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Selected AbstractsMeasuring the effect of husband's health on wife's labor supplyHEALTH ECONOMICS, Issue 6 2006Michele J. SiegelArticle first published online: 31 JAN 200 Abstract A sizable proportion of women remain married well into late life and an increasing proportion of them participate in the labor force. Since women tend to marry men older than themselves and men tend to experience serious illnesses at younger ages than women, women frequently witness declining health in their husbands. This is likely to affect a wife's labor,leisure trade-off in offsetting ways. Prior studies have not sought to disentangle the effect of a husband's poor health on his wife's reservation wage from the income effect of his ill health. We argue that, if we control for husband's earnings, the coefficient of husband's health in models of his wife's labor force participation (and hours of work) will reflect, in part, her preference over whether to decrease her labor supply to provide health care for her husband or whether to instead increase it to purchase this care in the market. However, husband's earnings are likely to be endogenous in these models due to unobserved characteristics common to husbands and wives. We find that the estimated effect of husband's health depends on whether we instrument for husband's earnings and on the health measure used. This is indicative of the importance of using a variety of health measures and controlling for husband's earnings, and their endogeneity, in future research on the effect of husband's health on wife's labor supply. Copyright © 2006 John Wiley & Sons, Ltd. [source] Hydrology and water resources in monsoon Asia: a consideration of the necessity of establishing a standing research community of hydrology and water resources in the Asia Pacific regionHYDROLOGICAL PROCESSES, Issue 14 2003Katumi Musiake Abstract Hydrological and water resources issues appear very differently in different regions, and are strongly affected by geographical conditions. Hydrological knowledge and methodologies obtained in a specific region cannot necessarily be adapted to other regions. The purpose of this paper is to clarify one way to address adequately the regional characteristics of hydrology and water resources in monsoon Asia, especially the ,too much water' problems in the region. For this purpose, geomorphological factors, climatic factors and human intervention in the natural environment are taken into consideration as the three major factors governing the regional characteristics of the hydrology,water resources system. To identify geomorphological features macroscopically between the Asia Pacific region and other continental regions, the concepts ,tectonic zone' and ,stable region', which are two major subdivisions of continental masses in the world, are introduced. Also, a new climatic subdivision termed ,warm-humid' is proposed to express the abundant precipitation due to the Asian monsoon. Then, hydrological characteristics common or similar in ,warm-humid tectonic zones' in the Asia Pacific region, contrasted with those in stable regions, are enumerated together with the human intervention corresponding to these characteristics, and research targets peculiar to warm-humid tectonic zones are discussed. Finally, the establishment of a standing research community called ,Asia Pacific Association of Hydrology and Water Resources' is proposed to promote the exchange of operational knowledge and experience in water resources management, cooperative research activities, and professional education in the Asia Pacific region. Copyright © 2003 John Wiley & Sons, Ltd. [source] Establishment and Characterization of a Normal Melanocyte Cell Line Derived from Pig SkinPIGMENT CELL & MELANOMA RESEARCH, Issue 4 2003Sophia Julé Several minipig strains develop spontaneous malignant melanoma. As a first step toward the analysis of genes involved in the tumoral progression of melanoma in these animal models, we developed culture conditions for pig melanocytes whereby melanocytes from normal epidermis can be isolated directly onto mitotically inactivated keratinocytes in Eagle's minimal essential medium supplemented with fetal calf serum, tetradecanoyl phorbol acetate (TPA) and cholera toxin. We also derived an immortal line of pigmented melanocytes from the epidermis of a healthy Meishan pig. This cell line, designated PigMel, retains differentiation function in culture, dependence on TPA and cholera toxin and a diploid chromosome number. PigMel melanocytes exhibit morphological and molecular characteristics common to normal mammalian skin melanocytes. [source] Transcriptional control and gene silencing in Plasmodium falciparumCELLULAR MICROBIOLOGY, Issue 10 2008Bradley I. Coleman Summary Infection with the apicomplexan parasite Plasmodium falciparum is associated with a high burden of morbidity and mortality across the developing world, yet the mechanisms of transcriptional control in this organism are poorly understood. While P. falciparum possesses many of the characteristics common to eukaryotic transcription, including much of the canonical machinery, it also demonstrates unique patterns of gene expression and possesses unusually AT-rich intergenic sequences. Importantly, several biological processes that are critical to parasite virulence involve highly regulated patterns of gene expression and silencing. The relative scarcity of transcription-associated proteins and specific cis -regulatory motifs recognized in the P. falciparum genome have been thought to reflect a reduced role for transcription factors in transcriptional control in these parasites. New approaches and technologies, however, have led to the discovery of many more of these elements, including an expanded family of DNA-binding proteins, and a re-assessment of this hypothesis is required. We review the current understanding of transcriptional control in P. falciparum, specifically highlighting promoter-driven and epigenetic mechanisms involved in the control of transcription initiation. [source] |