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Biomimetic Process (biomimetic + process)
Selected AbstractsMineral-Coated Polymer Microspheres for Controlled Protein Binding and ReleaseADVANCED MATERIALS, Issue 19 2009Leenaporn Jongpaiboonkit Polymer microspheres with a bone-like mineral coatings are generated via a biomimetic process, and this biodegradable coating is used as a carrier for delivery of biological molecules. Acidic and basic proteins are controllably bound and released from these microspheres, suggesting that this approach can be used for binding and delivery of a broad range of biologically active molecules. [source] Composite coating of bonelike apatite particles and collagen fibers on poly L-lactic acid formed through an accelerated biomimetic coprecipitation processJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 2 2006Yun Chen Abstract Collagen and apatite were coprecipitated as a composite coating on poly L-lactic acid (PLLA) in an accelerated biomimetic process. The incubation solution contained collagen (1 g/L) and simulated body fluid with 5 times inorganic ionic concentrations as human blood plasma. The coating formed on PLLA films and scaffolds after a 24-h incubation was characterized by using energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM). It was shown that the coating contained carbonated bonelike apatite and collagen, which was similar in composition to natural bone. SEM showed a complex composite coating of submicron bonelike apatite particulates combined with collagen fibrils. It is expected that such biocomposite coating may better facilitate cell interaction and osteoconductivity. This work provided an efficient process to obtain bonelike apatite/collagen composite coating, which is potentially useful in bone tissue engineering. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006 [source] Micropattern formation of apatite by combination of a biomimetic process and transcription of resist patternJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 4 2002Naoshi Ozawa Abstract Two kinds of methods combining a biomimetic process and transcription of resist pattern were conducted to form an apatite micropattern. For method 1, apatite nuclei were formed on a resist pattern printed substrate by setting it in contact with CaO-SiO2 -based glass in a simulated body fluid (SBF) with inorganic ion concentrations nearly equal to those of human blood plasma. Next, apatite was grown from the nuclei by soaking the substrate in an aqueous solution with ion concentrations 1.5 times those of SBF (1.5 SBF). Then, the resist material was dissolved off by organic solvent with the apatite just formed on it. Apatite micropattern transcribing the resist pattern was obtained. For method 2, apatite nuclei were formed on a resist pattern printed substrate by setting it in contact with CaO-SiO2 -based glass in SBF. Next, the resist material was dissolved off with the apatite nuclei just formed on it. Then, the substrate was soaked in 1.5 SBF to grow the remaining nuclei and an apatite micropattern transcribing the resist pattern was obtained. For both methods, minute apatite patterns with various shapes as straight lines, bending lines, and blocks were clearly formed. The minimum line width of the obtained pattern was 2 ,m. These methods are promising for producing multifunctional materials with bioaffinity. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 62: 579,586, 2002 [source] Osseointegration of titanium alloy and HA-coated implants in healthy and ovariectomized animals: a histomorphometric studyCLINICAL ORAL IMPLANTS RESEARCH, Issue 11 2009Guaracilei Maciel Vidigal Jr Abstract Objectives: The objective of the present study is to evaluate the response to dental implants in healthy and osteoporotic bone. Materials and methods: Ten ovariectomized (OVX) New Zealand rabbits submitted to a hypocalcic diet and 10 sham-aged rabbits were used. All animals were submitted to bone mineral density (BMD) measurements before ovariectomy, and also 4 months afterwards, using dual energy X-ray absorptiometry. The BMD measurements showed a significant loss of bone mass, between the first and second examinations, only in the experimental group (P<0.05). After the bone mass loss induction period, three different implants were installed in the proximal tibia metaphisis of each animal: a titanium alloy implant (Ti), a plasma-spray hydroxyapatite-coated implant (HA-PS), and another implant coated with hydroxyapatite with the biomimetic process (HA-B). Results: After 3 months, histomorphometry showed a bone-to-implant contact (BIC) for Ti implants of 73.09±13.74% in healthy and 66.09±30.01% in OVX animals. The BIC for the HA-PS was 64.83±15.65% and 90.17±8.14% for healthy and OVX animals, respectively, and 88.66±5.30% and 87.96±10.71% for the HA-B implants placed in the same conditions. The differences between the implants in healthy and OVX conditions were not statistically significant (P>0.05). The only significant difference within groups was observed in the healthy animals between HA-B and Ti implants (P<0.06). Conclusion: Within the parameters used in this animal model it was not possible to observe BIC differences between osteoporotic and healthy animals. [source] | ||||||||||