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Coherence
Kinds of Coherence Terms modified by Coherence Selected AbstractsRATIONALITY, COHERENCE, CONVERGENCE: A CRITICAL COMMENT ON MICHAEL SMITH'S ETHICS AND THE A PRIORIANALYTIC PHILOSOPHY, Issue 2 2007David Enoch First page of article [source] Illusions of Coherence: George F. Kennan, U.S. Strategy and Political Warfare in the Early Cold War, 1946,1950*DIPLOMATIC HISTORY, Issue 1 2009Scott Lucas First page of article [source] Health-related quality of life, symptom distress and sense of coherence in adult survivors of allogeneic stem-cell transplantationEUROPEAN JOURNAL OF CANCER CARE, Issue 2 2001L. Edman This is the first Swedish study to evaluate the health-related quality of life and sense of coherence in adult survivors of allogeneic, haematopoietic stem cell transplantation (HSCT). Twenty-five recipients completed three questionnaires 2,4 years after the transplantation. The questionnaires used were the Sickness Impact Profile (SIP), the Symptom Frequency Intensity and Distress (SFID-BMT) scale and the Sense of Coherence (SOC) scale measuring subjective functional status, symptom distress and coping ability. Impairments in functional status were found, as compared with a population norm. The most common impairments were found in the areas of social interaction and sleep and rest. Eye problems, dry mouth, cough, sexual problems, tiredness, anxiety and changes of taste were symptoms reported by more than half of the patients. Despite impaired functioning and a high incidence of symptoms, the general health was described as quite good or excellent by 80% (n = 20) of the patients. The majority (20/22) had also been able to return to work or to attend school. No difference in the sense of coherence was seen, as compared with the population norm. Functional impairments were significantly correlated to a lower degree of sense of coherence. [source] Looking for Coherence within the European Community*EUROPEAN LAW JOURNAL, Issue 2 2005Stefano Bertea It focuses on a specific dimension of this relationship and shows how the appeals to coherence made by the European Court of Justice have shaped a particular branch of the European legal order, namely, the judicial review of Community acts. The analysis of the Court of Justice's case law in this field shows that in its extensive use of coherence the Court of Justice explored and brought into play different types of coherence and, while it failed to distinguish between them, it made use of sorts of coherence that thus far legal theorists have disregarded. The article concludes that a closer collaboration between legal theory and legal practice would be profitable for both legal theorists and Community law specialists. [source] Horizontal Coherence and the External Competences of the European UnionEUROPEAN LAW JOURNAL, Issue 1 2004Pascal Gauttier First considered as a political requirement, its best expression is located in the Article 3 of the Treaty on the European Union. The practice of European foreign policy has demonstrated the importance of this requirement: the control of exports of dual-use goods as well as the adoption of sanctions, whether on the basis of Article 301 EC, or in application of international agreements with third states, have given the example of overlapping competences. Besides, this overlap has been reflected in the internal organisation of the institutions (allocation of portfolios in the European Commission, conflict between the Political Committee and the Committee of the Permanent Representatives in the Council of the EU). However, the answers to these problems have been far too timid: the adoption of an integrated approach (conflict prevention) as well as the institutional adaptations of the Treaty of Amsterdam do not compensate for the absence of a vision of the European foreign policy which would overcome the old cleavage between federalism and intergovernmentalism. Indeed, it seems to us that much more innovative solutions are needed, such as an evolution towards the binding character of the coherence requirement, which would pave the way to a coherent European foreign policy, comprising external relations and CFSP (including the defence dimension). [source] Factors influencing the temporal coherence of five lakes in the English Lake DistrictFRESHWATER BIOLOGY, Issue 3 2000D. G. George 1. The lakes in the Windermere catchment are all deep, glacial lakes but they differ in size, shape and general productivity. Here, we examine the extent to which year-to-year variations in the physical, chemical and biological characteristics of these lakes varied synchronously over a 30,40-year period. 2. Coherence was estimated by correlating time-series of the spring, summer, autumn and winter characteristics of five lakes: Esthwaite Water, Blelham Tarn, Grasmere and the North and South Basins of Windermere. Three physical, four chemical and two biological time-series were analysed and related to year-to-year variations in a number of key driving variables. 