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Selected AbstractsDevelopment Section, April 2008GEOGRAPHY COMPASS (ELECTRONIC), Issue 3 2008Cheryl McEwan EDITORIAL It is a great privilege to serve as Editor for the Development section of Geography Compass. The journal is an exciting new venture in electronic publishing that aims to publish state-of-the-art peer-reviewed surveys of key contemporary issues in geographical scholarship. As the first Editor of this section, it is my responsibility to establish the key aims and innovations for this section of the journal. These include: publishing reviews of scholarship on topics of contemporary relevance that are accessible and useful to researchers, teachers, students and practitioners; developing the range of topics covered across the spectrum of development geography; helping to set agendas in development geography by identifying gaps in existing empirical and conceptual research; commissioning articles from both established and graduate/early career researchers who are working at the frontiers of development geography; and communicating the distinctiveness of Geography Compass. Part of this distinctiveness is in publishing articles that are both of scholarly excellence and accessible to a wide audience. The first volume of Geography Compass was published in 2007, covering a wide range of topics (e.g. migration, children, technology, grassroots women's organizations, civil society, biodiversity, tourism, inequality, agrarian change, participatory development, disability, spirituality) in a number of specific geographical areas (e.g. Africa/southern Africa, Caribbean, China, Peru). Forthcoming in 2008/2009 are articles on the Gambia, Latin America, the Philippines, Southeast Asia, Bangladesh and South Africa, focusing on topics such as food security, comparative post-socialism, foreign aid and fair trade. Building on these diverse and excellent articles, I plan to communicate the distinctiveness of Development in a number of ways. First, I encourage an ecumenical approach to the notion of ,development geography' and welcome contributions from scholars across a range of social science disciplines whose work would be useful to a geography audience. This is important, not least because both development and geography, in disciplinary terms, are largely European inventions. Many scholars in Latin America, Africa and Asia, for example, do not refer to themselves as either development specialists or geographers but are producing important research in areas of direct relevance to students and researchers of ,development geography'. As the first editions illustrate, I also seek to publish articles that reflect ,development' in its broadest sense, encompassing economic, (geo)political, social, cultural and environmental issues. 2008 will be an interesting year for development, with a number of important issues and events shaping discourse and policy. These include: the Beijing Olympics and increasing focus on China's role in international development; political change in a number of African countries (Kenya, Zimbabwe, South Africa); the US presidential elections and potential shifts in policy on climate change, trade and security; the impacts of the Bali roadmap on climate change in the current economic context; the increasing number of impoverished people in Asia (notably China and India), sub-Saharan Africa and Latin America (notably Brazil) that even the World Bank has acknowledged; the implications of the increasing role of philanthropic foundations (e.g. the Gates Foundation and those emerging in India and Russia) in international development. I hope to see some of these issues covered in this journal. Second, I am keen to break down the association between ,development' and parts of the world variously categorized as ,Third World', ,Global South' or ,Developing World' by publishing articles that cut across North and South, East and West. The intellectual and disciplinary practices within (Western) geography that separate those researching issues in the South and post-socialist contexts from those researching similar issues in advanced capitalist economies are, it seems, no longer sustainable or sensible. Moreover, while studies of transnational and ethical trade, neoliberalism, household economies and ,commodity chains', for example, incorporate a multitude of case studies from across the world, these tend to be understood through conceptual lenses that almost always have their theoretical antecedents in Western theorization. The notion of ,learning from' debates, policy and practice in other parts of the world is still relatively alien within the discipline. There are thus issues in how we research and teach ethically and responsibly in and about different parts of the world, and in which this journal might make a contribution. Third, and related, part of my responsibility is to ensure that Compass reflects the breadth of debate about ,development' by publishing articles written by a truly international range of scholars. This has proved to be a challenge to date, in part reflecting the newness of the journal and the difficulties posed by English language publication. However, an immediate aim is to publish the work and ideas of scholars based outside of Anglophone contexts, in the Global South and in post-socialist contexts, and to use international referees who are able to provide valuable commentaries on the articles. A longer-term aim is to also further internationalize the Editorial Board. Currently, one-third of the Editorial Board is non-UK and I plan to increase this to at least 50% in future. Fourth, I plan to ensure that the Development section takes full advantage of electronic publication and the opportunities this offers. Thus, while I am keen to retain a word limit in the interest of publishing accessible articles, the lack of constraint regarding page space enables authors to include a wide range of illustrative and other material that is impossible in print journals. I plan to encourage authors to make greater use of visual materials (maps, photographs/photo-essays, video, sound recordings, model simulations and datasets) alongside text as well as more innovative forms of presentation where this might be appropriate. Finally, in the coming year, I intend to work more closely with other Compass