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Absorption Profile (absorption + profile)
Selected AbstractsHigh-Efficiency Polymer Tandem Solar Cells with Three-Terminal StructureADVANCED MATERIALS, Issue 8 2010Srinivas Sista Tandem solar cells have the advantage of enhancing the absorption range of polymer solar cells. A three-terminal tandem cell based on two polymer bulk heterojunctions that have complementary absorption profile is demonstrated. In this device configuration the two subcells are connected in parallel through a common semitransparent metal interlayer and an efficiency of 4.8% with short circuit current of 15.1,mA cm,2 is achieved. [source] Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drugJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 3 2005Greg A. Kossena Abstract The influence of different model intestinal phases (modelled on those likely to be produced in vivo after the digestion of commonly used formulation lipids) on the absorption profile of cinnarizine has been studied. Combinations of C8, C12, or C18:1 fatty acid and monoglyceride and simulated endogenous intestinal fluid were formulated to provide examples of liquid (L1), lamellar (L,), and cubic (C) liquid crystalline phases. Phases containing cinnarizine were dosed intraduodenally and absorption was assessed in an anesthetized rat model. Bile duct ligation was performed to inhibit the effects of digestion/dilution on the phase structure. Absorption from the L, phases (C8 and C12 lipids) was statistically higher (p,<,0.05) than a cinnarizine suspension: however, a statistically significant difference was not observed from the L1 and C phases. The rigid C18:1 C phase showed evidence of providing for sustained drug absorption. Experiments in bile intact rats with the C8 L, and C18:1 C phase highlighted that the absorption-modifying properties of these phases were influenced by dilution in the endogenous bile milieu, with absorption from L, phase reducing (possibly through precipitation of solubilized drug) and increasing in the case of the C18:1 C phase, possibly through the coexistence of L1 and C upon dilution permitting more efficient transfer of solubilized drug. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:481,492, 2005 [source] On the anomalous silicate absorption feature of the prototypical Seyfert 2 galaxy NGC 1068MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY: LETTERS (ELECTRONIC), Issue 1 2010M. Köhler ABSTRACT The first detection of the silicate absorption feature in Active Galactic Nuclei (AGNs) was made at 9.7 ,m for the prototypical Seyfert 2 galaxy NGC 1068 35 yr ago, indicating the presence of a large column of silicate dust in the line of sight to the nucleus. It is now well recognized that type 2 AGNs exhibit prominent silicate absorption bands, while the silicate bands of type 1 AGNs appear in emission. More recently, using the Mid-Infrared Interferometric Instrument on the Very Large Telescope Interferometer, Jaffe et al. for the first time spatially resolved the parsec-sized dust torus around NGC 1068 and found that the 10 ,m silicate absorption feature of the innermost hot component exhibits an anomalous profile differing from that of the interstellar medium and that of common olivine-type silicate dust. While they ascribed the anomalous absorption profile to gehlenite (Ca2Al2SiO7, a calcium aluminium silicate species), we propose a physical dust model and argue that, although the presence of gehlenite is not ruled out, the anomalous absorption feature mainly arises from silicon carbide. [source] Signals from the epoch of cosmological recombination , Karl Schwarzschild Award Lecture 2008ASTRONOMISCHE NACHRICHTEN, Issue 7 2009R. A. Sunyaev Abstract The physical ingredients to describe the epoch of cosmological recombination are amazingly simple and well-understood. This fact allows us to take into account a very large variety of physical processes, still finding potentially measurable consequences for the energy spectrum and temperature anisotropies of the Cosmic Microwave Background (CMB). In this contribution we provide a short historical overview in connection with the cosmological recombination epoch and its connection to the CMB. Also we highlight some of the detailed physics that were studied over the past few years in the context of the cosmological recombination of hydrogen and helium. The impact of these considerations is two-fold: (i) The associated release of photons during this epoch leads to interesting and unique deviations of