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Breast Metastasis (breast + metastasis)
Selected AbstractsBreast metastasis from prostate cancer and interpretation of immunoreactivity to prostate-specific antigenINTERNATIONAL JOURNAL OF UROLOGY, Issue 4 2006CHI-WAI CHENG Abstract, A case of prostate cancer metastasized to the breast is presented, the latter being prostate-specific antigen (PSA) positive. This is the first of such cases reported in Hong Kong and China in the English literature. As PSA expression also can be found in primary breast cancer, prostatic acid phosphatase staining was employed to confirm the diagnosis. The relationship of PSA and non-prostatic tissues is reviewed. The differential diagnosis of breast enlargement in patients known to have prostate malignancy also is discussed. [source] Metastatic osteosarcoma to the breast: A rare caseJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (ELECTRONIC), Issue 4 2010Sabas Carlos Vieira Abstract Osteosarcoma is the most common malignant bone neoplasia and metastasizes mainly to the lung. Breast metastasis is an extremely rare event and poorly reported in the literature. We present a case of a 51-year-old patient, with a past surgical history of thigh osteosarcoma presented metastasis to the right breast and lung. She underwent the metastasis resection and later abandoned the treatment. Metastasis of osteosarcoma to the breast is an extremely rare event, but this diagnosis should be considered when meeting patients with a large breast nodule and a past history of osteosarcoma. [source] Embryonic transcription factors in human breast cancerIUBMB LIFE, Issue 3 2006Karoline J. Briegel Abstract Growing evidence suggests that breast cancer cells often reactivate latent developmental programs in order to efficiently execute the multi-step process of tumorigenesis. This review focuses on key transcriptional regulators of embryonic development that are deregulated in breast cancer and discusses the molecular mechanisms by which these proteins control carcinogenesis. Reminiscent of their function during development, embryonic transcription factors regulate changes in gene expression that promote tumor cell growth, cell survival and motility, as well as a morphogenetic process called epithelial-mesenchymal transition (EMT), which is implicated in both breast metastasis and tumor recurrence. Because of their pivotal roles in breast tumor progression, these factors represent valuable new biomarkers for breast cancer detection as well as promising new targets for anti-invasive drugs. IUBMB Life, 58: 123-132, 2006 [source] Secondary breast cancer: a 5-year population-based study with review of the literatureAPMIS, Issue 10 2009TOR AUDUN KLINGEN Secondary tumours in the breast are rare. Based on literature, an incidence of 0.4,2% is reported. In this population-based study, secondary breast tumours from a 5-year period (2001,2005), not including metastasis from contralateral breast carcinoma, were reviewed (Vestfold County, Norway). A total of 722 patients with breast malignancies were found in this population (89.3% from Vestfold County Hospital). Ten of these, approximately 1.4%, were metastatic tumours, representing four cutaneous melanomas, three pulmonary carcinomas and three malignant lymphomas. The tumours were often solitary, palpable and close to the skin. Radiologically, the lesions mostly resembled primary carcinomas by mammography and ultrasound, which differs from other studies. Comparison with a known primary tumour and use of immunohistochemical profiling is of crucial importance. Melanoma markers (Melan-A, HMB-45, S-100 protein), lung cancer markers (Cytokeratins, TTF1, Chromogranin, Synapthophysin) and lymphoid markers (CD3, CD20) usually help to confirm a secondary breast tumour diagnosis. This approach is especially indicated in diffusely growing tumours with lack of glandular structure and high-grade cytological features, and staining for ER and GCDFP15 may be helpful. Thus, the diagnosis of a breast metastasis may be suspected by careful mammography and ultrasound imaging, although some cases have atypical radiological features, and histological examination might be necessary to ensure a correct diagnosis and appropriate treatment. [source] | ||||||||||