section Editors to realize the potential for fostering debate that cuts across subdisciplinary and even disciplinary boundaries. The journal publishes across the full spectrum of the discipline and there is thus scope for publishing articles and/or special issues on development-related topics that might best be approached through dialogue between the natural and social sciences. Such topics might include resources (e.g. water, oil, bio-fuels), hazard and risk (from environmental issues to human and state security), and sustainability and quality of life (planned for 2008). Part of the distinctiveness of Compass is that electronic-only publication ensures that articles are published in relatively quick time , in some cases less than 3 months from initial submission to publication. It thus provides an important outlet for researchers working in fast-changing contexts and for those, such as graduate and early-career researchers, who might require swift publication for career purposes. Of course, as Editor I am reliant on referees both engaging with Manuscript Central and providing reports on articles in a relatively short space of time to fully expedite the process. My experience so far has been generally very positive and I would like to thank the referees for working within the spirit of the journal. Editing a journal is, of course, a collaborative and shared endeavour. The Development Editorial Board has been central to the successful launch of Development by working so generously to highlight topics and potential authors and to review articles; I would like to take this opportunity to thank Tony Bebbington, Reg Cline-Cole, Sara Kindon, Claire Mercer, Giles Mohan, Warwick Murray, Richa Nagar, Rob Potter, Saraswati Raju, Jonathan Rigg, Jenny Robinson and Alison Stenning. The Editors-in-Chief , Mike Bradshaw and Basil Gomez , have provided invaluable advice while adding humour (and colour) to the editorial process. Colleagues at Wiley-Blackwell have provided superb support, in particular, Helen Ashton who is constantly on hand to provide advice and assistance. I look forward to working closely with these people again in the coming year, as well as with the authors and readers who are vital to ensuring that Geography Compass fulfils its remit. [source] Molecular identification and population dynamics of two species of Pemphigus (Homoptera: Pemphidae) on cabbageINSECT SCIENCE, Issue 2 2009Naiqi Chen Abstract The poplar petiole gall aphid, Pemphigus populitransversus Riley, has been one of the major pests on cruciferous vegetable in the Rio Grande Valley (LRGV) of Texas since the late 1940s. It normally migrates from poplar trees to cruciferous vegetables in the fall, and migrates back to the trees in early spring of the coming year. Some root-feeding aphids were found on cruciferous vegetables in late spring and early summer in 1998 and the following years. Those aphids have been identified as Pemphigus obesinymphae Moran. This discovery completely changed the current knowledge about the root-feeding aphids on cruciferous vegetables in the LRGV. Due to their small size, morphological and feeding similarities between P. populitransversus and P. obesinymphae, their identification and distinction are difficult. In this study, random amplification of polymorphic DNA (RAPD) and amplified fragment length polymorphism (AFLP) were used to distinguish these two species over a period of time when the two species occurred together, or separately, in cabbage fields. The two species occurred on cabbage at different times of the year, and overlapped from October to June. From May to October, both species migrated to their primary hosts. The apterous aphids found on cabbage in winter contained mainly P. obesinymphae, whereas in early spring more apterous P. populitransversus were recovered. The root-feeding aphids would feed on cabbage plants as long as this host was available even during the hot, dry summer in the LRGV, although their populations were generally low. Both RAPD and AFLP techniques were efficient in discriminating the two species that showed obviously genetic variability. These molecular techniques confirmed the existence of the two aphid species in apterous samples collected from the soil in cabbage fields in the LRGV, and the results performed by RAPD were confirmed by AFLP. Furthermore, the results suggest that RAPD technique was a better choice despite its reproducibility problem, as it was less time-consuming and required less technology, labor and expense than AFLP. [source] A scenario-based stochastic programming model for water supplies from the highland lakesINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 3 2000D.W. Watkins Jr Abstract A scenario-based, multistage stochastic programming model is developed for the management of the Highland Lakes by the Lower Colorado River Authority (LCRA) in Central Texas. The model explicitly considers two objectives: (1) maximize the expected revenue from the sale of interruptible water while reliably maintaining firm water supply, and (2) maximize recreational benefits. Input data can be represented by a scenario tree, built empirically from a segment of the historical flow record. Thirty-scenario instances of the model are solved using both a primal simplex method and Benders decomposition, and results show that the first-stage (,here and now') decision of how much interruptible water to contract for the coming year is highly dependent on the initial (current) reservoir storage levels. Sensitivity analysis indicates that model results can be improved by using a scenario generation technique which better preserves the serial correlation of flows. Ultimately, it is hoped that use of the model will improve the LCRA's operational practices by helping to identify flexible policies that appropriately hedge against unfavorable inflow scenarios. [source] To stay or to go: voluntary survivor turnover following an organizational downsizingJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 6 2002Gretchen M. Spreitzer This paper examines the relationship between survivor reactions to a downsizing and retention subsequent to a downsizing. We hypothesize that survivors who experience the downsizing as distributively, procedurally, and interactionally just and who see top management as trustworthy will feel more attached