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Colony Stimulation Factor (colony + stimulation_factor)

Distribution by Scientific Domains
Medical Sciences100%

Kinds of Colony Stimulation Factor

  • granulocyte colony stimulation factor
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    Selected Abstracts

    Sweet's syndrome in chronic lymphocytic leukemia associated with neutropenic fever and granulocyte colony stimulation factor

    AMERICAN JOURNAL OF HEMATOLOGY, Issue 9 2006
    Michael A. Thompson
    Abstract Granulocyte colony stimulation factor (G-CSF) is commonly used in the treatment of chemotherapy-induced myelosuppression. We report the case of a 62-year-old man with chronic lymphocytic leukemia who presented with neutropenic fever and sepsis. After treatment with G-CSF he developed Sweet's syndrome. Sweet's syndrome is a rare disorder but has been associated with cancer recurrence as well as administration of G-CSF. We present clinical and pathologic images that highlight the salient features of this entity. Am. J. Hematol., 2006. © 2006 Wiley-Liss, Inc. [source]

    Granulocyte colony stimulation factor (G-CSF) suppresses interleukin (IL)-12 and/or IL-2 induced interferon (IFN)-,production and cytotoxicity of decidual mononuclear cells

    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 1 2003
    Kenji Sugita
    Problem: The placenta is one of the few non-hematopoietic tissues to express granulocyte colony stimulation factor (G-CSF). Placental G-CSF production is considered to be one of the major causes of granulocytosis during pregnancy although its physiological role in pregnancy has not yet been examined. Method of study: The effects of G-CSF on interleukin (IL)-2 and/or IL-12 induced interferon (IFN)-, production of magnetic cell sorting (MACS) sorted decidual lymphocytes was examined by enzyme-linked immunosorbent spot-forming cell assay (ELISPOT). The effect of G-CSF on cytotoxicity of decidual lymphocytes against the choriocarcinoma cell line JEG-3 was examined by lactate dehydrogenase (LDH) release assay. Results: As previously reported by us, IL-2 and/or IL-12 activated decidual mononuclear cells were capable of killing choriocarcinoma cells. We observed that G-CSF abolished IFN-, production and cytotoxicity of decidual mononuclear cells and MACS sorted CD56+ cells. Conclusions: In addition to its well-known trophic effects on hematopoiesis, our results suggest about new roles of G-CSF in reproductive immunology. [source]