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Acid Chlorides (acid + chloride)
Selected AbstractsChemInform Abstract: First Synthesis of Non-Symmetrical "Phthalimidoyl Active Ester" Bi-Dentate Cross-Linking Reagents Having an Acid Chloride, 2-Benzothiazole, or 1-Benzotriazol Group.CHEMINFORM, Issue 18 2009Md. Chanmiya Sheikh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Tributyltin Hydride in NMP-Promoted Reduction of Acid Chlorides to Aldehydes under Transition-Metal-Free Conditions.CHEMINFORM, Issue 34 2010Patrick Le Menez Abstract A simple and general procedure uses Bu3SnH in NMP for the partial reduction of the acid chloride substrates. [source] ChemInform Abstract: Facile Synthesis of Benzothiazoles via Cascade Reactions of 2-Iodoanilines, Acid Chlorides and Lawesson,s Reagent.CHEMINFORM, Issue 14 2010Qiuping Ding Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Catalytic, Asymmetric ,-Fluorination of Acid Chlorides: Dual Metal,Ketene Enolate Activation.CHEMINFORM, Issue 20 2009Daniel H. Paull Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: [3 + 3] Cyclization Reactions of ,-Nitroenamines and ,-Enaminonitriles with ,,,-Unsaturated Carboxylic Acid Chlorides.CHEMINFORM, Issue 47 2008Mihaly V. Pilipecz Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Copper-Free Sonogashira Coupling of Acid Chlorides with Terminal Alkynes in the Presence of a Reusable Catalyst: An Improved Synthesis of 3-Iodochromenones (= 3-Iodo-4H-1-benzopyran-4-ones).CHEMINFORM, Issue 26 2008Pravin R. Likhar Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of ,,,-Unsaturated Ketones from Acid Chlorides Through Carbon,Pentamethylcyclopentadienyl Bond Formation and Cleavage.CHEMINFORM, Issue 15 2008Minoru Uemura Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Preparation of 2-Amino-4H-5,6-dihydro-1,3-selenazin-4-ones by Reaction of N,N-Unsubstituted Selenoureas with ,,,-Unsaturated Acid Chlorides.CHEMINFORM, Issue 2 2008Koichi Kanoh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Catalytic Asymmetric Formation of ,-Lactones by [4 + 2] Cycloaddition of Zwitterionic Dienolates Generated from ,,,-Unsaturated Acid Chlorides.CHEMINFORM, Issue 44 2007Paolo S. Tiseni Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Acyl Palladium Species in Synthesis: Single-Step Synthesis of ,,,-Unsaturated Ketones from Acid Chlorides.CHEMINFORM, Issue 22 2007Russell J. Cox Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Pd(0)-Catalyzed PMHS Reductions of Aromatic Acid Chlorides to Aldehydes.CHEMINFORM, Issue 35 2006Kyoungsoo Lee Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Room-Temperature Palladium-Catalyzed and Copper(I)-Mediated Coupling Reactions of Acid Chlorides with Boronic Acids under Neutral Conditions.CHEMINFORM, Issue 4 2006Yasushi Nishihara No abstract is available for this article. [source] Synthesis of ,-Ketoamides from a Carbamoylsilane and Acid Chlorides.CHEMINFORM, Issue 47 2004Jianxin Chen Abstract For Abstract see ChemInform Abstract in Full Text. [source] Palladium-Catalyzed Multicomponent Coupling of Alkynes, Imines, and Acid Chlorides: A Direct and Modular Approach to Pyrrole Synthesis.CHEMINFORM, Issue 22 2004Rajiv Dhawan Abstract For Abstract see ChemInform Abstract in Full Text. [source] InBr3 -Catalyzed Alkynylation and Allylation of Acid Chlorides: A Facile Synthesis of Alkynyl and Allyl Ketones.CHEMINFORM, Issue 11 2004J. S. Yadav Abstract For Abstract see ChemInform Abstract in Full Text. [source] Reactivity of 2-Methyl Thioisomuenchnone with Acid Chlorides.CHEMINFORM, Issue 38 2003Martin Avalos Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: An Efficient and Simple Procedure for Preparation of Esters and Anhydrides from Acid Chlorides in the Presence of 1,4-Diazabicyclo[2.2.2]octane (DABCO) under Solvent-Free Conditions.CHEMINFORM, Issue 24 2002A. R. Hajipour Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Reactive Ketenes Through a Carbonate/Amine Shuttle Deprotonation