to the organization because each reduces the threat inherent in downsizing. In addition, we hypothesize that survivors who feel empowered will also feel more attached to the organization because they feel better able to cope with the downsizing. We further hypothesize that those survivors who feel more attached to the organization following the downsizing will be more likely to remain with the organization in the coming year. The theoretical model is tested on a sample of aerospace employees who survived an organizational downsizing. The trustworthiness of management, distributive justice, procedural justice, and three dimensions of empowerment are found to facilitate more organizational attachment. Higher levels of attachment are found, in turn, to facilitate less voluntary turnover in the year following the downsizing. Copyright © 2002 John Wiley & Sons, Ltd. [source] Partnership Dissolution in the UK , the Role of Economic CircumstancesOXFORD BULLETIN OF ECONOMICS & STATISTICS, Issue 2 2001Rene Boheim Estimates based on couples with dependent children in the first eight years of the British Household Panel Study (1991-98) indicate that changes in a couple's economic circumstances affect the probability that a partnership dissolves. In particular, unexpected improvements in finances substantially reduce the dissolution risk, which strongly supports the importance of new information in decisions concerning partnership dissolution. Measures of a couple's own expectations concerning their financial situation over the coming year have been used in conjunction with realised changes to gauge the impact of unexpected changes. The study also finds that the risk of partnership dissolution increases with the number of children. [source] Problematic internet use: Proposed classification and diagnostic criteriaDEPRESSION AND ANXIETY, Issue 4 2003Nathan A. Shapira M.D., Ph.D. Abstract Since the mid-1990s, there have been frequent reports of individuals whose use of the computer and internet is problematic. Given the recent expansion and the expected increase in internet availability and usage in the coming years, it is important that healthcare professionals be informed about this behavior and its associated problems. Recently, psychological and psychiatric literature has described individuals that exhibit problematic internet use who often suffer from other psychiatric disorders. In the face of this comorbidity, it is essential to evaluate whether these individuals represent a distinct class of disorder, or a manifestation/coping mechanism related to other underlying diagnosis. In either event, problematic internet use negatively impacts social and emotional functioning. Based on the current limited empirical evidence, problematic internet use may best be classified as an impulse control disorder. It is therefore imperative that problematic internet use be appropriately identified among symptomatic individuals. For these reasons, we propose specific diagnostic criteria that will allow for consistent identification and assist in further study of this behavior. Depression and Anxiety 17:207,216, 2003. © 2003 Wiley-Liss, Inc. [source] IS IT ETHICAL TO STUDY WHAT OUGHT NOT TO HAPPEN?1DEVELOPING WORLD BIOETHICS, Issue 2 2006STUART RENNIE ABSTRACT In the Democratic Republic of Congo, only an estimated 2% of all AIDS patients have access to treatment. As AIDS treatment access is scaled-up in the coming years, difficult rationing decisions will have to be made concerning who will come to gain access to this scarce medical resource. This article focuses on the position, expressed by representatives of Médecins sans Frontières (MSF), that the practice of AIDS treatment access rationing is fundamentally unethical because it conflicts with the ideal of universal treatment access and the human right to health. The conclusion is that MSF's position lacks coherence, has negative practical implications, and is unfair to governments struggling to increase patient's access to AIDS treatment in unfavorable circumstances. [source] UK Household Debt: A Threat to Growth or Stability?ECONOMIC OUTLOOK, Issue 1 2005Article first published online: 2 FEB 200 The liberalisation of credit constraints in the 1970s for UK consumers has had important implications for the housing market and consumer spending. This paper by John Muellbauer1 examines the factors that have driven soaring consumer debt and house price levels; in particular those observed since the mid-1990s. By relying on recent econometric evidence and trends in credit availability, real income per head, nominal and real after tax mortgage rates, measures of perceived risk and broad demographic trends, it also analyses the prospects for house prices, mortgage debt and unsecured debt over the coming years. The outlook is for a ,soft landing' in the housing market and associated declines in the rate of growth of consumer debt, which, although probably not smooth, does suggest the underlying situation is more benign and less crisis-prone than it was in 1988,89. [source] Intra- and interlaboratory calibration of the DR CALUX® bioassay for the analysis of dioxins and dioxin-like chemicals in sedimentsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 12 2004Harrie T. Besselink Abstract In the Fourth National Policy Document on Water Management in the Netherlands [1], it is defined that in 2003, in addition to the assessment of chemical substances, special guidelines for the assessment of dredged material should be recorded. The assessment of dredged material is based on integrated chemical and biological effect measurements. Among others, the DR CALUX® (dioxin responsive,chemically activated luciferase expression) bioassay has tentatively been recommended for inclusion in the dredged material assessment. To ensure the reliability of this bioassay, an intra- and interlaboratory validation study, or ring test, was performed, organized by the Dutch National Institute for Coastal and Marine Management (RIKZ) in cooperation with BioDetection Systems BV (BDS). The intralaboratory repeatability and reproducibility and the limit of detection (LOD) and quantification (LOQ) of the DR CALUX bioassay were determined by analyzing sediment extracts and dimethyl sulfoxide (DMSO) blanks. The highest observed repeatability was found to be 24.1%, whereas