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Ceiling
Kinds of Ceiling Terms modified by Ceiling Selected AbstractsTHE EFFECTS OF THE 1.03 MILLION YEN CEILING IN A DYNAMIC LABOR SUPPLY MODELCONTEMPORARY ECONOMIC POLICY, Issue 2 2009YUKIKO ABE In this paper I examine the effects of a means-tested transfer system in Japan ("1.03 million yen ceiling") in a dynamic labor supply model with endogenous retirement. In Japan, married women have reason to limit their annual earnings to no more than 1.03 million yen in order to receive a number of benefits available to low-income wives, and in fact often choose to do so. In a dynamic model, the optimal labor supply schedule follows a pattern that is not seen in a static framework, which I call the "spillover effect." The paper also examines the properties of dynamic welfare cost of this ceiling. (JEL J22, H24, H55) [source] THE IMMACULATE BODY IN THE SISTINE CEILINGART HISTORY, Issue 2 2009KIM E. BUTLER A new reading of textual evidence roots the imagery of Michelangelo's Sistine Ceiling frescoes in contemporary theological commitment to the doctrine of the Immaculate Conception. The cluster of abstract metaphors contained in a sermon written by Pope Sixtus IV, dedicated to the Immaculate Conception, and the liturgical and devotional texts the sermon inspired, offers foundational source material for the ceiling programme. It is proposed that such an Immaculacy message exists alongside and mutually supports Incarnationist and Eucharistic ones, all rooted in a metaphor of bodily perfection that Michelangelo ,figures' at the level of gender as well. [source] Distorted Views Through the Glass Ceiling: The Construction of Women's Understandings of Promotion and Senior Management PositionsGENDER, WORK & ORGANISATION, Issue 1 2001Sonia Liff The article explores the issue of whether women's under-representation in senior management positions can be explained in part by the messages they are given about the promotion process and the requirements of senior jobs. Through interviews with over 50 male and female junior and senior managers in a UK high street bank, issues relating to the required personality and behaviour characteristics seen to be associated with success and with the long hours culture emerged as important. In many cases men and women identified the same issues but the significance of them for their own decision-making and the way others interpreted their behaviour varied , particularly in relation to the perceived incompatibility between active parenting and senior roles. The findings provide an account of the context in which women make career choices which highlights the limitations of analyses which see women's absence as the result either of procedural discrimination or women's primary orientation towards home and family. The findings also highlight the problems of treating commitments towards gender equality as an isolated issue and stress the importance of understanding responses to policies and ways of achieving change within the broader context of an analysis of the organization's culture. [source] Glass Ceiling or Sticky Floor?THE ECONOMIC RECORD, Issue 259 2006Exploring the Australian Gender Pay Gap Using the Household, Income and Labour Dynamics in Australia survey, this paper analyses the gender wage gaps across the wage distribution in both the public and private sectors in Australia. Quantile regression techniques are used to control for various characteristics at different points of the wage distributions. Counterfactual decomposition analysis, adjusted for the quantile regression framework, is used to examine if the gap is attributed to gender differences in characteristics, or to the differing returns between genders. The main finding is that a strong glass ceiling effect is detected only in the private sector. A second finding is that the acceleration in the gender gap across the distribution does not vanish even after account is taken of an extensive set of statistical controls. This suggests that the observed wage gap is a result of differences in returns to genders. By focusing only on the mean gender wage gap, substantial variations of the gap will be hidden. [source] Head Banging: Engineering Neutrality + the Parametric CeilingARCHITECTURAL DESIGN, Issue 6 2009Francesca Hughes Abstract Through the work of Unit 15 at the Architectural Association in London, Francesca Hughes and Noam Andrews have been exploring the limits of parametric systems. Here Francesca Hughes questions whether parametricism has now hit a ,developmental ceiling'. What are the full cultural implications of the promised instantaneity of completed components in architectural production? Where does the ,strange engineered neutrality' of ,optimisation' take us? Is there a real danger that an ambivalence to context is returning us to the tabula rasa of Modernism?. Copyright © 2009 John Wiley & Sons, Ltd. [source] Debt and Deficit Ceilings, and Sustainability of Fiscal Policies: an Intertemporal AnalysisOXFORD BULLETIN OF ECONOMICS & STATISTICS, Issue 2 2000Merih Uctum First page of article [source] THE EFFECTS OF THE 1.03 MILLION YEN CEILING IN