3. The highest levels of coherence were recorded for the physical and chemical variables where the average coherence was 0.81. The average coherence for the biological variables was 0.11 and there were a number of significant negative relationships. The average coherence between all possible lake pairs was 0.59 and average values ranged from 0.50 to 0.74. A graphical analysis of these results demonstrated that the coherence between individual lake pairs was influenced by the relative size of the basins as well as their trophic status. 4. A series of examples is presented to demonstrate how a small number of driving variables influenced the observed levels of coherence. These range from a simple example where the winter temperature of the lakes was correlated with the climatic index known as the North Atlantic Oscillation, to a more complex example where the summer abundance of zooplankton was correlated with wind-mixing. 5. The implications of these findings are discussed and a conceptual model developed to illustrate the principal factors influencing temporal coherence in lake systems. The model suggests that our ability to detect temporal coherence depends on the relative magnitude of three factors: (a) the amplitude of the year-to-year variations; (b) the spatial heterogeneity of the driving variables and (c) the error terms associated with any particular measurement. [source] Temporal coherence of two alpine lake basins of the Colorado Front Range, U.S.A.FRESHWATER BIOLOGY, Issue 3 2000J. I. L. L. S. Baron 1. Knowledge of synchrony in trends is important to determining regional responses of lakes to disturbances such as atmospheric deposition and climate change. We explored the temporal coherence of physical and chemical characteristics of two series of mostly alpine lakes in nearby basins of the Colorado Rocky Mountains. Using year-to-year variation over a 10-year period, we asked whether lakes more similar in exposure to the atmosphere be-haved more similarly than those with greater influence of catchment or in-lake processes. 2. The Green Lakes Valley and Loch Vale Watershed are steeply incised basins with strong altitudinal gradients. There are glaciers at the heads of each catchment. The eight lakes studied are small, shallow and typically ice-covered for more than half the year. Snowmelt is the dominant hydrological event each year, flushing about 70% of the annual discharge from each lake between April and mid-July. The lakes do not thermally stratify during the period of open water. Data from these lakes included surface water temper-ature, sulphate, nitrate, calcium, silica, bicarbonate alkalinity and conductivity. 3. Coherence was estimated by Pearson's correlation coefficient between lake pairs for each of the different variables. Despite close geographical proximity, there was not a strong direct signal from climatic or atmospheric conditions across all lakes in the study. Individual lake characteristics overwhelmed regional responses. Temporal coherence was higher for lakes within each basin than between basins and was highest for nearest neighbours. 4. Among the Green Lakes, conductivity, alkalinity and temperature were temporally coherent, suggesting that these lakes were sensitive to climate fluctuations. Water tem-perature is indicative of air temperature, and conductivity and alkalinity concentrations are indicative of dilution from the amount of precipitation flushed through by snowmelt. 5. In Loch Vale, calcium, conductivity, nitrate, sulphate and alkalinity were temporally coherent, while silica and temperature were not. This suggests that external influences are attenuated by internal catchment and lake processes in Loch Vale lakes. Calcium and sulphate are primarily weathering products, but sulphate derives both from deposition and from mineral weathering. Different proportions of snowmelt versus groundwater in different years could influence summer lake concentrations. Nitrate is elevated in lake waters from atmospheric deposition, but the internal dynamics of nitrate and silica may be controlled by lake food webs. Temperature is attenuated by inconsistently different climates across altitude and glacial meltwaters. 6. It appears that, while the lakes in the two basins are topographically close, geologically and morphologically similar, and often connected by streams, only some attributes are temporally coherent. Catchment and in-lake processes influenced temporal patterns, especially for temperature, alkalinity and silica. Montane lakes with high altitudinal gradients may be particularly prone to local controls compared to systems where coherence is more obvious. [source] Coherence and Ambiguity in HistoryHISTORY AND THEORY, Issue 2 2000Thijs Pollmann This article is about the logic of the concept of "coherence" as used by historians to justify an argument. Despite its effectiveness in historical arguments, coherence is problematic for epistemologists and some theorists of history. The main purpose of this article is to present some insights that bear upon the logical status of coherence. As will be demonstrated, this will also shed some light on the allegedly dubious epistemological position of coherence. In general I will argue that, logically seen, coherence is a property of a set of related beliefs that makes it possible to justify a