the highest observed reproducibility was calculated to be 19.9%. Based on the obtained results, the LOD and LOQ to be applied for the bioassay are 0.3 and 1.0 pM, respectively. The interlaboratory calibration study was divided into three phases, starting with analyzing pure chemicals. During the second phase, sediment extracts were analyzed, whereas in the third phase, whole sediments had to be extracted, cleaned, and analyzed. The average interlaboratory repeatability increased from 14.6% for the analysis of pure compound to 26.1% for the analysis of whole matrix. A similar increase in reproducibility with increasing complexity of handlings was observed with the interlaboratory reproducibility of 6.5% for pure compound and 27.9% for whole matrix. The results of this study are intended as a starting point for implementing the integrated chemical,biological assessment strategy and for systematic monitoring of dredged materials and related materials in the coming years. [source] ACCRUAL ACCOUNTING REFORMS: ONLY FOR BUSINESSLIKE (PARTS OF) GOVERNMENTSFINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 1 2008Johan Christiaens Based on governmental accounting experiences and on the rising criticism of accrual accounting, this paper proposes that accrual accounting in governments will only succeed in businesslike (parts of) governments in the coming years. This proposition leans on the inappropriate transfer of the accrual accounting framework from the profit sector, the underestimation of difficulties considering accrual budgeting and the lack of attention to the political dimension. This paper points out that the advocates of accrual accounting have neglected some important considerations. [source] Liraglutide: can it make a difference in the treatment of type 2 diabetes?INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 2010J. Unger Summary Despite advances in the management of type 2 diabetes, glycaemic control remains suboptimal for many patients because of the complexities of disease progression and the need to balance improved glycaemic control against adverse treatment effects, particularly weight gain and hypoglycaemia. Thus, the development of new antidiabetes therapies continues in earnest. Incretin hormones have been the recent focus of research, as they account for up to 70% of the insulin response following a meal. There is also a high concordance between the physiological actions of one hormone, glucagon-like peptide-1 (GLP-1), and the therapeutic needs of patients. As native human GLP-1 has a half life of only approximately 2 min, researchers have developed molecules that act as GLP-1 receptor agonists or inhibit the enzyme responsible for GLP-1 degradation (dipeptidyl peptidase-4). Liraglutide, a human GLP-1 analogue sharing 97% of its amino acid sequence identity with native GLP-1, has been approved for use as monotherapy (not in Europe) and in combination with selected oral agents. In this supplement, we summarise key liraglutide data, offer practical insight into what we might expect of liraglutide in clinical use and examine selected case studies. For reasons of the safety and efficacy of GLP-1 receptor agonists, many thought leaders believe that these will become background therapy for majority of patients in the coming years. This supplement will serve as a resource from which readers can extract information concerning the potential benefits for patients who are overweight, losing pancreatic beta-cell function and drifting towards the ravaging effects of chronic hyperglycaemia. [source] The Globalization of Taxation?INTERNATIONAL STUDIES QUARTERLY, Issue 2 2003Electronic Commerce, the Transformation of the State The anticipated growth of new communications technologies, including the Internet and other digital networks, will make it increasingly difficult for states to tax global commerce effectively. Greater harmonization and coordination of national tax policies will likely be required in the coming years in order to address this problem. Given that the history of the state is inseparable from the history of taxation, this "globalization of taxation" could have far-reaching political implications. The modern state itself emerged out of a fiscal crisis of medieval European feudalism, which by the 14th and 15th centuries was increasingly incapable of raising sufficient revenues to support the mounting expenses of warfare. If new developments in the technology of commerce are now undermining the efficiency of the state as an autonomous taxing entity, fiscal pressures may produce a similar shift in de facto political authority away from the state and toward whatever international mechanisms are created to expedite the taxation of these new forms of commerce. [source] Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactorsJOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 3 2009Philip W Miller Abstract This mini-review covers the issues concerning the application of microfluidics towards radiolabelling with short-lived isotopes used for PET (positron emission tomography), and surveys the literature in this area. The application of microfluidic reactors to radiolabelling reactions is currently receiving a great deal of interest because of the potential advantages they have over conventional labelling systems. The volume and variety of radiolabelling reactions for PET is expected to grow markedly over the coming years due to increased demands for PET scanning. High demands and expectations for radiolabelled compounds will have to be met by exploiting new types of chemistry and technologies, such as microfluidics, to improve the production and development of PET tracers. Copyright © 2008 Society of Chemical Industry [source] Pharmacist prescribing in the UK , a literature review of current practice and researchJOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 6 2007A. P. Tonna MRPharmS MSc Abstract Objective:, To review the research literature to date on pharmacist prescribing in the United Kingdom (UK) and to explore the main areas of care and practice settings including any benefits and limitations. Findings:, There are two models of pharmacist prescribing in the UK: pharma\cist supplementary prescribing (SP) introduced in 2003, involving a voluntary partnership between the responsible independent prescriber (a physician