A DYNAMIC LABOR SUPPLY MODELCONTEMPORARY ECONOMIC POLICY, Issue 2 2009YUKIKO ABE In this paper I examine the effects of a means-tested transfer system in Japan ("1.03 million yen ceiling") in a dynamic labor supply model with endogenous retirement. In Japan, married women have reason to limit their annual earnings to no more than 1.03 million yen in order to receive a number of benefits available to low-income wives, and in fact often choose to do so. In a dynamic model, the optimal labor supply schedule follows a pattern that is not seen in a static framework, which I call the "spillover effect." The paper also examines the properties of dynamic welfare cost of this ceiling. (JEL J22, H24, H55) [source] Clinical issues in using buprenorphine in the treatment of opiate dependenceDRUG AND ALCOHOL REVIEW, Issue 3 2000Dr A. Chadderton MB Abstract This paper looks at the current role of buprenorphine in the treatment of opiate dependence. It suggests that buprenorphine is a useful alternative to methadone and that in at least some cases it may be the preferred option. Buprenorphineis a partial agonist and a partial antagonist with a ceiling of opiate activity probably approximately equal to 30mg methadone. It achieves this at a dose of 10-12mg, although there is considerable individual variation. Because of its ceiling effect it has a good safety profile compared to full agonists such as methadone although some overdose deaths, particularly in conjunction with benzodiazepine abuse, have been reported in France. Induction of buprenorphine may take slightly longer than for methadone and there is a higher dropout rate compared to methadone in the first 2 weeks. This is probably due to the antagonist action of buprenorphine causing more withdrawal symptoms in comparison to methadone. Also, the ceiling effect for buprenorphine means that some clients do not experience sufficient opiate activity to satisfy them. Buprenorphine has a long half-life and dissociates slowly from opiate receptors. Most clients can be dosed second-daily but some find this unacceptable due to mood swings and/or withdrawal symptomson the second day. For these clients daily dosing is required. Transferring from buprenorphine to methadone is straightforward and well tolerated by clients. Transferring from methadone to buprenorphine, however, is more difficult because of the partial antagonist action of buprenorphine. Clients experience withdrawal symptoms that can take up to 2 weeks to settle. Most clients find these symptoms unacceptable when transferring from doses of over 30mg of methadone. The optimum method for transferring from methadone to buprenorphine is still to be determined. Withdrawal from buprenorphine appears to be relatively easier than from methadone. This is presumably due to buprenorphine's partial agonist effect at mureceptors. It is expected that during 2000 buprenorphine will be approved for use in Australia for the treatment of opiate dependence. It may well becomea first-line choice for opiate replacement in heroin dependence. It is also likely to be useful in assisting detoxification fromboth methadone and heroin. [source] Efficiency Pricing, Tenancy Rent Control and Monopolistic LandlordsECONOMICA, Issue 278 2003Kaushik Basu This paper presents a model of ,tenancy rent control' where rent increases on, and evictions of, sitting tenants are prohibited but nominal rents for new tenants are unrestricted. If there is any inflation, landlords prefer to take short-staying tenants. If there is no way for landlords to tell a tenant's type, an adverse selection problem arises. If landlords have monoply power, then they may prefer not to raise the rent even when there is excess demand for housing. These ,efficiency rents' show that tenancy rent control can give rise to equilibria that look as if there were a flat ceiling on rents. [source] A Method for Simulating Signal Evolution Using Real AnimalsETHOLOGY, Issue 10 2000Björn Forkman We studied response biases to visual stimulation using a new experimental technique. The subjects (hens, Gallus gallus domesticus) were confronted with several rewarding and non-rewarding patterns on a computer screen. In contrast with standard discrimination tasks the rewarding patterns were not identical and varied in a dimension differentiating them from the non-rewarding patterns. The rewarding patterns changed in response to hens' biases in selection of patterns. The aim of the study was to examine the possibility of receivers being a driving force in signal evolution. In one of the experiments a clear-cut result was obtained. During the course of the experiment the rewarding patterns became gradually more different from the non-rewarding one, a result expected from theoretical studies of the effect of response bias in signal evolution. A second similar experiment was less conclusive, with ceiling and floor effects influencing the results. [source] Experimental study on water spray suppression on burning upholstered chair in an enclosure with different application timesFIRE AND MATERIALS, Issue 5 2009Q. Y. Xie Abstract The objective of this work is to investigate the