the CosmicMicrowave Background (CMB) energy spectrum from a perfect blackbody, which, in particular at decimeter wavelength and the Wien part of the CMB spectrum, may become observable in the near future. Despite the fact that the abundance of helium is rather small, it still contributes a sizeable amount of photons to the full recombination spectrum, leading to additional distinct spectral features. Observing the spectral distortions from the epochs of hydrogen and helium recombination, in principle would provide an additional way to determine some of the key parameters of the Universe (e.g. the specific entropy, the CMB monopole temperature and the pre-stellar abundance of helium). Also it permits us to confront our detailed understanding of the recombination process with direct observational evidence. In this contribution we illustrate how the theoretical spectral template of the cosmological recombination spectrum may be utilized for this purpose. We also show that because hydrogen and helium recombine at very different epochs it is possible to address questions related to the thermal history of our Universe. In particular the cosmological recombination radiation may allow us to distinguish between Compton y -distortions that were created by energy release before or after the recombination of the Universe finished. (ii) With the advent of high precision CMB data, e.g. as will be available using the PLANCK Surveyor or CMBPOL, a very accurate theoretical understanding of the ionization history of the Universe becomes necessary for the interpretation of the CMB temperature and polarization anisotropies. Here we show that the uncertainty in the ionization history due to several processes, which until now were not taken in to account in the standard recombination code RECFAST, reaches the percent level. In particular He II , He I recombination occurs significantly faster because of the presence of a tiny fraction of neutral hydrogen at z , 2400. Also recently it was demonstrated that in the case of H I Lyman , photons the timedependence of the emission process and the asymmetry between the emission and absorption profile cannot be ignored. However, it is indeed surprising how inert the cosmological recombination history is even at percent-level accuracy. Observing the cosmological recombination spectrum should in principle allow us to directly check this conclusion, which until now is purely theoretical. Also it may allow to reconstruct the ionization history using observational data (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3- a]pyridine, a novel and selective p38, inhibitor: identification of an active metabolite in preclinical species and human liver microsomesBIOPHARMACEUTICS AND DRUG DISPOSITION, Issue 8 2006Amit S. Kalgutkar Abstract The disposition of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3- a]pyridine (1), a potent and selective inhibitor of mitogen activated protein (MAP) kinase p38,, was characterized in several animal species in support of its selection for preclinical safety studies and potential clinical development. 1 demonstrated generally favorable pharmacokinetic properties in all species examined. Following intravenous (i.v.) administration, 1 exhibited low volumes of distribution at steady state (Vdss) ranging from 0.4,1.3 l/kg (2.4,26 l/m2) in the rat, dog and monkey. Systemic plasma clearance was low in cynomolgus monkeys (6.00 ml/min/kg, 72.0 ml/min/m2) and Sprague-Dawley rats (7.65±1.08 ml/min/kg, 45.9±6.48 ml/min/m2 in male rats and 3.15±0.27 ml/min/kg, 18.9±1.62 ml/min/m2 in female rats) and moderate in beagle dogs (12.3±5.1 ml/min/kg, 246±102 ml/min/m2) resulting in plasma half-lives ranging from 1 to 5 h in preclinical species. Moderate to high bioavailability of 1 was observed in rats (30,65%), dogs (87%) and monkeys (40%) after oral (p.o.) dosing consistent with the in vitro absorption profile of 1 in the Caco-2 permeability assay. In rats, the oral pharmacokinetics were dose dependent over the dose range studied (5, 50 and 100 mg/kg). The principal route of clearance of 1 in rat, dog, monkey and human liver microsomes and in vivo in preclinical species involved oxidative metabolism mediated by cytochrome P450 enzymes. The major metabolic fate of 1 in preclinical species and humans involved hydroxylation on the isopropyl group to yield the tertiary alcohol metabolite 2. In human liver microsomes, this transformation was catalysed by CYP3A4 as judged from reaction phenotyping analysis using isozyme-specific inhibitors and recombinant CYP enzymes. Metabolite 2 was also shown to possess inhibitory potency against p38, in a variety of in vitro assays. 