Cardia Adenocarcinoma (cardia + adenocarcinoma)

Distribution by Scientific Domains
Distribution within Medical Sciences

Kinds of Cardia Adenocarcinoma

  • gastric cardia adenocarcinoma


  • Selected Abstracts


    Helicobacter pylori Infection may be Implicated in the Topography and Geographic Variation of Upper Gastrointestinal Cancers in the Taihang Mountain High-Risk Region in Northern China

    HELICOBACTER, Issue 5 2010
    Denggui Wen
    Abstract Backgrounds:,Helicobacter pylori infection is prevalent in China. Chronic infection of the bacterial not only causes distal stomach cancer, but also confers risk to gastric cardia adenocarcinoma. Because H. pylori infection is inversely associated with esophageal adenocarcinoma, globally the infection rate is significantly correlated with the ratio of squamous carcinoma to adenocarcinoma of the esophagus. These agree with the topography of upper gastrointestinal cancer observed in the Taihang Mountain high-risk region where both gastric cardia and non-cardia adenocarcinoma coincide with esophageal squamous cancer, but with almost no distal esophageal adenocarcinoma. Moreover, as altitude increases from plain to mountains, we observed progressively increasing incidence rates of gastric adenocarcinomas in recent years in the region. Because H. pylori infection is a definite carcinogen to gastric adenocarcinoma and is more prevalent in the mountain than in plain areas due to undeveloped living conditions, the observation gives the impression as though H. pylori infection is implicated. Aims:, This article aims to note the role of H. pylori infection in upper gastrointestinal cancer in the Taihang Mountain high-risk region in northern China. Materials and Methods:, First the unique topography and geographic variation of upper gastrointestinal cancer in the region is described to indicate a possible role of H. pylori infection, then we review studies on prevalence of H. pylori infection in the high-risk region and describe difference in socioeconomic development and water hygiene between the plains and the mountains as related to the prevalence of H. pylori infection. Results:, Coincidence of gastric cancer in the region and a progressively increasing rate of the cancer from the plain towards the mountains indicate H. pylori infection may be implicated in upper gastrointestinal cancer. Conclusion:, International collaboration is needed to study H. pylori and upper gastrointestinal cancer in the region when rapid industrialization is just beginning. [source]


    Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: Comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression

    JOURNAL OF SURGICAL ONCOLOGY, Issue 2 2002
    Atsushi Kawabe MD
    Abstract Background and Objectives Cyclooxygenase-2 (COX-2) expression may contribute to the synthesis of prostanoids, which have been related to carcinogenesis and tumor progression. It is well known that the gastric remnant is at greater risk of the development of gastric cancer than is the whole stomach; incidence rates for gastric cardia adenocarcinoma are rising in the United States and Europe. Our objective was to determine the involvement of COX-2 in primary and remnant gastric cancer tissues as well as in adjacent noncancerous mucosa. Methods We investigated the expression of COX-2 in 91 human gastric cancer tissue and adjacent noncancerous mucosa samples (40 remnant gastric cancer, 37 gastric cardia cancer, and 14 gastric corpus and antrum cancer), using immunohistochemistry. In addition, p53 expression, Helicobacter pylori infection, and vascular endothelial growth factor in the tissues were evaluated by immunohistochemical staining and compared with COX-2 expression. Results There were no significant differences in clinicopathological data in the gastric cancer tissues. There was a significant relation between the expression of COX-2 and p53 in gastric cancer tissues (P,=,0.0048). However, vascular endothelial growth factor expression and Helicobacter pylori infection showed no correlation with the expression of COX-2. In the case of adjacent noncancerous mucosa, the positive rate of COX-2 expression was significantly higher in the remnant gastric cancers (75.0%) than in the primary gastric cancers (25.5%) (P,<,0.0001). Conclusions This information may help in the analysis of the carcinogenesis of gastric cancer; there is also a possibility that the COX-2 selective inhibitor to the remnant gastric cancer has a chemopreventive effect. J. Surg. Oncol. 2002;80:79,88. © 2002 Wiley-Liss, Inc. [source]