effects of the application time of water spray on the burning upholstered chair in an enclosure. A series of experiments are conducted with the same water flow rate in an ISO 9705 fire test room in which a water spray system is installed. Several identical upholstered chairs are used in the experiments with the application times 20, 25, 30, 40 and 45,s after the ignition of upholstered chair, respectively. The results show that there is nearly an exponential relationship between the peak heat release rates and the relative application times of water spray. It is also shown that there is a polynomial relationship between the relative time for the peak heat release rate and the relative application time of water spray. However, there is an exponential relationship between the whole relative extinguishing time and the relative application time of water spray. A sudden increase is detected before the decreasing of CO generation rates after the water spray is applied on the burning upholstered chair. The average temperatures of the upper hot smoke layer under the ceiling will generally be lower with the earlier application of water spray. Copyright © 2009 John Wiley & Sons, Ltd. [source] Setting management limits for the production and utilization of herbage for out-of-season grazingGRASS & FORAGE SCIENCE, Issue 1 2000Laidlaw Three experiments were carried out on perennial ryegrass-dominant swards to provide a basis for recommendations for the limits to (a) building up and timing of utilization of a herbage ,bank' for out-of-season grazing and (b) duration and intensity of early spring grazing in the United Kingdom and Ireland. In experiment 1, the effect of regrowth interval (from 7 September, 20 October, 17 November or 15 December) in autumn on herbage accumulation, leaf turnover and on subsequent spring growth was investigated. Swards regrown from early September reached maximum herbage mass (about 3 t ha,1 DM) and leaf lamina content in mid-November, by which time senescence rate exceeded rate of production of new leaves. New leaf production and senescence rates were greater in swards remaining uncut until December than in those cut in October or November. Time of defoliation up to December had no effect on spring herbage mass in the subsequent spring. Defoliating in March reduced herbage mass in late May by less than 20%. Experiment 2 investigated the progress in herbage growth and senescence in swards regrowing from different times in late summer and autumn to produce herbage for utilization beyond the normal grazing season. Treatments in a randomized block design with three replicates were regrowths from 19 July, 8 August, 30 August and 20 September. Based on a lower ceiling of leaf and total herbage mass being reached with progressively later regrowths, beyond which leaf senescence generally exceeded leaf production and herbage mass declined, it was concluded that currently recommended rotation lengths for this period should extend from 3 weeks in late July to 8 weeks for swards previously grazed in mid-September. In both experiments, leaf senescence commenced earlier (by one leaf-age category) than previously published estimates and so brought forward the time at which senescence rates balanced leaf growth rates. In experiment 3, designed to evaluate the effect of daily grazing period and intensity in early spring on herbage regrowth, dairy cows grazed successive plots (replicates) for 2 or 4 h each day at two intensities (target residual heights of 5 or 7 cm) in March to mid-April. Regrowth rate was similar in all treatments including the ungrazed control, despite soil moisture content being relatively high on occasions. Tiller density was significantly reduced in May by grazing plots in early or mid-April. It is concluded that in autumn there are limits to which rotation lengths should be extended to produce herbage for out-of-season grazing owing to attainment of ceiling yields. Although utilization in early spring may reduce herbage availability in spring, out-of-season utilization need not reduce herbage growth rates in early spring. [source] Behavioral Facilitation of Medical Treatment of Headache: Implications of Noncompliance and Strategies for Improving AdherenceHEADACHE, Issue 2006Jeanetta C. Rains PhD Clinical recommendations were gleaned from a review of treatment adherence published in the regular issue of Headache (released in tandem with this supplement). The recommendations include: (1) Nonadherence is prevalent among headache patients, undermines treatment efficacy, and should be considered as a treatment variable; (2) Calling patients to remind them of appointments and recalling those who miss a scheduled appointment are fundamentally the most cost-effective adherence-enhancing strategies, insofar as failed appointment-keeping acts as a ceiling on all future treatment and adherence efforts; (3) Simplified and tailored medication regimens improve adherence (eg, minimized number of medications and dosings, fixed-dose combinations, cue-dose training, stimulus control); (4) Screening and management of psychiatric comorbidities, especially depression and anxiety, is