choice out of different factually justifiable interpretations. Coherence disambiguates vague or ambiguous observations. As words lose their vagueness or ambiguity in contexts, so do contexts disambiguate historical facts. My argument will be based on some relatively recent findings about the cognitive processes underlying vision and reading. Research in the field of text linguistics is used to show what kinds of relationships exist between historical representations that might be considered to cohere. [source] Coherence in consciousness: Paralimbic gamma synchrony of self-reference links conscious experiencesHUMAN BRAIN MAPPING, Issue 2 2010Hans C. Lou Abstract A coherent and meaningful percept of the world is essential for human nature. Consequently, much speculation has focused on how this is achieved in the brain. It is thought that all conscious experiences have reference to the self. Self-reference may either be minimal or extended, i.e., autonoetic. In minimal self-reference subjective experiences are self-aware in the weak sense that there is something it feels like for the subject to experience something. In autonoetic consciousness, consciousness emerges, by definition, by retrieval of memories of personally experienced events (episodic memory). It has been shown with transcranial magnetic stimulation (TMS) that a medial paralimbic circuitry is critical for self-reference. This circuitry includes anterior cingulate/medial prefrontal and posterior cingulate/medial parietal cortices, connected directly and via thalamus. We here hypothesized that interaction in the circuitry may bind conscious experiences with widely different degrees of self-reference through synchrony of high frequency oscillations as a common neural event. This hypothesis was confirmed with magneto-encephalography (MEG). The observed coupling between the neural events in conscious experience may explain the sense of unity of consciousness and the severe symptoms associated with paralimbic dysfunction. Hum Brain Mapp, 2010. © 2009 Wiley-Liss, Inc. [source] Coherence of climatic reconstruction from historical documents in China by different studiesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 8 2008Quansheng Ge Abstract Much effort has been spent in the last few decades to reconstruct the climate over China using a variety of historical documents. However, differences in the results of reconstructions exist even when people are using similar documents. In order to address this issue, 14 published temperature series by different studies were analyzed for coherence and mutual consistency. The analyses on their temporal fluctuations indicate that for the individual time series (standardized) on the 10-years time scales, 57 of the 91 correlation coefficients reach the significance level of 99%. The spatial patterns among the different time series also show high coherency. In addition, consistency also exhibit when comparing the reconstructions with other available natural climate change indicators. Above information was subsequently used to synthesize the temperature series for the last 500 and 1000 years. Copyright © 2007 Royal Meteorological Society [source] Trafficking in Persons and Development: Towards Greater Policy CoherenceINTERNATIONAL MIGRATION, Issue 4 2010Gergana Danailova-Trainor Poverty is often regarded as the "root cause" of trafficking, but the linkages between poverty, a lack of development and trafficking are complex. For example, there is some evidence to suggest that victims of cross-border trafficking are more likely to originate from middle-income rather than lower-income countries. Trafficking and development have tended to be treated as very separate policy areas and the assessment of the development impact of counter-trafficking programmes is still at an early stage. This paper outlines a possible framework for a more evidence-based approach to understanding the linkages between trafficking, trafficking policy and human development. The paper argues that the human development gains from greater mobility could be significantly enhanced if there was greater coherence between policies to combat trafficking and policies to promote development. [source] Temporal Coherence of Chlorophyll a during a Spring Phytoplankton Bloom in Xiangxi Bay of Three-Gorges Reservoir, ChinaINTERNATIONAL REVIEW OF HYDROBIOLOGY, Issue 6 2009Yao-Yang Xu Abstract Algal bloom phenomenon was defined as "the rapid growth of one or more phytoplankton species which leads to a rapid increase in the biomass of phytoplankton", yet most estimates of temporal coherence are based on yearly or monthly sampling frequencies and little is known of how synchrony varies among phytoplankton or of the causes of temporal coherence during spring algal bloom. In this study, data of chlorophyll a and related environmental parameters were weekly gathered at 15 sampling sites in Xiangxi Bay of Three-Gorges Reservoir (TGR, China) to evaluate patterns of temporal coherence for phytoplankton during spring bloom and test if spatial heterogeneity of nutrient and inorganic suspended particles within a single ecosystem influences synchrony of spring phytoplankton dynamics. There is