1 as well as the active metabolite 2 were moderately to highly bound to plasma proteins (fu,0.1,0.33) in rat, mouse, dog, monkey and human. 1 as well as the active metabolite 2 did not exhibit competitive inhibition of the five major cytochrome P450 enzymes namely CYP1A2, 2C9, 2C19, 2D6 and 3A4 (IC50>50 µM). Overall, these results indicate that the absorption, distribution, metabolism and excretion (ADME) profile of 1 is relatively consistent across preclinical species and predict potentially favorable pharmacokinetic properties in humans, supporting its selection for toxicity/safety assessment studies and possible investigations in humans as an anti-inflammatory agent. Copyright © 2006 John Wiley & Sons, Ltd. [source] A study on the spectral changes of reactive textile dyes and their implications for online control of dyeing processesCOLORATION TECHNOLOGY, Issue 1 2009Jorge G Santos Evidence is presented that confirms the colour changes of a widely used trichromatic mixture of bifunctional reactive dyes (Levafix CA) under alkaline conditions, showing that they occur slowly and throughout the dyeing time, and not instantly after alkali addition to the dyebath. Thus, it is impossible to determine the specific absorptivity of the dyes at each moment of the dyeing process. An investigation into the relationship of the type of reactive group to the dye and the visible spectral changes over time was undertaken. Model reactive dyes were studied. The samples collected from the simulated dyebaths were monitored online using an automated system and their absorption on the whole of the visible spectrum was measured. The studies of dyes that included halo- s -triazinyl groups revealed the existence of hypochromic shifts in the spectra of the dyes in the presence of an electrolyte (sodium chloride or sodium sulphate) and bathochromic and hyperchromic shifts, when evaluated in the presence of alkaline agents. However, the vinylsulphonyl derivatives present a more stable spectral profile. The use of buffer solution at pH 5 was an efficient method to stabilise the absorption profile of Levafix CA trichromatic samples. [source] Determination of the rate coefficients of the SO2 + O + M , SO3 + M reactionINTERNATIONAL JOURNAL OF CHEMICAL KINETICS, Issue 3 2010S. M. Hwang Rate coefficients of the title reaction R31 (SO2 + O + M , SO3 + M) and R56 (SO2 + HO2, SO3 + OH), important in the conversion of S(IV) to S(VI), were obtained at T = 970,1150 K and ,ave = 16.2 ,mol cm,3 behind reflected shock waves by a perturbation method. Shock-heated H2/O2/Ar mixtures were perturbed by adding small amounts of SO2 (1%, 2%, and 3%) and the OH temporal profiles were then measured using laser absorption spectroscopy. Reaction rate coefficients were elucidated by matching the characteristic reaction times acquired from the individual experimental absorption profiles via simultaneous optimization of k31 and k56 values in the reaction modeling (for satisfactory matches to the observed characteristic times, it was necessary to take into account R56). In the experimental conditions of this study, R31 is in the low-pressure limit. The rate coefficient expressions fitted using the combined data of this study and the previous experimental results are k31,0/[Ar] = 2.9 × 1035 T,6.0 exp(,4780 K/T) + 6.1 × 1024 T,3.0 exp(,1980 K/T) cm6 mol,2 s,1 at T = 300,2500 K; k56 = 1.36 × 1011 exp(,3420 K/T) cm3 mol,1 s,1 at T = 970,1150 K. Computer simulations of typical aircraft engine environments, using the reaction mechanism with the above k31,0 and k56 expressions, gave the maximum S(IV) to S(VI) conversion yield of ca. 3.5% and 2.5% for the constant density and constant pressure flow condition, respectively. Moreover, maximum conversions occur at rather higher temperatures (,1200 K) than that where the maximum k31,0 value is located (,800 K). This is because the conversion yield is dependent upon not only the k31,0 and k56 values (production flux) but also the availability of H, O, and HO2 in the system (consumption flux). © 2010 Wiley Periodicals, Inc., Int J Chem Kinet 42: 168,180, 2010 [source] Probing feedback in protogalaxies: multiphase gas in a DLA at z, 2.4MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2008N. Lehner ABSTRACT We investigate the physical processes occurring in the multiphase gas of a damped Ly, absorber (DLA). We base our analysis on a high-quality Keck High-Resolution