encouraged; (5) The concept of self-efficacy as a modifiable psychological process often can be employed to predict and improve adherence. [source] The effects of pay and job satisfaction on the labour supply of hospital consultantsHEALTH ECONOMICS, Issue 12 2007Divine Ikenwilo Abstract There is little evidence about the responsiveness of doctors' labour supply to changes in pay. Given substantial increases in NHS expenditure, new national contracts for hospital doctors and general practitioners that involve increases in pay, and the gradual imposition of a ceiling on hours worked through the European Working Time Directive, knowledge of the size of labour supply elasticities is crucial in examining the effects of these major changes. This paper estimates a modified labour supply model for hospital consultants, using data from a survey of consultants in Scotland. Rigidities in wage setting within the NHS mean that the usual specification of the labour supply model is extended by the inclusion of job quality (job satisfaction) in the equation explaining the optimal number of hours worked. Generalised Method of Moments estimation is used to account for the endogeneity of both earnings and job quality. Our results confirm the importance of pay and non-pay factors on the supply of labour by consultants. The results are sensitive to the exclusion of job quality and show a slight underestimation of the uncompensated earnings elasticity (of 0.09) without controlling for the effect of job quality, and 0.12 when we controlled for job quality. Pay increases in the new contract for consultants will only result in small increases in hours worked. Small and non-significant elasticity estimates at higher quantiles in the distribution of hours suggest that any increases in hours worked are more likely for consultants who work part time. Those currently working above the median number of hours are much less responsive to changes in earnings. Copyright © 2007 John Wiley & Sons, Ltd. [source] Effect of an Expenditure Cap on Low-Income Seniors' Drug Use and Spending in a State Pharmacy Assistance ProgramHEALTH SERVICES RESEARCH, Issue 3 2009Christine E. Bishop Objective. To estimate the impact of a soft cap (a ceiling on utilization beyond which insured enrollees pay a higher copayment) on low-income elders' use of prescription drugs. Data Sources and Setting. Claims and enrollment files for the first year ( June 2002 through May 2003) of the Illinois SeniorCare program, a state pharmacy assistance program, and Medicare claims and enrollment files, 2001 through 2003. SeniorCare enrolled non-Medicaid-eligible elders with income less than 200 percent of Federal Poverty Level. Minimal copays increased by 20 percent of prescription cost when enrollee expenditures reached $1,750. Research Design. Models were estimated for three dependent variables: enrollees' average monthly utilization (number of prescriptions), spending, and the proportion of drugs that were generic rather than brand. Observations included all program enrollees who exceeded the cap and covered two periods, before and after the cap was exceeded. Principle Findings. On average, enrollees exceeding the cap reduced the number of drugs they purchased by 14 percent, monthly expenditures decreased by 19 percent, and the proportion generic increased by 4 percent, all significant at p<.01. Impacts were greater for enrollees with greater initial spending, for enrollees without one of five chronic illness diagnoses in the previous calendar year, and for enrollees with lower income. Conclusions. Near-poor elders enrolled in plans with caps or coverage gaps, including Part D plans, may face sharp declines in utilization when they exceed these thresholds. [source] The glass ceiling in human resources: Exploring the link between women's representation in management and the practices of strategic human resource management and employee involvementHUMAN RESOURCE MANAGEMENT, Issue 3 2008Shaun Pichler Research on sex stereotypes suggests that gender bias is an invisible barrier,the so-called glass ceiling,preventing women from breaking into the highest levels of management in business organizations. Using data from a state-based professional HR organization, we investigated this phenomenon in the field of HR management. Building on the lack of fit model of gender discrimination and previous research, we tested two hypotheses: that women in HR are more likely to be concentrated in lower-level managerial positions in organizations that emphasize employee involvement (because of a related emphasis on stereotypically feminine managerial abilities) and that women in HR also are more likely to be concentrated in lower-level managerial positions in organizations that emphasize strategic human resource management (because of a related emphasis on stereotypically masculine characteristics). Our results support the first but not the second hypothesis. Theoretical and practical implications related to the glass ceiling are discussed. © 2008 Wiley Periodicals, Inc. [source] Diffusion Characteristics of VOCs IndoorsIEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING, Issue 