Careful Attention (careful + attention)

Distribution by Scientific Domains


Selected Abstracts


Application of the New Keystone-Species Concept to Prairie Dogs: How Well Does It Work?

CONSERVATION BIOLOGY, Issue 6 2000
Natasha B. Kotliar
This prompted Power et al. (1996) to refine the definition: keystone species have large effects on community structure or ecosystem function (i.e., high overall importance), and this effect should be large relative to abundance (i.e., high community importance). Using prairie dogs (Cynomys spp.) as an example, I review operational and conceptual difficulties encountered in applying this definition. As applied to prairie dogs, the implicit assumption that overall importance is a linear function of abundance is invalid. In addition, community importance is sensitive to abundance levels, the definition of community, and sampling scale. These problems arise largely from the equation for community importance, as used in conjunction with removal experiments at single abundance levels. I suggest that we shift from the current emphasis on the dualism between keystone and nonkeystone species and instead examine how overall and community importance vary (1) with abundance, (2) across spatial and temporal scales, and (3) under diverse ecological conditions. In addition, I propose that a third criterion be incorporated into the definition: keystone species perform roles not performed by other species or processes. Examination of how these factors vary among populations of keystone species should help identify the factors contributing to, or limiting, keystone-level functions, thereby increasing the usefulness of the keystone-species concept in ecology and conservation. Although the quantitative framework of Power et al. falls short of being fully operational, my conceptual guidelines may improve the usefulness of the keystone-species concept. Careful attention to the factors that limit keystone function will help avoid misplaced emphasis on keystone species at the expense of other species. Resumen: Se ha sugerido que el concepto de especie pilar no sea usado más en ecología y conservación, principalmente debido a que el concepto ha sido pobremente definido. Esto instigó a Power et al. (1996) a refinar la definición: las especies pilar tienen grandes efectos en la estructura de una comunidad o la función de un ecosistema (alta importancia en lo general), y este efecto debe ser grande en relación con la abundancia (alta importancia en la comunidad). Usando los perros de pradera (Cynomys spp) como ejemplo, revisé las dificultades operativas y conceptuales encontradas durante la aplicación de esta definición. Al aplicarse a perros de pradera, la suposición implícita de que la importancia en lo general es una función lineal de la abundancia es inválida. Además, la importancia en la comunidad es sensible a los niveles de abundancia, a la definición de comunidad y a la escala de muestreo. Estos problemas surgen, en gran medida, de la ecuación para la importancia en la comunidad, al ser usada conjuntamente con experimentos de remoción a un solo nivel de abundancia. Sugiero que el énfasis actual en la dualidad sobre especies pilares/no pilares cambie para examinar cómo varía la importancia en lo general y en la comunidad; (1) con la abundancia, (2) a lo largo de escalas espaciales y temporales, y (3) bajo diversas condiciones ecológicas. Además, propongo que sea incorporado un tercer criterio en la definición: las especies pilar llevan a cabo funciones no llevadas a cabo por otras especies o procesos. El análisis de cómo varían estos factores entre poblaciones de especies pilar ayudará a identificar los factores que contribuyen, o limitan las funciones a nivel pilar, incrementando con ello la utilidad del concepto de especie pilar en ecología y conservación. Aunque el marco de trabajo cuantitativo de Power et al. no llega a ser completamente operacional, mis guías conceptuales pueden mejorar la utilidad de este concepto. Una atención especial a los factores que limitan el funcionamiento pilar ayudaría a evitar un énfasis mal ubicado en especies pilar a costa de otras especies. [source]


Intraoperative diagnosis of tanycytic ependymoma: Pitfalls and differential diagnosis

DIAGNOSTIC CYTOPATHOLOGY, Issue 4 2001
Marc A. Dvoracek M.D.
Abstract Smear preparations have become increasingly popular in the intraoperative assessment of central nervous system pathology. The cytological features of a histologically proven tanycytic ependymoma are presented with the pitfalls and differential diagnosis. The smear preparation showed a glial neoplasm composed of cells with long, bipolar glial processes and oval to spindle-shaped nuclei resembling those seen in pilocytic astrocytoma smears. The smear characteristics of an ependymoma usually show remarkably uniform round-to-oval nuclei, fluffy glial processes, and a perivascular nuclear-free zone (pseudorosetting). None of these features were present in our case. The accompanying frozen section showed a fascicular spindle-cell tumor that resembled a schwanomma, a commonly reported misinterpretation of the histology of tanycytic ependymomas on frozen sections. Careful attention to the radiological findings, the surgeon's impression, and the intraoperative smear preparation details should allow one to include this uncommon entity in the differential diagnosis of spinal neoplasms. Diagn. Cytopathol. 24:289,292, 2001. © 2001 Wiley-Liss, Inc. [source]


Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors

GLIA, Issue 1 2008
Jonathan R. Weinstein
Abstract Lipopolysaccharide (LPS/endotoxin) is a potent immunologic stimulant. Many commercial-grade reagents used in research are not screened for LPS contamination. LPS induces a wide spectrum of proinflammatory responses in microglia, the immune cells of the brain. Recent studies have demonstrated that a broad range of endogenous factors including plasma-derived proteins and bioactive phospholipids can also activate microglia. However, few of these studies have reported either the LPS levels found in the preparations used or the effect of LPS inhibitors such as polymyxin B (PMX) on factor-induced responses. Here, we used the Limulus amoebocyte lysate assay to screen a broad range of commercial- and pharmaceutical-grade proteins, peptides, lipids, and inhibitors commonly used in microglia research for contamination with LPS. We then characterized the ability of PMX to alter a representative set of factor-induced microglial activation parameters including surface antigen expression, metabolic activity/proliferation, and NO/cytokine/chemokine release in both the N9 microglial cell line and primary microglia. Significant levels of LPS contamination were detected in a number of commercial-grade plasma/serum- and nonplasma/serum-derived proteins, phospholipids, and synthetic peptide preparations, but not in pharmaceutical-grade recombinant proteins or pharmacological inhibitors. PMX had a significant inhibitory effect on the microglia-activating potential of a number of commercial-, but not pharmaceutical-grade, protein preparations. Novel PMX-resistant responses to ,2 -macroglobulin and albumin were incidentally observed. Our results indicate that LPS is a frequent and significant contaminant in commercial-grade preparations of previously reported microglia-activating factors. Careful attention to LPS levels and appropriate controls are necessary for future studies in the neuroinflammation field. © 2007 Wiley-Liss, Inc. [source]


The nurse,family partnership: An evidence-based preventive intervention

INFANT MENTAL HEALTH JOURNAL, Issue 1 2006
David L. Olds
Pregnancy and the early years of the child's life offer an opportune time to prevent a host of adverse maternal, child, and family outcomes that are important in their own right, but that also reflect biological, behavioral, and social substrates in the child and family that affect family formation and future life trajectories. This article summarizes a 27-year program of research that has attempted to improve early maternal and child health and future life options with prenatal and infancy home visiting by nurses. The program is designed for low-income mothers who have had no previous live births. The home-visiting nurses have three major goals: to improve the outcomes of pregnancy by helping women improve their prenatal health, to improve the child's health and development by helping parents provide more sensitive and competent care of the child, and to improve parental life course by helping parents plan future pregnancies, complete their education, and find work. The program has been tested in three separate large-scale, randomized controlled trials with different populations living in different contexts. Results from these trials indicate that the program has been successful in achieving two of its most important goals: (a) the improvement of parental care of the child as reflected in fewer injuries and ingestions that may be associated with child abuse and neglect and better infant emotional and language development; and (b) the improvement of maternal life course, reflected in fewer subsequent pregnancies, greater work-force participation, and reduced dependence on public assistance and food stamps. The impact on pregnancy outcomes is equivocal. In the first trial, the program also produced long-term effects on the number of arrests, convictions, emergent substance use, and promiscuous sexual activity of 15-year-old children whose nurse-visited mothers were low-income and unmarried when they registered in the study during pregnancy. In general, the impact of the program was greater on those segments of the population at greater risk for the particular outcome domain under examination. Since 1996, the program has been offered for public investment outside of research contexts. Careful attention has been given to ensuring that organizational and community contexts are favorable for development of the program, to providing excellent training and guidance to the nurses in their use of the program's visit-by-visit guidelines, to monitoring the functioning of the program with a comprehensive clinical information system, and to improving the performance of the programs over time with continuous improvement strategies. [source]


Prevalence of storage and voiding symptoms among men aged 40 years and older in a US population-based study: results from the Male Attitudes Regarding Sexual Health study

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 8 2007
D. B. Glasser
Summary Aims:, Lower urinary tract symptoms (LUTS) are categorised as storage (urgency, frequency, nocturia and incontinence), voiding (sensation of incomplete emptying, hesitancy, weak stream and straining) or mixed symptoms. Methods:, In this US population-based study, we investigated the prevalence of male LUTS and the relative frequency of the LUTS subtypes, and we evaluated associations between LUTS and age, race/ethnicity and erectile dysfunction (ED). The Male Attitudes Regarding Sexual Health study included a nationally representative sample of non-Hispanic black, non-Hispanic white and Hispanic men aged , 40 years. Participants completed a questionnaire including items on ED and the International Prostate Symptom Score (IPSS). The prevalence and subtypes of LUTS were investigated post hoc by age, race/ethnicity and the presence of ED. Results:, The overall prevalence rates of storage (13%) and mixed (9%) symptoms were higher than that of voiding symptoms (6%). The prevalence of storage symptoms was similar across age groups, whereas voiding and mixed symptoms increased with age. Among men with IPSS , 8, the rates of storage (29%) and mixed (38%) symptoms were also higher than voiding symptoms (23%). Distributions of the LUTS subtypes were comparable among black, white and Hispanic respondents with IPSS , 8. The overall prevalence rate of ED (40%) increased with age among those with IPSS , 8. Isolated storage symptoms were more than twice as common as isolated voiding symptoms among US men , 40 years of age. Conclusion:, Careful attention to individual symptoms may help distinguish storage LUTS from voiding LUTS, a distinction that has important implications for treatment. [source]


Effect of Nonsteroidal Anti-Inflammatory Drug Use on the Rate of Gastrointestinal Hospitalizations Among People Living in Long-Term Care