or a dentist), the supplementary prescriber and the patient, to implement an agreed patient-specific clinical management plan; and pharmacist independent prescribing (IP) introduced in 2006, responsible for the assessment and consequent management, including prescribing of both undiagnosed and diagnosed conditions. There have been narrative reports of pharmacist SP in different health care settings including primary care, community pharmacies, secondary care and at the primary/secondary care interface; published research within these areas of care is conflicting as to which setting is more suitable for pharmacist prescribing. Initial research reports that almost 50% of pharmacist supplementary prescribers self-reported prescribing with both benefits of and barriers to implementing SP. Research involving other healthcare professionals has indicated that encroachment of traditional roles is likely to occur because of the advent of pharmacist prescribing. A small-scale study has concluded that patients are likely to accept pharmacist prescribing favourably, with another study showing pharmacist prescribing leading to improved adherence to guidelines. There is no published research yet available about practices involving pharmacist IP. Discussion:, Most of the literature focuses on pharmacists' perceptions of SP, with little information referring to other stakeholders, including patients. There is also limited published research focusing on clinical and economic outcomes of pharmacist SP. Conclusion:, This is a rapidly changing aspect of pharmacy practice in the UK, particularly with the more recent introduction of pharmacist IP. It is likely that this area of research will expand rapidly over the coming years. [source] Veterinary pharmacovigilance: between regulation and scienceJOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 6 2001G. Keck Veterinary pharmacovigilance has shown a remarkable development in recent years. After presenting briefly the regulatory context, this paper considers the scope of veterinary pharmacovigilance, causality assessment of suspected adverse drug reactions (ADRs), the systems existing in different countries and the evolution for the coming years. The involvement of veterinary research and teaching institutions should certainly become more important in this cross-road activity. [source] Proteomics by FTICR mass spectrometry: Top down and bottom upMASS SPECTROMETRY REVIEWS, Issue 2 2005Bogdan Bogdanov Abstract This review provides a broad overview of recent Fourier transform ion cyclotron resonance (FTICR) applications and technological developments relevant to the field of proteomics. Both the "bottom up" (peptide level) and "top down" (intact protein level) approaches are discussed and illustrated with examples. "Bottom up" topics include peptide fragmentation, the accurate mass and time (AMT) tag approach and dynamic range extension technology, aspects of quantitative proteomics measurements, post-translational modifications, and developments in FTICR operation software focused on peptide and protein identification. Topics related to the "top down" approach include various aspects of high mass measurements, protein tandem mass spectrometry, methods for the study of protein conformations, and protein complexes as well as advanced technologies that may become of practical utility in the coming years. Finally, early examples of the integration of both FTICR approaches to biomedical proteomics applications are presented, along with an outlook for future directions. © 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:168,200, 2005 [source] Plant genome sequencing: applications for crop improvementPLANT BIOTECHNOLOGY JOURNAL, Issue 1 2010David Edwards Summary DNA sequencing technology is undergoing a revolution with the commercialization of second generation technologies capable of sequencing thousands of millions of nucleotide bases in each run. The data explosion resulting from this technology is likely to continue to increase with the further development of second generation sequencing and the introduction of third generation single-molecule sequencing methods over the coming years. The question is no longer whether we can sequence crop genomes which are often large and complex, but how soon can we sequence them? Even cereal genomes such as wheat and barley which were once considered intractable are coming under the spotlight of the new sequencing technologies and an array of new projects and approaches are being established. The increasing availability of DNA sequence information enables the discovery of genes and molecular markers associated with diverse agronomic traits creating new opportunities for crop improvement. However, the challenge remains to convert this mass of data into knowledge that can be applied in crop breeding programs. [source] On the Tasks of a Population Commission: A 1971 Statement by Donald RumsfeldPOPULATION AND DEVELOPMENT REVIEW, Issue 3 2003Article first published online: 20 APR 200 In its most familiar form, analytic assessment of the impact of demographic change on human affairs is the product of a decentralized cottage industry: individual scholars collecting information, thinking about its meaning, testing hypotheses, and publishing their findings. Guidance through the power of the purse and through institutional design that creates and sustains cooperating groups of researchers can impose some order and coherence on such spontaneous activity. But the sum total of the result may lack balance and leave important aspects of relevant issues inadequately explored. Even when research findings are picked up by the media and reach a broader public, the haphazardness of that process helps further to explain why the salience of population change to human welfare and its importance in public policymaking are poorly understood. The syndrome is not unique to the field of population, but the typically long time-lags with which aggregate population change affects economic and social phenomena make it particularly difficult for the topic to claim public attention. A time-tested, if less than fool-proof remedy is the periodic effort to orchestrate a systematic and thorough examination of the causes, consequences, and policy implications of demographic processes. Because the most potent frame for policymaking