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Boswellic Acid (boswellic + acid)
Selected AbstractsAn Efficient Method for the Large-Scale Preparation of 3- O -Acetyl-11-oxo-,-boswellic Acid and Other Boswellic AcidsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 24 2003Johann Jauch Abstract 3- O -Acetyl-11-oxo-,-boswellic acid (AKBA), found in incense, is a potent inhibitor of 5-lipoxygenase, p38 and p42 MAP kinase and topoisomerases. Starting from crude extracts from incense, procedures are presented for the efficient large-scale synthesis of AKBA and other boswellic acids (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) [source] Recent developments in anti-inflammatory natural productsMEDICINAL RESEARCH REVIEWS, Issue 5 2009Raju Gautam Abstract Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure,activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed. © 2009 Wiley Periodicals, Inc. Med Res Rev, 29, No. 5, 767,820, 2009 [source] High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.PHYTOCHEMICAL ANALYSIS, Issue 6 2001K. Krohn Abstract A rapid and simple high-performance thin layer chromatographic (HPTLC) method was developed for the simultaneous quantitative estimation of the biologically active triterpenoids ,-boswellic acid, 3- O -acetyl-,-boswellic acid, 11-keto-,-boswellic acid and 3- O -acetyl-11-keto-,-boswellic acid from the gum resin of Boswellia serrata. The assay combines the isolation and separation of boswellic acid derivatives on silica gel 60F254 -HPTLC plates with spot visualisation and scanning at 250,nm. Methanol was found to be the most appropriate solvent for the exhaustive extraction of boswellic acid derivatives. Copyright © 2001 John Wiley & Sons, Ltd. [source] An Efficient Method for the Large-Scale Preparation of 3- O -Acetyl-11-oxo-,-boswellic Acid and Other Boswellic AcidsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 24 2003Johann Jauch Abstract 3- O -Acetyl-11-oxo-,-boswellic acid (AKBA), found in incense, is a potent inhibitor of 5-lipoxygenase, p38 and p42 MAP kinase and topoisomerases. Starting from crude extracts from incense, procedures are presented for the efficient large-scale synthesis of AKBA and other boswellic acids (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) [source] Structural analysis of 3-,-acetyl-20(29)-lupene-24-oic acid, a novel pentacyclic triterpene isolated from the gum resin of Boswellia serrata, by NMR spectroscopyMAGNETIC RESONANCE IN CHEMISTRY, Issue 8 2003Klaus Belsner Abstract 3,-Acetyl-20(29)-lupene-24-oic acid (1) was isolated from the gum resin of Boswellia serrata. Its presence evidently suggests, that the oxidosqualene triterpene pathway of Boswellia serrata closely resembles the biosynthetic route already found in other plants. Complete 1H and 13C spectral assignments were derived from 1D and 2D NMR spectra. This is the first compound with the lupene backbone combining a 3,-hydroxy or 3,-acetyl group with the 24-carboxyl group, a configuration which is typical of the classical boswellic acids. Copyright © 2003 John Wiley & Sons, Ltd. [source] | ||||||||||