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2001
Kate L. Lapane PhD
OBJECTIVES: Gastrointestinal (GI) complications are the most-common serious adverse reactions associated with nonsteroidal anti-inflammatory drugs (NSAIDs). We quantified the effect of specific NSAIDs on the rate of GI hospitalizations among older people living in long-term care. DESIGN: Retrospective cohort study. SETTING: All Medicare/Medicaid certified nursing homes in four states (Maine, Minnesota, New York, and South Dakota). PARTICIPANTS: We identified 125,516 newly admitted residents from a database of all residents (1992,1996) of all Medicare/Medicaid certified nursing homes in four states. Using the federally mandated Minimum Data Set, which includes information on all drugs received (prescription and over-the-counter), we identified patients who received at least one prescription for aspirin (n = 19,101) or NSAIDs (n = 9,777). The control population consisted of all institutionalized persons who did not receive these drugs. MEASUREMENTS: From Health Care Financing Administration inpatient claims, we identified the first hospitalization for GI perforation, ulcer, or hemorrhage that occurred during the year of follow up (ICD9-CM discharge codes: 531,534, 578). Cox proportional hazards models provided adjusted estimates of rate ratios. RESULTS: NSAID exposure increased the GI-event-related hospitalization rate in both men (rate ratios (RR) = 2.64; 95% confidence interval (CI) = 1.17,5.99) and women (RR = 3.23; 95% CI = 1.85,5.65). The rate of GI hospitalizations for both men and women taking sulindac, naproxen, or indomethacin was higher than for nonusers. The risk of GI-event-related hospitalizations was greatest among women exposed to diflunisal (RR = 6.08; 95% CI = 2.27,16.26) or oxaprozin (RR = 6.03; 95% CI = 2.49,14.58). CONCLUSIONS: Despite the high background rate of GI events, most NSAIDs increased the risk of GI hospitalization. Careful attention to choice of agent and dosing is needed in prescribing NSAIDs in this frail, older population. [source]


Deinstitutionalization in Ontario, Canada: Understanding Who Moved When

JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES, Issue 3 2010
Lynn Martin
Abstract The results of deinstitutionalization are well known, but less information is available on the process of deinstitutionalization itself. This study sought to understand the process of deinstitutionalization in Ontario by examining the timing of individuals' transitions to the community and the characteristics of individuals who experienced a change in the timing of their move. Data used were based on census information collected between 2005 and 2008 using the interRAI Intellectual Disability assessment instrument on all persons residing in Ontario's specialized institutions. Analyses of characteristics at baseline by the anticipated transition year revealed the existence of significant differences between the groups. Comparisons of anticipated and actual transition years revealed that about 40% of individuals experienced a change in their transition year. Age, bladder incontinence, and number of medical diagnoses were associated with increased likelihood of moving earlier than anticipated, whereas family contact, presence of a strong and supportive relationship with family, psychiatric diagnoses, destructive behavior, and aggression were associated with higher likelihood of moving later. Careful attention to characteristics and level of need was paid at the onset of the deinstitutionalization planning process; however, the timing of transitions to the community was not "set in stone." In the future, studies should not only examine the individual's outcomes and quality of life in the community, but also should seek to qualitatively describe the individual's and family's experiences of the transition process. This type of information is invaluable for other jurisdictions in which deinstitutionalization is planned or under way. [source]


Characteristics of professional development that effect change in secondary science teachers' classroom practices

JOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 6 2005
Bobby Jeanpierre
We studied the outcome of a professional development opportunity that consisted of 2-week-long resident institutes for teams consisting of a secondary science teacher and two students. The science content of the National Science Foundation (NSF)-funded professional development institute was monarch butterfly ecology. The first institute took place in Minnesota during the summer, and the second in Texas during the fall. Staff scientists provided intense instruction in inquiry, with numerous opportunities for participants to conduct short inquiry-based research projects. Careful attention was paid to introducing each step of the full inquiry process, from asking questions to presenting research findings. All participants conducted independent team full inquiry projects between the two institutes. Project findings show that the number of teachers providing opportunities for their students to conduct full inquiry increased significantly after their participation. A mixed-methodology analysis that included qualitative and quantitative data from numerous sources, and case studies of 20 teachers, revealed that the characteristics of the program that helped teachers successfully translate inquiry to their classrooms were: deep science content and process knowledge with numerous opportunities for practice; the requirement that teachers demonstrate competence in a tangible and assessable way; and providers with high expectations for learning and the capability to facilitate multifaceted inquiry experiences. © 2005 Wiley Periodicals, Inc. [source]


Radiological protection for diagnostic examination of pregnant women

CONGENITAL ANOMALIES, Issue 1 2002
Tomoko Kusama
ABSTRACT, Application of diagnostic X-ray examination to pregnant women is complicated since risks to both mother and embryo/fetus must be considered. Embryos and fetuses are more sensitive to radiation than adults or children. The threshold doses for fetal death, malformations and mental retardation which are deterministic effects, are reported to be 100,200 mGy or higher. The relative risk for childhood cancer due to radiation at an absorbed dose of 10 mGy during embryonic/fetal development has been estimated at 1.4. However, the absorbed dose of the embryo/fetus during X-ray diagnostic examination in which the X-ray beam does not irradiate the embryo/fetus directly such as maternal skull and chest X-ray is extremely low, less than 0.01 mGy. Thus these diagnostic procedures are not a problem from the perspective of radiological protection of the embryo/fetus. However, for pelvic CT scan and barium enema in which the uterus is directly within the X-ray beam, the absorbed doses to the embryo/fetus are about 20,80 mGy and 10,20 mGy, respectively. Therefore, medical staff must pay careful attention to the embryo/fetus in application of these examinations. Pregnant women who were not aware of pregnancy at the time of their diagnostic exposure have great anxiety about radiation from such X-ray examinations. However, fetal doses below 100 mGy should not be considered a reason for terminating a pregnancy. [source]