a clear spatial and temporal variation in chlorophyll a across Xiangxi Bay. The degree of temporal coherence for chlorophyll a between pairs of sites located in Xiangxi Bay ranged from ,0.367 to 0.952 with mean and median values of 0.349 and 0.321, respectively. Low levels of temporal coherence were often detected among the three stretches of the bay (Down reach, middle reach and upper reach), while high levels of temporal coherence were often found within the same reach of the bay. The relative difference of DIN between pair sites was the strong predictor of temporal coherence for chlorophyll a in down and middle reach of the bay, while the relative difference in Anorganic Suspended Solids was the important factor regulating temporal coherence in middle and upper reach. Contrary to many studies, these results illustrate that, in a small geographic area (a single reservoir bay of approximately 25 km), spatial heterogeneity influence synchrony of phytoplankton dynamics during spring bloom and local processes may override the effects of regional processes or dispersal. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Sense of Coherence and Mood States: Exploring the Causal RelationshipsJOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 1 2009Rivka Berger The current study seeks to explore the effect of an academic course on sense of coherence (SOC) and transitory mood states. Moreover, the causal relationships between SOC and transitory mood states was evaluated. Second-year pharmacology students completed pencil-and-paper questionnaires at the beginning of the semester and 3-1/2 months later. The study group (n = 37) participated in an academic course developed to teach cognitive behavior concept and practice, whereas the control group (n = 43) had additional sessions of laboratory work. SOC increased significantly after the course while tension,anxiety and confusion decreased significantly. Structural equation analyses in the study group suggested that SOC was modified by confusion and perceived stress. No such pattern was observed in the control group. [source] Coherence and correspondence criteria for rationality: experts' estimation of risks of sexually transmitted infectionsJOURNAL OF BEHAVIORAL DECISION MAKING, Issue 3 2005Mary B. Adam Abstract The aim of this study is to examine both coherence and correspondence criteria for rationality in experts' judgments of risk. We investigated biases in risk estimation for sexually transmitted infections (STIs) predicted by fuzzy-trace theory, i.e., that specific errors would occur despite experts' knowledge of correct responses. One hundred twenty professionals with specific knowledge of STI risks in adolescents were administered a survey questionnaire to test predictions concerning: knowledge deficits (producing underestimation of risks); gist-based representation of risk categories (producing overestimation of condom effectiveness); retrieval failure for risk knowledge (producing lower risk estimates); and processing interference in combining risk estimates (producing biases in post-test diagnosis of infection). Retrieval was manipulated by asking estimation questions that "unpacked" the STI category into infection types or did not specify infection types. Other questions differentiated processing biases from knowledge deficits or retrieval failure by directly providing requisite knowledge. Experts' knowledge of STI transmission and infection risks was verified empirically. Nevertheless, under predictable conditions, they misestimated risk, overestimated the effectiveness of condoms, and also suffered from processing biases. When questions provided better retrieval supports (unpacked format), risk estimates improved. Biases were linked to gist representations, retrieval failures, and processing errors, as opposed to knowledge about STIs. Results support fuzzy-trace theory's dual-process assumptions that different types of errors are dissociated from one another, and separate failures of coherence and correspondence among the same sample of experts. Copyright © 2005 John Wiley & Sons, Ltd. [source] Developing interdisciplinary maternity services policy in Canada.JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 1 2010Evaluation of a consensus workshop Abstract Context, Four maternity/obstetrical care organizations, representing women, midwives, obstetricians and family doctors conducted interdisciplinary policy research under auspices of four key stakeholder groups. These projects teams and key stakeholders subsequently collaborated to develop consensus on strategies for improved maternity services in Ontario. Objectives, The objective of this study is to evaluate a 2-day research synthesis and consensus building conference to answer policy questions in relation to new models of interdisciplinary maternity care organizations in different settings in Ontario. Methods, The evaluation consisted of a scan of individual project activities and findings as were presented to an invited audience of key stakeholders at the consensus conference. This involved: participant observation with key informant consultation; a survey of attendees; pattern processing and sense making