Cancer Protection (cancer + protection)

Distribution by Scientific Domains
Medical Sciences50%

Selected Abstracts

Ovarian Cancer Protection from Oral Contraceptives Is Greatest with the Lowest Doses of Hormones

PERSPECTIVES ON SEXUAL AND REPRODUCTIVE HEALTH, Issue 3 2007
D. Hollander
No abstract is available for this article. [source]

Tomatoes Beat Lycopene Alone for Prostate Cancer Protection

CA: A CANCER JOURNAL FOR CLINICIANS, Issue 2 2004
Article first published online: 31 DEC 200
No abstract is available for this article. [source]

Anti-aging activity of the Ink4/Arf locus

AGING CELL, Issue 2 2009
Ander Matheu
Summary The proteins encoded by the Ink4/Arf locus, p16Ink4a, p19Arf and p15Ink4b are major tumour suppressors that oppose aberrant mitogenic signals. The expression levels of the locus are progressively increased during aging and genome-wide association studies have linked the locus to a number of aging-associated diseases and frailty in humans. However, direct measurement of the global impact of the Ink4/Arf locus on organismal aging and longevity was lacking. In this work, we have examined the fertility, cancer susceptibility, aging and longevity of mice genetically modified to carry one (Ink4/Arf -tg) or two (Ink4/Arf -tg/tg) intact additional copies of the locus. First, increased gene dosage of Ink4/Arf impairs the production of male germ cells, and in the case of Ink4/Arf -tg/tg mice results in a Sertoli cell-only-like syndrome and a complete absence of sperm. Regarding cancer, there is a lower incidence of aging-associated cancer proportional to the Ink4/Arf gene dosage. Interestingly, increased Ink4/Arf gene dosage resulted in lower scores in aging markers and in extended median longevity. The increased survival was also observed in cancer-free mice indicating that cancer protection and delayed aging are separable activities of the Ink4/Arf locus. In contrast to these results, mice carrying one or two additional copies of the p53 gene (p53 -tg and p53 -tg/tg) had a normal longevity despite their increased cancer protection. We conclude that the Ink4/Arf locus has a global anti-aging effect, probably by favouring quiescence and preventing unnecessary proliferation. [source]