Parameters governing reproducibility of flow properties of porous monoliths photopatterned within microfluidic channels

ELECTROPHORESIS, Issue 14 2010
Mei He
Abstract We report the patternability as well as the reproducibility and stability of flow resistance of polymer monolithic beds photopatterned within microfluidic channels as a function of initial reagent composition and preparation conditions. 2-Hydroxyethyl methacrylate and ethylene dimethacrylate-based polymer monoliths were selectively photopatterned within microchannels and their flow resistance was evaluated using a photobleaching, TOF linear flow rate measurement method developed in our lab. This measurement technique was found to be significantly more informative for columns formed in microfluidic channels compared with bulk monolith characterization by mercury intrusion porosimetry. 1-Octanol was determined to provide sharp bed edge formation and relatively low flow resistance by photopatterning relative to other porogenic solvents. Compared with literature formulations which did not achieve good flow stability and reproducibility from batch to batch, using 2-hydroxyethyl methacrylate, ethylene dimethacrylate and 1-octanol as porogenic solvents, less than 4% RSD was achieved in flow stability over 7 days for monoliths prepared with 60,80% crosslinker(monomer+crosslinker) ratio. Column-to-column variation of 5% RSD was obtained in this composition range. These results demonstrate that photopatterning of uniform polymer monolithic beds, which is critical for applications in multiplexed microfluidic systems, requires careful attention to the parameters that affect reproducibility, specifically the porogenic solvent choice and the crosslinker to monomer ratio. [source]


Effects of dietary N -acetylcysteine on the oxidative stress induced in tilapia (Oreochromis Niloticus) exposed to a microcystin-producing cyanobacterial water bloom,

ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 8 2009
María Puerto
Abstract Fish can be exposed to toxic cyanobacterial cells in natural waters and fish farms and suffer from oxidative damage. The present study investigates the effects of N-acetylcysteine (NAC), a glutathione (GSH) precursor, on the oxidative stress induced by Microcystis cyanobacterial cells containing microcystins (MCs) in tilapia fish (Oreochromis niloticus). Variation in lipid peroxidation (LPO) levels, carbonyl group content, reduced glutathione to oxidized glutathione ratio (GSH: GSSG), and catalase (Enzyme Commission [EC] 1.11.1.6), superoxide dismutase (SOD; EC 1.15.1.1), glutathione reductase (GR; EC 1.8.1.7), glutathione peroxidase (GPx; EC 1.11.1.9), and glutathione S-transferase (EC 2.5.1.18) activities in liver and kidney of tilapia exposed to a single oral dose of 120 ,g MC-LR (with leucine [L] and arginine [R])/fish and killed in 24 h were investigated in the absence and presence of 20.0, 44.0, and 96.8 mg NAC/fish/d. Results showed a protective role of NAC, depending on the dose and the biomarker considered. The increase in LPO (1.9-and 1.4-fold in liver and kidney, respectively) and the decreased protein content and GSH:GSSG in the liver induced by MCs were recovered mainly by the lower doses of NAC employed. Antioxidant enzyme activities increased (range, 1.4-to 1.7-fold) by MCs also were ameliorated by NAC, although the highest level used induced significant alteration of some enzymatic activities, such as SOD, GPx, and GR. Thus, NAC can be considered to be a useful chemoprotectant that reduces hepatic and renal oxidative stress in the prophylaxis and treatment of MC-related intoxications in fish when careful attention is given to its application dose because of its own pro-oxidant activity, as shown in the present study at 96.8 mg NAC/ fish/d. [source]


Radiological interpretation of the navicular bone

EQUINE VETERINARY EDUCATION, Issue 5 2008
S. Dyson
Summary Acquisition of a sufficient number of high quality radiographic views is an essential prerequisite to accurate radiological interpretation of the navicular bone. This requires appropriate preparation of the foot, careful attention to limb position and to both centring and direction of the x-ray beam, according to hoof capsule conformation. Artefacts are easily created. Potentially significant radiological abnormalities include: entheseiophytes at the proximomedial and proximolateral aspect of the bone; proximal or distal extension of the flexor border of the bone, distal border fragments, 8 or more large and variably shaped distal border radiolucent zones; discrete radiolucent areas in the spongiosa with or without detectable communication with the flexor cortex; new bone at the sagittal ridge; increased thickness of the flexor cortex; sclerosis of the spongiosa; and a bipartite bone. [source]


Aerodynamic shape optimization on overset grids using the adjoint method

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 12 2010
Wei Liao
Abstract This paper deals with the use of the continuous adjoint equation for aerodynamic shape optimization of complex configurations with overset grids methods. While the use of overset grid eases the grid generation process, the non-trivial task of ensuring communication between overlapping grids needs careful attention. This need is effectively addressed by using a practically useful technique known as the implicit hole cutting (IHC) method. The method depends on a simple cell selection process based on the criterion of cell size, and all grid points including interior points and fringe points are treated indiscriminately in the computation of the flow field. This paper demonstrates the simplicity of the IHC method for the adjoint equation. Similar to the flow solver, the adjoint equations are solved on conventional point-matched and overlapped grids within a multi-block framework. Parallel computing with message passing interface is also used to improve the overall efficiency of the optimization process. The method is successfully demonstrated in several two- and a three-dimensional shape optimization cases for both external and internal flow problems. Copyright © 2009 John Wiley & Sons, Ltd. [source]