Strategy: Catalytic, Enantioselective ,-Bromination of Acid Chlorides.CHEMINFORM, Issue 41 2001Ahmed M. Hafez Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: NMR Kinetic Studies on the Decomposition of ,-Amidozinc Reagents: Optimization of Palladium-Catalyzed Cross-Coupling with Acid Chlorides.CHEMINFORM, Issue 11 2001Charles S. Dexter Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Microbial Studies of New Pyridine Derivatives-IIICHINESE JOURNAL OF CHEMISTRY, Issue 9 2007N. B. Patel Abstract 2-Amino substituted benzothiazole 4a,4l and p -acetamidobenzenesulfonyl chloride 2 were used to prepare 2-(p -aminophenylsulfonamido) substituted benzothiazole 6a,6l using mixture of pyridine and acetic anhydride which formed an electrophilic complex (N -acetyl pyridinium) to facilitate condensation to give desired product by removal of HCl. 2-{p -[(3-Carboxypyrid-2-yl)amino]phenylsulfonamido}benzothiazoles 8a,8l were synthesized from 2-chloropyridine-3-carboxylic acid 7 and 6a,6l in 2-ethoxy ethanol using Cu-powder and K2CO3. Acid chlorides 9a,9l were condensed with 2-hydroxyethyl piperazine 10 and 2,3-dichloropiperazine 11 for amide derivatives 2-(p -((3-(4-(2-hydroxyethyl)piperazin-1-ylcarbonyl)pyrid-2-yl)amino)phenylsulfonamido)benzothiazoles 12a,12l and 2-{p -[3-(2,3-dichloropiperazin-1-ylcarbonyl)pyrid-2-ylamino]phenylsulfonamido}benzothiazoles 13a,13l respectively. The structures of the new compounds have been established on the basis of their chemical analysis and spectral data (IR, 1H NMR and mass). All the compounds have been screened for their antibacterial and antifungal activities. [source] Selective Analysis of Secondary Amines Using Liquid Chromatography with Electrochemical Detection (LC-EC)ELECTROANALYSIS, Issue 21 2006Celia Abstract In a mixture of primary and secondary aliphatic amines, the primary amines were derivatized (masked) with o -phthalaldehyde (OPA) followed by derivatization of the remaining secondary amines with ferrocenecarboxylic acid chloride (FAC). The "tagged" amines were analyzed by LC-EC (liquid chromatography with electrochemical detection) using in-series dual electrode detection. Chemically-reversible oxidation of the FAC tagged secondary amines and their subsequent complementary oxidation and reduction signals coupled with chemically-irreversible oxidation of OPA tagged primary amines provided the selectivity for quantitative secondary amine analysis. The procedure was also applied for the selective identification of fragment 4,11 (N -terminus-proline) of Substance P in the presence of other Substance P fragments with primary amino acids as their N -termini. [source] Asymmetric Synthesis of Isoquinoline Derivatives from Amino AcidsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 4 2005Oxana Sieck Abstract Reaction of isoquinolines 1 with N -arylsulfonylamino acid fluorides 2 provides a highly stereoselective access to new dihydroimidazo[2,1 -a]isoquinolin-3-ones 5 via intermediate N -acylisoquinolinium salts 3. Addition reactions to the en-amine double bond, such as hydrogenation or epoxidation with dimethyldioxirane, leads to tetrahydroimidazo[2,1 -a]isoquinoline-3-ones 6, 7 and oxiranes 8, respectively. Opening of the oxirane ring of the 8 with nucleophiles allows the synthesis of hydroxytetrahydroimidazo[2,1 -a]isoquinolin-3-ones 10 or 12 or of the polycyclic 1,4-dioxane 13 in high stereoselectivity. The regioselectivity of the oxiran ring opening depends on the kind of nucleophile and the conditions. Reaction of dihydroisoquinoline with O -TBDMS-mandelic acid chloride 15 leads to a tetrahydrooxazolo[2,3 -a]isoquinoline 17 with opposite facial selectivity as compared with dihydroimidazo[2,1 -a]isoquinolin-3-ones 5. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source] A New Neighbouring-Group Reaction to Form PyridopyrrolobenzoxazinedionesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 16 2004Gerhard Hamprecht Abstract The azaphthalimide 2a is the first phthalimide oxygen found to undergo a neighboring-group participation reaction with a vicinal N -phenyl carboxylic acid chloride upon nucleophilic addition with alcohols. Owing to the free rotation of the N -phenyl moiety, hetero-anellated benzoxazinedione isomers 3 and 4 are accessible, whereby 3 is preferred to 4 as the pyridine nitrogen in 2a preferentially activates the o -carbonyl group. Yields of up to 92% were obtained when bases such as HCl acceptors were avoided by heating 2a with alcohols. The reaction is restricted to primary and secondary alcohols, as 2a is nonplanar in respect of the heterocyclic and benzene moiety, which prevents tertiary alcohols attacking the pyrrolidinedione carbonyl group. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source] Scope and Limitations of Palladium-Catalyzed Cross-Coupling Reactions with Organogold CompoundsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 8 2010A. Stephen Abstract Five different alkenylgold(I) phosphane complexes were prepared and then investigated in [1,1,-bis(diphenylphosphino)ferrocene]palladium(II) dichloride-catalyzed cross-coupling reactions with different aryl halides, heterocyclic halides, an alkenyl halide, an alkynyl halide, allylic substrates, benzyl bromide and an acid chloride. With regard to the halides, the iodides were highly reactive, bromides or chlorides gave significantly reduced yields or failed, allylic acetates failed, too. The cross-coupling partners contained a number of different functional groups, while free carboxylic acids did not deliver cross-coupling products and o,o -disubstituted arenes failed as well, a broad range of other functional groups like nitro groups, nitrile groups, ester groups, ,,,-unsaturated ester groups and lactones, aldehydes, alkoxy groups, pyridyl groups, thienyl groups, unprotected phenols and anilines, even aryl azides were tolerated. The structures of one alkenylgold(I) species and of four of the cross-coupling products were proved by crystal structure analyses. [source] Mechanism of the Nucleophilic Substitution of Acyl Electrophiles using Lithium OrganocupratesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 7-8 2008Naohiko Yoshikai Abstract The mechanism of nucleophilic substitution reaction at an sp2 carbon center of a thioester or an acid chloride with a lithium organocuprate reagent has been investigated. Density functional calculations indicated that the thioester undergoes oxidative addition of the CS bond to the copper(I) atom through a three-centered transition state to afford an organocopper(III) intermediate, which gives the product through reductive elimination of the alkyl and the acyl groups. On the other hand, the acid chloride loses a chloride anion very easily when it interacts with the cuprate, because the chloride anion is captured by a lithium(I) cation rather than a copper(I) atom. 13C kinetic isotope effect (KIE) experiments showed excellent agreement with computational predictions for the thioester reaction, but suggested that the nucleophilic displacement transition state of the acid chloride occurs much more advanced than the calculations predict. [source] Chemo-Enzymatic Approach to Statin Side-Chain Building BlocksADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6-7 2003R. Öhrlein Abstract A versatile statin side-chain building block is obtained by an enzymatic desymmetrisation of the symmetrical glutaric acid diethyl ester. The monoacid is produced in almost quantitative yield in the desired high optical purity. The monoacid is easily converted to the corresponding acid chloride, which is a key compound to be elaborated to some statin side-chain derivatives. The optically active C-5 chain is subsequently elongated by two carbon atoms and syn -reduced to the final diol fragment. [source] Microwave-assisted synthesis of quinolone derivatives and related compoundsJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2010Suhas Pednekar The