3 2010Shin-ichi Shibata Student Member Abstract Diffusion characteristics of volatile organic compounds (VOCs) were investigated indoors using tin oxide gas sensors. The chemicals cause various kinds of symptoms in humans, for example, the sick house syndrome. In this study, eight sensors were installed in a vertical direction and on a plane surface. These sensors were of the same type. The VOC is placed in a generation source, and the sensor output increases as the chemical diffuses. The sensor output becomes higher as the concentration increases. The following chemicals were tried as air pollutants: formaldehyde, toluene, and xylene. The sensor output changes in short, quick steps by slight fluctuations of the wind velocity. Therefore, the differential characteristic of the sensor output was adopted and the noise component was removed as far as possible. A threshold time tth to the characteristic was set up. It is assumed that the examining chemical reaches the installed sensor point in a time greater than this time. The new speed of arrival is proposed using the threshold time. The speed s [cm/min] is indicated using the distance d and the reaching time tth, namely, s = d/tth. Here, d means the distance between the sensor position and the polluting source. As a result, the speed for the sensor that is installed near the ceiling (at a height of 260 cm from the floor) is the highest. And, it became obvious that s was larger for the chemical with a smaller molecule. The speed of formaldehyde for the sensor installed near the ceiling was 700 cm/min and that for the sensor installed at the height of 100 cm from the floor was 370 cm/min. There is almost a two times difference in the speed. Copyright © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. [source] Experimental study of ventilation performance and contaminant distribution of underfloor ventilation systems vs. traditional ceiling-based ventilation systemINDOOR AIR, Issue 5 2004C. Y. Chao First page of article [source] ADHD rating scale IV: psychometric properties from a multinational study as clinician-administered instrumentINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 4 2005S. Zhang Abstract The development of rating scales for attention-deficit/hyperactivity disorder (ADHD) has traditionally focused on parent- or teacher-rated scales. However, clinician-based instruments are valuable tools for assessing ADHD symptom severity The ADHD Rating Scale IV (ADHD RS), clinician administered and scored, has been validated as a useful instrument to assess ADHD symptoms among American children and adolescents. In this study, we assessed the psychometric properties of the scale in a recent clinical trial conducted mainly in Europe with over 600 children and adolescents diagnosed with ADHD. The trial was conducted in 11 European countries plus Australia, Israel, and South Africa. Results based on data in the study indicate that this version of the scale has acceptable psychometric properties including inter-rater reliability, test-retest reliability, internal consistency, factor structure, convergent and divergent validity, discriminant validity, and responsiveness. There were low-to-moderate ceiling and floor effects. The psychometric properties were comparable with other validated scales for assessing ADHD symptom severity. These results were consistent across the 14 countries participating in this trial. Overall, the data from this study support the use of the ADHD RS as a clinician-rated instrument for assessing the severity of ADHD symptoms in children and adolescents in Europe. Copyright © 2005 John Wiley & Sons, Ltd. [source] To be and to continue being a cog: the conservation of the Bremen Cog of 1380INTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 1 2001Per Hoffmann The conservation project for the Bremen Cog of 1380 took 38 years from salvage to presentation of the ship to the public in the Deutsches Schiffahrtsmuseum in 2000. The ship was salvaged from the River Weser in about 2000 pieces, and stored in water tanks. A new museum was built, and the Cog reassembled from the waterlogged timbers. The ship was reconstructed with most of the weight being taken by the ceiling of the hall via a steel-rod hanging system. Then a conservation tank was built around the hull, and a novel two-step PEG-treatment applied, especially developed for the Cog. In two consecutive baths PEG 200 and PEG 3000 stabilized lesser degraded and heavily degraded wood against shrinkage, splitting, and warping. After cleaning, the wood looks dark brown, dry, and natural. The extraordinary project is regarded a success. [source] Prevalence of renal cell carcinoma: A nation-wide survey in Japan, 2002INTERNATIONAL JOURNAL OF UROLOGY, Issue 6 2007Ken Marumo Objective: To investigate the incidence of renal cell carcinoma, classified by sex, age group and region in Japan, following a 5-year interval after a previous survey performed in 1997. Methods: The survey was conducted between the beginning of January 2002 and the end of December 2002. A total of 1288 institutions in all 47 prefectures throughout Japan were requested to register