of project materials, consensus statements derived at the conference in the light of participant observation and survey material as pertaining to a complex system. The development of a systems framework for maternity care policy in Ontario was based on secondary analysis of the material. Findings, Conference participants were united on the importance of investment in maternity care for Ontario and the impending workforce crisis if adaptation of the workforce did not take place. The conference participants proposed reforming the current system that was seen as too rigid and inflexible in relation to the constraints of legislation, provider scope of practice and remuneration issues. However, not one model of interdisciplinary maternity/obstetrical care was endorsed. Consistency and coherence of models (rather than central standardization) through self-organization based on local needs was strongly endorsed. An understanding of primary maternity care models as subsystems of networked providers in complex health organizations and a wider social system emerged. The patterns identified were incorporated into a complexity framework to assist sense making to inform policy. Discussion, Coherence around core values, holism and synthesis with responsiveness to local needs and key stakeholders were themes that emerged consistent with complex adaptive systems principles. Respecting historical provider relationships and local history provided a background for change recognizing that systems evolve in part from where they have been. The building of functioning relationships was central through education and improved communication with ongoing feedback loops (positive and negative). Information systems and a flexible improved central and local organization of maternity services was endorsed. Education and improved communication through ongoing feedback loops (positive and negative) were central to building functioning relationships. Also, coordinated central organization with a flexible and adaptive local organization of maternity services was endorsed by participants. Conclusions, This evaluation used an approach comprising scoping, pattern processing and sense making. While the projects produced considerable typical research evidence, the key policy questions could not be addressed by this alone, and a process of synthesis and consensus building with stakeholder engagement was applied. An adaptive system with local needs driving a relationship based network of interdisciplinary groupings or teams with both bottom up and central leadership. A complexity framework enhanced sense making for the system approaches and understandings that emerged. [source] Invisible Time Lines in the Fabric of Events: Temporal Coherence in Yucatec NarrativesJOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 2 2003Jürgen Bohnemeyer This article examines how narratives are structured in a language in which event order is largely not coded. Yucatec Maya lacks both tense inflections and temporal connectives corresponding to English after and before. It is shown that the coding of events in Yucatec narratives is subject to a strict iconicity constraint within paragraph boundaries. Aspectual viewpoint shifting is used to reconcile iconicity preservation with the requirements of a more flexible narrative structure. [source] Sulfoalkyl ether-alkyl ether cyclodextrin derivatives, their synthesis, NMR characterization, and binding of 6,-methylprednisoloneJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 11 2005Serena Tongiani Abstract The objective of this study is to see if random alkyl ethers of various sulfoalkyl ether cyclodextrins can be synthesized and characterized. The purpose of the alkylation was to test the hypothesis that an increase in the "height" of a cyclodextrins cavity would help in the binding/complexation of larger more structurally complex molecules. The synthesis of new cyclodextrin derivatives comprising a mixture of sulfoalkyl ether and alkyl ether substituents on the same cyclodextrin ring was performed in aqueous alkaline solutions using various sultones and alkylsulfates. The method presented provided an easy and efficient way to modify cyclodextrins avoiding the use of organic solvents and high quantities of alkylating agents and could be carried out in either a two step or "one pot" single step process. Purification was by neutralization followed by ultrafiltration. The derivatives were characterized by 1D, (1H and 13C), and a 2D NMR technique (HMQC, Heteronuclear Multiple Quantum Coherence). The combination of these techniques allowed an analysis of the degree of substitution and the site of substitution on the cyclodextrin (CD) nucleus. For both ,- and ,-CD, sulfoakylation was preferred on the 2,>,3,>,6 hydroxyls while alkylation was preferred 6,>,2,>,3. Due to the simultaneous presence of short alkyl ether chains and negatively charged sulfoalkyl ether chains, these mixed water-soluble cyclodextrin derivatives, especially those of ,-cyclodextrin, should be able to bind more complex drugs. The improved binding capacity of these new modified CDs with the model drug 6,-methylprednisolone is reported. