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Cationic Porphyrin (cationic + porphyrin)
Selected AbstractsThe role of cobalt, copper, nickel, and zinc in the DNA replication inhibitory activity of p -aminophenyl triphenylporphyrinAPPLIED ORGANOMETALLIC CHEMISTRY, Issue 7 2004Efraín Barragán Abstract Cationic porphyrins have been widely used as tumor localizers in cancer therapies. When cationic porphyrins are flat they intercalate with double-stranded DNA, duplexes of RNA or RNA,DNA. The antitumor activity of some cationic porphyrins depends on their interaction with human telomeric quadruplexes. Here, we report that noncationic meso -(4-aminophenyl)triphenylporphyrin (H2TPPNH2) (3) and its cobalt, copper, nickel, and zinc metallo derivatives (4,7) have DNA replication inhibitory activity in B16 mouse melanoma line cells. By means of quantification of 3HdTT radio-labeled DNA, we observed that the nonplanar porphyrin [CoTPPNH2] has the highest activity against carcinogenic DNA replication. Copyright © 2004 John Wiley & Sons, Ltd. [source] Binding of cationic porphyrin to human serum albumin studied using comprehensive spectroscopic methodsJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 1 2009Bo Zhou Abstract The interaction between cationic porphyrin, a potential valuable anti-tumor and antibiotic drug, and human serum albumin (HSA) was investigated using spectroscopy methods. The binding constants were obtained using fluorescence quenching method (KSV,=,(3.24,±,0.29),×,104 M,1) and surface plasmon resonance (SPR) spectroscopy (KA,=,(6.287,±,0.407),×,104 M,1). The association rate constant (ka,=,1622,±,72.9 M,1,s,1) and dissociation rate constant (Kd,=,0.02589,±,0.0024 s,1) of the binding process were also calculated. Compared with the two results, it was known that one of the binding sites was near the tryptophan residue and also there existed other binding sites. The Fourier transform infrared (FT-IR) spectroscopy and circular dichroism (CD) spectroscopy indicated that the confirmation of HSA was nearly not affected with the addition of porphyrin. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:105,113, 2009 [source] The role of cobalt, copper, nickel, and zinc in the DNA replication inhibitory activity of p -aminophenyl triphenylporphyrinAPPLIED ORGANOMETALLIC CHEMISTRY, Issue 7 2004Efraín Barragán Abstract Cationic porphyrins have been widely used as tumor localizers in cancer therapies. When cationic porphyrins are flat they intercalate with double-stranded DNA, duplexes of RNA or RNA,DNA. The antitumor activity of some cationic porphyrins depends on their interaction with human telomeric quadruplexes. Here, we report that noncationic meso -(4-aminophenyl)triphenylporphyrin (H2TPPNH2) (3) and its cobalt, copper, nickel, and zinc metallo derivatives (4,7) have DNA replication inhibitory activity in B16 mouse melanoma line cells. By means of quantification of 3HdTT radio-labeled DNA, we observed that the nonplanar porphyrin [CoTPPNH2] has the highest activity against carcinogenic DNA replication. Copyright © 2004 John Wiley & Sons, Ltd. [source] Synthesis, and DNA-Binding and DNA-Photocleavage Properties of Multiply Charged PorphyrinsCHEMISTRY & BIODIVERSITY, Issue 3 2007Kai Wang Abstract Four new cationic porphyrins, compounds 1,4, with five to seven positive charges, were synthesized, characterized, and investigated for their binding properties towards calf-thymus DNA (CT-DNA). UV/VIS and fluorescence-titration data indicated strong binding, the apparent binding constants (Kapp; (1.3,10)×10,6M) increasing with increasing number of charges, as determined by competitive fluorescence titration using ethidium bromide (EB) as molecular probe. These results were qualitatively confirmed by the observed photocleavage efficiency of the porphyrins towards plasmid pBR322 DNA. [source] | ||||||||||