cases. Results: There were 7405 persons with renal cell carcinoma, consisting of 5063 males and 2342 females. Crude incidence rates were 8.2 and 3.6 per 100 000 population for men and women, respectively. Incidence rates in the Hokkaido region were highest followed by the Shikoku region. Conclusions: Despite incidence of renal cell carcinoma increasing to 7405 from the 6358 persons in 1997, statistical data reported by the Ministry of Health, Labor and Welfare indicate that rising age-adjusted death rate for this tumor reached a ceiling in the past decade. Early detection may have contributed to this current trend; however, further epidemiological research is required to fully elucidate this. [source] An Overview of the Design, Implementation, and Analyses of Longitudinal Studies on AgingJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 2010Anne B. Newman MD Longitudinal studies have contributed substantially to understanding of aging and geriatric syndromes. These efforts have provided a base of knowledge of the critical factors to consider in designing and implementing new longitudinal studies in older adults. This review highlights some of the major considerations in planning and implementing this type of study. Longitudinal studies can assess change over time and specific disease endpoints. Such projects require multidisciplinary teams with expertise in the many health and contextual factors that must be considered. Recent advances in study design include the use of imaging and biomarkers to assess mechanisms and approaches that raise the ceiling on measurement and integrate assessment of exposures over time. Study implementation requires careful planning and monitoring to maintain fidelity to the scientific goals. Analysis of longitudinal data requires approaches that account for inevitable missing data. New studies should take advantage of the experience obtained from longitudinal studies on aging already conducted. [source] A fixed energetic ceiling to parental effort in the great tit?JOURNAL OF ANIMAL ECOLOGY, Issue 2 2000J. M. Tinbergen Summary 1.,To elucidate the links between avian brood size, parental effort and parental investment, we measured daily energy expenditure (DEEfem), condition (residuals of mass on tarsus) and feeding rate in female great tits Parus major L. rearing broods in which the number of young was either reduced, unmanipulated or enlarged. 2.,Female condition was negatively correlated with manipulation when measured at the nestling age of 8 days (measured during the day), which suggests a shift in allocation from self-feeding to chick-feeding. However, there was no detectable manipulation effect on condition measured at the nestling age of 12 days (measured during the night). Either female condition was only affected by manipulation in the early nestling phase or the females adjusted their diurnal mass trajectory in response to brood size manipulation. More detailed data are required to verify this point. There were no indications of a fitness cost associated with the condition during the day, but condition at night was positively related to winter survival. Since manipulation only affected condition during the day, there was no link between manipulation and winter survival. 3.,The duration of the working day was not affected by manipulation and female feeding rate tended to flatten off with manipulated brood size. Similarly, brood reduction resulted in a lower DEEfem, whilst brood enlargement had no effect. This suggests that females worked at an energetic ceiling when rearing an unmanipulated brood. However, the level of this ,ceiling' in DEEfem was not fixed: it differed between years. This leads us to conclude that the observed ceiling was imposed by extrinsic factors (e.g. available foraging time) and not by an intrinsic factor such as maximum energy assimilation rate. We hypothesize that time limitation was the cause for the observed ceiling in energy expenditure and that the annual variation in the level of this ceiling was due to annual variation in ambient temperature. 4.,A cost of reproduction was previously demonstrated in this population: brood enlargement caused a reduction in the incidence of second clutches. However, since DEEfem did not differ between control and enlarged broods, we judge it unlikely that daily energy expenditure is a general predictor for parental investment. [source] Non-invasive ventilation in do-not-intubate patients: five-year follow-up on a two-year prospective, consecutive cohort studyACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 9 2009H.