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:2380-2392, 2005 [source] Relationships Among Risk, Sense of Coherence, and Well-Being in Parents of Children With and Without Intellectual DisabilitiesJOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES, Issue 4 2008Malin B. Olsson ABSTRACT The authors studied the nature and function of the relationships of the comparative level of risk, sense of coherence (SOC), and well-being, over time, in mothers and fathers of preschool children with and without intellectual disabilities (IDs). The hypothesis that SOC functions as a moderator between risk and well-being was tested. Parents of children with IDs (mothers: n = 62 (46 at follow-up) and fathers: n = 49 (37 at follow-up)) and control parents (mothers: n = 178 (131 at follow-up) and fathers: n = 141 (97 at follow-up)) answered self-report measures on risk factors (i.e., child behavior problems, negative impact on the family and socioeconomic situation) and sense of coherence. Well-being and quality of life were used as outcomes, and were measured at baseline and at a one-year follow-up. The hypothesis of moderation was tested conducting multiple linear regression analyses. The level of well-being was moderately stable over the two time points, with parents of children with ID having lower level of well-being than control parents both initially and after one year. Well-being was also related to level of SOC and cumulative risk with parents experiencing lower SOC or more risk also reporting lower well-being. The hypothesis of SOC acting as a moderator in the relation between cumulative risk and well-being found some support in the longitudinal analyses, but only for well-being (BDI-2r) among control mothers. [source] Coherence and wavefront characterization of Si-111 monochromators using double-grating interferometryJOURNAL OF SYNCHROTRON RADIATION, Issue 3 2010Ana Diaz A study of the coherence and wavefront properties of a pseudo-channel-cut monochromator in comparison with a double-crystal monochromator is presented. Using a double-grating interferometer designed for the hard X-ray regime, the complex coherence factor was measured and the wavefront distortions at the sample position were analyzed. A transverse coherence length was found in the vertical direction that was a factor of two larger for the channel-cut monochromator owing to its higher mechanical stability. The wavefront distortions after different optical elements in the beam, such as monochromators and mirrors, were also quantified. This work is particularly relevant for coherent diffraction imaging experiments with synchrotron sources. [source] A hybrid approach to Web forum interactional coherence analysisJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 8 2008Tianjun Fu Despite the rapid growth of text-based computer-mediated communication (CMC), its limitations have rendered the media highly incoherent. This poses problems for content analysis of online discourse archives. Interactional coherence analysis (ICA) attempts to accurately identify and construct CMC interaction networks. In this study, we propose the Hybrid Interactional Coherence (HIC) algorithm for identification of web forum interaction. HIC utilizes a bevy of system and linguistic features, including message header information, quotations, direct address, and lexical relations. Furthermore, several similarity-based methods including a Lexical Match Algorithm (LMA) and a sliding window method are utilized to account for interactional idiosyncrasies. Experiments results on two web forums revealed that the proposed HIC algorithm significantly outperformed comparison techniques in terms of precision, recall, and F-measure at both the forum and thread levels. Additionally, an example was used to illustrate how the improved ICA results can facilitate enhanced social network and role analysis capabilities. [source] Coherence as an Explanation for Theory of Mind Task Failure in AutismMIND & LANGUAGE, Issue 3 2002Deepthi Kamawar O'Loughlin and Thagard (2000) present a specific computational implementation of the idea that the problems encountered by a child with autism in classic False Belief tasks derive from a failure to maintain coherence among multiple propositions. They argue that this failure can be explained as a structural feature of a connectionist network attempting to maintain coherence. The current paper criticizes this implementation because it falsely predicts that the same children will have a parallel problem with the False Photographs task. The fact that the content of representations makes a difference while the structure remains constant casts doubt upon their claim. [source] Coherence of Structural Optimization and Configurational MechanicsPROCEEDINGS IN APPLIED MATHEMATICS & MECHANICS, Issue 1 2006Daniel Materna This contribution is concerned with the similarities of structural optimization and configurational mechanics. In structural optimization sensitivity analysis is used to obtain the sensitivity of continuum mechanical functions with respect to variations of the material body, i.e. the reference configuration. In the same manner in configurational mechanics we are interested in changes of the material body, e.g. crack propagation or phase transition problems. Consequently, variational design sensitivity analysis and the numerical techniques from structural optimization are applicable to problems fromconfigurational mechanics. