Cardiac Electrophysiological Properties (cardiac + electrophysiological_property)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Effects of Sex and Age on Electrocardiographic and Cardiac Electrophysiological Properties in Adults

PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 1 2001
TARESH TANEJA
TANEJA, T., et al.: Effects of Sex, and Age on Electrocardiographic and Cardiac Electrophysiological Properties in Adults. Although differences in patient sex in heart rate and QT interval have been well characterized, sexual differences in other cardiac electrophysiological properties have not been well defined. The study population consisted of 354 consecutive patients without structural heart disease or preexcitation who underwent clinically indicated electrophysiological testing in the drug-free state. Atrial, AV nodal, and ventricular effective refractory periods (AERP, AVNERP, VERP) were determined at a pacing cycle length of 500 ms using an 8-beat drive train and 3-second intertrain pause. There were 124 men and 230 women with a mean age of 45 ± 19 and 47 ± 18 years, respectively The sinus cycle length (SCL) was longer in men than in women (864 ± 186 and 824 ± 172 ms, respectively, P < 0.05). The QRS duration was significantly longer in men (90 ± 12 ms) than women (86 ± 13 ms) (P < 0.005). The HV interval was 48 ± 9 ms in men and 45 ± 8 ms in women (P < 0.05). The sinus node recovery time (SNRT) was significantly longer in men than in women (1215 ± 297 ms and 1135 ± 214 ms, respectively, P < 0.05). AERP and VERP were similar in both sexes. Aging did not influence sexual differences in cardiac electrophysiological properties, although, it independently prolonged the SCL, PR, and QT intervals, AH and HV intervals, SNRT, AVNERP, and the AV Wenckebach cycle length. The SCL, QRS duration, HV interval, and SNRT were significantly longer in men than in women. Aging prolonged cardiac conduction and increased the SCL but the effects were similar in both sexes. AERP and VERP were unaffected by aging or sex. [source]

Acute Effects of Low Doses of Red Wine on Cardiac Conduction and Repolarization in Young Healthy Subjects

ALCOHOLISM, Issue 12 2009
Matteo Cameli
Background:, Moderate to high blood concentrations of ethanol have been shown to yield acute changes in cardiac electrophysiological properties, but the effect of low concentrations have never been assessed. The role of concomitant changes in clinical variables or cardiac dimensions is also still unknown. This study aimed at exploring the acute effects of low doses of ethanol, administered as Italian red wine, on conduction, depolarization, and repolarization electrocardiographic (ECG) intervals in a population of healthy subjects. Methods:, Forty healthy young volunteers drank a low quantity of red wine (5 ml/kg), and an equal volume of fruit juice in separate experiments. Heart rate, P-wave duration, PR interval, QRS duration, QT interval, corrected QT interval, QT dispersion, and corrected QT dispersion were assessed at baseline and after 60 minutes from challenge. Results:, Mean blood ethanol concentration after drinking was 0.48 ± 0.06 g/l. Compared to the control challenge, significant changes after red wine intake were observed in P-wave duration (from 101 ± 11 to 108 ± 14 milliseconds, p = 0.0006), PR interval (from 153 ± 15 to 167 ± 17 milliseconds, p < 0.0001), QT interval (from 346 ± 28 to 361 ± 24 milliseconds, p < 0.0001), and corrected QT interval (from 388 ± 24 to 402 ± 30 milliseconds, p = 0.0006). None of these changes showed correlations with modifications in clinical or echocardiographic variables. In multivariate analyses aimed at exploring predictors of ECG changes, none of the variables entered the final models. Conclusions:, Low doses of red wine acutely slow cardiac conduction and prolong repolarization in normal individuals. These changes are poorly predictable. The potential arrhythmogenic impact of these effects is worthy of exploration. [source]

Effects of Sex and Age on Electrocardiographic and Cardiac Electrophysiological Properties in Adults

PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 1 2001
TARESH TANEJA
TANEJA, T., et al.: Effects of Sex, and Age on Electrocardiographic and Cardiac Electrophysiological Properties in Adults. Although differences in patient sex in heart rate and QT interval have been well characterized, sexual differences in other cardiac electrophysiological properties have not been well defined. The study population consisted of 354 consecutive patients without structural heart disease or preexcitation who underwent clinically indicated electrophysiological testing in the drug-free state. Atrial, AV nodal, and ventricular effective refractory periods (AERP, AVNERP, VERP) were determined at a pacing cycle length of 500 ms using an 8-beat drive train and 3-second intertrain pause. There were 124 men and 230 women with a mean age of 45 ± 19 and 47 ± 18 years, respectively The sinus cycle length (SCL) was longer in men than in women (864 ± 186 and 824 ± 172 ms, respectively, P < 0.05). The QRS duration was significantly longer in men (90 ± 12 ms) than women (86 ± 13 ms) (P < 0.005). The HV interval was 48 ± 9 ms in men and 45 ± 8 ms in women (P < 0.05). The sinus node recovery time (SNRT) was significantly longer in men than in women (1215 ± 297 ms and 1135 ± 214 ms, respectively, P < 0.05). AERP and VERP were similar in both sexes. Aging did not influence sexual differences in cardiac electrophysiological properties, although, it independently prolonged the SCL, PR, and QT intervals, AH and HV intervals, SNRT, AVNERP, and the AV Wenckebach cycle length. The SCL, QRS duration, HV interval, and SNRT were significantly longer in men than in women. Aging prolonged cardiac conduction and increased the SCL but the effects were similar in both sexes. AERP and VERP were unaffected by aging or sex. [source]