Exploratory study in tourism: designing an initial, qualitative phase of sequenced, mixed methods research

INTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 5 2010
Peter Mason
Abstract Exploratory studies in the social sciences are being increasingly advocated, particularly in relation to new research themes or when addressing an existing issue from a new perspective. Although exploration is usually the starting point, it is frequently part of a sequence of research stages. However, until recently the actual process of conducting such exploratory research within the leisure and tourism field has received little attention. This is due not just to perceptions that exploration is merely the initial step in a longer research process, but significantly, because there is a lack of guidance on how to conduct such research. This paper argues that when the overall tourism research study involves the use of mixed methods, an initial exploratory stage conducted as part of a sequential research process, requires a systematic approach to achieve a reliable platform for further investigation. The paper shows how and why a systematic research design process in the exploratory stage can enhance the value of studies, when the initial qualitative stage is to be followed by a quantitative phase. Three phases of an exploratory qualitative research design process are identified: preparation, development and refinement. Criteria for assessing the suitability of qualitative data collection techniques are proposed. It is argued that careful attention to the process of designing the initial exploratory qualitative stage constitutes the necessary condition for achieving results that will form a sound basis for the next quantitative sequence of research. Copyright © 2009 John Wiley & Sons, Ltd. [source]


A Multidisciplinary Program for Delivering Primary Care to the Underserved Urban Homebound: Looking Back, Moving Forward

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 8 2006
Kristofer L. Smith BA
The coming decades will see a dramatic rise in the number of homebound adults. These individuals will have multiple medical conditions requiring a team of caregivers to provide adequate care. Home-based primary care (HBPC) programs can coordinate and provide such multidisciplinary care. Traditionally, though, HBPC programs have been small because there has been little institutional support for growth. Three residents developed the Mount Sinai Visiting Doctors (MSVD) program in 1995 to provide multidisciplinary care to homebound patients in East Harlem, New York. Over the past 10 years, the program has grown substantially to 12 primary care providers serving more than 1,000 patients per year. The program has met many of its original goals, such as helping patients to live and die at home, decreasing caregiver burden, creating a home-based primary care training experience, and becoming a research leader. These successes and growth have been the result of careful attention to providing high-quality care, obtaining hospital support through the demonstration of an overall positive cost,benefit profile, and securing departmental and medical school support by shouldering significant teaching responsibilities. The following article will detail the development of the program and the current provision of services. The MSVD experience offers a model of growth for faculty and institutions interested in starting or expanding a HBPC program. [source]


Biotic homogenization: a new research agenda for conservation biogeography

JOURNAL OF BIOGEOGRAPHY, Issue 12 2006
Julian D. Olden
Abstract Aim, Biotic homogenization describes the process by which species invasions and extinctions increase the genetic, taxonomic or functional similarity of two or more biotas over a specified time interval. The study of biotic homogenization is a young and rapidly emerging research area in the budding field of conservation biogeography, and this paper aims to synthesize our current knowledge of this process and advocate a more systematic approach to its investigation. Methods, Based on a comprehensive examination of the primary literature this paper reviews the process of biotic homogenization, including its definition, quantification, underlying ecological mechanisms, environmental drivers, the empirical evidence for different taxonomic groups, and the potential ecological and evolutionary implications. Important gaps in our knowledge are then identified, and areas of new research that show the greatest promise for advancing our current thinking on biotic homogenization are highlighted. Results, Current knowledge of the patterns, mechanisms and implications of biotic homogenization is highly variable across taxonomic groups, but in general is incomplete. Quantitative estimates are almost exclusively limited to freshwater fishes and plants in the United States, and the principal mechanisms and drivers of homogenization remain elusive. To date research has focused on taxonomic homogenization, and genetic and functional homogenization has received inadequate attention. Trends over the past decade, however, suggest that biotic homogenization is emerging as a topic of greater research interest. Main conclusions, My investigation revealed a number of important knowledge gaps and priority research needs in the science of biotic homogenization. Future studies should examine the homogenization process for different community properties (species occurrence and abundance) at multiple spatial and temporal scales, with careful attention paid to the various biological mechanisms (invasions vs. extinctions) and environmental drivers (environmental alteration vs. biotic interactions) involved. Perhaps most importantly, this research should recognize that there are multiple possible outcomes resulting from the accumulation of species invasions and extinctions, including biotic differentiation whereby genetic, taxonomic or functional similarity of biotas decreases over time. [source]


Strategies for enhancing the adoption of school-based prevention programs: Lessons learned from the Blueprints for Violence Prevention replications of the Life Skills Training program

JOURNAL OF COMMUNITY PSYCHOLOGY, Issue 3 2003
Abigail A. Fagan
Widespread implementation of effective programs is unlikely to affect the incidence of violent crime unless there is careful attention given to the quality of implementation, including identification of the problems associated with the process of implementation and strategies for overcoming these obstacles. Here we describe the results of a process evaluation focused on discovering common implementation obstacles faced by schools implementing the Life Skills Training (LST) drug prevention program. The evaluation was conducted by the Center for the Study and Prevention of Violence (CSPV) under the Blueprints for Violence Prevention Initiative in conjunction with the designer of the LST program, Dr. Gilbert Botvin and his dissemination agency, National Health Promotion Associates (NHPA), and was funded by the Office of Juvenile Justice and Delinquency Prevention (OJJDP). This evaluation revealed that the 70 sites involved in the project faced many obstacles when implementing this science-based program in the "real" classroom setting, outside the rigorous controls of a research trial. Nonetheless, the schools were very successful in delivering the program in its entirety and with a high level of fidelity to the program model, and we attribute much of this success to the high level of independent monitoring provided by CSPV, as well as our ongoing efforts to work with schools to identify and overcome problems associated with implementation. © 2003 Wiley Periodicals, Inc. J Comm Psychol 31: 235,253, 2003. [source]