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Temperature-induced reversible conformational change in the first 100 residues of ,-synucleinPROTEIN SCIENCE, Issue 3 2006Brian C. McNulty Abstract Natively disordered proteins are a growing class of anomalies to the structure,function paradigm. The natively disordered protein ,-synuclein is the primary component of Lewy bodies, the cellular hallmark of Parkinson's disease. We noticed a dramatic difference in dilute solution 1H- 15N Heteronuclear Single Quantum Coherence (HSQC) spectra of wild-type ,-synuclein and two disease-related mutants (A30P and A53T), with spectra collected at 35°C showing fewer cross-peaks than spectra acquired at 10°C. Here, we show the change to be the result of a reversible conformational exchange linked to an increase in hydrodynamic radius and secondary structure as the temperature is raised. Combined with analytical ultracentrifugation data showing ,-synuclein to be monomeric at both temperatures, we conclude that the poor quality of the 1H- 15N HSQC spectra obtained at 35°C is due to conformational fluctuations that occur on the proton chemical shift time scale. Using a truncated variant of ,-synuclein, we show the conformational exchange occurs in the first 100 amino acids of the protein. Our data illustrate a key difference between globular and natively disordered proteins. The properties of globular proteins change little with solution conditions until they denature cooperatively, but the properties of natively disordered proteins can vary dramatically with solution conditions. [source] Predictors of Depressive Symptoms in Chinese American College Students: Parent and Peer Attachment, College Challenges and Sense of CoherenceAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 2 2007Yu-Wen Ying PhD Based on Antonovsky's salutogenic model, the authors hypothesized that sense of coherence would mediate the effects of parent and peer attachment and college challenges on depressive symptoms as well as moderate the relationship between college challenges and depressive symptoms in Chinese Americans. To test our hypotheses, 353 Chinese American college students completed paper-pencil measures. Supporting our hypotheses, sense of coherence fully mediated the effects of parent and peer attachment on depressive symptom level and served as a partial mediator and moderator of the effect of college challenges on depressive symptoms. Implications of the study findings for promoting the mental health of Chinese American students are discussed. [source] Sense of coherence as a protective factor for demoralisation in women with a recent diagnosis of gynaecological cancerPSYCHO-ONCOLOGY, Issue 3 2007Nadia Boscaglia Abstract Background: Demoralisation is a dysphoric mood state commonly seen in the medically ill. Its core features comprise hopelessness, helplessness, loss of purpose and meaning, despair, and existential distress. Sense of Coherence (SOC) is a quantifiable dispositional orientation that captures the character traits likely to protect against demoralisation. In this study, we hypothesised on theoretical grounds that a strong SOC would be associated with lower levels of demoralisation in the context of gynaecological cancer (GC). Method: One hundred and twenty women with a recent (<12 months) diagnosis of GC were recruited from outpatient clinics. Participants were interviewed and completed questionnaire measures of demoralisation and SOC. A multiple regression analysis was performed using the five subscales of the Demoralisation Scale as predictor variables and SOC as the dependent variable. Results: Together, the five subscales of the Demoralisation Scale accounted for 60% of the variance in SOC. Conclusions: The results supported the hypothesis, suggesting that SOC may be protective against demoralisation in the context of serious illness. Larger, multivariate studies that examine additional variables (such as coping) would be required to further clarify the relationship between SOC and demoralisation. In the meantime, clinicians may want to consider efforts to enhance SOC in patients. Copyright © 2006 John Wiley & Sons, Ltd. [source] Exploring comprehensibility and manageability in palliative home care: An interview study of dying cancer patients' informal carersPSYCHO-ONCOLOGY, Issue 9 2004Anna Milberg The presence of an informal carer is often a prerequisite for successful palliative home care, and the staff's ability to support informal carers' coping in such situations is important. Recent research has revealed that it is possible to achieve positive psychological states in palliative care despite the burdening situation. As there is a lack of theory-based coping studies, the aim of this study was to describe, within the context of palliative home care, two concepts in Antonovsky's theory of Sense of Coherence: comprehensibility (a perception that the challenge is understood) and manageability (a perception that the resources to cope are available). Tape-recorded semi-structured interviews with 19 informal carers during ongoing palliative home care were transcribed and analysed with a qualitative hermeneutic approach. Elements that facilitated comprehensibility included open information, symbolic information, basic life assumptions and previous knowledge. These were important for creating a congruent inner reality (as opposed to chaos). Resources contributing to manageability dealt with power, support, competence and accessibility, which on a more abstract level resulted in a feeling of togetherness (as opposed to isolation). The findings are discussed in relation to the complexity of communication between staff and carers within palliative care. Copyright © 2003 John Wiley & Sons, Ltd. [source] On "Coherence" and "Law": An Analysis of Different ModelsRATIO JURIS, Issue 2 2001Aldo Schiavello The aim of this paper is to compare different conceptions of the role of (normative) coherence in the legal field. More precisely, it aims to deepen Neil MacCormick's theory of legal reasoning, in which coherence is essentially considered an interpretative tool, and Ronald Dworkin's legal theory, in which coherence occupies a more crucial place. The main results of this paper can be summarized in two points. A) For Dworkin, coherence is not just an interpretative standard but constitutes the hard core of his theory of law. B) As a consequence of A, Dworkin's reflections on coherence (as an interpretative standard) cannot be separated from his theory of law grounded on the concept of integrity. [source] Environmental exposure to carcinogens causing lung cancer: Epidemiological evidence from the medical literatureRESPIROLOGY, Issue 4 2003Melissa J. WHITROW Objective: In 2000 there were 1.1 million lung or bronchial cancer deaths worldwide, with relatively limited evidence of causation other than for smoking. We aimed to search and appraise the literature regarding evidence for a causal relationship between air pollution and lung cancer according to the 10 Bradford Hill criteria for causality. Methodology: A MEDLINE search was performed using the following key words: ,lung neoplasm', ,epidemiology', ,human', ,air pollution'and ,not molec*'. The criteria for inclusion was: cited original research that described the study population, measured environmental factors, was of case control or cohort design, and was undertaken after 1982. Results: Fourteen papers (10 case control, four cohort studies) fulfilled the search criteria, with a sample size ranging from 101 cases and 89 controls, to a cohort of 552 cases and 138 controls. Of the 14 papers that fulfilled the search criteria the number of papers addressing each of the Bradford Hill critera were as follows: Strength of association: eight studies demonstrated significant positive associations between environmental exposure and lung cancer with a relative risk range of 1.14,5.2. One study found a negative association with relative risk 0.28. Consistency: eight of 14 studies found significant positive associations and one of 14 a significant negative association. Specificity: tobacco smoking and occupational exposure were addressed in all studies (often crudely with misclassification). Temporality: exposure prior to diagnosis was demonstrated in nine studies. Dose,response relationship: evident in three studies. Coherence, analogy: not addressed in any study. Conclusion: Evidence for causality is modest, with intermediate consistency of findings, limited dose,response evidence and crude adjustment for important potential confounders. Large studies with comprehensive risk factor quantification are required to clarify the potentially small effect of air pollution given the relatively large effects of tobacco smoking and occupational carcinogen exposure. [source] Historical Truth, National Myths and Liberal Democracy: On the Coherence of Liberal Nationalism*THE JOURNAL OF POLITICAL PHILOSOPHY, Issue 3 2004Arash Abizadeh First page of article [source] Experience, Coherence, and Culture: The Significance of Dilthey's 'Descriptive Psychology' for the Anthropology of ConsciousnessANTHROPOLOGY OF CONSCIOUSNESS, Issue 1 2002C. Jason Throop This paper explores Dilthey's "descriptive psychology "and its significance for the anthropology of consciousness. To do justice to the complexities of Dilthey's project a significant portion of the paper is devoted to an exposition of the basic tenets of his"descriptive psychology." Most notably, his views on"experience,""aconsciousness,""introspection,"and"objectified mind"are discussed before turning to examine his concept of the"acquired psychicnexus." After outlining these basic tenets the paper turns to explore how Dilthey's "descriptive psychology"can serve to shed light on current anthropological research on the experience of pain. Finally, the paper concludes with a discussion of the contemporary relevance of Dilthey's project as it explores how his ideas may further inform current theoretical perspectives in anthropology about the relationship between consciousness, culture, and experience. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||