Echelle Spectrometer (HIRES) spectrum of the QSO J1211+0422 in which a DLA is detected at z, 2.377. There is little contamination of the high-ion (O vi, N v, C iv, Si iv) absorption, allowing us to explore the properties of the highly ionized gas and its connection to other gas phases. The metallicity ([Z/H]=,1.41 ± 0.08), H i column density [], full-width velocity (,vneut, 70 km s,1) and relative abundances ([Si/Fe]=+0.23 ± 0.05 and [N/Si]=,0.88 ± 0.07) of this DLA are not unusual. However, we derive the lowest C ii* cooling rate in a DLA, lc < 10,27.8 erg s,1 per H atom (3,). Using this stringent limit, we show that the neutral gas (confined at |v| < +39 km s,1) must be warm and the star formation rate is <7.1 × 10,3 M, yr,1 kpc,2. Surprisingly, the gas shows strong, complex absorption profiles from highly ionized gas whose kinematics appear connected to each other and the low ions. The total amount of highly and weakly ionized gas is very large with ,1.5. At |v| ,+39 km s,1, the gas is fully and highly ionized []. Based on ionization models, O vi and N v are generally difficult to produce by hard photons, while Si iv and C iv can be photoionized to a large extent. There is, however, no evidence of O vi -bearing gas at T, 106 K associated with this DLA. In contrast, there is some evidence for narrow O vi, N v and C iv components (unexplained by photoionization), implying too low temperatures (T < 105 K) for simple collisional ionization models to produce their observed column densities. Stellar feedback is a possible source for producing the high ions, but we cannot rule out accretion of non-pristine material on to the protogalaxy. [source] Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatographyBIOMEDICAL CHROMATOGRAPHY, Issue 8 2009Zhanguo Wang Abstract An effective, accurate and reliable HPLC with UV detection method was developed and validated for quantitation of six components: baicalin, berberine hydrochloride, quercetin, kaempferol, isorhamnetin and baicalein in intestinal perfusate using rotundin as an internal standard. The chromatographic separation was performed on a Welchrom-C18 column (250 × 4.6 mm i.d. with 5.0 µm particle size) with a mobile phase consisting of acetonitrile, water, phosphoric acid and triethylamine (30:70:0.2:0.1,v/v) at a flow rate of 1.0 mL/min and a UV detection at 270 nm. The method had a chromatographic run time of 30 min and excellent linear behavior over the investigated concentration ranges observed with the values of r higher than 0.99 for all the analytes. The lower limit of quantification of the analytical method was 0.09 µg/mL for berberine hydrochloride, quercetin, kaempferol and baicalein and 0.18 µg/mL for baicalin and isorhamnetin. The intra- and inter-day precisions measured at three concentration levels were all less than 10% for all analytes. The bias ranged from ,6.91 to 4.33%. The validated method has been successfully applied to investigate the rat intestine absorption profiles of baicalin, berberine hydrochloride, quercetin, kaempferol, isorhamnetin and baicalein. Copyright © 2009 John Wiley & Sons, Ltd. [source] Pharmacokinetics of a novel histone deacetylase inhibitor, apicidin, in ratsBIOPHARMACEUTICS AND DRUG DISPOSITION, Issue 2 2006Beom Soo Shin Abstract This study is the first report of the pharmacokinetics of a novel histone deacetylase inhibitor, apicidin, in rats after i.v. and oral administration. Apicidin was injected intravenously at doses of 0.5, 1.0, 2.0 and 4.0 mg/kg. The terminal elimination half-life (t1/2), systemic clearance (Cl) and steady-state volume of distribution (Vss) remained unaltered as a function of dose, with values in the range 0.8,1.1 h, 59.6,68.0 ml/min/kg and 2.4,2.7 l/kg, respectively. Whereas, the initial serum concentration (C0) and AUC increased linearly as the dose was increased. Taken together, the pharmacokinetics of apicidin were linear over the i.v. dose range studied. The extent of urinary and biliary excretion of apicidin was minimal (0.017%,0.020% and 0.049%±0.016%, respectively). Oral pharmacokinetic studies were conducted in fasting and non-fasting groups of rats at a dose of 10 mg/kg. The Tmax, Cl/F and Vz/F were in the range 0.9,1.1 h, 520.3,621.2 ml/min/kg and 67.6,84.4 l/kg, respectively. No significant difference was observed in the oral absorption profiles between the two groups of rats. Apicidin was poorly absorbed, with the absolute oral bioavailability of 19.3% and 14.2% in fasting and non-fasting rats. 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