The burgeoning field of statistical phylogeography

JOURNAL OF EVOLUTIONARY BIOLOGY, Issue 1 2004
L. L. Knowles
Abstract In the newly emerging field of statistical phylogeography, consideration of the stochastic nature of genetic processes and explicit reference to theoretical expectations under various models has dramatically transformed how historical processes are studied. Rather than being restricted to ad hoc explanations for observed patterns of genetic variation, assessments about the underlying evolutionary processes are now based on statistical tests of various hypotheses, as well as estimates of the parameters specified by the models. A wide range of demographical and biogeographical processes can be accommodated by these new analytical approaches, providing biologically more realistic models. Because of these advances, statistical phylogeography can provide unprecedented insights about a species' history, including decisive information about the factors that shape patterns of genetic variation, species distributions, and speciation. However, to improve our understanding of such processes, a critical examination and appreciation of the inherent difficulties of historical inference and challenges specific to testing phylogeographical hypotheses are essential. As the field of statistical phylogeography continues to take shape many difficulties have been resolved. Nonetheless, careful attention to the complexities of testing historical hypotheses and further theoretical developments are essential to improving the accuracy of our conclusions about a species' history. [source]


Understanding leadership for cross-cultural knowledge management

JOURNAL OF LEADERSHIP STUDIES, Issue 4 2009
Nhu T. B. Nguyen
This article examines the role of leadership in cross-cultural knowledge management (CCKM) because both knowledge management and cross-cultural management are now regarded as popular topics in both academic and practical research in the age of globalization. We discuss the existing literature on the relationship between leadership and cross-cultural management as well as the relationship between leadership and knowledge management to illustrate the importance of leadership in each field. The concept of cross-cultural knowledge management,an ambiguous term,will be presented from Nguyen, Umemoto, and Medeni's (2007) work, establishing an expanded role of cross-cultural management, which could be viewed as a subset of knowledge management. To emphasize the impact of leadership on CCKM, we discuss the influence of leadership on each factor in the theoretical model of CCKM. Our understanding of the role of leadership in CCKM suggests that international leaders should pay careful attention to managing fragmentation, integration, and differentiation when they want to create and manage the cross-cultural knowledge of their employees. [source]


Review article: recent advances in the management of bleeding gastric varices

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 1 2006
D. TRIPATHI
Summary Gastric variceal bleeding can be challenging to the clinician. Tissue adhesives can control acute bleeding in over 80%, with rebleeding rates of 20,30%, and should be first-line therapy where available. Endoscopic ultrasound can assist in better eradication of varices. The potential risks of damage to equipment and embolic phenomena can be minimized with careful attention to technique. Variceal band ligation is an alternative to tissue adhesives for the management of acute bleeding, but not for secondary prevention due to a higher rate of rebleeding. Endoscopic therapy with human thrombin appears promising, with initial haemostasis rates typically over 90%. The lack of controlled studies for thrombin prevents universal recommendation outside of clinical trials. Balloon occluded retrograde transvenous obliteration is a recent technique for patients with gastrorenal shunts, although its use is limited to clinical trials. Transjugular intrahepatic portosystemic stent shunt is an option for refractory bleeding and secondary prophylaxis, with uncontrolled studies demonstrating initial haemostasis obtained in over 90%, and rebleeding rates of 15,30%. Non-cardioselective , -blockers are an alternative to transjugular intrahepatic portosystemic stent shunt for secondary prophylaxis, although the evidence is limited. Shunt surgery should be considered in well-compensated patients. Splenectomy or embolization is an option in patients with segmental portal hypertension. [source]


Detection of enterotoxigenic Staphylococcus aureus isolates in raw milk cheese

LETTERS IN APPLIED MICROBIOLOGY, Issue 6 2007
P. Cremonesi
Abstract Aim:, To develop an easy, rapid and efficient DNA extraction procedure for Staphylococcus aureus detection with a low number of steps and removing completely the PCR inhibitors, applicable to raw milk cheese samples, and to compare phenotypical and genotypical method to detect Staph. aureus isolates and staphylococcal enterotoxins (SEs) production. Methods and Results:, A total of 33 bovine and caprine raw milk cheese samples were analysed by means of both classic microbiological and molecular techniques. All samples were positive for Staph. aureus contamination. The DNA extraction protocol optimized was found to achieve a detection limit of 100 CFU g,1 for Staph. aureus. None of the samples tested with immunological assays contained SEs but in 14 of 33 samples a mixture of se positive (sea, sec, sed, seg, sel, sej) isolates were identified. Conclusions:,Staphylococcus aureus is a food-borne pathogen mainly detected in finished dairy products. The rapid and efficient detection of Staph. aureus isolates from dairy products is essential for consumer safety. The direct detection of pathogens from food is possible with careful attention to sample preparation and nucleic acid amplification optimization. Significance and Impact of the Study:, This study shows that raw milk cheese samples can be tested for Staph. aureus contamination with a rapid, simple and reproducible procedure. [source]


