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Cognitive Correlates (cognitive + correlate)
Selected AbstractsCognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderlyINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 1 2006Gad A. Marshall Abstract Objective To investigate the relationship between magnetic resonance imaging (MRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non-demented community dwelling elderly. Methods The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the semi-quantitative rating scale of Scheltens et al. (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH. Results Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span (R,=,,0.64, p,<,0.01) and the Stroop Color Word Tests (R,=,,0.64, p,<,0.01). Severity of WMH was related to worsening performance on the Trail Making Test (R,=,0.67, p,<,0.005). Conclusions These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory. Copyright © 2005 John Wiley & Sons, Ltd. [source] Mathematical development in spina bifidaDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 1 2009Lianne H. English Abstract Spina bifida (SB) is a neural tube defect diagnosed before or at birth that is associated with a high incidence of math disability often without co-occurring difficulties in reading. SB provides an interesting population within which to examine the development of mathematical abilities and disability across the lifespan and in relation to the deficits in visual-spatial processing that are also associated with the disorder. An overview of math and its cognitive correlates in preschoolers, school-age children and adults with SB is presented including the findings from a longitudinal study linking early executive functions in infancy to the development of later preschool and school age math skills. These findings are discussed in relation to socio-historical perspectives on math education and implications for intervention and directions for further research are presented. © 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009;15:28,34. [source] Prefrontal gyral folding and its cognitive correlates in bipolar disorder and schizophreniaACTA PSYCHIATRICA SCANDINAVICA, Issue 3 2009A. M. McIntosh Objective:, We sought to address whether dorsal or ventral prefrontal gyrification is abnormal in bipolar disorder and to determine its diagnostic specificity and cognitive associations. Method:, Forty-two out-patients with bipolar disorder, 28 with schizophrenia and 37 controls underwent magnetic resonance imaging. All subjects also underwent IQ and executive assessments using tasks whose performance has been localized to the ventral or dorsal prefrontal cortex. Cortical folding was quantified using the gyrification index (GI) and related to the cognitive measures. Results:, Patients with bipolar disorder showed reduced prefrontal gyrification compared with controls but did not differ from patients with schizophrenia. Neither ventral nor dorsal GI was preferentially affected in either disorder. Current IQ was positively and significantly correlated with GI. Conclusion:, Patients with bipolar disorder and patients with schizophrenia have reduced prefrontal gyrification affecting both ventral and dorsal subregions. These reductions were significantly associated with cognitive impairments occurring in both disorders. [source] Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerebral,craniofacial morphogenesis and cognitive functionJOURNAL OF ANATOMY, Issue 3 2005Robin J. Hennessy Abstract Over early fetal life the anterior brain, neuroepithelium, neural crest and facial ectoderm constitute a unitary, three-dimensional (3D) developmental process. This intimate embryological relationship between the face and brain means that facial dysmorphogenesis can serve as an accessible and informative index of brain dysmorphogenesis in neurological and psychiatric disorders of early developmental origin. There are three principal challenges in seeking to increase understanding of disorders of early brain dysmorphogenesis through craniofacial dysmorphogenesis: (i) the first, technical, challenge has been to digitize the facial surface in its inherent three-dimensionality; (ii) the second, analytical, challenge has been to develop methodologies for extracting biologically meaningful shape covariance from digitized samples, making statistical comparisons between groups and visualizing in 3D the resultant statistical models on a ,whole face' basis; (iii) the third, biological, challenge is to demonstrate a relationship between facial morphogenesis and brain morphogenesis not only in anatomical,embryological terms but also at the level of brain function. Here we consider each of these challenges in turn and then illustrate the issues by way of our own findings. These use human sexual dimorphism as an exemplar for 3D laser surface scanning of facial shape, analysis using geometric morphometrics and exploration of cognitive correlates of variation in shape of the ,whole face', in the context of studies relating to the early developmental origins of schizophrenia. [source] | ||||||||||