Gould-Jacob type of reaction for the synthesis of ethyl 5-ethyl-8-oxo-5,8-dihydro-[1,3]-dioxolo[4,5-g]quinoline-7-carboxylate 4 has been carried out conventionally by the condensation between N -ethyl-3,4-methylenedioxyaniline 1 and diethyl ethoxymethylenemalonate 2 gave the unsaturated ester 3 and thermal cyclization in refluxing diphenyl oxide gave quinolone ethyl ester 4 and the results obtained were compared with single step microwave irradiation under solvent free conditions for the synthesis of 4. The esters on basic hydrolysis formed free acid 5, which, upon treatment with thionyl chloride gave the acid chloride 6. Treatment of acid chloride with o -phenylenediamine, hydrazine hydrate, ammonia, urea, and thiourea gave the amides (7,11). CS2 treatment in presence of KOH on 8 gave 12. We prepared 7,12 derivatives by conventional as well as microwave irradiation. These compounds have been characterized on the basis of IR, 1H NMR, MS, and elemental analysis. All the compounds prepared herein were screened for their antibacterial activity. Compounds 4, 5 possess promising antibacterial activity and compound 8 showed significant antibacterial activity. J. Heterocyclic Chem., (2010). [source] Synthesis and some reactions of 4-(ethoxycarbonyl)-1,5-diphenyl-1H -pyrazole-3-carboxylic acidJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2007Ahmet, ener 1,5-Diphenyl-1H -pyrazole-3,4-dicarboxylic acid-4-ethyl ester 2, obtained from the 4-ethoxycarbonyl-5-phenyl-2,3-furandione 1 and N -benzylidene- N,-phenyl hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester 5 or amide derivatives 6, respectively. In addition, 2 was decarboxylated to give ethyl 1,5-diphenylpyrazole-4-carboxylate 4. Nitrile 7 derivative of 2 was also obtained by dehydration of 6a in a mixture of SOCl2 and DMF. While cyclocondensation reaction of 2 with hydrazine hydrate leads to the formation of pyrazolo[3,4- d]pyridazine-4,7-dione 8, the reaction of 3 with anhydrous hydrazine provided a new bis pyrazole derivative 9. [source] Studies on the reactions of cyclic oxalyl compounds with hydrazines or hydrazones : Synthesis and reactions of 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H -pyrazole-3-carboxylic acidJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2002Ahmet, ener The 1H -pyrazole-3-carboxylic acid 2, obtained from the furan-2,3-dione 1 and N -Benzylidene- N'-(3-nitrophenyl) hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleo-philes into the corresponding ester or amide derivatives 4 or 5, respectively. Nitrile 6 and anilino-pyrazole acid 7 derivatives of 2 were also obtained by dehydration of 5a in a mixture of SOCl2 with DMF and reduction of 2 with sodium polysulphide, respectively. While cyclocondensation reactions of 2 or 7 with phenyl hydrazine or hydrazine hydrate and 6 with only anhydrous hydrazine lead to derivatives of pyrazolo[3,4- d]-pyridazinone 8 and pyrazolo[3,4- d]pyridazine amine 9, respectivel. The reaction of 2 with 2-hydrazinopyri-dine provided hydrazono-pyrazole acid derivative 10, which was decarboxylated to give hydrazono-pyra-zole derivative 11. Pyrazolo[4,3- d]oxazinone 12 and 2-quinolyl pyrazolo[3,4- d]pyridazine 13 derivatives were also prepared by cyclocondensation reactions of 2 with hydroxylamine hydrochloride and 7 with acetaldehyde, respectively. [source] A short synthesis of the parp inhibitor 2-(4-trifluoro-methylphenyl)benzimidazole-4-carboxamide (NU1077)JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 4 2001Steven C. Austen A four-step synthesis of the PARP inhibitor 2-(4-trifluoromethylphenyl)benzimidazole-4-carboxamide (1, NU1077) is presented. Condensation of 2,3-diaminotoluene and 4-trifluoromethylbenzaldehyde afforded 4-methyl-2-(4-trifluoromethylphenyl)benzimidazole. Oxidation of the methyl group with potassium permanganate in warm t -butanol afforded the carboxylic acid that was converted to the corresponding carboxamide via,/ the acid chloride. [source] | ||||||||||