offering a solution in terms of a response-dependent account of practical rationality. Gilbert Harman and Judith Jarvis Thomson, Moral Relativism & Moral Objectivity (Cambridge, MA: Blackwell, 1996). Harman argues against the objectivity of moral value, while Thomson defends it. Each then responds to the other. Frank Jackson, From Metaphysics to Ethics (Oxford: Clarendon Press, 1998). Jackson argues that reductive conceptual analysis is possible in ethics, offering a unique naturalistic account of moral properties and facts. Mark Timmons, Morality without Foundations (Oxford: Oxford University Press, 1999). Timmons distinguishes moral cognitivism from moral realism, interpreting moral judgments as beliefs that have cognitive content but do not describe moral reality. He also provides a particularly illuminating discussion of nonanalytic naturalism. Philippa Foot, Natural Goodness (New York, NY: Oxford University Press, 2001). A Neo-Aristotelian perspective: moral facts are natural facts about the proper functioning of human beings. Russ Shafer-Landau, Moral Realism: A Defence (New York, NY: Oxford University Press, 2003). In this recent defense of a Moorean, nonnaturalist position, Shafer-Landau engages rival positions in a remarkably thorough manner. Terence Cuneo, The Normative Web (New York, NY: Oxford University Press, 2007). Cuneo argues for a robust version of moral realism, developing a parity argument based on the similarities between epistemic and moral facts. Mark Schroeder, Slaves of the Passions (New York, NY: Oxford University Press, 2007). Schroeder defends a reductive form of naturalism in the tradition of Hume, identifying moral and normative facts with natural facts about agents' desires. Online Materials: PEA Soup: http://peasoup.typepad.com A blog devoted to philosophy, ethics, and academia. Its contributors include many active and prominent metaethicists, who regularly post about the moral realism and naturalism debates. Metaethics Bibliography: http://www.lenmanethicsbibliography.group.shef.ac.uk/Bib.htm Maintained by James Lenman, professor of philosophy at the University of Sheffield, this online resource provides a selective list of published research in metaethics. Stanford Encyclopedia of Philosophy: http://plato.stanford.edu See especially the entries under ,metaethics'. Sample Syllabus: Topics for Lecture & Discussion Note: unless indicated otherwise, all the readings are found in R. Shafer-Landau and T. Cuneo, eds., Foundations of Ethics: An Anthology (Malden: Blackwell, 2007). (FE) Week 1: Realism I (Classic Nonnaturalism) G. E. Moore, Principia Ethica, 2nd ed. (FE ch. 35). W. K. Frankena, ,The Naturalistic Fallacy,'Mind 48 (1939): 464,77. S. Finlay, ,Four Faces of Moral Realism', Philosophy Compass 2/6 (2007): 820,49 [DOI: 10.1111/j.1747-9991.2007.00100.x]. Week 2: Antirealism I (Classic Expressivism) A. J. Ayer, ,Critique of Ethics and Theology' (1952) (FE ch. 3). C. Stevenson, ,The Nature of Ethical Disagreement' (1963) (FE ch. 28). Week 3: Antirealism II (Error Theory) J. L. Mackie, ,The Subjectivity of Values' (1977) (FE ch. 1). R. Joyce, Excerpt from The Myth of Morality (2001) (FE ch. 2). Week 4: Realism II (Nonanalytic Naturalism) R. Boyd, ,How to be a Moral Realist' (1988) (FE ch. 13). P. Railton, ,Moral Realism' (1986) (FE ch. 14). T. Horgan and M. Timmons, ,New Wave Moral Realism Meets Moral Twin Earth' (1991) (FE ch. 38). Week 5: Antirealism III (Contemporary Expressivism) A. Gibbard, ,The Reasons of a Living Being' (2002) (FE ch. 6). S. Blackburn, ,How To Be an Ethical Anti-Realist' (1993) (FE ch. 4). T. Horgan and M. Timmons, ,Nondescriptivist Cognitivism' (2000) (FE ch. 5). W. Sinnott-Armstrong, ,Expressivism and Embedding' (2000) (FE ch. 37). Week 6: Realism III (Sensibility Theory) J. McDowell, ,Values and Secondary Qualities' (1985) (FE ch. 11). D. Wiggins, ,A Sensible Subjectivism' (1991) (FE ch. 12). Week 7: Realism IV (Subjectivism) & Antirealism IV (Constructivism) R. Firth, ,Ethical Absolutism and the Ideal Observer' (1952) (FE ch. 9). G. Harman, ,Moral Relativism Defended' (1975) (FE ch. 7). C. Korsgaard, ,The Authority of Reflection' (1996) (FE ch. 8). Week 8: Realism V (Contemporary Nonnaturalism) R. Shafer-Landau, ,Ethics as Philosophy' (2006) (FE ch. 16). T. M. Scanlon, What We Owe to Each Other (Cambridge, MA: Harvard University Press, 1998), ch. 1. T, Cuneo, ,Recent Faces of Moral Nonnaturalism', Philosophy Compass 2/6 (2007): 850,79 [DOI: 10.1111/j.1747-9991.2007.00102.x]. 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