is the state, the logical primary locus for such stocktaking is at the country level. The Commission on Population Growth and the American Future was a uniquely ambitious enterprise of this sort. The Commission was established by the US Congress in 1970 as a result of a presidential initiative. Along with the work of two earlier British Royal Commissions on population, this US effort, mutatis mutandis, can serve as a model for in-depth examinations conducted at the national level anywhere. Chaired by John D. Rockefeller 3rd, the Commission submitted its final report to President Richard M. Nixon in March 1972. The background studies to the report were published in seven hefty volumes; an index to these volumes was published in 1975. Reproduced below is a statement to the Commission delivered on April 14, 1971 by Donald Rumsfeld, then Counsellor to President Nixon and in charge of the Office of Economic Opportunity. (Currently, Mr. Rumsfeld serves as US Secretary of Defense.) The brief statement articulates with great clarity the objectives of the Commission and the considerations that prompted them. The text originally appeared in Vol. 7 (pp. 1-3) of the Commission's background reports, which contains the statements at public hearings conducted by the Commission. National efforts toward comprehensive scientific reviews of population issues have their analogs at the international level. Especially notable on that score were the preparatory studies presented at the 1954 Rome and 1965 Belgrade world population conferences. The world population conferences that took place in Bucharest in 1974, in Mexico City in 1984, and in Cairo in 1994 were intergovernmental and political rather than scientific and technical meetings, but they also generated a fair amount of prior research. The year 2004 will break the decadal sequence of large-scale international meetings on population, and apart from the quadrennial congresses of the IUSSP, which showcase the voluntary research offerings of its members, none is being planned for the coming years. A partial substitute will be meetings organized by the UN's regional economic and social commissions. The first of these took place in 2002 for the Asia-Pacific region; the meetings for the other regions will be held in 2003-04. The analytic and technical contribution of these meetings, however, is expected to be at best modest. National efforts of the type carried out 30 years ago by the Commission on Population Growth and the American Future would be all the more salutary. [source] The Oxford International Diabetes Summit: Implications of the DAWN studyPRACTICAL DIABETES INTERNATIONAL (INCORPORATING CARDIABETES), Issue 6 20028 April 200, Oxford The DAWN (Diabetes Attitudes, Wishes and Needs) study was instigated by Novo Nordisk in order to assess the perceptions and attitudes of people with diabetes and health care providers to the management and care of diabetes. The study was conducted between August 2000 and September 2001 in 11 countries or regions: Australia, France, Germany, India, Japan, Poland, Spain, The Netherlands, United Kingdom, Scandinavia (Denmark, Norway and Sweden) and the USA, with the focus on drivers of effective self-management amongst over 5400 people with diabetes and over 3800 diabetes health care providers (specialist doctors, GPs and nurses). The objective of the DAWN study was to provide information of value in improving diabetes care and the well being of diabetic patients and to enhance and complement data derived from other reported psychosocial studies. To this end, the first Oxford DAWN International Summit met to consider its implications and resolve ways in which the findings of the DAWN study could be implemented. The interactive nature of the summit was enhanced by the use of computer-linked individual keypads, so that delegates could participate interactively and vote on a range of issues. Following presentations on the key issues surrounding DAWN, a series of participant workshops considered the issues that had been raised and produced their recommendations for future action. Opening the Summit, Chairman Dr David Matthews (Chairman of the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK) commented on its multi-national and multi-disciplinary nature and how this was bringing together different stakeholder perspectives. Use of the keypads showed that Denmark, USA, Germany and the UK (in that order) were the best represented. Delegates included diabetologists, nurses, behavioural scientists, GPs, patients and health payors. These different perspectives would be important in arriving at conclusions. The DAWN study had endeavoured to discover the person behind the patient and to establish to what degree self-care management truly involved a partnership between patient and health care provider. Dr Matthews emphasised the psychosocial nature of the survey and the ways in which this aspect of care had perhaps been somewhat neglected in the past. DAWN represented an opportunity for change; this challenge should be welcomed. He hoped that the outcome of the summit would have a long lasting effect over the coming years. Copyright © 2002 John Wiley & Sons, Ltd. [source] The role of bioinformatics in two-dimensional gel electrophoresisPROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 8 2003Andrew W. Dowsey Abstract Over the last two decades, two-dimensional electrophoresis (2-DE) gel has established itself as the de facto approach to separating proteins from cell and tissue samples. Due to the sheer volume of data and its experimental geometric and expression uncertainties, quantitative analysis of these data with image processing and modelling has become an actively pursued research topic. The results of these analyses include accurate protein quantification, isoelectric point and relative molecular mass estimation, and the detection of differential expression between samples run on different gels. Systematic errors such as current leakage and regional expression inhomogeneities are corrected for, followed by each protein spot in the gel being segmented and modelled for quantification. To assess differential expression of protein spots in different samples run on a series of two-dimensional gels, a number of image registration techniques for correcting geometric distortion have been proposed. This