-H. BÜLOW Background: End-of-life decisions are common in intensive care units (ICUs), and increasingly, non-invasive ventilation (NIV) is used as a ceiling of ventilatory care. However, little is known about the outcome following that decision. Methods: An observational, single-center, retrospective, follow-up study with no interventions, on ICU patients treated with NIV and a do-not-intubate (DNI) order. The patients were followed until a 5-year survival rate could be calculated. Results: One hundred and fifty-seven patients were treated with NIV during 2002 and 2003, and among 38 a DNI order was in effect. Of the 38 DNI patients, 11 died in the ICU, 16 died on the ward and 11 survived the hospital stay. Five of these 11 survivors died within 6 months, two died after 2.7 and 3.3 years, respectively, but four were still alive after 5 years. The long-term (>6 months) survivors have, surprisingly only been admitted to the hospital 0,2 times a year , and seldom with the need for ICU treatment. Conclusions: According to this study, and previous ones, it seems worthwhile treating DNI patients with NIV. Twenty-five to 35% leave the hospital alive, every 6th patient lives for at least 1 year, and this paper shows that 10% may survive for 5 years or more. However, only chronic obstructive pulmonary disease and chronic heart failure patients (both with a concomitant low APACHE score) seem to have a reasonable outcome, and patients should be informed about this. So far, no study has investigated the quality of life of these survivors. [source] Variations of sperm release in three batches of zebrafishJOURNAL OF FISH BIOLOGY, Issue 2 2004J. R. Kemadjou Njiwa By collecting and counting the number of sperm released during separate matings in three batches of zebrafish Danio rerio, aged 3,4, 4,5 and 5,6 months, males were observed to release sperm before the female started laying their eggs. After the female left the nest, the number and motility of sperm and life span of sperm of younger fish were higher than those of older fish in water samples collected under the nest and at the surface of the tank. Sperm were released in the form of sperm trails laid on the nest surface, subsequently active spermatozoa left the trails and moved in the water for several minutes. Sperm trails consisted of bands of viscous material in which the sperm were embedded. In most cases eggs were not laid directly over the sperm trail, suggesting that sperm may contact the eggs after the latter are released into the water. In all the three tested groups there was no significant difference (P > 0·05) between the number of sperm collected on some portions of the acetate sheets which lined the nest ceiling. This result demonstrated that the greater activity of younger fish accelerated the sperm dispersal in water. Male sperm duct glands, seminal vesicles, known to secrete mucosubstances are probably involved in the production of sperm trails. The possible influence of insemination on the mating style of zebrafish is discussed. [source] Trial of fenobam, an mGluR5 antagonist, in adults with Fragile X SyndromeJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 10 2008R. Hagerman Background: Recent advances in the study of the Fragile X knockout mouse model have demonstrated enhanced activity of the metabolic glutamate receptor 5 (mGluR5) pathway. The use of mGluR5 antagonists has rescued behavioural, cognitive and dendritic structural abnormalities in the knockout mouse. An initial phase II trial in adults with FXS was approved by the FDA. Method: We have completed this initial trial of fenobam (50 mg to 150 mg/dose) in twelve adults with FXS (mean age 23.9 (SD 5.4; range 18.7,30.7 years) seen either at UC Davis MIND Institute or at RUSH, University in Chicago, to assess safety, side-effects, and metabolism after a single dose. Results: Outcome measures included prepulse inhibition (PPI) and a continuous performance task (CPT). All patients tolerated this single dose without significant side-effects. The metabolism of fenobam in patients with FXS is similar to controls and peaks at approximately 180 minutes after oral dose. Fifty percent of the patients had a 20% or more improvement in PPI that is significantly different from test-retest changes in PPI previously reported in individuals with FXS (p = 0.03). This effect was more pronounced in males. The majority of patients scored at ceiling on the CPT so it was not a helpful measure to assess medication benefits. Conclusion: This work documents the safety and aspects of the metabolism of fenobam in patients with FXS and will facilitate further expansion of fenobam trials in patients with FXS. Although fenobam is a targeted treatment for FXS, subgroups of autism may also benefit from fenobam treatment. [source] Functional morphology of the sonic apparatus in the fawn cusk-eel Lepophidium profundorum (Gill, 1863)JOURNAL OF MORPHOLOGY, Issue 11 2007Michael L. Fine Abstract Recent reports of high frequency sound production by cusk-eels cannot be explained adequately by known mechanisms, i.e., a forced response driven by fast sonic muscles on the swimbladder. Time to complete a contraction-relaxation cycle places a ceiling on frequency and is unlikely to explain sounds with dominant frequencies above 1 kHz. We investigated sonic morphology in the fawn cusk-eel Lepophidium profundorum to determine morphology potentially associated with high frequency sound production and quantified development and sexual dimorphism of sonic structures. Unlike other sonic systems in fishes in which muscle relaxation is caused by internal pressure or swimbladder elasticity, this system utilizes antagonistic pairs of muscles: ventral and intermediate