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Cold Agglutinin (cold + agglutinin)

Distribution by Scientific Domains
Medical Sciences100%

Terms modified by Cold Agglutinin

  • cold agglutinin disease
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    Selected Abstracts

    Axonal Neuropathy Associated With Cold Agglutinins: A Vasculitic-Ischaemic Neuropathy

    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Issue 1 2001
    G Bezzi
    Cold agglutinin (CA) disease is an autoimmune hemolytic process characterized by chronic anemia, hemoglobinuria, cold induced rash, and acrocyanosis of exposed body parts. Although few cases of peripheral neuropathies have been observed in patients with CA, the mechanism of peripheral nervous system involvement is still uncertain. However, similar to other neuropathies due to IgM paraproteinaemia, such as anti-myelin associated glycoprotein, or anti-acidic glycolipid sulphate-3-glucuronyl paragloboside, the direct effect of the antibody on nerve constituents is considered the pathogenetic mechanism causing the demyelinating neuropathy. We report a patient with CA and sensorimotor peripheral neuropathy with electrophysiological and histological findings of a severe acute axonal neuropathy. Pathological findings show vascular damage in the nerve, suggesting a major role for ischaemic/vasculitic pathogenetic mechanism of the peripheral neuropathy in CA. [source]

    Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab,

    AMERICAN JOURNAL OF HEMATOLOGY, Issue 2 2009
    Joshua Ruch
    Cold agglutinin disease occurring with cryoglobulinemia is a rare occurrence. Here, we report a patient with mixed cryoglobulinemia that was treated with rituximab and, after response, developed an anti-Pr cold agglutinin that manifested with hemolysis and microvascular occlusion causing mesenteric ischemia and cerebral infarction. Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested. Am. J. Hematol, 2009. © 2008 Wiley-Liss, Inc. [source]

    Extensive cutaneous necrosis associated with low titres of cold agglutinins

    CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 7 2009
    S. H. Oh
    No abstract is available for this article. [source]