paper provides a comprehensive review of the computation techniques used in the analysis of 2-DE gels, together with a discussion of current and future trends in large scale analysis. We examine the pitfalls of existing techniques and highlight some of the key areas that need to be developed in the coming years, especially those related to statistical approaches based on multiple gel runs and image mining techniques through the use of parallel processing based on cluster computing and the grid technology. [source] The release of genetically modified crops into the environmentTHE PLANT JOURNAL, Issue 1 2003Part I. Overview of current status, regulations Summary In the past 6 years, the global area of commercially grown, genetically modified (GM) crops has increased more than 30-fold to over 52 million hectares. The number of countries involved has more than doubled. Especially in developing countries, the GM crop area is anticipated to increase rapidly in the coming years. Despite this high adoption rate and future promises, there is a multitude of concerns about the impact of GM crops on the environment. Regulatory approaches in Europe and North America are essentially different. In the EU, it is based on the process of making GM crops; in the US, on the characteristics of the GM product. Many other countries are in the process of establishing regulation based on either system or a mixture. Despite these differences, the information required for risk assessment tends to be similar. Each risk assessment considers the possibility, probability and consequence of harm on a case-by-case basis. For GM crops, the impact of non-use should be added to this evaluation. It is important that the regulation of risk should not turn into the risk of regulation. The best and most appropriate baseline for comparison when performing risk assessment on GM crops is the impact of plants developed by traditional breeding. The latter is an integral and accepted part of agriculture. [source] Learning in Newbern: Rural Studio in Year TenARCHITECTURAL DESIGN, Issue 4 2005John Forney Abstract Amidst the regulated and increasingly fraught business of architectural practice, particularly within its homestead of the town of Newbern, Hale County, Alabama, Rural Studio has entered its second decade as a force to contradict normative modes of architectural education and practice. In the coming years, we will see if the wider consequences triggered by this innovative organisation will take root elsewhere. In the meantime, John Forney's reflective examination of its roots substantiates the condition that, in times of change, the periphery is a place that matters greatly. Copyright © 2005 John Wiley & Sons, Ltd. [source] Towards using modern data assimilation and weather forecasting methods in solar physicsASTRONOMISCHE NACHRICHTEN, Issue 3-4 2007A. S. BrunArticle first published online: 7 MAR 200 Abstract We discuss how data assimilation and forecasting methods developed in Earth's weather prediction models could be used to improve our capability to anticipate solar dynamical phenomena and assimilate the huge amount of data that new solar satellites, such as SDO or Hinode, will provide in the coming years. We illustrate with some simple examples such as the solar magnetic activity cycle, the eruption of CMEs, the real potential of such methods for solar physics. We believe that we now need to jointly develop solar forecasting models, whose purpose are to assimilate observational data in order to improve our predictability power, with "first principle" solar models, whose purpose is to understand the underpinning physical processes behind the solar dynamics. These two complementary approaches should lead to the development of a solar equivalent of Earth's general circulation model. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The record-breaking cold temperatures during the winter of 2009/2010 in the Northern Hemisphere,ATMOSPHERIC SCIENCE LETTERS, Issue 3 2010Dr Chunzai Wang Abstract In this study, we show that the record-breaking cold temperatures from North America to Europe and Asia during the period of 28 December 2009 to 13 January 2010 are associated with extremely negative values of the North Atlantic Oscillation (NAO) index, which produce northerly surface wind anomalies and cause the southward advection of the cold Arctic air. Corresponded to longer-term variations of Pacific and Atlantic Sea Surface Temperatures (SSTs), the downward trend of the NAO has occurred since the early 1990s. It is speculated that if the downward trend of the NAO continues, more frequent cold outbreaks and heavy snow are likely in the coming years. Published 2010 by John Wiley and Sons, Ltd. [source] The Roles of Some Key Stakeholders in the Future of Accounting Education in AustraliaAUSTRALIAN ACCOUNTING REVIEW, Issue 3 2009Phil Hancock This article explores the role of institutional and systemic leadership in changing higher education in accounting in Australia. In particular, it discusses the roles of the Australian Learning and Teaching Council, the Australian Business Deans' Council Teaching and Learning Network, and the professional accounting bodies in meeting the challenges confronting accounting education in the tertiary sector today and in the coming years. The intersection of these leadership roles is exemplified in an accounting discipline research project that explores the critical non-technical skills stakeholders require in graduate students and discusses stakeholders' roles and responsibilities in their development. [source] Too small for concern?AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2007Public health, nanotechnology Abstract While advances in nanotechnology promise to deliver significant benefits to many aspects of health care, there is increasing concern that regulatory regimes do not adequately capture the potential risks associated with this new technology. Concerns have arisen due to preliminary evidence suggesting that some engineered nanoparticles may display undesirable toxicological properties, presenting potential risks to human and environmental health and safety. Within this context, the role of Australia's National Industrial Chemicals and Assessment Scheme and the Therapeutic Goods Administration in regulating nano-based substances is explored. Drawing