Sheep blowfly strike risk and management in Great Britain: a survey of current practice

MEDICAL AND VETERINARY ENTOMOLOGY, Issue 4 2008
B. BISDORFF
Abstract The methods used for the control of sheep blowfly strike (ovine cutaneous myiasis) and the farm management factors associated with strike prevalence were examined using data from questionnaire survey returns provided by 966 sheep farmers in Great Britain, based on the period between March 2003 and February 2004. Overall, 91% of participants treated prophylactically with insecticides against blowfly strike; 39% treated twice and 11% treated more than three times in the year. Insect growth regulators (IGRs) were the most commonly chosen product (40%), especially the IGR cyromazine. Only 12% of farmers opted to dip their sheep in organophosphate insecticide against fly strike and 2% of farmers reported applying inappropriate products against strike to their sheep, such as ivermectin or ,drenches'. Farmers worming their ewes more often were 0.8 times less likely to report blowfly strike, but those who wormed their lambs more often were 1.2 times more likely to report strike. Pure-breed flocks were 0.7 times less likely to record an outbreak of blowfly strike than cross-breed flocks. Strike was less likely in ewe flocks grazed at higher altitude; however, this relationship with altitude was not seen in lambs. The results show that insecticides remain the primary tool used by almost all farmers to prevent strike and that the type of insecticides used and means of application have altered dramatically over the past 15 years. However, the prevalence of strike has remained almost unchanged over this period. Clearly careful attention to the type and timing of insecticide application, in association with a detailed understanding of the husbandry factors that predispose sheep to higher strike risk, is essential to allow the optimal management of strike problems. [source]


Falling forward: Lessons learned from critical reflection on an evaluation process with a prisoner reentry program

NEW DIRECTIONS FOR EVALUATION, Issue 127 2010
Barbara Hooper
A formative evaluation of life-skills learning modules with men and women in a residential prisoner reentry program where careful attention was given to voice, power, and engagement, is described and analyzed. The author reflects on the evaluation process through the critical theory lens of "being self-critical can illuminate how practices maintain oppressive conditions." Questions about whose voices remained dominant and whose power was suppressed are discussed. © Wiley Periodicals, Inc., and the American Evaluation Association. [source]


Morphological spectrum of cyclin D1-positive mantle cell lymphoma: Study of 168 cases

PATHOLOGY INTERNATIONAL, Issue 10 2001
Yasushi Yatabe
Immunostaining for cyclin D1 is essential for reliable diagnosis of mantle cell lymphoma (MCL). However, a small number of cyclin D1-positive lymphomas other than MCL have been encountered. Our goal was to investigate the morphological spectrum of MCL as a disease entity, based on cyclin D1 overexpression. We reviewed 181 biopsy specimens obtained from 168 cases of cyclin D1-positive MCL. Typical findings were the presence of nodular (53.9% of cases) or diffuse (46.1%) histological patterns, containing mantle zone patterns (16.8%), naked germinal centers (33.5%) and perivascular hyaline deposition (83.2%). Unusual findings of residual germinal centers with a mantle cuff (four cases) and follicular colonization (two cases) were seen. High magnification showed a monotonous proliferation of tumor cells with cytological diversity including small (3.0%), intermediate (43.1%), medium (34.1%), medium, large (13.2%) and large (6.6%) cells. Pleomorphic and blastic / blastoid variants were encountered in 9.6 and 7.2% of cases, respectively. Three cases had foci of cells of considerable size, with a moderately abundant pale cytoplasm resembling marginal zone B cells. Two cases showed an admixture of cells which appeared transformed and mimicked the histology of chronic lymphocytic leukemia / small lymphocytic leukemia. In one, neoplastic mantle zones were surrounded by sheets of mature plasma cells, resembling the plasma cell type of Castleman's disease. An admixture of areas characteristic of MCL and of other larger cells, indicating histological progression or a composite lymphoma, were observed in seven cases. In high-grade lesions of five cases, nuclear staining of cyclin D1 was rarely detected. In our experience, cyclin D1 expression was also found in nine lymphomas other than MCL (five plasma cell myelomas, three Hodgkin's disease and one anaplastic large cell lymphoma). The application of cyclin D1 staining prompted us to recognize the broad morphological spectrum of MCL. MCL can be diagnosed with the application of cyclin D1 immunostaining, if careful attention is given to architectural and cytological features. [source]


Utilization of hospital and outpatient care for adverse cutaneous reactions to medications

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 10 2005
Robert S. Stern MD
Abstract Purpose To quantify hospitalizations, visits to office based physicians, hospital clinics and emergency departments with primary diagnoses of skin conditions that are often due to drug reaction. Methods I analyzed data from the National Hospital Discharge Summary (1997,2001), National Ambulatory Care Survey (1995,2000) and National Hospital Ambulatory Care Survey (1995,2000) to determine the number of hospitalizations and visits with primary diagnoses of skin conditions that are often attributed to drugs. Using statistical methods for surveys, I determined the demographic characteristics of patients with these diagnoses and compared them with patients seeking care for other reasons. Results In the United States, there are about 5000 hospitalizations each year with a primary diagnosis of erythema multiform, Stevens,Johnson Syndrome or Toxic Epidermal Necrolysis, of which 35% are specifically ascribed to drugs. Annually, there are more than 100,000 outpatient visits for these diagnoses and about two million visits for immediate hypersensitivity reactions that may be due to drugs. Outpatient visits for drug eruptions and drug allergies that include a skin component exceed 500,000 annually. Conclusions Skin conditions often attributed to drugs are frequent reasons for hospitalization and physician visits. Optimal care of the individual patients with these conditions requires careful attention to drugs as a possible cause. Copyright © 2005 John Wiley & Sons, Ltd. [source]