    Occupation and risk of esophageal and gastric cardia adenocarcinoma,

    AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 1 2002
    Lawrence S. Engel PhD
    Abstract Background Adenocarcinomas of the esophagus and gastric cardia have risen dramatically in incidence over the past few decades, however, little research has been conducted on the occupational risk factors for these cancers. Methods In this population-based case-control study, lifetime job histories were compared between cases of esophageal adenocarcinoma (n,=,283), gastric cardia adenocarcinoma (n,=,259), and population controls (n,=,689). Odds ratios (OR) and 95% confidence intervals (CI) for ever employment and by duration in various occupational and industrial categories were calculated using unconditional logistic regression. Results The risk of esophageal adenocarcinoma was elevated for persons ever employed in administrative support (OR,=,1.5; 95%CI,=,1.0,2.1); financial, insurance, and real estate (OR,=,1.6; 95%CI,=,1.0,2.4); and health services (OR,=,2.2; 95%CI,=,1.2,3.9). The risk of gastric cardia adenocarcinoma was increased among transportation workers (OR,=,1.7; 95%CI,=,1.1,2.6), as well as among carpenters (OR,=,1.8; 95%CI,=,0.9,3.9) and workers in the furniture manufacturing industry (OR,=,2.4; 95%CI,=,0.9,6.3). However, we observed few duration,response relations between length of employment in any category and cancer risk. Conclusions This study revealed associations of esophageal adenocarcinoma with employment in administrative support, health services, and a category of financial, insurance, and real estate industries, and of gastric cardia adenocarcinoma with transportation and certain woodworking occupations. Some of these findings may be due to the play of chance associated with the multiple comparisons made in this study. Our results suggest that, overall, workplace exposures play a minor role in the etiology and upward trend of esophageal and gastric cardia adenocarcinomas. Am. J. Ind. Med. 42:11,22, 2002. Published 2002 Wiley-Liss, Inc. [source]


    Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study

    INTERNATIONAL JOURNAL OF CANCER, Issue 7 2007
    Mendez M.A.
    Abstract Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25,70 years completed dietary questionnaires in 1992,98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48,0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22,0.86], but not intestinal type [HR 0.98, 0.54,1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships. © 2007 Wiley-Liss, Inc. [source]


    Occupation and risk of esophageal and gastric cardia adenocarcinoma,

    AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 1 2002
    Lawrence S. Engel PhD
    Abstract Background Adenocarcinomas of the esophagus and gastric cardia have risen dramatically in incidence over the past few decades, however, little research has been conducted on the occupational risk factors for these cancers. Methods In this population-based case-control study, lifetime job histories were compared between cases of esophageal adenocarcinoma (n,=,283), gastric cardia adenocarcinoma (n,=,259), and population controls (n,=,689). Odds ratios (OR) and 95% confidence intervals (CI) for ever employment and by duration in various occupational and industrial categories were calculated using unconditional logistic regression. Results The risk of esophageal adenocarcinoma was elevated for persons ever employed in administrative support (OR,=,1.5; 95%CI,=,1.0,2.1); financial, insurance, and real estate (OR,=,1.6; 95%CI,=,1.0,2.4); and health services (OR,=,2.2; 95%CI,=,1.2,3.9). The risk of gastric cardia adenocarcinoma was increased among transportation workers (OR,=,1.7; 95%CI,=,1.1,2.6), as well as among carpenters (OR,=,1.8; 95%CI,=,0.9,3.9) and workers in the furniture manufacturing industry (OR,=,2.4; 95%CI,=,0.9,6.3). However, we observed few duration,response relations between length of employment in any category and cancer risk. Conclusions This study revealed associations of esophageal adenocarcinoma with employment in administrative support, health services, and a category of financial, insurance, and real estate industries, and of gastric cardia adenocarcinoma with transportation and certain woodworking occupations. Some of these findings may be due to the play of chance associated with the multiple comparisons made in this study. Our results suggest that, overall, workplace exposures play a minor role in the etiology and upward trend of esophageal and gastric cardia adenocarcinomas. Am. J. Ind. Med. 42:11,22, 2002. Published 2002 Wiley-Liss, Inc. [source]


    Recent incidence trends and sociodemographic features of oesophageal and gastric cancer types in an English region

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 8 2009
    C. GAJPERIA
    Aliment Pharmacol Ther,30, 873,880 Summary Background, Oesophageal and gastric cancers comprise various common tumour types with possible different aetiology and historically different incidence trends. Aim, To enhance and update evidence about the descriptive epidemiology of oesophageal and gastric cancers. Methods, Population-based information from the East of England was available on 16 319 (65% male) incident cases of oesophago-gastric cancer (ICD-10 C150,169) diagnosed during 1995,2006. Age-standardized incidence trends by gender and deprivation groups and sex ratios were compared for four different tumour types [oesophageal squamous cell carcinoma (OSCC), oesophageal adenocarcinoma (OAC), junctional/cardia adenocarcinoma (JCA), and non-cardia gastric adenocarcinoma (NCGA)]. Results, Between 1995,1997 and 2004,2006, the age-standardized incidence of OAC and JCA increased slightly (by 4% and 6% in men and 17% and 8% in women respectively), with a sex ratio >4 for both. Conversely, OSCC and NCGA incidence decreased (,20% and ,32% in men and ,15% and ,26% in women respectively), with sex ratio of <2 for both. In men, OSCC and NCGA incidence was associated with increasing deprivation. Conclusions, Within the study context, there was a modest rise in OAC and JCA incidence. OAC and JCA share common incidence trends and sociodemographic features (contrasting with those of OSCC and NCGA cancers). [source]