muscles pull the winglike process and swimbladder forward and pivot the neural arch (neural rocker) above the first vertebra backward. This action stretches a fenestra in the swimbladder wall and imparts strain energy to epineural ribs, tendons and ligaments connected to the anterior swimbladder. Relatively short antagonistic dorsal and dorsomedial muscles pull on the neural rocker, releasing strain energy, and use a lever advantage to restore the winglike process and swimbladder to their resting position. Sonic components grow isometrically and are typically larger in males although the tiny intermediate muscles are larger in females. Although external morphology is relatively conservative in ophidiids, sonic morphology is extremely variable within the family. J. Morphol., 2007. © 2007 Wiley-Liss, Inc. [source] A Raman spectroscopic and combined analytical approach to the restoration of severely damaged frescoes: the Palomino projectJOURNAL OF RAMAN SPECTROSCOPY, Issue 4 2008Howell G. M. Edwards Abstract The deterioration of art objects is normally relatively minor, controllable and attributable to environmental changes or bacterial invasion, and until now there has not been any recorded attempt to analyse an artwork that has been deliberately and significantly destroyed. The analytical problems are correspondingly larger but the potential reward from any information that can be forthcoming is thereby proportionately greater. The 17th Century Palomino frescoes on the vaulted ceiling of the Church of Sant Joan del Mercat in Valencia were largely destroyed by insurgents in the Spanish Civil War in 1936. The ensuing gunfire and a series of seven conflagrations inside the church had a devastating effect upon the artwork, and the surviving areas were also rendered unstable with respect to their detachment from the substrate. During the current restoration project being undertaken on these frescoes, an opportunity was provided for the application of several analytical techniques to secure information about the original pigment palette employed, the technology of application used by Palomino and the changes consequent upon the destruction process. Here, we report for the first time the use of analytical Raman spectroscopy, supported by scanning electron microscopy (SEM) and voltammetry of microparticles, for the combined identification of pigments, binders, substrate treatments and pigment alteration in an important, although badly damaged, wall painting for the informing of the ongoing conservation and restoration strategy. Copyright © 2008 John Wiley & Sons, Ltd. [source] Gender, Status, and LeadershipJOURNAL OF SOCIAL ISSUES, Issue 4 2001Cecilia L. Ridgeway More than a trait of individuals, gender is an institutionalized system of social practices. The gender system is deeply entwined with social hierarchy and leadership because gender stereotypes contain status beliefs that associate greater status worthiness and competence with men than women. This review uses expectation states theory to describe how gender status beliefs create a network of constraining expectations and interpersonal reactions that is a major cause of the "glass ceiling." In mixed-sex or gender-relevant contexts, gender status beliefs shape men's and women's assertiveness, the attention and evaluation their performances receive, ability attributed to them on the basis of performance, the influence they achieve, and the likelihood that they emerge as leaders. Gender status beliefs also create legitimacy reactions that penalize assertive women leaders for violating the expected status order and reduce their ability to gain complaince with directives. [source] Aerosolization as novel sanitizer delivery system to reduce food-borne pathogensLETTERS IN APPLIED MICROBIOLOGY, Issue 1 2005S.-W. Oh Abstract Aims:, As a preliminary experiment on new sanitizer delivery tools, the efficacy of aerosolized sanitizer on food-borne pathogens was investigated in larger model chamber system. Methods:, Peroxyacetic acid and hydrogen peroxide were aerosolized in a model system against artificially inoculated target micro-organisms on laboratory media. Cultures of four different food-borne pathogens were inoculated and affixed onto three different heights (bottom, wall and ceiling), and three different orientations (face-down, vertical and face-down) inside a commercial semi-trailer cabinet (14·6 × 2·6 × 2·8 m). Sanitizer was aerosolized into 2 ,m droplet size fog and treated for 1 h at ambient temperature. Results:, Populations of Bacillus cereus, Listeria innocua, Staphylococcus aureus, and Salmonella typhimurium were reduced by an average of 3·09, 7·69, 6·93 and 8·18 log units per plate respectively. Interestingly, L. innocua, Staph. aureus, and Salm. typhimurium showed statistically not different (P , 0·05) reduction patterns relative to height and orientation that were never expected in a spraying system. Conclusions:, Aerosolized sanitizers diffuse like gaseous sanitizers. Significance and Impact of the Study:, Aerosolization has great potential for use in commercial applications. [source] | |||||||||||||||||||||||||||||||||||||||||||