on earlier regulatory failures, combined with the scientific uncertainty surrounding nanotechnology, this article recommends that Australia adopt a proactive regulatory approach to nanotechnology through amendments to present legislative regimes. The approach articulated in this article strikes a balance between the current approach and that of the European Union's comprehensive new chemicals regime. Immediate regulatory change is called for in order to ensure that the health of the Australian public is adequately protected over the coming years. [source] Fast pyrolysis technology developmentBIOFUELS, BIOPRODUCTS AND BIOREFINING, Issue 2 2010RH Venderbosch Abstract While the intention of slow pyrolysis is to produce mainly charcoal, fast pyrolysis is meant to convert biomass to a maximum quantity of liquids (bio-oil). Both processes have in common that the biomass feedstock is densified to reduce storage space and transport costs. A comfortable, more stable and cleaner intermediate energy carrier is obtained, which is much more uniform and well defined. In this review, the principles of fast pyrolysis are discussed, and the main technologies reviewed (demo scale: fluid bed, rotating cone and vacuum pyrolysis; pilot plant: ablative and twin screw pyrolysis). Possible product applications are discussed in relation to the bio-oil properties. General mass and energy balance are provided as well, together with some remarks on the economics. Challenges for the coming years are (1) improvement of the reliability of pyrolysis reactors and processes; (2) the demonstration of the oil's utilization in boilers, engines and turbines; and (3) the development of technologies for the production of chemicals and biofuels from pyrolysis oils. One important conclusion in relation to biofuel production is that the type of oxygen functionalities (viz. as an alcohol, ketone, aldehyde, ether, or ester) in the oil should be controlled, rather then merely focusing on a reduction of just the oxygen content itself. Copyright © 2010 Society of Chemical Industry and John Wiley & Sons, Ltd [source] Molecular targets of lithium actionACTA NEUROPSYCHIATRICA, Issue 6 2003B Corbella Lithium is an effective drug for both the treatment and prophylaxis of bipolar disorder. However, the precise mechanism of lithium action is not yet well understood. Extensive research aiming to elucidate the molecular mechanisms underlying the therapeutic effects of lithium has revealed several possible targets. The behavioral and physiological manifestations of the illness are complex and are mediated by a network of interconnected neurotransmitter pathways. Thus, lithium's ability to modulate the release of serotonin at presynaptic sites and modulate receptor-mediated supersensitivity in the brain remains a relevant line of investigation. However, it is at the molecular level that some of the most exciting advances in the understanding of the long-term therapeutic action of lithium will continue in the coming years. The lithium cation possesses the selective ability, at clinically relevant concentrations, to alter the PI second-messenger system, potentially altering the activity and dynamic regulation of receptors that are coupled to this intracellular response. Subtypes of muscarinic receptors in the limbic system may represent particularly sensitive targets in this regard. Likewise, preclinical data have shown that lithium regulates arachidonic acid and the protein kinase C signaling cascades. It also indirectly regulates a number of factors involved in cell survival pathways, including cAMP response element binding protein, brain-derived neurotrophic factor, bcl-2 and mitogen-activated protein kinases, and may thus bring about delayed long-term beneficial effects via under-appreciated neurotrophic effects. Identification of the molecular targets for lithium in the brain could lead to the elucidation of the pathophysiology of bipolar disorder and the discovery of a new generation of mood stabilizers, which in turn may lead to improvements in the long-term outcome of this devastating illness (1). [source] The epidemiology of age-related macular degeneration in the Indian subcontinentACTA OPHTHALMOLOGICA, Issue 3 2009Jyh Haur Woo Abstract. Context:, The Indian subcontinent is one of the most populous regions in the world. Given the projected rapid population growth and ageing of the population, age-related macular degeneration (AMD) is likely to emerge as a major public health threat in the near future. However, existing literature on AMD in the region is scarce. Methods:, This paper reviews the epidemiology and risk factors of AMD in the Indian subcontinent. Results:, Data on AMD in India show prevalences ranging from 1.8% to 4.7%. Blindness prevalence studies in Pakistan, Bangladesh and Nepal have also reported rates of 2.1% to 8.7% for all blindness attributable to AMD. Age-related macular degeneration is therefore a significant cause of visual morbidity in these countries. To date, no reliable epidemiological data on AMD or blindness have been published for Sri Lanka, Afghanistan, Maldives or Bhutan. Conclusions:, The prevalence of AMD in the region is likely to follow a trend similar to that seen in the developed world in the coming years. Eye care policies should therefore make provisions for this chronic age-related eye disease. In addition, there is an urgent need for more data on the epidemiology of AMD in the Indian subcontinent. [source] Young people in Britain at the beginning of a new centuryCHILDREN & SOCIETY, Issue 4 2000John Coleman The intention of this review article is to consider some of the major social changes that have had an impact on adolescents during the latter part of the last century, and to suggest ways in which the behaviour and development of young people in the present century will alter in response to such a change. It is argued that alteration in the labour market and in family composition and structure will have particular effects on young people in the coming years. The article also considers race, gender, sexuality, mental health and social exclusion. The review concludes with some tentative predictions concerning the attitudes and likely behaviours of young people in the twenty first century. Copyright © 2000 John Wiley & Sons, Ltd. [source] | |||||||||||||||||||||||||