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Cascade Synthesis (cascade + synthesis)
Selected AbstractsA Simple Copper-Catalyzed Cascade Synthesis of 2-Amino-1H -indole-3-carboxylate DerivativesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010Xiaobo Yang Abstract We have developed a simple and efficient copper-catalyzed method for the synthesis of 2-amino-1H -indole-3-carboxylate derivatives via cascade reactions of substituted N -(2-halophenyl)-2,2,2-trifluoroacetamide with alkyl 2-cyanoacetate or malononitrile under mild conditions, and the method is of wide practical application. [source] ChemInform Abstract: Cascade Synthesis of New Tetracyclic Heteroaromatic Thieno[2,3-b]pyridine-Containing Ring Systems.CHEMINFORM, Issue 18 2010R. Alan Aitken Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cascade Synthesis of (E)-2-Alkylidenecyclobutanols.CHEMINFORM, Issue 10 2010J. R. Falck Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: One Step Cascade Synthesis of 4,5-Disubstituted-1,2,3-(NH)-triazoles.CHEMINFORM, Issue 35 2008Sujata Sengupta Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A New Organocatalyst for Friedel,Crafts Alkylation of 2-Naphthols with Isatins: Application of an Organo-Click Strategy for the Cascade Synthesis of Highly Functionalized Molecules.CHEMINFORM, Issue 5 2008Dhevalapally B. Ramachary Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Polyfunctionalized Aryllead Triacetates in a Cascade Synthesis of Tetracyclic Isochromanocoumarin-Type Compounds.CHEMINFORM, Issue 41 2005Mikael I. Naumov Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: Palladium Catalyzed 3-Component Cascade Synthesis of Bis(2-arylallyl) Tertiary Amines from Aryl Iodides, Allene and Primary Amines.CHEMINFORM, Issue 2 2002Xinjie Gai Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] One-Pot Catalytic Asymmetric Cascade Synthesis of Cycloheptane DerivativesCHEMISTRY - A EUROPEAN JOURNAL, Issue 9 2008Jan Vesely Dr. Abstract A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98, >99,ee). [source] Linear passive stationary scattering systems with Pontryagin state spacesMATHEMATISCHE NACHRICHTEN, Issue 13-14 2006D. Z. Arov Abstract Passive scattering systems having Pontryagin state spaces and their minimal conservative dilations are investigated. The transfer functions of passive scattering systems are generalized Schur functions. In the case of a simple conservative system, the right and left Kre,n,Langer factorizations of the transfer function correspond to natural cascade syntheses of systems. A generalization of Sz.,Nagy and Foias criteria for a cascade synthesis of two simple conservative systems to be simple is obtained for systems with Pontryagin state spaces. It is shown that the state space of a simple passive system admits certain unique fundamental decompositions, which give rise to a notion of stability and a characterization of simple conservative systems whose transfer functions have unitary boundary values a.e. on the unit circle. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] A Mutant D -Fructose-6-Phosphate Aldolase (Ala129Ser) with Improved Affinity towards Dihydroxyacetone for the Synthesis of Polyhydroxylated CompoundsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010Abstract A mutant of D -fructose-6-phosphate aldolase (FSA) of Escherichia coli, FSA A129S, with improved catalytic efficiency towards dihydroxyacetone (DHA), the donor substrate in aldol addition reactions, was explored for synthetic applications. The kcat/KM value for DHA was 17-fold higher with FSA A129S than that with FSA wild type (FSA wt). On the other hand, for hydroxyacetone as donor substrate FSA A129S was found to be 3.5-fold less efficient than FSA wt. Furthermore, FSA A129S also accepted glycolaldehyde (GA) as donor substrate with 3.3-fold lower affinity than FSA wt. This differential selectivity of both FSA wt and FSA A129S for GA makes them complementary biocatalysts allowing a control over donor and acceptor roles, which is particularly useful in carboligation multi-step cascade synthesis of polyhydroxylated complex compounds. Production of the mutant protein was also improved for its convenient use in synthesis. Several carbohydrates and nitrocyclitols were efficiently prepared, demonstrating the versatile potential of FSA A129S as biocatalyst in organic synthesis. [source] Block copolymers by chemoenzymatic cascade polymerization: A comparison of consecutive and simultaneous reactionsJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 14 2006Matthijs de Geus Abstract The synthetic parameters for the chemoenzymatic cascade synthesis of block copolymers combining enzymatic ring-opening polymerization (EROP) and atom transfer radical polymerization (ATRP) in one pot were investigated. A detailed analysis of the mutual interactions between the single reaction components revealed that the ATRP catalyst system could have a significant inhibiting effect on the enzyme activity. The inhibition of the enzyme was less pronounced in the presence of multivalent ligands such as dinonyl bipyridine, which thus could be used in this reaction as an ATRP catalyst. Moreover, the choice of the ATRP monomer was investigated. Methyl methacrylate interfered with EROP by transesterification, whereas t -butyl methacrylate was inert. Block copolymers were successfully synthesized with this cascade approach by the activation of ATRP after EROP by the addition of the ATRP catalyst and, with lower block copolymer yields, by the mixing of all the components before the copolymerization. Adetailed kinetic analysis of the reactions and the structure of the block copolymers showed that the first procedure proceeded smoothly to high block copolymer yields, whereas in the latter a noteworthy amount of the poly(t -butyl methacrylate) homopolymer was detected. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 4290,4297, 2006 [source] Linear passive stationary scattering systems with Pontryagin state spacesMATHEMATISCHE NACHRICHTEN, Issue 13-14 2006D. Z. Arov Abstract Passive scattering systems having Pontryagin state spaces and their minimal conservative dilations are investigated. The transfer functions of passive scattering systems are generalized Schur functions. In the case of a simple conservative system, the right and left Kre,n,Langer factorizations of the transfer function correspond to natural cascade syntheses of systems. A generalization of Sz.,Nagy and Foias criteria for a cascade synthesis of two simple conservative systems to be simple is obtained for systems with Pontryagin state spaces. It is shown that the state space of a simple passive system admits certain unique fundamental decompositions, which give rise to a notion of stability and a characterization of simple conservative systems whose transfer functions have unitary boundary values a.e. on the unit circle. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] One-Pot Catalytic Asymmetric Cascade Synthesis of Cycloheptane DerivativesCHEMISTRY - A EUROPEAN JOURNAL, Issue 9 2008Jan Vesely Dr. Abstract A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98, >99,ee). [source] | ||||||||||