Bright Spots (bright + spot)

Distribution by Scientific Domains

Selected Abstracts

The Annual Meeting: A Bright Spot in 2009

Craig D. Newgard MD
No abstract is available for this article. [source]

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

Gabriela Bomfim Ferreira
Abstract Dendritic cells (DC) have always been present on the bright spot of immune research. They have been extensively studied for the last 35 years, and much is known about their different phenotypes, stimulatory capacity, and role in the immune system. During the last 15 years, great attention has been given to studies on global gene and protein expression profiles during the differentiation and maturation processes of these cells. It is well understood that studying the proteome, together with information on the role of protein post-translational modifications (PTM), will reveal the real dynamics of a living cell. The rapid increase of proteomic studies during the last decade describing the differentiation and maturation process in DCs, as well as modifications brought by the use of different compounds that either increase or decrease their immunogenicity, reflects the importance of understanding the molecular processes behind the functional properties of these cells. In the present review, we will give an overview of proteomic studies focusing on DCs. Thereby we will concentrate on the importance of these studies in understanding DC behavior from a molecular point of view and how these findings have aided in understanding the differences in functional properties of these cells. [source]

Effect of convergent beam semiangle on image intensity in HAADF STEM images

Koji Kuramochi
In this study, we experimentally and theoretically show that the intensities of bright spots in a spherical aberration (Cs)-uncorrected high-angle annular dark-field (HAADF) scanning transmission electron microscope (STEM) image of [011]-oriented Co3O4, which has two different numbers of Co atoms in the projected atomic columns, are reversed with increasing sample thickness. However, Cs -corrected HAADF STEM images produce intensities that correctly depend on the average number of atoms in the projected atomic columns. From an analysis based on the Bloch-wave theorem, it is found that an insufficient semiangle of the incident convergent beam yields intensities that do not depend on the average atomic number in the atomic columns. [source]

Double-helix structure in multiwall boron nitride nanotubes

Ayten Celik-Aktas
A new nanotube structural form is reported that resembles a double helix in multiwall boron nitride nanotubes (MW-BNNT) grown by a carbon-free chemical-vapor-deposition process as documented by evidence obtained by transmission electron diffraction and microscopy. The double-helix structure is found in MW-BNNTs exhibiting the same chirality in its different walls. The MW-BNNTs deviate from the structure of ideal nested coaxial cylindrical tubes. Most significantly, bright- and dark-field electron imaging reveals regular zigzag dark and bright spots on the side walls of the nanotubes. The repeating distance between the bright, or dark, spots is related to the chiral angle of the nanotube. Electron diffraction patterns recorded from individual nanotubes show additional diffraction spots belonging to the ,201, zone axes, which are not allowed in a perfectly cylindrical nanotube. These additional diffraction spots become asymmetrical as smaller sections of the nanotube are probed. A series of diffraction patterns recorded along the tube axis showed that the imperfections giving rise to these spots move in a regular fashion around the circumference of the tube. It is shown that all experimental evidence supports the structure model of two helices; one is polygonal in cross section and highly crystalline and the other is circular and less ordered. It is further suggested that the double-helix structure is a result of stronger wall,wall interactions associated with the ionic bonding in boron nitride. [source]

A catalogue of stars suspected of bright active regions

M. Zboril
Abstract We present a catalogue of field stars across the HR diagram suspected of bright active regions in their atmospheres. We aim at developing the first version of a database of active stars with bright regions (bright spots). Using a variety of databases and the internet we found and gathered all relevant archival data starting about 1973 and being important for developing such a catalogue. We found that the phenomenon starspot is now common to a variety of spectral type and luminosity classes. Our primary goal was to identify active solar and late type stars suspicious of bright active regions but the search offers expanded results including young T Tauri stars, eclipsing binaries with equal or mixed spectral types components (Algols,WUMa stars) and in some cases other types of objects. Moreover, the light curves analyses for eclipsing binaries offer reliable estimates for spot properties and it was found that 20% of binaries in the catalogue had a spot located near the L point (neck zone). At present, the catalogue consists of 134 stars and overall characteristics for them are organised in several files in ASCII format. The catalogue is electronically available ( 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]

Gas seeps linked to salt structures in the Central Adriatic Sea

BASIN RESEARCH, Issue 4 2008
Riccardo Geletti
ABSTRACT The analyses of about 800 km of Chirp sub-bottom profilers and 600 km2 of Multibeam data acquired during the 2005 and 2007 surveys of the R/V OGS Explora, and their correlation with one new, and several public, multichannel seismic profiles, allow us to propose a relation between the distribution of gas seepages, fracture systems and deep salt features present in the Central Adriatic Sea. Gas seepage is evident from pockmarks on the seabed and in the shallow sub-bottom, where acoustic chimneys and bright spots have been highlighted and analyzed. The Mid-Adriatic Depression (MAD) is a distinct morphological feature in the Central Adriatic Sea elongated in a NE,SW direction. The area is affected by salt doming of Triassic evaporites which cause the two main alignments of the Mid-Adriatic Ridge as far as the Palagruza High and the Jabuka Ridge. These salt tectonics have existed since, at least, Paleogene times and are still active: they characterize sectors with less resistance to deformation produced by successive regional compressive regimes that have affected the area differently during the different geodynamic phases. Gas-seep features are distributed preferentially above and along the fracture systems produced above and around the salt mounds. [source]

Drusen in adaptive optics and SD-OCT

Purpose The study objective was to explore the microscopic structure of soft macular drusen and surrounding retinal areas using an adaptive optics (AO) camera and to compare the findings to those from standard clinical examinations. Methods 18 patients of age between 65 and 85 and presenting soft macular drusen were recruited after aninitial scanning laser ophthalmoscope (SLO) examination. We used an AO flood-illumination system to acquire high-resolution images of selected drusen areas. Every acquisition provided a series of 20 consecutive reflectance images, out of which 10 were numerically averaged to produce an enhanced final image. The resulting AO images were analyzed in comparison with conventional infrared and autofluorescence fundus images and spectral optical coherence tomography scans. Results The soft drusen were visible in AO images as generally round areas delimited by a peripheral low-reflectance line. Hyper reflective spots of size comprised between 2 and 15 ,m were observed in many drusen inner areas. These bright spots were sometimes isolated, sometimes grouped into tight aggregates of 2 to 40 components. Cone photoreceptors were visible in areas between drusen in most AO images. Conclusion The microscopic structures observed in the AO images of soft drusen presents analogies with their described anatomopathologic characteristics, which could not be identified using other in vivo imaging techniques. AO technology could help to refine the clinical classification of macular drusen and obtain deeper insight in their link with the development of different types of advanced AMD. Author Disclosure Information: N. Massamba, None; B. Lamory, Imagine Eyes, G. Soubrane, None. [source]