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Broad Approaches (broad + approach)
Selected AbstractsTrait variability and stress: canalization, developmental stability and the need for a broad approachECOLOGY LETTERS, Issue 2 2001Hoffmann Trait variability (particularly fluctuating asymmetry) may provide a general measure of environmental stress applicable across taxa but consistent empirical support is lacking. Historically, stress effects were considered to act independently on trait canalization, developmental noise and trait size. However, in trait comparisons these processes are often assumed to be associated. Here we reconsider this issue and implications for detecting stress effects using trait variability. Published studies that consider multiple environments report little association between the effects of environmental variation on trait canalization and on developmental noise measured as fluctuating asymmetry, sug-gesting that environmental effects often act independently on these processes. To further test the usefulness of trait variability as an indicator of stress, comparisons across environ-ments should take a broad approach and report on several measures of trait variability, rather than focusing on only one index of fluctuating asymmetry as is commonly done. [source] Emerging patterns in the comparative analysis of phylogenetic community structureMOLECULAR ECOLOGY, Issue 4 2009S. M. VAMOSI Abstract The analysis of the phylogenetic structure of communities can help reveal contemporary ecological interactions, as well as link community ecology with biogeography and the study of character evolution. The number of studies employing this broad approach has increased to the point where comparison of their results can now be used to highlight successes and deficiencies in the approach, and to detect emerging patterns in community organization. We review studies of the phylogenetic structure of communities of different major taxa and trophic levels, across different spatial and phylogenetic scales, and using different metrics and null models. Twenty-three of 39 studies (59%) find evidence for phylogenetic clustering in contemporary communities, but terrestrial and/or plant systems are heavily over-represented among published studies. Experimental investigations, although uncommon at present, hold promise for unravelling mechanisms underlying the phylogenetic community structure patterns observed in community surveys. We discuss the relationship between metrics of phylogenetic clustering and tree balance and explore the various emerging biases in taxonomy and pitfalls of scale. Finally, we look beyond one-dimensional metrics of phylogenetic structure towards multivariate descriptors that better capture the variety of ecological behaviours likely to be exhibited in communities of species with hundreds of millions of years of independent evolution. [source] Bayesian Optimal Designs for Phase I Clinical TrialsBIOMETRICS, Issue 3 2003Linda M. Haines Summary. A broad approach to the design of Phase I clinical trials for the efficient estimation of the maximum tolerated dose is presented. The method is rooted in formal optimal design theory and involves the construction of constrained Bayesian c - and D -optimal designs. The imposed constraint incorporates the optimal design points and their weights and ensures that the probability that an administered dose exceeds the maximum acceptable dose is low. Results relating to these constrained designs for log doses on the real line are described and the associated equivalence theorem is given. The ideas are extended to more practical situations, specifically to those involving discrete doses. In particular, a Bayesian sequential optimal design scheme comprising a pilot study on a small number of patients followed by the allocation of patients to doses one at a time is developed and its properties explored by simulation. [source] Examining the Potential of Indigenous Institutions for Development: A Perspective from Borana, EthiopiaDEVELOPMENT AND CHANGE, Issue 2 2003Elizabeth E. Watson This article examines an institutional approach to development in which indigenous institutions are viewed as a resource for achieving development. It concentrates on indigenous natural resource management (NRM) institutions which have been seen by some development agencies to be a means to address the needs of people and the environment in a way that is also participatory. Using material from Borana, Ethiopia, the article describes the indigenous NRM institutions and examines the outcome of one attempt to work with them. In the process, it shows that partnerships between development agencies and indigenous NRM institutions are often fragile, and tend to dissolve when they fail to meet the preconceptions of the developers. Through an examination of this approach to development, the article also examines the usefulness of recent broad approaches to institutions. [source] Best Practices to Reduce Migration PressuresINTERNATIONAL MIGRATION, Issue 3 2002Philip Martin Are there best practices to foster economic development, reduce population growth, and protect the environment in source countries of unauthorized migration, in a manner that reduces emigration pressures and redirects migration towards legal channels? This paper outlines cooperative actions that can be undertaken by both source and receiving countries to better manage the movements of people over national borders. There are two broad approaches to foster wanted migration and to reduce unwanted migration. First, maximize migration's payoffs by ensuring that the 3 Rs of recruitment, remittances, and returns foster economic and job growth in emigration areas. Second, make emigration unnecessary by adapting trade, investment and aid policies, and programmes that accelerate economic development and thus make it unnecessary for people to emigrate for jobs and wages. Most of the changes needed for stay,at,home development must occur in emigration areas, but immigration areas can cooperate in the management of immigration, guest workers, and students, as well as in promoting freer trade and investment, and in targeting aid funds. In a globalizing world, selective immigration policies may have important development impacts, as with immigration country policies toward students, and workers in particular occupations, such as nurses and computer programmers, as well as with mutual recognition of occupational licenses and professional credentials. Trade policies affecting migration are also important, such as trade in services and laws regulating contracts between firms in different countries that allow the entry of lower wage workers as part of the contract. opening channels for legal migration can deter irregular migration. [source] Dispute resolution in federal systemsINTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 167 2001Michael Crommelin This article deals selectively with four broad approaches