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Cholesteryl Ester Transfer Protein Gene (cholesteryl + ester_transfer_protein_gene)
Selected AbstractsCHOLESTERYL ESTER TRANSFER PROTEIN GENE AND CORONARY HEART DISEASE MORTALITY: THE ROTTERDAM STUDYJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2007M. Carolina Pardo Silva MD No abstract is available for this article. [source] Lack of genetic association between cholesteryl ester transfer protein and Japanese sporadic Alzheimer's diseasePSYCHOGERIATRICS, Issue 4 2006Akiyoshi KITAJIMA Abstract Background:, Cholesteryl ester transfer protein regulates the plasma high density lipoprotein cholesterol level, which is considered to play an antiatherogenic role in humans. The presence of apolipoprotein E epsilon4 allele is a strong risk factor for developing Alzheimer's disease (AD). Since apolipoprotein E is a regulator of lipid metabolism, it is reasonable to assume that lipids play important roles in the pathogenesis of AD. Methods:, We studied the relationship between polymorphisms of the cholesteryl ester transfer protein gene and risk for AD, analyzing two common polymorphisms of the gene and the relationship between them and plasma cholesterol level control samples. Results:, These polymorphisms showed no association with risk for AD. In rs5882, there was no significant difference in the mean plasma cholesterol concentrations found between patients with the A/A, A/G and G/G genotype. For rs2303790, no significant difference in the mean baseline cholesterol concentrations was found between patients with the A/A genotype and carriers of the G allele. Conclusion:, Our study indicates that these polymorphisms, rs5882 and rs2303790 were not associated with risk for AD. We also pointed out that these two polymorphisms do not affect plasma cholesterol levels in our Japanese AD samples. [source] Variations in high-density lipoprotein cholesterol in relation to physical activity and Taq 1B polymorphism of the cholesteryl ester transfer protein geneCLINICAL GENETICS, Issue 5 2004M Mukherjee The aim of the study was to determine any association of physical activity and Taq 1B polymorphism in the cholesteryl ester transfer protein gene on high-density lipoprotein (HDL) cholesterol. Five hundred and four subjects, 390 males and 114 females consisting of an equal number of age- and sex-matched healthy controls and patients with coronary artery disease, were included. The mean age (±SD) of the patients and controls were 57.5 ± 10.6 years and 56.8 ± 11.0 years, respectively. All the patients underwent coronary angiography; 33, 58, 63, and 98 patients had normal coronaries, single-, two-, or triple-vessel disease, respectively. A third of the patients had suffered from a myocardial infarction. The genotype distribution conforming to Hardy,Weinberg equilibrium was similar for cases and controls. The mean HDL cholesterol increased from B1B1 through B2B2 genotype in controls and sedentary male patients. Self-reported leisure time physical activity, consisting mostly of an hour of morning walk daily, was associated with a rise in mean HDL cholesterol in male controls (33.6 ± 7.9 mg/dl to 36.2 ± 8.9 mg/dl, p = 0.037) and patients (32.4 ± 7.9 mg/dl to 35.7 ± 11.0 mg/dl; p = 0.018). The exercise-associated rise in HDL cholesterol was most pronounced in controls (32.1 ± 9.1 mg/dl to 36.8 ± 9.3 mg/dl, p = 0.05) and male patients (30.5 ± 7.4 mg/dl to 37.2 ± 9.7 mg/dl, p = 0.007) with B1B1 rather than B1B2 or B2B2 genotype. The results suggest a possible gene-environment interaction in the regulation of HDL cholesterol that needs to be confirmed in other populations and larger samples to rule out a chance occurrence. [source] | ||||||||||