Home  About us  Contact
 

Common Result (common + result)

Distribution by Scientific Domains
Medical Sciences75%

Selected Abstracts

Comparing Dementia Diagnostic Methods Used with People with Intellectual Disabilities

JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES, Issue 2 2005
Diana B. Burt
Abstract, Accurate detection of dementia in adults with intellectual disabilities is important for clinical care, program planning, and clinical research. This paper reports on a study that examined two major diagnostic methods that varied in the following ways: (1) the extent to which they relied on clinical judgment; (2) the statistical method used to detect declines; and (3) the sensitivity to declines in functioning. Two methods based on testing were compared with one based on clinical judgment. Data were drawn from annual sequential assessments of 168 adults with intellectual disabilities (78 with Down syndrome and 90 with other etiologies). Agreement between testing and clinical judgment methods was 72,75% depending on testing method used. Clinical judgment produced a higher rate of dementia diagnosis for adults with Down syndrome compared with testing methods, suggesting a possible bias. The authors found that diagnostic criteria were useful both for identifying dementia and for describing its characteristics. Our results suggest that clinical judgment could result in a higher number of adults with Down syndrome diagnosed with dementia than methods based on test batteries. Common results across research studies indicate that combinations of sources of information (interviews/direct testing) would be most useful for dementia diagnosis. Future collaboration across research sites is needed to promote rapid progress in this important area, with emphasis on differential diagnosis. [source]

Vertical merger: monopolization for downstream quasi-rents

MANAGERIAL AND DECISION ECONOMICS, Issue 3 2009
Richard S. Higgins
This paper provides a welfare analysis of vertical merger between an input monopolist and downstream firms that compete perfectly in a homogeneous product market. The distinguishing feature of the present model is that the downstream firms face capacity constraints. As a result of downstream quasi-rents, vertical merger,the extent of merger is gauged by the capacity share of the acquired downstream firm,may either raise or lower final output. An analytical criterion for distinguishing pro- and anti-competitive mergers is derived, which relies entirely on pre-merger market quantities and the capacity share of the downstream target. A common result is that vertical merger is output-increasing even when unaffiliated downstream rivals are completely foreclosed. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Risk assessment of genetically modified crops for nutrition and health

NUTRITION REVIEWS, Issue 1 2009
Javier A Magaña-Gómez
The risk assessment of genetically modified (GM) crops for human nutrition and health has not been systematic. Evaluations for each GM crop or trait have been conducted using different feeding periods, animal models, and parameters. The most common result is that GM and conventional sources induce similar nutritional performance and growth in animals. However, adverse microscopic and molecular effects of some GM foods in different organs or tissues have been reported. Diversity among the methods and results of the risk assessments reflects the complexity of the subject. While there are currently no standardized methods to evaluate the safety of GM foods, attempts towards harmonization are on the way. More scientific effort is necessary in order to build confidence in the evaluation and acceptance of GM foods. [source]

McLeod neuroacanthocytosis: Genotype and phenotype,

ANNALS OF NEUROLOGY, Issue 6 2001
Adrian Danek MD
McLeod syndrome is caused by mutations of XK, an X-chromosomal gene of unknown function. Originally defined as a peculiar Kell blood group variant, the disease affects multiple organs, including the nervous system, but is certainly underdiagnosed. We analyzed the mutations and clinical findings of 22 affected men, aged 27 to 72 years. Fifteen different XK mutations were found, nine of which were novel, including the one of the eponymous case McLeod. Their common result is predicted absence or truncation of the XK protein. All patients showed elevated levels of muscle creatine phosphokinase, but clinical myopathy was less common. A peripheral neuropathy with areflexia was found in all but 2 patients. The central nervous system was affected in 15 patients, as obvious from the occurrence of seizures, cognitive impairment, psychopathology, and choreatic movements. Neuroimaging emphasized the particular involvement of the basal ganglia, which was also detected in 1 asymptomatic young patient. Most features develop with age, mainly after the fourth decade. The resemblance of McLeod syndrome with Huntington's disease and with autosomal recessive chorea-acanthocytosis suggests that the corresponding proteins,XK, huntingtin, and chorein,might belong to a common pathway, the dysfunction of which causes degeneration of the basal ganglia. [source]