to conflict management in federal systems of government: formal dispute resolution,informal dispute resolution, dispute avoidance, and popular dispute resolution. Courts undertake the task of formal dispute resolution through judicial review: issues of current significance include judicial concepts of federalism, the reference jurisdiction, Scottish devolution, and supranational federalism and the European Court of Justice. Examples of informal dispute resolution are few. The South African Constitution includes a provision, requiring parties to an intergovernmental dispute to exhaust all other remedies before resorting to litigation. The dispute resolution process contained in chapter 20 of the North American Free Trade Agreement may stimulate experimentation with similar models in federal systems. Dispute avoidance techniques are many and varied; they include the drafting of constitutional instruments and the use of intergovernmental forums within and outside the constitutional framework. The electoral process may be employed in federal systems to determine the fate of governments, specific legislative measures and proposed constitutional amendments. Each federal society has its own culture of conflict management, which exerts a subtle but significant influence on the operation of, and the relationship among, dispute resolution systems. [source] MORE THAN ONE WAY TO STUDY A BUILDING: APPROACHES TO PREHISTORIC HOUSEHOLD AND SETTLEMENT SPACEOXFORD JOURNAL OF ARCHAEOLOGY, Issue 3 2006MARION CUTTING Summary. This article reviews a number of research methodologies used to record household and settlement architecture and assesses their value in the investigation of the human use of prehistoric built space. It exemplifies, through case studies, five broad approaches to, and research techniques associated with, the investigation of such architecture. These approaches are: architectural form; the spatial distribution of activities; continuity and standardization; the relationship between built and non-built space; and human patterns of movement. Then, drawing mainly on Near Eastern, and particularly Anatolian, material, it shows how a sixth approach, the use of ethnographic observation and analogy, provides insights into functional and seasonal variations in spatial use, patterns of movement and social organization. It identifies seven categories of data collection and nine observations drawn from the ethnographic material which together provide an investigative and interpretative framework for the study of early farming communities in the Near East and elsewhere. [source] Understanding how advance care planning is approached in the residential aged care setting: A continuum model of practice as an explanatory deviceAUSTRALASIAN JOURNAL ON AGEING, Issue 4 2009Christopher Shanley Objective:, To gain an understanding of how advance care planning (ACP) is understood and approached by managers of residential aged care facilities. Methods:, Qualitative interviews with managers from 41 residential aged care facilities from South Western Sydney, Australia. Content and thematic analysis of interview transcripts. Results:, The majority of facilities do not have a systematic approach to ACP, but tend to initiate discussions about end-of-life treatments late in a resident's illness. There are varying degrees to which these discussions are used in ongoing care planning or made explicit if the resident is transferred to hospital. A number of factors are identified that support the implementation of ACP. Conclusion:, A continuum model of practice is proposed that describes four broad approaches to practice under the domains of initiation, scope, follow-up and documentation of ACP as well as the organisational leadership adopted around ACP. [source] Approaches and perspectives in social and environmental accounting: an overview of the conceptual landscapeBUSINESS STRATEGY AND THE ENVIRONMENT, Issue 2 2006Judy Brown Abstract In recent years there has been a marked resurgence of interest in the areas of corporate social responsibility (CSR) and social and environmental accounting (SEA) among business, governments, public policymakers, investors, unions, environmentalists and others. While at one level there appears to be widespread agreement that CSR and SEA are worthy topics of attention, different groups have very different understandings of these fields. This article provides an analysis of these differences by comparing three broad approaches to SEA: the business case, stakeholder-accountability and critical theory approaches. It also responds to concerns a number of commentators have expressed regarding the current dominance of ,business case' perspectives. While not seeking to impose on readers a ,correct' way of viewing SEA and CSR, exposure to competing perspectives is viewed as one way of challenging us to think more reflectively about the frames available to us and their implications for the social realities we construct, embed or seek to change. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment. [source] Proceedings of the Australian Physiological and Pharmacological Society Symposium: New Frontiers in Muscle Research Gene transfer: manipulating and monitoring function in cells and tissuesCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 8 2001Rekha G Panchal SUMMARY 1. The ectopic expression of genes has proven to be an extremely valuable tool for biologists. The most widely used systems involve electrically or chemically mediated transfer of genes to immortalized cell lines and, at the other end of the spectrum, transgenic animal models. As would be expected, there are compromises to be made when using either of these broad approaches. Immortalized cell lines have limited ,physiological relevance' and transgenic approaches are costly and out of the reach of many laboratories. There is also significant time required for the de novo generation of a transgenic animal. 2. As a viable alternative to these approaches, we describe the use of recombinant adenovirus and Sindbis virus to deliver genes to cells and tissues. 3. We exemplify this approach with studies from our laboratories: (i) an investigation of Ca2+ handling deficits in cardiac myocytes of hypertrophied hearts using infection with recombinant adenovirus encoding either green fluorescent protein (GFP) or the sarcoplasmic/endoplasmic reticulum calcium-ATPase (Serca2a); (ii) a study of the mechanism of macrophage/microglial migration by infection of embryonic phagocytes with a GFP-encoding virus and coculture with brain slices to then track the movement of labelled cells; and (iii) we are also exploiting the natural tropism of the Sindbis virus to label neurons in hippocampal brain slices in culture to resolve high-resolution structure and to map neuronal connectivity. 4. Further development of these approaches should open new avenues of investigation for the study of physiology in a range of cells and tissues. [source] | ||||||||||||||||