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Clinical Research Networks (clinical + research_network)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Rare Diseases Clinical Research Network

NURSING FOR WOMENS HEALTH, Issue 1 2004
Article first published online: 9 MAR 200
No abstract is available for this article. [source]

Clinical research networks in diabetes: the evolving role of the research nurse

EUROPEAN DIABETES NURSING, Issue 1 2007
P Chester PhD Visiting Academic
Abstract The importance of evidence-based care for patients with diabetes is well established, and the evidence required to make decisions about patient care is generated through research and audit. The rigours of the research process and the need to enrol large numbers of patient volunteers in a timely manner has meant that most studies are now conducted at multiple sites. Research infrastructure is costly to implement, but is important for successful clinical research projects. By establishing permanent networks this infrastructure can be maintained and built upon. Research nursing has evolved as a new but very important discipline within the nursing profession in recent years and it has been pivotal for the success of many studies. In this article we examine the potential for clinical research networks to facilitate high quality clinical research and in particular the development of the research nurse role. Copyright © 2007 FEND. [source]

A clinical research network in diabetes for the UK

DIABETIC MEDICINE, Issue 10 2004
S. Heller
No abstract is available for this article. [source]

Clinical research networks in diabetes: the evolving role of the research nurse

EUROPEAN DIABETES NURSING, Issue 1 2007
P Chester PhD Visiting Academic
Abstract The importance of evidence-based care for patients with diabetes is well established, and the evidence required to make decisions about patient care is generated through research and audit. The rigours of the research process and the need to enrol large numbers of patient volunteers in a timely manner has meant that most studies are now conducted at multiple sites. Research infrastructure is costly to implement, but is important for successful clinical research projects. By establishing permanent networks this infrastructure can be maintained and built upon. Research nursing has evolved as a new but very important discipline within the nursing profession in recent years and it has been pivotal for the success of many studies. In this article we examine the potential for clinical research networks to facilitate high quality clinical research and in particular the development of the research nurse role. Copyright © 2007 FEND. [source]

Structure and Function of Emergency Care Research Networks: Strengths, Weaknesses, and Challenges

ACADEMIC EMERGENCY MEDICINE, Issue 10 2009
Linda Papa MD
Abstract The ability of emergency care research (ECR) to produce meaningful improvements in the outcomes of acutely ill or injured patients depends on the optimal configuration, infrastructure, organization, and support of emergency care research networks (ECRNs). Through the experiences of existing ECRNs, we can learn how to best accomplish this. A meeting was organized in Washington, DC, on May 28, 2008, to discuss the present state and future directions of clinical research networks as they relate to emergency care. Prior to the conference, at the time of online registration, participants responded to a series of preconference questions addressing the relevant issues that would form the basis of the breakout session discussions. During the conference, representatives from a number of existing ECRNs participated in discussions with the attendees and provided a description of their respective networks, infrastructure, and challenges. Breakout sessions provided the opportunity to further discuss the strengths and weaknesses of these networks and patterns of success with respect to their formation, management, funding, best practices, and pitfalls. Discussions centered on identifying characteristics that promote or inhibit successful networks and their interactivity, productivity, and expansion. Here the authors describe the current state of ECRNs and identify the strengths, weaknesses, and potential pitfalls of research networks. The most commonly cited strengths of population- or disease-based research networks identified in the preconference survey were access to larger numbers of patients; involvement of physician experts in the field, contributing to high-level study content; and the collaboration among investigators. The most commonly cited weaknesses were studies with too narrow a focus and restrictive inclusion criteria, a vast organizational structure with a risk of either too much or too little central organization or control, and heterogeneity of institutional policies and procedures among sites. Through the survey and structured discussion process involving multiple stakeholders, the authors have identified strengths and weaknesses that are consistent across a number of existing ECRNs. By leveraging the strengths and addressing the weaknesses, strategies can be adopted to enhance the scientific value and productivity of these networks and give direction to future ECRNs. [source]

Facilitating Emergency Care Research Networks: Integration into the Clinical Translational and Science Award (CTSA) Infrastructure

ACADEMIC EMERGENCY MEDICINE, Issue 10 2009
Judd E. Hollander MD
Abstract Emergency care research (ECR) does not fit neatly into the traditional National Institutes of Health (NIH) funding model, because emergency research involves undifferentiated disease presentations involving multiple disciplines and time-sensitive interventions. A task force of emergency care researchers and other stakeholders was convened to discuss the present and future state of clinical research networks. Integration of ECR with the Clinical Translational and Science Award (CTSA) program through a multidisciplinary emergency care research network (ECRN) would obviate the duplication of research efforts by disease-specific or institute-specific multicenter networks and reduce startup and maintenance costs. Strategies to enhance integration must include the training of emergency physician investigators in biostatistical and epidemiologic methods, as well as educating collaborative investigators in emergency care,related methodologies. Thus, an ECRN would be of great benefit to CTSA awardees and applicants and should be considered a priority. [source]

Treatment of ANCA-associated systemic small-vessel vasculitis

APMIS, Issue 2009
DAVID JAYNE
Much has been learnt over the last 30 years to optimize the use of immunosuppressive and glucocorticoid therapies that has allowed the publication of treatment guidelines. However, major unmet needs remain in the treatment of ANCA-associated vasculitis (AAV) and include refractory disease, only partial efficacy and toxicity of current drugs and the need for long-term regimens. Newer therapies, including mycophenolate mofetil, leflunomide and rituximab, are providing a real opportunity for improved outcomes of AAV in the future. The development of therapy has been facilitated by international clinical research networks but delayed by the complexities of studying an uncommon, multi-system disease. [source]