Computer Simulation and the Philosophy of Science

PHILOSOPHY COMPASS (ELECTRONIC), Issue 5 2009
Eric Winsberg
There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have a lot to learn by paying closer attention to the practice of simulation. [source]


Why Freedoms Do Not Exist by Degrees

POLITICAL STUDIES, Issue 2 2002
Matthew H. Kramer
The overall freedom of an individual or a society is something that exists in differing degrees. By contrast, anyone's particular freedom to engage in this or that mode of conduct is something that exists (or does not exist) in an all-or-nothing manner. Many political philosophers have taken a contrary view, however, and have contended that each particular freedom exists to a greater or lesser extent in proportion to the easiness or difficulty of exercising it. This essay argues that the temptation to view particular freedoms as matters of degree can be overcome when careful attention is paid to three distinctions: overall liberty versus particular liberties, the existence of any particular liberty versus the probability of its emergence, and becoming more free to do something versus becoming free to do something in more ways. By properly marking these distinctions, one can readily apprehend that the existence or inexistence of each particular freedom is characterized by no gradations , an insight that improves one's understanding of the necessary and sufficient conditions for the existence of any such freedom. [source]


Anxiety and depression of patients with digestive cancer

PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 5 2005
TOSHIKO MATSUSHITA phd
Abstract This study sought to characterize the psychological status of digestive cancer patients, and to investigate the relationship between psychological characteristics and clinical factors. Subjects were 85 inpatients scheduled to undergo surgery for digestive cancer and 26 control patients. The Japanese versions of Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS) were administered for all subjects before surgery, before discharge, and 6 months after discharge. Changes in HADS and SDS scores across the three examination days for three groups of subjects (advanced-phase, early phase, and control groups) were compared. The mean scores of anxiety and depression were significantly higher in the advanced-phase group than in the other two groups. Examination day showed a significant effect on depression; depression increased from before surgery to before discharge, and did not return to the preoperative level at 6 months after discharge, but no significant effect on anxiety. As for the relationship between psychological trends and clinical factors, anxiety in the ,middle age' and ,chemotherapy' groups was more severe than in the ,elderly' and ,no chemotherapy' groups. Depression in the ,medical treatment equipment', ,chemotherapy', and ,long-term hospitalization' groups was more severe than in the ,no equipment', ,no chemotherapy', and ,standard-term hospitalization' groups. These results suggest that we should pay careful attention to cancer patients undergoing surgery, especially young patients who are constantly at risk of anxiety, and assess their depression taking into account their disease and treatment conditions, especially after the time when their discharge is determined. [source]


The Piccolomini library in Siena Cathedral: a new reading with particular reference to two compartments of the vault decoration

RENAISSANCE STUDIES, Issue 3 2005
Susan J. May
The murals of the Piccolomini Library in Siena Cathedral, featuring episodes from the life of Pope Pius II, are usually discussed as distinctly separate from the vault imagery, predominantly all'antica and mythological scenes. The latter, combined with the centrally-placed, antique statue of The Three Graces, has led some authors to comment on the library's overtly 'pagan' content as shockingly incongruent with its setting in the sacred precincts of the duomo. Little attention is paid to the significance of the stucco relief above the entrance, The Expulsion from Paradise. The article pro-poses that such a prestigious project for so powerful and erudite a patron as Cardinal Francesco Todeschini Piccolomini, and painted by the highly acclaimed artist Pinturicchio, is unlikely to have been devised without careful attention to its iconographical programme. Focussing primarily on the two largest compartments of the vault, it is demonstrated that the four principal figures there should be interpreted as representatives of the four temperaments. By defining their relationship as such to the Expulsion from Paradise relief and to the historical narratives on the walls, this article shows that the mythological scenes in the vault play an allegorical role within the broader scheme and that a coherent programme underpins the entire decoration, with the writings of Saint Augustine and of his fifteenth century followers at its core. [source]


Neural control of shortening and lengthening contractions: influence of task constraints

THE JOURNAL OF PHYSIOLOGY, Issue 24 2008
Jacques Duchateau
Although the performance capabilities of muscle differ during shortening and lengthening contractions, realization of these differences during functional tasks depends on the characteristics of the activation signal discharged from the spinal cord. Fundamentally, the control strategy must differ during the two anisometric contractions due to the lesser force that each motor unit exerts during a shortening contraction and the greater difficulty associated with decreasing force to match a prescribed trajectory during a lengthening contraction. The activation characteristics of motor units during submaximal contractions depend on the details of the task being performed. Indexes of the strategy encoded in the descending command, such as coactivation of antagonist muscles and motor unit synchronization, indicate differences in cortical output for the two types of anisometric contractions. Furthermore, the augmented feedback from peripheral sensory receptors during lengthening contractions appears to be suppressed by centrally and peripherally mediated presynaptic inhibition of Ia afferents, which may also explain the depression of voluntary activation that occurs during maximal lengthening contractions. Although modulation of the activation during shortening and lengthening contractions involves both supraspinal and spinal mechanisms, the association with differences in performance cannot be determined without more careful attention to the details of the task. [source]